| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huimeng Qi, Li Yao, Qiang Li. MicroRNA-96 regulates pancreatic β cell function under the pathological condition of diabetes mellitus through targeting Foxo1 and Sox6. Biochemical and biophysical research communications. vol 519. issue 2. 2020-06-29. PMID:31506178. |
increased fasting blood glucose and homa-ir, as well as decreased plasma insulin and homa-%b were observed in microrna-96 ko mice. |
2020-06-29 |
2023-08-13 |
mouse |
| Diego T Quiroga, Johanna G Miquet, Lorena Gonzalez, Ana I Sotelo, Marina C Muñoz, Pedro M Geraldes, Jorge F Giani, Fernando P Dominic. Mice lacking angiotensin type 2 receptor exhibit a sex-specific attenuation of insulin sensitivity. Molecular and cellular endocrinology. vol 498. 2020-06-24. PMID:31539597. |
in this study we further explored the role of the at2r on insulin action and glucose homeostasis by investigating the glycemic profile and in vivo insulin signaling status in insulin-target tissues from both male and female at2r knockout (ko) mice. |
2020-06-24 |
2023-08-13 |
mouse |
| Luiz F Barella, Mario Rossi, Lu Zhu, Yinghong Cui, Fang C Mei, Xiaodong Cheng, Wei Chen, Vsevolod V Gurevich, Jürgen Wes. β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion. The Journal of clinical investigation. vol 129. issue 9. 2020-06-23. PMID:31184597. |
however, glibenclamide and tolbutamide, two widely used antidiabetic drugs of the sulfonylurea (su) family, showed greatly reduced efficacy in stimulating insulin secretion in the ko mice in vivo and in perifused ko islets in vitro. |
2020-06-23 |
2023-08-13 |
mouse |
| Ping Ye, Jijun Liu, Wuping Xu, Denghai Liu, Xiangchao Ding, Sheng Le, Hao Zhang, Shanshan Chen, Manhua Chen, Jiahong Xi. Dual-Specificity Phosphatase 26 Protects Against Nonalcoholic Fatty Liver Disease in Mice Through Transforming Growth Factor Beta-Activated Kinase 1 Suppression. Hepatology (Baltimore, Md.). vol 69. issue 5. 2020-06-15. PMID:30582764. |
in our study, hepatic steatosis, inflammatory responses, and insulin resistance were exacerbated in liver-specific dusp26-knockout (ko) mice but ameliorated in liver-specific dusp26-transgenic mice induced by a high-fat diet. |
2020-06-15 |
2023-08-13 |
mouse |
| Xudong Wang, Ying-Tang Gao, Dan Jiang, Yuzhou Wang, Hongyan Du, Jili Lv, Shu Jie L. Hv1-deficiency protects β cells from glucotoxicity through regulation of NOX4 level. Biochemical and biophysical research communications. vol 513. issue 2. 2020-04-27. PMID:30967259. |
following 48 h of treatment with 30 mm high glucose, hv1 ko β cells showed higher cell viability, lower cell apoptosis and a more stable insulin gene expression level compared to wt β cells. |
2020-04-27 |
2023-08-13 |
Not clear |
| Filip Roudnicky, Yanjun Lan, Max Friesen, Gregor Dernick, Jitao David Zhang, Andreas Staempfli, Natalie Bordag, Antje Wagner-Golbs, Klaus Christensen, Martin Ebeling, Martin Graf, Mark Burcin, Claas Aiko Meyer, Chad A Cowan, Christoph Patsc. Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype. International journal of molecular sciences. vol 20. issue 24. 2020-04-23. PMID:31835296. |
the kinase akt2 (pkb) is an important mediator of insulin signaling, for which loss-of-function knockout (ko) mutants lead to early onset diabetes mellitus, and dominant active mutations lead to early development of obesity and endothelial cell (ec) dysfunction. |
2020-04-23 |
2023-08-13 |
human |
| Pryscila D S Teixeira, Gisele C Couto, Isadora C Furigo, Edward O List, John J Kopchick, Jose Donat. Central growth hormone action regulates metabolism during pregnancy. American journal of physiology. Endocrinology and metabolism. vol 317. issue 5. 2020-03-30. PMID:31479305. |
additionally, both brain ghr ko and lepr ghr ko mice had lower glucose tolerance and glucose-stimulated insulin secretion during pregnancy, despite presenting increased insulin sensitivity, compared with control pregnant animals. |
2020-03-30 |
2023-08-13 |
mouse |
| Seung Joo Lee, Jeong Suk Kang, Hong Min Kim, Eun Soo Lee, Ji-Hye Lee, Choon Hee Chung, Eun Young Le. CCR2 knockout ameliorates obesity-induced kidney injury through inhibiting oxidative stress and ER stress. PloS one. vol 14. issue 9. 2020-03-12. PMID:31498850. |
glucose, insulin, total cholesterol, and triglycerides levels increased in hfd wt mice were decreased in hfd ko mice. |
2020-03-12 |
2023-08-13 |
mouse |
| Seung Joo Lee, Jeong Suk Kang, Hong Min Kim, Eun Soo Lee, Ji-Hye Lee, Choon Hee Chung, Eun Young Le. CCR2 knockout ameliorates obesity-induced kidney injury through inhibiting oxidative stress and ER stress. PloS one. vol 14. issue 9. 2020-03-12. PMID:31498850. |
insulin resistance, increased insulin secretion, and lipid accumulation showed in hfd wt mice were improved in hfd ko mice. |
2020-03-12 |
2023-08-13 |
mouse |
| Yutian Li, Shan Deng, Jiangtong Peng, Xiaohong Wang, Kobina Essandoh, Xingjiang Mu, Tianqing Peng, Zhuo-Xian Meng, Guo-Chang Fa. MicroRNA-223 is essential for maintaining functional β-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways. The Journal of biological chemistry. vol 294. issue 27. 2020-03-10. PMID:31118273. |
interestingly, mir-223 knockout (ko) mice exhibit impaired glucose tolerance and insulin resistance. |
2020-03-10 |
2023-08-13 |
mouse |
| Salvatore Fusco, Matteo Spinelli, Sara Cocco, Cristian Ripoli, Alessia Mastrodonato, Francesca Natale, Marco Rinaudo, Giulia Livrizzi, Claudio Grass. Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms. Nature communications. vol 10. issue 1. 2020-01-16. PMID:31641124. |
bdnf administration to hfd-fed mothers or preserved insulin sensitivity in hfd-fed p66shc ko mice also prevents the intergenerational transmission of brain damage to the progeny. |
2020-01-16 |
2023-08-13 |
mouse |
| Yifei Yang, Boyang Zhang, Masanori Nakata, Jun Nakae, Masatomo Mori, Toshihiko Yad. Islet β-cell-produced NUCB2/nesfatin-1 maintains insulin secretion and glycemia along with suppressing UCP-2 in β-cells. The journal of physiological sciences : JPS. vol 69. issue 5. 2020-01-06. PMID:31228099. |
in a glucose tolerance test at 12 weeks, insulin secretion at 15 min was reduced and blood glucose at 2 h increased in βnucb2 ko mice fasted 8 h. |
2020-01-06 |
2023-08-13 |
mouse |
| Yifei Yang, Boyang Zhang, Masanori Nakata, Jun Nakae, Masatomo Mori, Toshihiko Yad. Islet β-cell-produced NUCB2/nesfatin-1 maintains insulin secretion and glycemia along with suppressing UCP-2 in β-cells. The journal of physiological sciences : JPS. vol 69. issue 5. 2020-01-06. PMID:31228099. |
in islets isolated from βnucb2 ko mice, high glucose-stimulated insulin secretion (gsis) was impaired. |
2020-01-06 |
2023-08-13 |
mouse |
| Pryscila D S Teixeira, Angela M Ramos-Lobo, Isadora C Furigo, Jose Donat. Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice. Endocrinology. vol 160. issue 12. 2019-12-23. PMID:31599926. |
nonetheless, brain-specific stat5 knockout (ko) mice that had the experience of pregnancy but did not lactate showed increased body weight and reduced energy expenditure later in life, whereas pregnancy ko and pregnancy+lactation ko mice exhibited improved insulin sensitivity compared with virgin ko mice. |
2019-12-23 |
2023-08-13 |
mouse |
| Takahiro Ohkura, Teizo Yoshimura, Masayoshi Fujisawa, Toshiaki Ohara, Rie Marutani, Kaya Usami, Akihiro Matsukaw. Spred2 Regulates High Fat Diet-Induced Adipose Tissue Inflammation, and Metabolic Abnormalities in Mice. Frontiers in immunology. vol 10. 2019-12-20. PMID:30723473. |
exacerbated adipose tissue inflammation in spred2 ko mice led to aggravated insulin resistance and fatty liver disease. |
2019-12-20 |
2023-08-13 |
mouse |
| Priya Pathak, Jitendra S Kanshana, BabuNageswar Kanuri, Sanjay C Rebello, Hobby Aggarwal, Kumaravelu Jagavelu, Madhu Dikshi. Vasoreactivity of isolated aortic rings from dyslipidemic and insulin resistant inducible nitric oxide synthase knockout mice. European journal of pharmacology. vol 855. 2019-12-20. PMID:31063772. |
recent study from this lab indicated enhanced susceptibility of inos ko mice for diet induced obesity (dio) and systemic insulin resistance (ir) as compared to c57bl/6 (wt) mice. |
2019-12-20 |
2023-08-13 |
mouse |
| Priya Pathak, Jitendra S Kanshana, BabuNageswar Kanuri, Sanjay C Rebello, Hobby Aggarwal, Kumaravelu Jagavelu, Madhu Dikshi. Vasoreactivity of isolated aortic rings from dyslipidemic and insulin resistant inducible nitric oxide synthase knockout mice. European journal of pharmacology. vol 855. 2019-12-20. PMID:31063772. |
the present study investigates aortic vasoreactivity in high fat diet (hfd) induced insulin resistant inos ko mice. |
2019-12-20 |
2023-08-13 |
mouse |
| Wenmin Xia, Ariane R Pessentheiner, Dina C Hofer, Melina Amor, Renate Schreiber, Gabriele Schoiswohl, Thomas O Eichmann, Evelyn Walenta, Bianca Itariu, Gerhard Prager, Hubert Hackl, Thomas Stulnig, Dagmar Kratky, Thomas Rülicke, Juliane G Bogner-Straus. Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance. Cell reports. vol 23. issue 7. 2019-12-02. PMID:29768196. |
neither insulin nor glucose treatments can suppress fa mobilization in global and conditional abhd15-knockout (ko) mice. |
2019-12-02 |
2023-08-13 |
mouse |
| Christine Deisl, Manuel Anderegg, Giuseppe Albano, Benjamin P Lüscher, David Cerny, Rodrigo Soria, Elisa Bouillet, Stefano Rimoldi, Urs Scherrer, Daniel G Fuste. Loss of Sodium/Hydrogen Exchanger NHA2 Exacerbates Obesity- and Aging-Induced Glucose Intolerance in Mice. PloS one. vol 11. issue 9. 2019-11-20. PMID:27685945. |
insulin levels remained similar in nha2 ko and wt mice during aging and high fat diet, but fasting insulin/glucose ratios were significantly lower in nha2 ko mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Christine Deisl, Manuel Anderegg, Giuseppe Albano, Benjamin P Lüscher, David Cerny, Rodrigo Soria, Elisa Bouillet, Stefano Rimoldi, Urs Scherrer, Daniel G Fuste. Loss of Sodium/Hydrogen Exchanger NHA2 Exacerbates Obesity- and Aging-Induced Glucose Intolerance in Mice. PloS one. vol 11. issue 9. 2019-11-20. PMID:27685945. |
high fat diet diminished insulin secretion capacity in both wt and nha2 ko islets and reduced expression of nha2 in wt islets. |
2019-11-20 |
2023-08-13 |
mouse |