| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brenda Bouter, Nori Geary, Wolfgang Langhans, Lori Asaria. Diet-genotype interactions in the early development of obesity and insulin resistance in mice with a genetic deficiency in tumor necrosis factor-alpha. Metabolism: clinical and experimental. vol 59. issue 7. 2010-06-17. PMID:20045154. |
through 4 weeks of hf feeding, ko mice, unlike wt mice, maintained normal insulin sensitivity. |
2010-06-17 |
2023-08-12 |
mouse |
| Haowei Song, Mary Wohltmann, Shunzhong Bao, Jack H Ladenson, Clay F Semenkovich, John Tur. Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet. American journal of physiology. Endocrinology and metabolism. vol 298. issue 6. 2010-06-08. PMID:20179248. |
we find that ko mice are resistant to wd-induced increases in body weight and adiposity and in blood levels of cholesterol, glucose, and insulin, even though wt and ko mice exhibit similar food consumption and dietary fat digestion and absorption. |
2010-06-08 |
2023-08-12 |
mouse |
| Haowei Song, Mary Wohltmann, Shunzhong Bao, Jack H Ladenson, Clay F Semenkovich, John Tur. Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet. American journal of physiology. Endocrinology and metabolism. vol 298. issue 6. 2010-06-08. PMID:20179248. |
ko mice are also relatively resistant to wd-induced insulin resistance, glucose intolerance, and altered patterns of fat vs. carbohydrate fuel utilization. |
2010-06-08 |
2023-08-12 |
mouse |
| Ryan S Friese, Jiaur R Gayen, Nitish R Mahapatra, Geert W Schmid-Schönbein, Daniel T O'Connor, Sushil K Mahat. Global metabolic consequences of the chromogranin A-null model of hypertension: transcriptomic detection, pathway identification, and experimental verification. Physiological genomics. vol 40. issue 3. 2010-05-10. PMID:19952279. |
adrenal gene expression pathway prediction of enhanced insulin sensitivity (p = 0.03) in chga ko was confirmed with glucose, insulin, and homeostasis model assessment of insulin resistance (homa-ir) measurements: blood glucose was normal in chga ko, blood insulin was reduced 4.5-fold (p < 0.0001), and homa-ir was decreased 3.8-fold (p < 0.002). |
2010-05-10 |
2023-08-12 |
mouse |
| Ryan S Friese, Jiaur R Gayen, Nitish R Mahapatra, Geert W Schmid-Schönbein, Daniel T O'Connor, Sushil K Mahat. Global metabolic consequences of the chromogranin A-null model of hypertension: transcriptomic detection, pathway identification, and experimental verification. Physiological genomics. vol 40. issue 3. 2010-05-10. PMID:19952279. |
exogenous pancreastatin treatment restored insulin sensitivity in the chga ko to near-normal levels. |
2010-05-10 |
2023-08-12 |
mouse |
| Goji Hasegawa, Masahiro Yamasaki, Mayuko Kadono, Muhei Tanaka, Mai Asano, Takafumi Senmaru, Yoshitaka Kondo, Michiaki Fukui, Hiroshi Obayashi, Naoki Maruyama, Naoto Nakamura, Akihito Ishigam. Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion. Endocrinology. vol 151. issue 2. 2010-02-26. PMID:19934374. |
insulin levels in smp30/gnl ko mice were significantly decreased by 37% at 30 min after glucose compared with wt mice. |
2010-02-26 |
2023-08-12 |
mouse |
| Goji Hasegawa, Masahiro Yamasaki, Mayuko Kadono, Muhei Tanaka, Mai Asano, Takafumi Senmaru, Yoshitaka Kondo, Michiaki Fukui, Hiroshi Obayashi, Naoki Maruyama, Naoto Nakamura, Akihito Ishigam. Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion. Endocrinology. vol 151. issue 2. 2010-02-26. PMID:19934374. |
interestingly, an insulin tolerance test showed a greater glucose-lowering effect in smp30/gnl ko mice. |
2010-02-26 |
2023-08-12 |
mouse |
| Goji Hasegawa, Masahiro Yamasaki, Mayuko Kadono, Muhei Tanaka, Mai Asano, Takafumi Senmaru, Yoshitaka Kondo, Michiaki Fukui, Hiroshi Obayashi, Naoki Maruyama, Naoto Nakamura, Akihito Ishigam. Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion. Endocrinology. vol 151. issue 2. 2010-02-26. PMID:19934374. |
in the static incubation study of islets, insulin secretion in response to 20 mm glucose or kcl was significantly decreased in smp30/gnl ko mice. |
2010-02-26 |
2023-08-12 |
mouse |
| Goji Hasegawa, Masahiro Yamasaki, Mayuko Kadono, Muhei Tanaka, Mai Asano, Takafumi Senmaru, Yoshitaka Kondo, Michiaki Fukui, Hiroshi Obayashi, Naoki Maruyama, Naoto Nakamura, Akihito Ishigam. Senescence marker protein-30/gluconolactonase deletion worsens glucose tolerance through impairment of acute insulin secretion. Endocrinology. vol 151. issue 2. 2010-02-26. PMID:19934374. |
collectively, these data indicate that impairment of the early phase of insulin secretion due to dysfunction of the distal portion of the secretion pathway underlies glucose intolerance in smp30/gnl ko mice. |
2010-02-26 |
2023-08-12 |
mouse |
| Sergi Soriano, Ana B Ropero, Paloma Alonso-Magdalena, Cristina Ripoll, Ivan Quesada, Birgit Gassner, Michaela Kuhn, Jan-Ake Gustafsson, Angel Nada. Rapid regulation of K(ATP) channel activity by 17{beta}-estradiol in pancreatic {beta}-cells involves the estrogen receptor {beta} and the atrial natriuretic peptide receptor. Molecular endocrinology (Baltimore, Md.). vol 23. issue 12. 2010-02-22. PMID:19855088. |
e2 rapidly inhibited k(atp) channel activity and enhanced insulin release in islets from wt mice but not in islets from gc-a ko mice. |
2010-02-22 |
2023-08-12 |
mouse |
| Guadalupe Sabio, Norman J Kennedy, Julie Cavanagh-Kyros, Dae Young Jung, Hwi Jin Ko, Helena Ong, Tamera Barrett, Jason K Kim, Roger J Davi. Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Molecular and cellular biology. vol 30. issue 1. 2010-01-14. PMID:19841069. |
however, muscle-specific jnk1-deficient (m(ko)) mice exhibit improved insulin sensitivity compared with control wild-type (m(wt)) mice. |
2010-01-14 |
2023-08-12 |
mouse |
| Michael R Morissette, Janelle C Stricker, Michael A Rosenberg, Cattleya Buranasombati, Emily B Levitan, Murray A Mittleman, Anthony Rosenzwei. Effects of myostatin deletion in aging mice. Aging cell. vol 8. issue 5. 2010-01-08. PMID:19663901. |
serum insulin and glucose levels were lower in ko mice. |
2010-01-08 |
2023-08-12 |
mouse |
| Kathrin Hatlapatka, Antje Wienbergen, Claudia Kühne, Anne Jörns, Michael Willenborg, Ingo Rustenbec. Selective enhancement of nutrient-induced insulin secretion by ATP-sensitive K+ channel-blocking imidazolines. The Journal of pharmacology and experimental therapeutics. vol 331. issue 3. 2009-12-22. PMID:19745109. |
insulin secretion by sulfonylurea receptor (sur)1 knockout (ko) islets, which have no functional k(atp) channels, was not increased by efaroxan (100 or 500 microm) or by 10 microm rx871024 but was increased by 100 microm rx871024. |
2009-12-22 |
2023-08-12 |
mouse |
| Takeharu Asano, Kiyotaka Watanabe, Naoto Kubota, Toshiaki Gunji, Masao Omata, Takashi Kadowaki, Shin Ohnish. Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis. Journal of gastroenterology and hepatology. vol 24. issue 10. 2009-12-11. PMID:19788607. |
adiponectin knockout (ko) mice have been reported to cause insulin resistance and neointimal formation of the artery. |
2009-12-11 |
2023-08-12 |
mouse |
| Jiaur R Gayen, Maziyar Saberi, Simon Schenk, Nilima Biswas, Sucheta M Vaingankar, Wai W Cheung, Sonia M Najjar, Daniel T O'Connor, Gautam Bandyopadhyay, Sushil K Mahat. A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. The Journal of biological chemistry. vol 284. issue 42. 2009-11-24. PMID:19706599. |
despite higher catecholamine and ketone body levels and muscle insulin resistance, ko mice maintained euglycemia due to increased liver insulin sensitivity. |
2009-11-24 |
2023-08-12 |
mouse |
| Jean-Claude Henquin, Myriam Nenquin, Andras Szollosi, Atsutaka Kubosaki, A L Notkin. Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. The Journal of endocrinology. vol 196. issue 3. 2009-10-01. PMID:18310453. |
in this study, we therefore characterized the dynamic changes in cytosolic ca2+([ca2+](c)) and insulin secretion in islets from ia-2/ia-2beta double knockout (ko) mice. |
2009-10-01 |
2023-08-12 |
mouse |
| Jean-Claude Henquin, Myriam Nenquin, Andras Szollosi, Atsutaka Kubosaki, A L Notkin. Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. The Journal of endocrinology. vol 196. issue 3. 2009-10-01. PMID:18310453. |
high glucose (15 mm) induced biphasic insulin secretion in ia-2/ia-2beta ko islets, with a similar first phase and smaller second phase compared with controls. |
2009-10-01 |
2023-08-12 |
mouse |
| Jean-Claude Henquin, Myriam Nenquin, Andras Szollosi, Atsutaka Kubosaki, A L Notkin. Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. The Journal of endocrinology. vol 196. issue 3. 2009-10-01. PMID:18310453. |
since the insulin content of ia-2/ia-2beta ko islets was approximately 45% less than that of controls, fractional insulin secretion (relative to content) was thus increased during first phase and unaffected during second phase. |
2009-10-01 |
2023-08-12 |
mouse |
| Jean-Claude Henquin, Myriam Nenquin, Andras Szollosi, Atsutaka Kubosaki, A L Notkin. Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. The Journal of endocrinology. vol 196. issue 3. 2009-10-01. PMID:18310453. |
the dual control of insulin secretion via the k(atp) channel-dependent triggering pathway and k(atp) channel-independent amplifying pathway was unaltered in ia-2/ia-2beta ko islets, and so were the potentiations by acetylcholine or camp (forskolin). |
2009-10-01 |
2023-08-12 |
mouse |
| Jean-Claude Henquin, Myriam Nenquin, Andras Szollosi, Atsutaka Kubosaki, A L Notkin. Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2beta. The Journal of endocrinology. vol 196. issue 3. 2009-10-01. PMID:18310453. |
intriguingly, amino acids, in particular the cationic arginine and lysine, induced larger fractional insulin secretion in ia-2/ia-2beta ko than control islets. |
2009-10-01 |
2023-08-12 |
mouse |