| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiang Wang, Konstantin Levay, Tatyana Chanturiya, Galina Dvoriantchikova, Karen L Anderson, Suzy D C Bianco, Cintia B Ueta, R Damaris Molano, Antonello Pileggi, Eugenia V Gurevich, Oksana Gavrilova, Vladlen Z Slepa. Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 11. 2011-12-27. PMID:21804131. |
surprisingly, with respect to body weight, the het mice display a phenotype opposite to that of the ko mice: by the age of 6 mo, they are ≥ 15% heavier than the wt and have increased adiposity, insulin resistance, and liver steatosis. |
2011-12-27 |
2023-08-12 |
mouse |
| Michael J Urban, Chengyuan Li, Cuijuan Yu, Yuanming Lu, Joanna M Krise, Michelle P McIntosh, Roger A Rajewski, Brian S J Blagg, Rick T Dobrowsk. Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice. ASN neuro. vol 2. issue 4. 2011-12-08. PMID:20711301. |
although ku-32 did not improve glucose levels, hba1c (glycated haemoglobin) or insulin levels, it reversed the ncv and sensory deficits in wt but not hsp70 ko mice. |
2011-12-08 |
2023-08-12 |
mouse |
| Anton Terasmaa, Ursel Soomets, Julia Oflijan, Marite Punapart, Mats Hansen, Vallo Matto, Kersti Ehrlich, Anne Must, Sulev Kõks, Eero Vasa. Wfs1 mutation makes mice sensitive to insulin-like effect of acute valproic acid and resistant to streptozocin. Journal of physiology and biochemistry. vol 67. issue 3. 2011-12-01. PMID:21461749. |
thus, acute valproic acid is effective in lowering blood glucose levels possibly by potentiating insulin action in both wfs1 ko mice and in streptozocin-induced type 1 diabetic mice. |
2011-12-01 |
2023-08-12 |
mouse |
| Iordanes Karagiannides, Dimitris Stavrakis, Kyriaki Bakirtzi, Efi Kokkotou, Tamara Pirtskhalava, Hamed Nayeb-Hashemi, Collin Bowe, James M Bugni, Miriam Nuño, Bao Lu, Norma P Gerard, Susan E Leeman, James L Kirkland, Charalabos Pothoulaki. Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Endocrinology. vol 152. issue 6. 2011-11-22. PMID:21467195. |
here, we assessed the contribution of substance p (sp) and nk-1r in diet-induced obesity using nk-1r deficient [knockout (ko)] mice and extended our previous findings to show the effects of sp-nk-1r interactions on adipose tissue-associated insulin signaling and glucose metabolic responses. |
2011-11-22 |
2023-08-12 |
mouse |
| Iordanes Karagiannides, Dimitris Stavrakis, Kyriaki Bakirtzi, Efi Kokkotou, Tamara Pirtskhalava, Hamed Nayeb-Hashemi, Collin Bowe, James M Bugni, Miriam Nuño, Bao Lu, Norma P Gerard, Susan E Leeman, James L Kirkland, Charalabos Pothoulaki. Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action. Endocrinology. vol 152. issue 6. 2011-11-22. PMID:21467195. |
compared with wt, nk-1 ko mice show reduced weight gain and circulating levels of leptin and insulin in response to hfd. |
2011-11-22 |
2023-08-12 |
mouse |
| Yong Qi, Kenneth A Longo, Derek J Giuliana, Samantha Gagne, Tom McDonagh, Elizabeth Govek, Anna Nolan, Chaoseng Zou, Kristen Morgan, Jeffrey Hixon, Jeffrey O Saunders, Peter S Distefano, Brad J Gedde. Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps. BMC physiology. vol 11. 2011-11-14. PMID:21211044. |
characterization of the insulin sensitivity of ghrelin receptor ko mice using glycemic clamps. |
2011-11-14 |
2023-08-12 |
mouse |
| Yong Qi, Kenneth A Longo, Derek J Giuliana, Samantha Gagne, Tom McDonagh, Elizabeth Govek, Anna Nolan, Chaoseng Zou, Kristen Morgan, Jeffrey Hixon, Jeffrey O Saunders, Peter S Distefano, Brad J Gedde. Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps. BMC physiology. vol 11. 2011-11-14. PMID:21211044. |
we and others have demonstrated previously that ghrelin receptor (ghrr) knock out (ko) mice fed a high fat diet (hfd) have increased insulin sensitivity and metabolic flexibility relative to wt littermates. |
2011-11-14 |
2023-08-12 |
mouse |
| Fan-Yan Wei, Takeo Suzuki, Sayaka Watanabe, Satoshi Kimura, Taku Kaitsuka, Atsushi Fujimura, Hideki Matsui, Mohamed Atta, Hiroyuki Michiue, Marc Fontecave, Kazuya Yamagata, Tsutomu Suzuki, Kazuhito Tomizaw. Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. The Journal of clinical investigation. vol 121. issue 9. 2011-10-31. PMID:21841312. |
mice with pancreatic β cell-specific ko of cdkal1 (referred to herein as β cell ko mice) showed pancreatic islet hypertrophy, a decrease in insulin secretion, and impaired blood glucose control. |
2011-10-31 |
2023-08-12 |
mouse |
| Jianke Ren, Zheng Chen, Wen Zhang, Limei Li, Ruilin Sun, Chunguang Deng, Zhaoliang Fei, Zejing Sheng, Long Wang, Xia Sun, Zhugang Wang, Jian Fe. Increased fat mass and insulin resistance in mice lacking pancreatic lipase-related protein 1. The Journal of nutritional biochemistry. vol 22. issue 7. 2011-10-14. PMID:21115337. |
here we show that the plrp1 ko mice displayed mature-onset obesity with increased fat mass, impaired glucose clearance and the resultant insulin resistance. |
2011-10-14 |
2023-08-12 |
mouse |
| Jianke Ren, Zheng Chen, Wen Zhang, Limei Li, Ruilin Sun, Chunguang Deng, Zhaoliang Fei, Zejing Sheng, Long Wang, Xia Sun, Zhugang Wang, Jian Fe. Increased fat mass and insulin resistance in mice lacking pancreatic lipase-related protein 1. The Journal of nutritional biochemistry. vol 22. issue 7. 2011-10-14. PMID:21115337. |
when fed on high-fat (hf) diet, the plrp1 ko mice exhibited an increased weight gain, fat mass and severe insulin resistance compared with wild-type mice. |
2011-10-14 |
2023-08-12 |
mouse |
| Igor Dzhura, Oleg G Chepurny, Colin A Leech, Michael W Roe, Elvira Dzhura, Xin Xu, Youming Lu, Frank Schwede, Hans-G Genieser, Alan V Smrcka, George G Hol. Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets. vol 3. issue 3. 2011-09-27. PMID:21478675. |
our analysis demonstrates that the epac activator 8-pcpt-2'-o-me-camp-am potentiates gsis from the islets of wild-type (wt) mice, whereas it has a greatly reduced insulin secretagogue action in the islets of epac2 (-/-) and plc-ε (-/-) knockout (ko) mice. |
2011-09-27 |
2023-08-12 |
mouse |
| Igor Dzhura, Oleg G Chepurny, Colin A Leech, Michael W Roe, Elvira Dzhura, Xin Xu, Youming Lu, Frank Schwede, Hans-G Genieser, Alan V Smrcka, George G Hol. Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets. vol 3. issue 3. 2011-09-27. PMID:21478675. |
since the ko of plc-ε disrupts the ability of 8-pcpt-2'-o-me-camp-am to potentiate gsis, while also disrupting its ability to stimulate an increase of β-cell [ca2+]i, the available evidence indicates that it is a rap1-regulated plc-ε that links epac2 activation to ca2+-dependent exocytosis of insulin. |
2011-09-27 |
2023-08-12 |
mouse |
| Yaacov Barak, Suyeon Ki. Genetic manipulations of PPARs: effects on obesity and metabolic disease. PPAR research. vol 2007. 2011-07-14. PMID:17389768. |
considering the effects of ppar ligands on critical aspects of systemic physiology, including obesity, lipid metabolism, insulin resistance, and diabetes, gene knockout (ko) in mice is the ideal platform for both hypothesis testing and discovery of new ppar functions in vivo. |
2011-07-14 |
2023-08-12 |
mouse |
| Kosuke Okada, Toru Yanagawa, Eiji Warabi, Keiko Yamastu, Junya Uwayama, Koichi Takeda, Hirotoshi Utsunomiya, Hiroshi Yoshida, Junichi Shoda, Tetsuro Ishi. The alpha-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice. Hepatology research : the official journal of the Japan Society of Hepatology. vol 39. issue 5. 2011-07-14. PMID:19207582. |
although the mechanism involved is not clear, sqstm1 gene knockout (ko) mice develop mature-onset obesity and insulin resistance, leading to type ii diabetes. |
2011-07-14 |
2023-08-12 |
mouse |
| Mica Ohara-Imaizumi, Masashi Yoshida, Kyota Aoyagi, Taro Saito, Tadashi Okamura, Hitoshi Takenaka, Yoshihiro Akimoto, Yoko Nakamichi, Rieko Takanashi-Yanobu, Chiyono Nishiwaki, Hayato Kawakami, Norihiro Kato, Shin-ichi Hisanaga, Masafumi Kakei, Shinya Nagamats. Deletion of CDKAL1 affects mitochondrial ATP generation and first-phase insulin exocytosis. PloS one. vol 5. issue 12. 2011-07-05. PMID:21151568. |
therefore, to determine the role of cdkal1 in insulin release from β cells, we studied insulin release profiles in cdkal1 gene knockout (cdkal1 ko) mice. |
2011-07-05 |
2023-08-12 |
mouse |
| U Razny, B Kiec-Wilk, A Polus, L Wator, G Dyduch, L Partyka, M Bodzioch, R Tomaszewska, I Wybransk. The adipose tissue gene expression in mice with different nitric oxide availability. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 61. issue 5. 2011-06-21. PMID:21081805. |
the 19 week old enos ko mice demonstrated significantly lower weight, higher circulating glucose, insulin, leptin and cholesterol concentrations. |
2011-06-21 |
2023-08-12 |
mouse |
| James W Perfield, Yunkyoung Lee, Gerald I Shulman, Varman T Samuel, Michael J Jurczak, Eugene Chang, Chen Xie, Phillip N Tsichlis, Martin S Obin, Andrew S Greenber. Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes. vol 60. issue 4. 2011-06-06. PMID:21346175. |
we used tpl2 knockout (ko) mice to investigate the role of tpl2 in mediating obesity-associated inflammation and insulin resistance. |
2011-06-06 |
2023-08-12 |
mouse |
| Yuya Tsurutani, Masaki Fujimoto, Minoru Takemoto, Hiroki Irisuna, Masaya Koshizaka, Shunichiro Onishi, Takahiro Ishikawa, Morito Mezawa, Peng He, Satoshi Honjo, Yoshiro Maezawa, Yasushi Saito, Koutaro Yokot. The roles of transforming growth factor-β and Smad3 signaling in adipocyte differentiation and obesity. Biochemical and biophysical research communications. vol 407. issue 1. 2011-05-31. PMID:21356196. |
smad3 ko mice were protected against hfd-induced insulin resistance. |
2011-05-31 |
2023-08-12 |
mouse |
| Diane M Jaworski, Olga Sideleva, Holly M Stradecki, Garret D Langlois, Aida Habibovic, Basanthi Satish, William G Tharp, James Lausier, Kyla Larock, Thomas L Jetton, Mina Peshavaria, Richard E Pratle. Sexually dimorphic diet-induced insulin resistance in obese tissue inhibitor of metalloproteinase-2 (TIMP-2)-deficient mice. Endocrinology. vol 152. issue 4. 2011-05-23. PMID:21285317. |
chow-fed timp-2 ko mice of both sexes became obese but maintained relatively normal glucose tolerance and insulin sensitivity. |
2011-05-23 |
2023-08-12 |
mouse |
| Diane M Jaworski, Olga Sideleva, Holly M Stradecki, Garret D Langlois, Aida Habibovic, Basanthi Satish, William G Tharp, James Lausier, Kyla Larock, Thomas L Jetton, Mina Peshavaria, Richard E Pratle. Sexually dimorphic diet-induced insulin resistance in obese tissue inhibitor of metalloproteinase-2 (TIMP-2)-deficient mice. Endocrinology. vol 152. issue 4. 2011-05-23. PMID:21285317. |
however, hfd-fed male, but not female, timp-2 ko mice developed insulin resistance with reduced glucose transporter 2 and pancreatic and duodenal homeobox 1 levels, despite increased β-cell mass and hyperplasia. |
2011-05-23 |
2023-08-12 |
mouse |