| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anders M Nää. miR-33: A Metabolic Conundrum. Trends in endocrinology and metabolism: TEM. vol 29. issue 10. 2019-04-08. PMID:29692333. |
showed that mir-33 knockout (ko) mice exhibit obesity, insulin resistance, and increased food intake, suggesting that metabolic regulation by mir-33 is more complex than was previously known. |
2019-04-08 |
2023-08-13 |
mouse |
| Erin S Coyne, Nathalie Bedard, Linda Wykes, Cynthia Stretch, Samer Jammoul, Sihan Li, Kezhuo Zhang, Robert S Sladek, Oliver F Bathe, Robert Thomas Jagoe, Barry I Posner, Simon S Win. Knockout of USP19 Deubiquitinating Enzyme Prevents Muscle Wasting by Modulating Insulin and Glucocorticoid Signaling. Endocrinology. vol 159. issue 8. 2019-02-26. PMID:29901692. |
insulin signaling was enhanced in the ko mice, as revealed by lower circulating insulin levels, increased insulin-stimulated glucose disposal and phosphorylation of akt and s6k in muscle, and improved overall glucose tolerance. |
2019-02-26 |
2023-08-13 |
mouse |
| Keman Xu, William Y Yang, Gayani Kanchana Nanayakkara, Ying Shao, Fan Yang, Wenhui Hu, Eric T Choi, Hong Wang, Xiaofeng Yan. GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg. Frontiers in immunology. vol 9. 2019-02-14. PMID:29434588. |
we made the following significant findings: (1) adipose tissues of diabetic patients with insulin resistance upregulated various th effector subset regulators; (2) in skin biopsy from patients with psoriasis, and in blood cells from patients with lupus, effector th subset regulators were more upregulated than downregulated; (3) in rosiglitazone induced failing hearts in apoe-deficient (ko) mice, various th subset regulators were upregulated rather than downregulated; (4) aortic endothelial cells activated by proatherogenic stimuli secrete several th subset-promoting cytokines; (5) in treg from follicular th (tfh)-transcription factor (tf) bcl6 ko mice, various th subset regulators were upregulated; whereas in treg from th2-tf gata3 ko mice and hdac6 ko mice, various th subset regulators were downregulated, suggesting that bcl6 inhibits, gata3 and hdac6 promote, treg plasticity; and (6) gata3 ko, and bcl6 ko treg upregulated mhc ii molecules and t cell co-stimulation receptors, suggesting that gata3 and bcl6 inhibit treg from becoming novel apc-treg. |
2019-02-14 |
2023-08-13 |
mouse |
| Forough Mohammadzadeh, James N Tsoporis, Shehla Izhar, Jean-Francois Desjardins, Thomas G Parke. Deficiency of S100B confers resistance to experimental diabetes in mice. Experimental cell research. vol 365. issue 1. 2019-01-02. PMID:29499206. |
s100b ko mice exhibited enhanced glucose tolerance, insulin sensitivity, prevented β-cell destruction and functional impairment in response to stz treatment. |
2019-01-02 |
2023-08-13 |
mouse |
| Ya-Rong Hao, Feng-Juan Tang, Xue Zhang, Hui Wan. Suppression of NF-κB activation by PDLIM2 restrains hepatic lipogenesis and inflammation in high fat diet induced mice. Biochemical and biophysical research communications. vol 503. issue 2. 2018-12-18. PMID:29852170. |
after 16 weeks on a high fat diet (hfd), obesity, insulin resistance, hepatic dyslipidemia and inflammation were markedly aggravated in pdlim2-knockout (ko) mice. |
2018-12-18 |
2023-08-13 |
mouse |
| Bernadette M Saunders, Caroline Rudnicka, Aleksandra Filipovska, Stefan Davies, Natalie Ward, Jana Hricova, Markus P Schlaich, Vance B Matthew. Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL-6 production. Immunology and cell biology. vol 96. issue 1. 2018-12-17. PMID:29359470. |
male tnfsf14 knockout (ko) and wild type mice were fed chow or high fat diet (hfd) for 12 weeks and were assessed for weight gain, glucose intolerance, insulin resistance, hepatosteatosis, mitochondrial dysfunction, and cytokine expression. |
2018-12-17 |
2023-08-13 |
mouse |
| Lili Sheng, Prasant Kumar Jena, Hui-Xin Liu, Karen M Kalanetra, Frank J Gonzalez, Samuel W French, Viswanathan V Krishnan, David A Mills, Yu-Jui Yvonne Wa. Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation. Scientific reports. vol 7. issue 1. 2018-12-11. PMID:28496104. |
our data revealed that male wd-fed fxr ko mice had the most severe steatosis and highest hepatic and serum lipids as well as insulin resistance among the eight studied groups. |
2018-12-11 |
2023-08-13 |
mouse |
| Babu Nageswararao Kanuri, Jitendra S Kanshana, Sanjay C Rebello, Priya Pathak, Anand P Gupta, Jiaur R Gayen, Kumaravelu Jagavelu, Madhu Dikshi. Altered glucose and lipid homeostasis in liver and adipose tissue pre-dispose inducible NOS knockout mice to insulin resistance. Scientific reports. vol 7. 2018-10-29. PMID:28106120. |
on the basis of diet induced obesity and ko mice models, nitric oxide is implied to play an important role in the initiation of dyslipidemia induced insulin resistance. |
2018-10-29 |
2023-08-13 |
mouse |
| Babu Nageswararao Kanuri, Jitendra S Kanshana, Sanjay C Rebello, Priya Pathak, Anand P Gupta, Jiaur R Gayen, Kumaravelu Jagavelu, Madhu Dikshi. Altered glucose and lipid homeostasis in liver and adipose tissue pre-dispose inducible NOS knockout mice to insulin resistance. Scientific reports. vol 7. 2018-10-29. PMID:28106120. |
the present study aimed to assess ir in inos ko mice after 5 weeks of lfd feeding by monitoring body composition, energy homeostasis, insulin sensitivity/signaling, nitrite content and gene expressions changes in the tissues. |
2018-10-29 |
2023-08-13 |
mouse |
| Kyung Eun Kim, Eun Ae Jeong, Jong Youl Lee, Chin-Ok Yi, Kyung-Ah Park, Zhen Jin, Jung Eun Lee, Tamas L Horvath, Gu Seob Ro. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29634925. |
we found that hfd-fed sirt1 ko mice had increased insulin resistance and macrophage infiltration in adipose tissue than wild type (wt) mice. |
2018-10-09 |
2023-08-13 |
mouse |
| Tizhong Shan, Yan Xiong, Pengpeng Zhang, Zhiguo Li, Qingyang Jiang, Pengpeng Bi, Feng Yue, Gongshe Yang, Yizhen Wang, Xiaoqi Liu, Shihuan Kuan. Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3. Nature communications. vol 7. 2018-08-27. PMID:27461402. |
consequently, ko mice have improved glucose tolerance and insulin sensitivity, and are more resistant to high-fat diet (hfd)-induced obesity. |
2018-08-27 |
2023-08-13 |
mouse |
| Boubacar Benziane, Melissa L Borg, Robby Z Tom, Isabelle Riedl, Julie Massart, Marie Björnholm, Marc Gilbert, Alexander V Chibalin, Juleen R Zierat. DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism. Journal of lipid research. vol 58. issue 12. 2018-07-16. PMID:29066466. |
although glucose tolerance was similar, insulin levels were reduced in high-fat diet (hfd)-fed dgkζ ko versus wild-type mice. |
2018-07-16 |
2023-08-13 |
mouse |
| Archana Vijayakumar, Pratik Aryal, Jennifer Wen, Ismail Syed, Reema P Vazirani, Pedro M Moraes-Vieira, Joao Paulo Camporez, Molly R Gallop, Rachel J Perry, Odile D Peroni, Gerald I Shulman, Alan Saghatelian, Timothy E McGraw, Barbara B Kah. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell reports. vol 21. issue 4. 2018-06-13. PMID:29069585. |
chow-fed adchrebp ko mice are insulin resistant with impaired insulin action in the liver, muscle, and at and increased at inflammation. |
2018-06-13 |
2023-08-13 |
mouse |
| Archana Vijayakumar, Pratik Aryal, Jennifer Wen, Ismail Syed, Reema P Vazirani, Pedro M Moraes-Vieira, Joao Paulo Camporez, Molly R Gallop, Rachel J Perry, Odile D Peroni, Gerald I Shulman, Alan Saghatelian, Timothy E McGraw, Barbara B Kah. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell reports. vol 21. issue 4. 2018-06-13. PMID:29069585. |
hfd-fed adchrebp ko mice are also more insulin resistant than controls. |
2018-06-13 |
2023-08-13 |
mouse |
| Sabina Paglialunga, Genevieve Simnett, Holly Robson, Monica Hoang, Renjitha Pillai, Alicia M Arkell, Jeremy A Simpson, Arend Bonen, Mark Huising, Jamie W Joseph, Graham P Hollowa. The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 42. issue 6. 2018-04-11. PMID:28177704. |
we examined the role of tbc1d1 in glucose homeostasis and insulin secretion utilizing a rat knockout (ko) model. |
2018-04-11 |
2023-08-13 |
human |
| Sabina Paglialunga, Genevieve Simnett, Holly Robson, Monica Hoang, Renjitha Pillai, Alicia M Arkell, Jeremy A Simpson, Arend Bonen, Mark Huising, Jamie W Joseph, Graham P Hollowa. The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 42. issue 6. 2018-04-11. PMID:28177704. |
chow-fed tbc1d1 ko rats had improved insulin action but impaired glucose-tolerance tests (gtt) and a lower insulin response during an intraperitoneal gtt compared with wild-type (wt) rats. |
2018-04-11 |
2023-08-13 |
human |
| Sabina Paglialunga, Genevieve Simnett, Holly Robson, Monica Hoang, Renjitha Pillai, Alicia M Arkell, Jeremy A Simpson, Arend Bonen, Mark Huising, Jamie W Joseph, Graham P Hollowa. The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 42. issue 6. 2018-04-11. PMID:28177704. |
glucose-stimulated insulin secretion was higher in isolated ko rat islets compared with wt animals, suggesting tbc1d1 is a negative regulator of insulin secretion. |
2018-04-11 |
2023-08-13 |
human |
| Shengbing Li, Cong Wang, Ke Li, Ling Li, Mingyuan Tian, Jing Xie, Mengliu Yang, Yanjun Jia, Junying He, Lin Gao, Guenther Boden, Hua Liu, Gangyi Yan. NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance. Scientific reports. vol 6. 2018-04-02. PMID:27229177. |
nampt knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in apoe ko mice with high-fat-induced insulin resistance. |
2018-04-02 |
2023-08-13 |
mouse |
| Christelle Douillet, Madelyn C Huang, R Jesse Saunders, Ellen N Dover, Chongben Zhang, Miroslav Stýbl. Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure. Archives of toxicology. vol 91. issue 7. 2018-03-26. PMID:27847981. |
however, only male ko mice were insulin resistant as indicated by high fbg, and high plasma insulin at fasting state and 15 min after glucose challenge. |
2018-03-26 |
2023-08-13 |
mouse |
| Christelle Douillet, Madelyn C Huang, R Jesse Saunders, Ellen N Dover, Chongben Zhang, Miroslav Stýbl. Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure. Archives of toxicology. vol 91. issue 7. 2018-03-26. PMID:27847981. |
exposure to ias increased fat mass and insulin resistance in both male and female ko mice, but had no significant effects on body composition or insulin resistance in wt mice. |
2018-03-26 |
2023-08-13 |
mouse |