| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer Rieusset, Jeremy Fauconnier, Melanie Paillard, Elise Belaidi, Emily Tubbs, Marie-Agnès Chauvin, Annie Durand, Amélie Bravard, Geoffrey Teixeira, Birke Bartosch, Maud Michelet, Pierre Theurey, Guillaume Vial, Marie Demion, Emilie Blond, Fabien Zoulim, Ludovic Gomez, Hubert Vidal, Alain Lacampagne, Michel Oviz. Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance. Diabetologia. vol 59. issue 3. 2016-12-13. PMID:26660890. |
here, we report on the mechanisms by which disruption of mam integrity induces hepatic insulin resistance in cypd (also known as ppif)-knockout (ko) mice. |
2016-12-13 |
2023-08-13 |
mouse |
| Chong Yew Tan, Samuel Virtue, Steven Murfitt, Lee D Roberts, Lee D Robert, Yi Hui Phua, Martin Dale, Julian L Griffin, Francisco Tinahones, Philipp E Scherer, Antonio Vidal-Pui. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Scientific reports. vol 5. 2016-11-01. PMID:26679101. |
both elovl6 ko and scd1 ko mice exhibit improved insulin sensitivity. |
2016-11-01 |
2023-08-13 |
mouse |
| Chong Yew Tan, Samuel Virtue, Steven Murfitt, Lee D Roberts, Lee D Robert, Yi Hui Phua, Martin Dale, Julian L Griffin, Francisco Tinahones, Philipp E Scherer, Antonio Vidal-Pui. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Scientific reports. vol 5. 2016-11-01. PMID:26679101. |
data from mouse models discordant for obesity and insulin resistance (akt2 ko, adiponectin ap2-transgenic), suggested that scwat tag elovl6 ratio was associated with insulin sensitivity, whereas scd1 ratio was associated with fat mass. |
2016-11-01 |
2023-08-13 |
mouse |
| Yongeun Kim, Wei Wang, Meshail Okla, Inhae Kang, Regis Moreau, Soonkyu Chun. Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes. Journal of lipid research. vol 57. issue 1. 2016-10-27. PMID:26628639. |
furthermore, supplementation of leptin-receptor ko mice with γt3 attenuated immune cell infiltration into adipose tissue, decreased circulating il-18 levels, preserved pancreatic β-cells, and improved insulin sensitivity. |
2016-10-27 |
2023-08-13 |
mouse |
| Matthew C Cane, John Parrington, Patrik Rorsman, Antony Galione, Guy A Rutte. The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion. Cell calcium. vol 59. issue 1. 2016-10-26. PMID:26769314. |
βtpcn2 ko mice displayed normal intraperitoneal and oral glucose tolerance, and glucose-stimulated ca(2+) dynamics and insulin secretion from islets were similarly normal. |
2016-10-26 |
2023-08-13 |
mouse |
| Masayuki Sugimoto, Yoichi Shimizu, Songji Zhao, Naoyuki Ukon, Ken-ichi Nishijima, Masato Wakabayashi, Takeshi Yoshioka, Kenichi Higashino, Yoshito Numata, Tomohiko Okuda, Nagara Tamaki, Hisatoshi Hanamatsu, Yasuyuki Igarashi, Yuji Kug. Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice. Biochimica et biophysica acta. vol 1861. issue 8 Pt A. 2016-09-07. PMID:27151272. |
insulin signaling was enhanced in the liver, white adipose tissue and skeletal muscle of sms2 ko mice compared with those of wt mice. |
2016-09-07 |
2023-08-13 |
mouse |
| Masayuki Sugimoto, Yoichi Shimizu, Songji Zhao, Naoyuki Ukon, Ken-ichi Nishijima, Masato Wakabayashi, Takeshi Yoshioka, Kenichi Higashino, Yoshito Numata, Tomohiko Okuda, Nagara Tamaki, Hisatoshi Hanamatsu, Yasuyuki Igarashi, Yuji Kug. Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice. Biochimica et biophysica acta. vol 1861. issue 8 Pt A. 2016-09-07. PMID:27151272. |
we also generated liver-conditional sms2 ko mice and performed glucose and insulin tolerance tests on mice with a high fat diet. |
2016-09-07 |
2023-08-13 |
mouse |
| Chen Huang, Miaomiao Wang, Lirong Ren, Liang Xiang, Jie Chen, Mengxia Li, Tianxia Xiao, Peigen Ren, Likuan Xiong, Jian V Zhan. CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet. Biochemical and biophysical research communications. vol 473. issue 2. 2016-09-06. PMID:26972253. |
cold exposure induced significant body mass decrease and improved glucose tolerance and insulin resistance in wild type hfd mice but had no obvious effect on cmklr1 ko hfd mice. |
2016-09-06 |
2023-08-13 |
mouse |
| Geetanjali Sharma, Eric R Prossnit. GPER/GPR30 Knockout Mice: Effects of GPER on Metabolism. Methods in molecular biology (Clifton, N.J.). vol 1366. 2016-08-29. PMID:26585159. |
studies of gper ko mice over the last years have revealed functions for gper in the regulation of obesity, insulin resistance and glucose intolerance, among other areas of (patho)physiology. |
2016-08-29 |
2023-08-13 |
mouse |
| Christopher J Lynch, Scot R Kimball, Yuping Xu, Anna C Salzberg, Yuka Imamura Kawasaw. Global deletion of BCATm increases expression of skeletal muscle genes associated with protein turnover. Physiological genomics. vol 47. issue 11. 2016-08-26. PMID:26351290. |
also in agreement with our previous observations, the abundance of mrnas associated with reduced body size, glycemia, plasma insulin, and lipid signaling pathways was altered in bcatm ko mice. |
2016-08-26 |
2023-08-13 |
mouse |
| Vanesa Viana-Huete, Carlos Guillén, Ana García-Aguilar, Gema García, Silvia Fernández, C R Kahn, Manuel Benit. Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity. Endocrinology. vol 157. issue 4. 2016-08-17. PMID:26910308. |
in addition, ko mice showed a sustained moderate hyperinsulinemia and hypertriglyceridemia upon time and hepatic insulin insensitivity associated with lipid accumulation, with the outcome of a global insulin resistance. |
2016-08-17 |
2023-08-13 |
mouse |
| Hitoshi Shiman. [SREBP-1c and Elovl6 as Targets for Obesity-related Disorders]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 135. issue 9. 2016-08-11. PMID:26329544. |
elovl6 ko mice exhibit obesity and fatty liver on a high energy diet, but unexpectedly were immune to insulin resistance (nat. |
2016-08-11 |
2023-08-13 |
mouse |
| Stavroula Bitsi, Houda Ali, Lauren Maskell, Samir Ounzain, Vidya Mohamed-Ali, Vishwanie S Budhram-Mahade. Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes. American journal of physiology. Endocrinology and metabolism. vol 310. issue 5. 2016-07-19. PMID:26670484. |
loss of this protein in brn-3b knockout (ko) mice causes profound hyperglycemia and insulin resistance (ir), normally associated with type 2 diabetes (t2d), whereas brn-3b is reduced in tissues taken from obese mice fed on high-fat diets (hfd), which also develop hyperglycemia and ir. |
2016-07-19 |
2023-08-13 |
mouse |
| David R Powell, Jason P Gay, Melinda Smith, Nathaniel Wilganowski, Angela Harris, Autumn Holland, Maricela Reyes, Laura Kirkham, Laura L Kirkpatrick, Brian Zambrowicz, Gwenn Hansen, Kenneth A Platt, Isaac van Sligtenhorst, Zhi-Ming Ding, Urvi Desa. Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque. Diabetes, metabolic syndrome and obesity : targets and therapy. vol 9. 2016-07-06. PMID:27382320. |
fads1 ko mice also had lower glucose and insulin excursions during oral glucose tolerance tests along with lower fasting glucose, insulin, triglyceride, and total cholesterol levels. |
2016-07-06 |
2023-08-13 |
mouse |
| Catalina Troche, Tolunay Beker Aydemir, Robert J Cousin. Zinc transporter Slc39a14 regulates inflammatory signaling associated with hypertrophic adiposity. American journal of physiology. Endocrinology and metabolism. vol 310. issue 4. 2016-06-20. PMID:26646099. |
a null mutation of zip14 (ko) revealed that phenotypic changes in adipose include increased cytokine production, increased plasma leptin, hypertrophied adipocytes, and dampened insulin signaling. |
2016-06-20 |
2023-08-13 |
mouse |
| Deepak Jain, Gesine Weber, Daniel Eberhard, Amir E Mehana, Jan Eglinger, Alena Welters, Barbara Bartosinska, Kay Jeruschke, Jürgen Weiss, Günter Päth, Hiroyoshi Ariga, Jochen Seufert, Eckhard Lammer. DJ-1 Protects Pancreatic Beta Cells from Cytokine- and Streptozotocin-Mediated Cell Death. PloS one. vol 10. issue 9. 2016-05-27. PMID:26422139. |
insulin concentrations were substantially reduced, and fasting blood glucose concentrations were significantly higher in mlds-treated dj-1 ko mice compared to equally treated wild type mice. |
2016-05-27 |
2023-08-13 |
mouse |
| Paul M Titchenell, Qingwei Chu, Bobby R Monks, Morris J Birnbau. Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo. Nature communications. vol 6. 2016-05-06. PMID:25963408. |
liver-specific ablation of the ir (l-insulin receptor ko) induces glucose intolerance, insulin resistance and prevents the appropriate transcriptional response to feeding. |
2016-05-06 |
2023-08-13 |
Not clear |
| Suzie Lavoie, Pascal Steullet, Anita Kulak, Frederic Preitner, Kim Q Do, Pierre J Magistrett. Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage. Frontiers in physiology. vol 7. 2016-05-05. PMID:27148080. |
the aim of the present study was to investigate the sensitivity to insulin in the mouse knockout (ko) for the modulatory subunit of the glutamate cysteine ligase (gclm), the rate-limiting enzyme of gsh synthesis. |
2016-05-05 |
2023-08-13 |
mouse |
| Per Antonson, Ivan Nalvarte, Mukesh Varshney, Li Xu, Sara H Windahl, Patricia Humire, Claes Ohlsson, Jan-Åke Gustafsson, Karin Dahlman-Wrigh. Identification of proteins highly expressed in uterine fluid from mice with hydrometra. Biochemical and biophysical research communications. vol 466. issue 4. 2016-04-26. PMID:26393907. |
in this study we observed that conditional erα knockout mice where the cre gene is regulated by the rat insulin promoter (rip), rip-cre/erα(ko) mice, have a 3.7-fold increase in serum 17β-estradiol levels, blocked estrous cycle, and develop a fluid-filled uterus (hydrometra). |
2016-04-26 |
2023-08-13 |
mouse |
| Lattoya J Lartey, João Pedro Werneck-de-Castro, InSug O-Sullivan, Terry G Unterman, Antonio C Bianc. Coupling between Nutrient Availability and Thyroid Hormone Activation. The Journal of biological chemistry. vol 290. issue 51. 2016-04-21. PMID:26499800. |
studies in the insulin receptor foxo1 ko mouse indicate that insulin is a key signaling molecule in this process. |
2016-04-21 |
2023-08-13 |
mouse |