| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos Escande, Veronica Nin, Tamar Pirtskhalava, Claudia C S Chini, Tamar Tchkonia, James L Kirkland, Eduardo N Chin. Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype. Diabetes. vol 64. issue 1. 2015-03-11. PMID:25053585. |
dbc1 ko mice fed a high-fat diet, although obese, remained insulin sensitive, had lower free fatty acid in plasma, were protected against atherosclerosis and liver steatosis, and lived longer. |
2015-03-11 |
2023-08-13 |
mouse |
| George G Holz, Colin A Leech, Oleg G Chepurn. New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice. Biochimica et biophysica acta. vol 1842. issue 12 Pt B. 2015-03-09. PMID:24980705. |
recently published findings indicate that a knockout (ko) of soluble adenylyl cyclase (sac, also known as ac-10) gene expression in mice leads to defective glucoregulation that is characterized by reduced pancreatic insulin secretion and reduced intraperitoneal glucose tolerance. |
2015-03-09 |
2023-08-13 |
mouse |
| Rand T Akasheh, Maria Pini, Jingbo Pang, Giamila Fantuzz. Increased adiposity in annexin A1-deficient mice. PloS one. vol 8. issue 12. 2015-02-19. PMID:24312665. |
a significant increase in fasting glucose and insulin levels as well as development of insulin resistance was observed in anxa1 ko mice on hfd compared to wt mice. |
2015-02-19 |
2023-08-12 |
mouse |
| Rand T Akasheh, Maria Pini, Jingbo Pang, Giamila Fantuzz. Increased adiposity in annexin A1-deficient mice. PloS one. vol 8. issue 12. 2015-02-19. PMID:24312665. |
these data indicate that anxa1 is an important modulator of adiposity in mice, with female anxa1 ko mice on balb/c background being more susceptible to weight gain and diet-induced insulin resistance compared to wt mice, without significant changes in inflammation. |
2015-02-19 |
2023-08-12 |
mouse |
| Marcelo A Mori, Thomas Thomou, Jeremie Boucher, Kevin Y Lee, Susanna Lallukka, Jason K Kim, Martin Torriani, Hannele Yki-Järvinen, Steven K Grinspoon, Aaron M Cypess, C Ronald Kah. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. The Journal of clinical investigation. vol 124. issue 8. 2015-02-18. PMID:24983316. |
here, we demonstrated that mice with a fat-specific ko of dicer develop a form of lipodystrophy that is characterized by loss of intra-abdominal and subcutaneous white fat, severe insulin resistance, and enlargement and "whitening" of interscapular brown fat. |
2015-02-18 |
2023-08-13 |
mouse |
| Melkam A Kebede, Angie T Oler, Trillian Gregg, Allison J Balloon, Adam Johnson, Kelly Mitok, Mary Rabaglia, Kathryn Schueler, Donald Stapleton, Candice Thorstenson, Lindsay Wrighton, Brendan J Floyd, Oliver Richards, Summer Raines, Kevin Eliceiri, Nabil G Seidah, Christopher Rhodes, Mark P Keller, Joshua L Coon, Anjon Audhya, Alan D Atti. SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells. The Journal of clinical investigation. vol 124. issue 10. 2015-02-09. PMID:25157818. |
however, multiple challenges of the sorcs1 ko ob/ob islets consistently revealed an insulin secretion defect. |
2015-02-09 |
2023-08-13 |
mouse |
| Melkam A Kebede, Angie T Oler, Trillian Gregg, Allison J Balloon, Adam Johnson, Kelly Mitok, Mary Rabaglia, Kathryn Schueler, Donald Stapleton, Candice Thorstenson, Lindsay Wrighton, Brendan J Floyd, Oliver Richards, Summer Raines, Kevin Eliceiri, Nabil G Seidah, Christopher Rhodes, Mark P Keller, Joshua L Coon, Anjon Audhya, Alan D Atti. SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells. The Journal of clinical investigation. vol 124. issue 10. 2015-02-09. PMID:25157818. |
chronic exposure of islets from lean sorcs1 ko mice to high glucose and palmitate depleted insulin content and evoked an insulin secretion defect. |
2015-02-09 |
2023-08-13 |
mouse |
| Cory M Dungan, David C Wright, David L Williamso. Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling. Biochemical and biophysical research communications. vol 453. issue 4. 2015-02-09. PMID:25445588. |
first, intraperitoneal (ip) injection of glucose or insulin were administered to redd1 wildtype (wt) versus knockout (ko) mice to examine changes in blood glucose over time. |
2015-02-09 |
2023-08-13 |
mouse |
| Cory M Dungan, David C Wright, David L Williamso. Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling. Biochemical and biophysical research communications. vol 453. issue 4. 2015-02-09. PMID:25445588. |
redd1 ko mice were both glucose and insulin intolerant when compared to wt mice, evident by higher circulating blood glucose concentrations and a greater area under the curve following ip injections of glucose or insulin. |
2015-02-09 |
2023-08-13 |
mouse |
| Cory M Dungan, David C Wright, David L Williamso. Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling. Biochemical and biophysical research communications. vol 453. issue 4. 2015-02-09. PMID:25445588. |
while the redd1 ko exhibited significant though blunted insulin-stimulated increases (p<0.05) in akt s473 and t308 phosphorylation versus the wt mice, acute insulin treatment has no effect (p<0.05) on redd1 ko skeletal muscle 4e-bp1 t37/46, s6k1 t389, irs-1 y1222, and erk 1/2 t202/y204 phosphorylation versus the wt mice. |
2015-02-09 |
2023-08-13 |
mouse |
| Juan Jose Ramos-Rodriguez, Sara Molina-Gil, Oscar Ortiz-Barajas, Margarita Jimenez-Palomares, German Perdomo, Irene Cozar-Castellano, Alfonso Maria Lechuga-Sancho, Monica Garcia-Alloz. Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models. PloS one. vol 9. issue 2. 2015-01-27. PMID:24586614. |
since brain atrophy and impaired neurogenesis have been observed both t2d and ad we analyzed central nervous system (cns) morphological alterations in the db/db mice (leptin receptor ko mice), as a model of long-term insulin resistance and t2d, and in c57bl6 mice fed with high fat diet (hfd), as a model of diet induced insulin resistance and prediabetes. |
2015-01-27 |
2023-08-12 |
mouse |
| Lalini Ramanathan, Jerome M Siege. Gender differences between hypocretin/orexin knockout and wild type mice: age, body weight, body composition, metabolic markers, leptin and insulin resistance. Journal of neurochemistry. vol 131. issue 5. 2015-01-14. PMID:25066943. |
conversely, insulin resistance was significantly higher in both male (73%) and female (93%) ko mice compared to age- and sex-matched wt mice. |
2015-01-14 |
2023-08-13 |
mouse |
| Jinyoung Park, Young-Sil Yoon, Hye-Sook Han, Yong-Hoon Kim, Yoshihiro Ogawa, Keun-Gyu Park, Chul-Ho Lee, Seong-Tae Kim, Seung-Hoi Ko. SIK2 is critical in the regulation of lipid homeostasis and adipogenesis in vivo. Diabetes. vol 63. issue 11. 2014-12-30. PMID:24898145. |
sik2 knockout (sik2 ko) mice exhibited higher blood glucose levels that were associated with impaired glucose and insulin tolerance. |
2014-12-30 |
2023-08-13 |
mouse |
| Preetha Shridas, Lubna Zahoor, Kathy J Forrest, Joseph D Layne, Nancy R Web. Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism. The Journal of biological chemistry. vol 289. issue 40. 2014-12-17. PMID:25122761. |
consistent with enhanced beta cell function, gx ko mice showed significantly increased plasma insulin levels following glucose challenge and were protected from age-related reductions in gsis and glucose tolerance compared with wt mice. |
2014-12-17 |
2023-08-13 |
mouse |
| Siming Liu, Yannan Xi, Ahmed Bettaieb, Kosuke Matsuo, Izumi Matsuo, Rohit N Kulkarni, Fawaz G Ha. Disruption of protein-tyrosine phosphatase 1B expression in the pancreas affects β-cell function. Endocrinology. vol 155. issue 9. 2014-11-04. PMID:24956127. |
furthermore, high-fat feeding promoted earlier impairment of glucose tolerance and attenuated glucose-stimulated insulin secretion in panc-ptp1b ko mice. |
2014-11-04 |
2023-08-13 |
mouse |
| Johann Guillemot, Rachid Essalmani, Josée Hamelin, Nabil G Seida. Is there a link between proprotein convertase PC7 activity and human lipid homeostasis? FEBS open bio. vol 4. 2014-10-28. PMID:25349778. |
plasma analyses revealed no change in the lipid profiles, insulin or glucose of wild type and pc7 ko mice. |
2014-10-28 |
2023-08-13 |
mouse |
| Diogo M L P Cavalcanti, Leandro M Castro, José C Rosa Neto, Marilia Seelaender, Rodrigo X Neves, Vitor Oliveira, Fábio L Forti, Leo K Iwai, Fabio C Gozzo, Mihail Todiras, Ines Schadock, Carlos C Barros, Michael Bader, Emer S Ferr. Neurolysin knockout mice generation and initial phenotype characterization. The Journal of biological chemistry. vol 289. issue 22. 2014-10-10. PMID:24719317. |
here, we have shown that nln ko mice have increased glucose tolerance, insulin sensitivity, and gluconeogenesis. |
2014-10-10 |
2023-08-13 |
mouse |
| Diogo M L P Cavalcanti, Leandro M Castro, José C Rosa Neto, Marilia Seelaender, Rodrigo X Neves, Vitor Oliveira, Fábio L Forti, Leo K Iwai, Fabio C Gozzo, Mihail Todiras, Ines Schadock, Carlos C Barros, Michael Bader, Emer S Ferr. Neurolysin knockout mice generation and initial phenotype characterization. The Journal of biological chemistry. vol 289. issue 22. 2014-10-10. PMID:24719317. |
isotopic label semiquantitative peptidomic analysis suggests an increase in specific intracellular peptides in gastrocnemius and epididymal adipose tissue, which likely is involved with the increased glucose tolerance and insulin sensitivity in the ko mice. |
2014-10-10 |
2023-08-13 |
mouse |
| Arthur T Suckow, David Polidori, Wen Yan, Suhyoun Chon, Jing Ying Ma, James Leonard, Celia P Brisco. Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion. The Journal of biological chemistry. vol 289. issue 22. 2014-10-10. PMID:24742677. |
consistent with previous reports, gpr120 ko mice are hyperglycemic and glucose intolerant; however, our ko mice display evidence of a hyperactive counter-regulatory response rather than insulin resistance during insulin tolerance tests. |
2014-10-10 |
2023-08-13 |
mouse |
| Marta Fabrizi, Valentina Marchetti, Maria Mavilio, Arianna Marino, Viviana Casagrande, Michele Cavalera, Josè Maria Moreno-Navarrete, Teresa Mezza, Gian Pio Sorice, Loredana Fiorentino, Rossella Menghini, Renato Lauro, Giovanni Monteleone, Andrea Giaccari, José Manuel Fernandez Real, Massimo Federic. IL-21 is a major negative regulator of IRF4-dependent lipolysis affecting Tregs in adipose tissue and systemic insulin sensitivity. Diabetes. vol 63. issue 6. 2014-09-16. PMID:24430438. |
in a context of diet-induced obesity, il-21 ko mice, compared with wt animals, exhibited lower body weight, improved insulin sensitivity, and decreased adipose and hepatic inflammation. |
2014-09-16 |
2023-08-12 |
mouse |