| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaohui L Wang, Ryo Suzuki, Kevin Lee, Thien Tran, Jenny E Gunton, Asish K Saha, Mary-Elizabeth Patti, Allison Goldfine, Neil B Ruderman, Frank J Gonzalez, C Ronald Kah. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell metabolism. vol 9. issue 5. 2009-07-17. PMID:19416713. |
l-arnt ko mice had normal blood glucose but increased fed insulin levels. |
2009-07-17 |
2023-08-12 |
mouse |
| Ting Wen, Bonnie Peng, John E Pinta. The MOR-1 opioid receptor regulates glucose homeostasis by modulating insulin secretion. Molecular endocrinology (Baltimore, Md.). vol 23. issue 5. 2009-07-13. PMID:19221053. |
we also found that mor-1 ko mice exhibit enhanced glucose tolerance that results from insulin hypersecretion that reflects increased beta-cell mass and increased secretory dynamics in the mor-1 mutant mice compared with wild type. |
2009-07-13 |
2023-08-12 |
mouse |
| Cheryl A Conover, Megan A Mason, James A Levine, Colleen M Nova. Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype. The Journal of endocrinology. vol 198. issue 3. 2009-07-10. PMID:18566100. |
both wt and papp-a ko mice exhibited mild insulin resistance with age, as assessed by fasting glucose/insulin ratios. |
2009-07-10 |
2023-08-12 |
mouse |
| Cheryl A Conover, Megan A Mason, James A Levine, Colleen M Nova. Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype. The Journal of endocrinology. vol 198. issue 3. 2009-07-10. PMID:18566100. |
oral glucose tolerance and insulin sensitivity were not significantly different between the two groups of mice, although there appeared to be a decrease in the average size of the pancreatic islets in papp-a ko mice. |
2009-07-10 |
2023-08-12 |
mouse |
| Miwako Koizumi, Barbara Cagniard, Niall P Murph. Endogenous nociceptin modulates diet preference independent of motivation and reward. Physiology & behavior. vol 97. issue 1. 2009-06-23. PMID:19138695. |
although nop ko mice re-fed following food-deprivation showed normal increases in plasma glucose and insulin, multidimensional scaling analysis showed that the relationship between these measures, body weight and plasma leptin was substantially disrupted in nop ko, particularly in fasted mice. |
2009-06-23 |
2023-08-12 |
mouse |
| Zhenmin Ye, Khawaja Ashfaque Ahmed, Siguo Hao, Xueshu Zhang, Yufeng Xie, Manju Ankathatti Munegowda, Qinghe Meng, Rajni Chibbar, Jim Xian. Active CD4+ helper T cells directly stimulate CD8+ cytotoxic T lymphocyte responses in wild-type and MHC II gene knockout C57BL/6 mice and transgenic RIP-mOVA mice expressing islet beta-cell ovalbumin antigen leading to diabetes. Autoimmunity. vol 41. issue 7. 2009-05-11. PMID:18855194. |
in this study, we further investigated cd4+ th cell's effect on stimulation of cd8 ctl responses in major histocompatibility complex (mhc ii) gene knockout (ko) mice and transgenic rat insulin promoter (rip)-mova mice with moderate expression of self ova by using cd4+ th cells or th cells with various gene deficiency. |
2009-05-11 |
2023-08-12 |
mouse |
| Ming-Jia Niu, Jin-Kui Yang, Shan-Shan Lin, Xiu-Juan Ji, Li-Min Gu. Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice. Endocrine. vol 34. issue 1-3. 2009-05-04. PMID:18956256. |
glucose tolerance test, insulin secretion test, and insulin tolerance test were performed in age-matched male ace2 knockout (ko) and wild-type (wt) mice. |
2009-05-04 |
2023-08-12 |
mouse |
| Ming-Jia Niu, Jin-Kui Yang, Shan-Shan Lin, Xiu-Juan Ji, Li-Min Gu. Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice. Endocrine. vol 34. issue 1-3. 2009-05-04. PMID:18956256. |
male ace2 ko mice displayed a selective decrease in first-phase insulin secretion in response to glucose and a progressive impairment of glucose tolerance compared with age- and sex-matched wt mice. |
2009-05-04 |
2023-08-12 |
mouse |
| Ming-Jia Niu, Jin-Kui Yang, Shan-Shan Lin, Xiu-Juan Ji, Li-Min Gu. Loss of angiotensin-converting enzyme 2 leads to impaired glucose homeostasis in mice. Endocrine. vol 34. issue 1-3. 2009-05-04. PMID:18956256. |
on the other hand, insulin sensitivity of the peripheral tissue in age-matched ace2 ko and wt mice showed no difference. |
2009-05-04 |
2023-08-12 |
mouse |
| Maria Pini, Melissa E Gove, Raja Fayad, Robert J Cabay, Giamila Fantuzz. Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice. American journal of physiology. Gastrointestinal and liver physiology. vol 296. issue 2. 2009-03-13. PMID:19074637. |
finally, apn deficiency did not lead to development of insulin resistance, either in apn ko or double il-10 apn ko mice. |
2009-03-13 |
2023-08-12 |
mouse |
| Els Louagie, Neil A Taylor, Daisy Flamez, Anton J M Roebroek, Nicholas A Bright, Sandra Meulemans, Roel Quintens, Pedro L Herrera, Frans Schuit, Wim J M Van de Ven, John W M Creemer. Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 34. 2008-10-24. PMID:18713856. |
pdx1-cre/loxp furin ko mice show decreased secretion of insulin and impaired processing of known pc2 substrates like propc2 and proinsulin ii. |
2008-10-24 |
2023-08-12 |
mouse |
| Helga Ellingsgaard, Jan A Ehses, Eva B Hammar, Leentje Van Lommel, Roel Quintens, Geert Martens, Julie Kerr-Conte, Francois Pattou, Thierry Berney, Daniel Pipeleers, Philippe A Halban, Frans C Schuit, Marc Y Donat. Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 35. 2008-10-06. PMID:18719127. |
however, despite these alpha-cell effects, high-fat feeding of il-6 ko mice results in increased fed glycemia due to impaired insulin secretion, with unchanged insulin sensitivity and similar body weights. |
2008-10-06 |
2023-08-12 |
mouse |
| Atul S Deshmukh, Jonas T Treebak, Yun Chau Long, Benoit Viollet, Jørgen F P Wojtaszewski, Juleen R Zierat. Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling. Molecular endocrinology (Baltimore, Md.). vol 22. issue 5. 2008-07-21. PMID:18276828. |
extensor digitorum longus muscle from ampk alpha2 knockout (ko), ampk gamma3 ko, and respective wild-type (wt) littermates (c57bl/6) were incubated in the presence of 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside (aicar), insulin, or aicar plus insulin. |
2008-07-21 |
2023-08-12 |
mouse |
| Atul S Deshmukh, Jonas T Treebak, Yun Chau Long, Benoit Viollet, Jørgen F P Wojtaszewski, Juleen R Zierat. Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling. Molecular endocrinology (Baltimore, Md.). vol 22. issue 5. 2008-07-21. PMID:18276828. |
insulin stimulation increased phosphorylation of s6k1 (thr389), ribosomal protein s6 (ser235/236), and 4e-bp1 (thr37/46) (p < 0.01) in wt, ampk alpha2 ko, and ampk gamma3 ko mice. |
2008-07-21 |
2023-08-12 |
mouse |
| Gareth G Lavery, David Hauton, Kylie N Hewitt, Sophie M Brice, Mark Sherlock, Elizabeth A Walker, Paul M Stewar. Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking hexose-6-phosphate dehydrogenase. Endocrinology. vol 148. issue 12. 2008-06-17. PMID:17823265. |
plasma insulin levels in fed and fasted ko mice are normal; however, insulin and plasma glucose levels are reduced 4 h after fasted animals are refed, indicating improved insulin sensitivity. |
2008-06-17 |
2023-08-12 |
mouse |
| Swasti Tiwari, Nikhil Sharma, Pritmohinder S Gill, Peter Igarashi, C Ronald Kahn, James B Wade, Carolyn M A Ecelbarge. Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 17. 2008-05-22. PMID:18424559. |
furthermore, acute insulin increased unox by 202% in the wt, relative to a significantly blunted rise (67%) in ko animals. |
2008-05-22 |
2023-08-12 |
mouse |
| Ellen E Ladenheim, Nahketah L Hamilton, Robert R Behles, Sheng Bi, Lori L Hampton, James F Battey, Timothy H Mora. Factors contributing to obesity in bombesin receptor subtype-3-deficient mice. Endocrinology. vol 149. issue 3. 2008-04-22. PMID:18039774. |
pair-feeding brs-3 ko mice normalized plasma insulin but failed to completely reverse increased adiposity and leptin levels. |
2008-04-22 |
2023-08-12 |
mouse |
| James L Trevaskis, Barbara Gawronska-Kozak, Gregory M Sutton, Michele McNeil, Jacqueline M Stephens, Steven R Smith, Andrew A Butle. Role of adiponectin and inflammation in insulin resistance of Mc3r and Mc4r knockout mice. Obesity (Silver Spring, Md.). vol 15. issue 11. 2008-04-10. PMID:18070757. |
to investigate the involvement of hypoadiponectinemia and inflammation in coupling obesity to insulin resistance in melanocortin-3 receptor and melanocortin-4 receptor knockout (ko) mice (mc3/4rko). |
2008-04-10 |
2023-08-12 |
mouse |
| Kevin J Pearson, Kaitlyn N Lewis, Nathan L Price, Joy W Chang, Evelyn Perez, Maria Victoria Cascajo, Kellie L Tamashiro, Suresh Poosala, Anna Csiszar, Zoltan Ungvari, Thomas W Kensler, Masayuki Yamamoto, Josephine M Egan, Dan L Longo, Donald K Ingram, Placido Navas, Rafael de Cab. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 7. 2008-03-13. PMID:18287083. |
however, cr extended lifespan and increased insulin sensitivity similarly in ko and wt mice. |
2008-03-13 |
2023-08-12 |
mouse |
| Katrina MacAulay, Bradley W Doble, Satish Patel, Tanya Hansotia, Elaine M Sinclair, Daniel J Drucker, Andras Nagy, James R Woodget. Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell metabolism. vol 6. issue 4. 2007-12-06. PMID:17908561. |
unlike gsk-3beta mutants, which die before birth, gsk-3alpha knockout (gsk-3alpha ko) animals are viable but display enhanced glucose and insulin sensitivity accompanied by reduced fat mass. |
2007-12-06 |
2023-08-12 |
mouse |