| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong He, Katie Holl, Sarah DeBehnke, Chay Teng Yeo, Polly Hansen, Abraham K Gebre, Sandra Leone-Kabler, Margarida Ruas, John S Parks, John Parrington, Leah C Solberg Wood. Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain. Physiological genomics. vol 50. issue 8. 2019-08-26. PMID:29750602. |
in addition, both male and female ko mice are protected against diet-induced weight gain, but this protection is likely independent from glucose tolerance, insulin sensitivity, and plasma lipid levels. |
2019-08-26 |
2023-08-13 |
mouse |
| Kenji Yoshida, Yoshihiro Kita, Suzumi M Tokuoka, Fumie Hamano, Maya Yamazaki, Kenji Sakimura, Masanobu Kano, Takao Shimiz. Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 2. 2019-08-26. PMID:30265576. |
mgl-deficient [mgl-knockout (ko)] mice fed a hfd gained less body weight than wild-type mice and were protected from insulin resistance and hepatic steatosis. |
2019-08-26 |
2023-08-13 |
mouse |
| Julie Charpentier, Aurélie Waget, Pascale Klopp, Christophe Magnan, Céline Cruciani-Guglielmacci, Shin Jae Lee, Rémy Burcelin, Estelle Grasse. Lixisenatide requires a functional gut-vagus nerve-brain axis to trigger insulin secretion in controls and type 2 diabetic mice. American journal of physiology. Gastrointestinal and liver physiology. vol 315. issue 5. 2019-08-16. PMID:30070580. |
we studied the effects of lixisenatide (intraperitoneal injection) on insulin secretion, gastric emptying, vagus nerve activity, and brain c-fos activation in naive, chronically vagotomized, glp-1 receptor knockout (ko), high-fat diet-fed diabetic mice, or db/db mice. |
2019-08-16 |
2023-08-13 |
mouse |
| Valentina Caracciolo, Jeanette Young, Donna Gonzales, Yingchun Ni, Stephen J Flowers, Ross Summer, Scott A Waldman, Jason K Kim, Dae Young Jung, Hye Lim Noh, Taekyoon Kim, Perry J Blackshear, Danielle O'Connell, Robert C Bauer, Caleb B Kalle. Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice. American journal of physiology. Endocrinology and metabolism. vol 315. issue 4. 2019-07-26. PMID:29509432. |
unexpectedly, in glucose tolerance testing and hyperinsulinemic-euglycemic clamp studies, myeloid zfp36 ko mice demonstrated improved insulin sensitivity compared with control mice. |
2019-07-26 |
2023-08-13 |
mouse |
| Chu-Lin Chou, Ching-Hao Li, Heng Lin, Mei-Hui Liao, Chin-Chen Wu, Jin-Shuen Chen, Yuh-Mou Sue, Te-Chao Fan. Role of activating transcription factor 3 in fructose-induced metabolic syndrome in mice. Hypertension research : official journal of the Japanese Society of Hypertension. vol 41. issue 8. 2019-07-26. PMID:29895822. |
atf3 ko in mice increased the serum levels of glucose, insulin, triglycerides, tumor necrosis factor-alpha, and intercellular adhesion molecule-1, impaired endothelium-dependent aortic relaxation, increased aorta wall thickness and lipid peroxide, and expanded visceral adiposity. |
2019-07-26 |
2023-08-13 |
mouse |
| Mirian A Kurauti, José M Costa-Júnior, Sandra M Ferreira, Gustavo J Santos, Carlos H G Sponton, Everardo M Carneiro, Guilherme D Telles, Mara P T Chacon-Mikahil, Cláudia R Cavaglieri, Luiz F Rezende, Antonio C Boscher. Interleukin-6 increases the expression and activity of insulin-degrading enzyme. Scientific reports. vol 7. 2019-07-22. PMID:28429777. |
il-6 ko mice displayed lower insulin clearance in the liver and skeletal muscle, compared with wild type (wt), due to reduced ide expression and activity. |
2019-07-22 |
2023-08-13 |
mouse |
| Angelina Hernandez-Carretero, Natalie Weber, Samuel A LaBarge, Veronika Peterka, Nhu Y Thi Doan, Simon Schenk, Olivia Osbor. Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle. American journal of physiology. Endocrinology and metabolism. vol 315. issue 2. 2019-07-09. PMID:29634311. |
high-fat diet-fed csrp3 knockout (ko) mice developed impaired glucose tolerance and insulin resistance as well as increased inflammation in skeletal muscle compared with wild-type (wt) mice. |
2019-07-09 |
2023-08-13 |
mouse |
| Angelina Hernandez-Carretero, Natalie Weber, Samuel A LaBarge, Veronika Peterka, Nhu Y Thi Doan, Simon Schenk, Olivia Osbor. Cysteine- and glycine-rich protein 3 regulates glucose homeostasis in skeletal muscle. American journal of physiology. Endocrinology and metabolism. vol 315. issue 2. 2019-07-09. PMID:29634311. |
csrp3-ko mice had significantly impaired insulin signaling, decreased glut4 translocation to the plasma membrane, and enhanced levels of phospho-pkcα in muscle, which all contributed to reduced insulin-stimulated glucose disposal in muscle in hfd-fed ko mice compared with wt mice. |
2019-07-09 |
2023-08-13 |
mouse |
| Takeshi Yamamotoya, Yusuke Nakatsu, Akifumi Kushiyama, Yasuka Matsunaga, Koji Ueda, Yuki Inoue, Masa-Ki Inoue, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Hiroshi Kiyonari, Hisamitsu Ishihara, Tomoichiro Asan. Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity. Scientific reports. vol 7. issue 1. 2019-06-26. PMID:29026155. |
interestingly, βtfg ko displayed marked glucose intolerance with reduced insulin secretion. |
2019-06-26 |
2023-08-13 |
mouse |
| Takeshi Yamamotoya, Yusuke Nakatsu, Akifumi Kushiyama, Yasuka Matsunaga, Koji Ueda, Yuki Inoue, Masa-Ki Inoue, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Hiroshi Kiyonari, Hisamitsu Ishihara, Tomoichiro Asan. Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity. Scientific reports. vol 7. issue 1. 2019-06-26. PMID:29026155. |
furthermore, glucose-induced insulin secretion was also markedly impaired in islets isolated from βtfg ko. |
2019-06-26 |
2023-08-13 |
mouse |
| Takeshi Yamamotoya, Yusuke Nakatsu, Akifumi Kushiyama, Yasuka Matsunaga, Koji Ueda, Yuki Inoue, Masa-Ki Inoue, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Hiroshi Kiyonari, Hisamitsu Ishihara, Tomoichiro Asan. Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity. Scientific reports. vol 7. issue 1. 2019-06-26. PMID:29026155. |
electron microscopic observation revealed endoplasmic reticulum (er) dilatation, suggestive of er stress, and smaller insulin crystal diameters in β-cells of βtfg ko. |
2019-06-26 |
2023-08-13 |
mouse |
| Marianne Böni-Schnetzler, Stéphanie P Häuselmann, Elise Dalmas, Daniel T Meier, Constanze Thienel, Shuyang Traub, Friederike Schulze, Laura Steiger, Erez Dror, Praxedis Martin, Pedro L Herrera, Cem Gabay, Marc Y Donat. β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion. Cell reports. vol 22. issue 7. 2019-06-04. PMID:29444430. |
βil-1ra ko mice had impaired insulin secretion, reduced β cell proliferation, and decreased expression of islet proliferation genes, along with impaired glucose tolerance. |
2019-06-04 |
2023-08-13 |
mouse |
| Fen Gong, Junfei Gu, Haijun Wan. Up regulated Tmbim1 activation promotes high fat diet (HFD)-induced cardiomyopathy by enhancement of inflammation and oxidative stress. Biochemical and biophysical research communications. vol 504. issue 4. 2019-05-28. PMID:30217448. |
we provided evidence that tmbim1 knockout (ko) accelerated hfd-induced metabolic disorders in mice, as supported by the remarkable increase of fasting serum glucose and insulin levels. |
2019-05-28 |
2023-08-13 |
mouse |
| Louise Lantier, Ashley S Williams, Curtis C Hughey, Deanna P Bracy, Freyja D James, Muhammad A Ansari, David Gius, David H Wasserma. SIRT2 knockout exacerbates insulin resistance in high fat-fed mice. PloS one. vol 13. issue 12. 2019-05-07. PMID:30533032. |
we hypothesized that genetic sirt2 knockout (ko) would lead to impaired insulin action, and that this impairment would be worsened in hf fed mice. |
2019-05-07 |
2023-08-13 |
mouse |
| Louise Lantier, Ashley S Williams, Curtis C Hughey, Deanna P Bracy, Freyja D James, Muhammad A Ansari, David Gius, David H Wasserma. SIRT2 knockout exacerbates insulin resistance in high fat-fed mice. PloS one. vol 13. issue 12. 2019-05-07. PMID:30533032. |
insulin sensitivity was tested using the hyperinsulinemic-euglycemic clamp in sirt2 ko mice and wt littermates. |
2019-05-07 |
2023-08-13 |
mouse |
| Louise Lantier, Ashley S Williams, Curtis C Hughey, Deanna P Bracy, Freyja D James, Muhammad A Ansari, David Gius, David H Wasserma. SIRT2 knockout exacerbates insulin resistance in high fat-fed mice. PloS one. vol 13. issue 12. 2019-05-07. PMID:30533032. |
liver insulin sensitivity was unaffected in lean sirt2 ko mice. |
2019-05-07 |
2023-08-13 |
mouse |
| Louise Lantier, Ashley S Williams, Curtis C Hughey, Deanna P Bracy, Freyja D James, Muhammad A Ansari, David Gius, David H Wasserma. SIRT2 knockout exacerbates insulin resistance in high fat-fed mice. PloS one. vol 13. issue 12. 2019-05-07. PMID:30533032. |
however, the insulin resistance that accompanies hf-feeding was worsened in sirt2 ko mice. |
2019-05-07 |
2023-08-13 |
mouse |
| Louise Lantier, Ashley S Williams, Curtis C Hughey, Deanna P Bracy, Freyja D James, Muhammad A Ansari, David Gius, David H Wasserma. SIRT2 knockout exacerbates insulin resistance in high fat-fed mice. PloS one. vol 13. issue 12. 2019-05-07. PMID:30533032. |
mitochondrial acetylation state and changes in feeding behavior that result in increased body weight correspond to the deleterious effects of sirt2 ko on insulin action. |
2019-05-07 |
2023-08-13 |
mouse |
| Wendy K Adams, Anna M D'souza, Jacob L Sussman, Sukhbir Kaur, Timothy J Kieffer, Catharine A Winstanle. Enhanced amphetamine-induced motor impulsivity and mild attentional impairment in the leptin-deficient rat model of obesity. Physiology & behavior. vol 192. 2019-04-22. PMID:29601831. |
notably, the expression of striatal dopaminergic markers was unchanged in ko rats, and neither chronic food restriction nor hfd intake altered the impairments in glucose or insulin metabolism previously reported in these animals. |
2019-04-22 |
2023-08-13 |
human |
| Jihwa Kim, Sanghyun Joo, Gwang Hyeon Eom, Seung Hoon Lee, Min-Ah Lee, Miyoung Lee, Ki Woo Kim, Do Han Kim, Hyun Kook, Tae Hwan Kwak, Woo Jin Par. CCN5 knockout mice exhibit lipotoxic cardiomyopathy with mild obesity and diabetes. PloS one. vol 13. issue 11. 2019-04-22. PMID:30485307. |
the ccn5 ko mice also exhibited mild diabetes characterized by high fasting glucose levels and impaired insulin and glucose tolerances. |
2019-04-22 |
2023-08-13 |
mouse |