| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Ahrén, Giovanni Pacini, David Wynick, Nils Wierup, Frank Sundle. Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15044363. |
during an iv glucose tolerance test, galanin ko mice had impaired glucose disposal (p = 0.005) due to a reduced insulin response (p < 0.001) and a reduced insulin-independent glucose elimination (glucose effectiveness; p = 0.040). |
2004-07-14 |
2023-08-12 |
mouse |
| Bo Ahrén, Giovanni Pacini, David Wynick, Nils Wierup, Frank Sundle. Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15044363. |
insulin sensitivity, as judged by a euglycemic, hyperinsulinemic clamp technique, was slightly increased in galanin ko mice (p = 0.032). |
2004-07-14 |
2023-08-12 |
mouse |
| Bo Ahrén, Giovanni Pacini, David Wynick, Nils Wierup, Frank Sundle. Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice. Endocrinology. vol 145. issue 7. 2004-07-14. PMID:15044363. |
we conclude that 1) galanin may contribute to sympathetic influences inhibiting insulin secretion in mice, and 2) galanin ko mice have a reduced glucose-induced insulin secretion. |
2004-07-14 |
2023-08-12 |
mouse |
| Martin Haluzik, Oksana Gavrilova, Derek LeRoit. Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies. Endocrinology. vol 145. issue 4. 2004-04-16. PMID:14670996. |
the aim of this study was to clarify the role of ppar-alpha in the development of insulin resistance using ppar-alpha knockout (ko) mice and wild-type controls (wt). |
2004-04-16 |
2023-08-12 |
mouse |
| Martin Haluzik, Oksana Gavrilova, Derek LeRoit. Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies. Endocrinology. vol 145. issue 4. 2004-04-16. PMID:14670996. |
both wt and ppar-alpha ko mice on hfd gained significantly more weight relative to chow-fed groups and displayed an increase in insulin levels and a decrease in adiponectin levels. |
2004-04-16 |
2023-08-12 |
mouse |
| Martin Haluzik, Oksana Gavrilova, Derek LeRoit. Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies. Endocrinology. vol 145. issue 4. 2004-04-16. PMID:14670996. |
suppression of endogenous glucose production during the clamp was markedly blunted in both wt and ppar-alpha ko hfd-fed mice, indicating liver insulin resistance. |
2004-04-16 |
2023-08-12 |
mouse |
| Martin Haluzik, Oksana Gavrilova, Derek LeRoit. Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies. Endocrinology. vol 145. issue 4. 2004-04-16. PMID:14670996. |
the magnitude of hfd-induced changes in the clamp parameters of insulin sensitivity was comparable in ppar-alpha ko and wt mice. |
2004-04-16 |
2023-08-12 |
mouse |
| Jason K Kim, Ruth E Gimeno, Takamasa Higashimori, Hyo-Jeong Kim, Hyejeong Choi, Sandhya Punreddy, Robin L Mozell, Guo Tan, Alain Stricker-Krongrad, David J Hirsch, Jonathan J Fillmore, Zhen-Xiang Liu, Jianying Dong, Gary Cline, Andreas Stahl, Harvey F Lodish, Gerald I Shulma. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. The Journal of clinical investigation. vol 113. issue 5. 2004-04-13. PMID:14991074. |
to investigate the role of fatp1 in glucose homeostasis and in the pathogenesis of insulin resistance, we examined the effect of acute lipid infusion or chronic high-fat feeding on insulin action in fatp1 ko mice. |
2004-04-13 |
2023-08-12 |
mouse |
| Jason K Kim, Ruth E Gimeno, Takamasa Higashimori, Hyo-Jeong Kim, Hyejeong Choi, Sandhya Punreddy, Robin L Mozell, Guo Tan, Alain Stricker-Krongrad, David J Hirsch, Jonathan J Fillmore, Zhen-Xiang Liu, Jianying Dong, Gary Cline, Andreas Stahl, Harvey F Lodish, Gerald I Shulma. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. The Journal of clinical investigation. vol 113. issue 5. 2004-04-13. PMID:14991074. |
whole-body adiposity, adipose tissue expression of adiponectin, intramuscular fatty acid metabolites, and insulin sensitivity were not altered in fatp1 ko mice fed a regular chow diet. |
2004-04-13 |
2023-08-12 |
mouse |
| Jason K Kim, Ruth E Gimeno, Takamasa Higashimori, Hyo-Jeong Kim, Hyejeong Choi, Sandhya Punreddy, Robin L Mozell, Guo Tan, Alain Stricker-Krongrad, David J Hirsch, Jonathan J Fillmore, Zhen-Xiang Liu, Jianying Dong, Gary Cline, Andreas Stahl, Harvey F Lodish, Gerald I Shulma. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. The Journal of clinical investigation. vol 113. issue 5. 2004-04-13. PMID:14991074. |
in contrast, fatp1 deletion protected the ko mice from fat-induced insulin resistance and intramuscular accumulation of fatty acyl-coa without alteration in whole-body adiposity. |
2004-04-13 |
2023-08-12 |
mouse |
| Frédéric Preitner, Mark Ibberson, Isobel Franklin, Christophe Binnert, Mario Pende, Asllan Gjinovci, Tanya Hansotia, Daniel J Drucker, Claes Wollheim, Rémy Burcelin, Bernard Thoren. Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors. The Journal of clinical investigation. vol 113. issue 4. 2004-03-26. PMID:14966573. |
after intraperitoneal injections, glucose intolerance was more severe in double- as compared to single-receptor ko mice, and euglycemic clamps revealed normal insulin sensitivity, suggesting a defect in insulin secretion. |
2004-03-26 |
2023-08-12 |
mouse |
| Evie Melanitou, Edwin Liu, Dongmei Miao, Liping Yu, Laurie H Glimcher, George Eisenbart. Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice. Annals of the New York Academy of Sciences. vol 1005. 2004-01-16. PMID:14679057. |
as the balance between th1- and th2-mediated immune responses plays a role in autoimmune-prone diseases, we have investigated the diabetes-related insulin autoantibody (iaa) and cellular immune responses (insulitis), in the absence of th1 lineage commitment, in t-bet ko balb/c mice, after immunization with the b9-23 insulin peptide. |
2004-01-16 |
2023-08-12 |
mouse |
| Evan D Rosen, Rohit N Kulkarni, Pasha Sarraf, Umut Ozcan, Terumasa Okada, Chung-Hsin Hsu, Daniel Eisenman, Mark A Magnuson, Frank J Gonzalez, C Ronald Kahn, Bruce M Spiegelma. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Molecular and cellular biology. vol 23. issue 20. 2003-11-25. PMID:14517292. |
additionally, while thiazolidinediones enhanced insulin secretion from cultured wild-type islets, administration of rosiglitazone to insulin-resistant control and beta gamma ko mice revealed that ppar gamma in beta cells is not required for the antidiabetic actions of these compounds. |
2003-11-25 |
2023-08-12 |
mouse |
| S Kim, S Urs, F Massiera, P Wortmann, R Joshi, Y-R Heo, B Andersen, H Kobayashi, M Teboul, G Ailhaud, A Quignard-Boulangé, A Fukamizu, B H Jones, J H Kim, N Moustaid-Mouss. Effects of high-fat diet, angiotensinogen (agt) gene inactivation, and targeted expression to adipose tissue on lipid metabolism and renal gene expression. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 34. issue 11-12. 2003-10-29. PMID:12660889. |
body weight, adiposity and insulin levels were significantly decreased (p < 0.05) in ko mice on a chow diet (cd) compared to wt mice, while circulating leptin levels were similar. |
2003-10-29 |
2023-08-12 |
mouse |
| S Kim, S Urs, F Massiera, P Wortmann, R Joshi, Y-R Heo, B Andersen, H Kobayashi, M Teboul, G Ailhaud, A Quignard-Boulangé, A Fukamizu, B H Jones, J H Kim, N Moustaid-Mouss. Effects of high-fat diet, angiotensinogen (agt) gene inactivation, and targeted expression to adipose tissue on lipid metabolism and renal gene expression. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 34. issue 11-12. 2003-10-29. PMID:12660889. |
on a high-fat diet, ko mice exhibited significantly lower bodyweight (p < 0.05), adiposity (p < 0.05), leptin, and insulin levels (p < 0.05) compared to wt mice. |
2003-10-29 |
2023-08-12 |
mouse |
| Jennifer M Chou-Green, Todd D Holscher, Mary F Dallman, Susan F Akan. Repeated stress in young and old 5-HT(2C) receptor knockout mice. Physiology & behavior. vol 79. issue 2. 2003-10-29. PMID:12834793. |
in the old ko mice, adrenocorticotrophic hormone (acth), corticosterone and insulin were increased compared with wt mice. |
2003-10-29 |
2023-08-12 |
mouse |
| Karim El-Haschimi, Scott D Dufresne, Michael F Hirshman, Jeffrey S Flier, Laurie J Goodyear, Christian Bjørbae. Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2. Diabetes. vol 52. issue 6. 2003-07-18. PMID:12765942. |
ko mice also have impaired glucose tolerance and elevated fasting insulin and glucose levels that are restored following administration of low amounts of leptin, which do not affect food intake. |
2003-07-18 |
2023-08-12 |
mouse |
| Mathias Z Strowski, Martin Kohler, Howard Y Chen, Myrna E Trumbauer, Zhihua Li, Deborah Szalkowski, Shobhna Gopal-Truter, Jill K Fisher, James M Schaeffer, Allan D Blake, Bei B Zhang, Hilary A Wilkinso. Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis. Molecular endocrinology (Baltimore, Md.). vol 17. issue 1. 2003-07-17. PMID:12511609. |
in the present study we describe the generation of srif receptor subtype 5 knockout (sst(5) ko) mice to examine the role of srif receptor subtypes (sst) in regulating insulin secretion and glucose homeostasis. |
2003-07-17 |
2023-08-12 |
mouse |
| Mathias Z Strowski, Martin Kohler, Howard Y Chen, Myrna E Trumbauer, Zhihua Li, Deborah Szalkowski, Shobhna Gopal-Truter, Jill K Fisher, James M Schaeffer, Allan D Blake, Bei B Zhang, Hilary A Wilkinso. Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis. Molecular endocrinology (Baltimore, Md.). vol 17. issue 1. 2003-07-17. PMID:12511609. |
pancreatic islets isolated from sst(5) ko mice displayed increased total insulin content as compared with islets obtained from wild-type (wt) mice. |
2003-07-17 |
2023-08-12 |
mouse |
| Mathias Z Strowski, Martin Kohler, Howard Y Chen, Myrna E Trumbauer, Zhihua Li, Deborah Szalkowski, Shobhna Gopal-Truter, Jill K Fisher, James M Schaeffer, Allan D Blake, Bei B Zhang, Hilary A Wilkinso. Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis. Molecular endocrinology (Baltimore, Md.). vol 17. issue 1. 2003-07-17. PMID:12511609. |
srif-28 inhibited insulin secretion from sst(5) ko islets with 16-fold less potency while the maximal effect of compound 5/1 was markedly diminished when compared with its effects in wt islets. |
2003-07-17 |
2023-08-12 |
mouse |