| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paloma Lillo Urzúa, Olinda Núñez Murillo, Mauricio Castro-Sepúlveda, María A Torres-Quintana, Álvaro Lladser Caldera, Andrew F G Quest, Carolina Espinoza Robles, Paola Llanos Vidal, Sergio Wehinge. Loss of Caveolin-1 Is Associated with a Decrease in Beta Cell Death in Mice on a High Fat Diet. International journal of molecular sciences. vol 21. issue 15. 2021-02-16. PMID:32718046. |
we observed that cav1 ko mice were resistant to weight gain when on hfd, although they had high serum cholesterol and ffa levels, impaired glucose tolerance and were insulin resistant. |
2021-02-16 |
2023-08-13 |
mouse |
| Muayad Al-Badrani, Punnag Saha, Ayan Mondal, Ratanesh K Seth, Sutapa Sarkar, Diana Kimono, Dipro Bose, Dwayne E Porter, Geoff I Scott, Bryan Brooks, Samir Raychoudhury, Mitzi Nagarkatti, Prakash Nagarkatti, Saurabh Chatterje. Early microcystin-LR exposure-linked inflammasome activation in mice causes development of fatty liver disease and insulin resistance. Environmental toxicology and pharmacology. vol 80. 2021-02-10. PMID:32687983. |
also, mechanistically, nlrp3 ko mice showed a significant decrease in the inflammation and nafld phenotype and resisted the metabolic changes such as insulin resistance and glucose metabolism in the liver. |
2021-02-10 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuchiro Yamada, Yutaka Sein. Islet adaptation in GIP receptor knockout mice. Peptides. vol 125. 2021-02-08. PMID:31522751. |
in this study, we examined the insulin response to intravenous glucose by measuring glucose, insulin and c-peptide after intravenous glucose (0.35 g/kg) in 5-h fasted female gip receptor ko mice and their wild-type (wt) littermates. |
2021-02-08 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuchiro Yamada, Yutaka Sein. Islet adaptation in GIP receptor knockout mice. Peptides. vol 125. 2021-02-08. PMID:31522751. |
the 1 min insulin and c-peptide responses to intravenous glucose were significantly enhanced in gip receptor ko mice (n = 26) compared to wt mice (n = 30) as was beta cell function (area under the 50 min c-peptide curve divided by area under the 50 min curve for glucose) (p = 0.001). |
2021-02-08 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuchiro Yamada, Yutaka Sein. Islet adaptation in GIP receptor knockout mice. Peptides. vol 125. 2021-02-08. PMID:31522751. |
we conclude that there is a beta cell adaptation in gip receptor ko mice resulting in enhanced insulin secretion after intravenous glucose to which slight long-term reduction in circulating glucose in these mice may contribute. |
2021-02-08 |
2023-08-13 |
mouse |
| Kristen E Syring, Karin J Bosma, Slavina B Goleva, Kritika Singh, James K Oeser, Christopher A Lopez, Eric P Skaar, Owen P McGuinness, Lea K Davis, David R Powell, Richard M O'Brie. Potential positive and negative consequences of ZnT8 inhibition. The Journal of endocrinology. vol 246. issue 2. 2021-01-25. PMID:32485672. |
both young and adult slc30a8 ko mice exhibit a delayed rise in insulin after glucose injection, but only the former exhibit increased basal insulin clearance and impaired glucose tolerance. |
2021-01-25 |
2023-08-13 |
mouse |
| Yuka Toyoshima, Katsuyuki Nakamura, Reiko Tokita, Naomi Teramoto, Hidetoshi Sugihara, Hisanori Kato, Keitaro Yamanouchi, Shiro Minam. Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats. The Journal of biological chemistry. vol 295. issue 33. 2021-01-22. PMID:32631952. |
studies using irs-2 knockout (ko) mice showed that the deletion of irs-2 causes type 2 diabetes due to peripheral insulin resistance and impaired β-cell function. |
2021-01-22 |
2023-08-13 |
mouse |
| Yuka Toyoshima, Katsuyuki Nakamura, Reiko Tokita, Naomi Teramoto, Hidetoshi Sugihara, Hisanori Kato, Keitaro Yamanouchi, Shiro Minam. Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats. The Journal of biological chemistry. vol 295. issue 33. 2021-01-22. PMID:32631952. |
compared with male wt rats, the glucose and insulin tolerance of male irs-2 ko rats were slightly enhanced, whereas a similar difference was not observed between female wt and irs-2 ko rats. |
2021-01-22 |
2023-08-13 |
mouse |
| Yuka Toyoshima, Katsuyuki Nakamura, Reiko Tokita, Naomi Teramoto, Hidetoshi Sugihara, Hisanori Kato, Keitaro Yamanouchi, Shiro Minam. Disruption of insulin receptor substrate-2 impairs growth but not insulin function in rats. The Journal of biological chemistry. vol 295. issue 33. 2021-01-22. PMID:32631952. |
besides the modestly increased insulin sensitivity, male irs-2 ko rats displayed the enhanced insulin-induced activation of the mtor complex 1 pathway in the liver compared with wt rats. |
2021-01-22 |
2023-08-13 |
mouse |
| Mara A Dedual, Stephan Wueest, Tenagne D Challa, Fabrizio C Lucchini, Tim R J Aeppli, Marcela Borsigova, Andrea A Mauracher, Stefano Vavassori, Jana Pachlopnik Schmid, Matthias Blüher, Daniel Konra. Obesity-Induced Increase in Cystatin C Alleviates Tissue Inflammation. Diabetes. vol 69. issue 9. 2021-01-15. PMID:32616516. |
in line, hfd-induced hepatic insulin resistance and impairment of glucose tolerance were further aggravated in ko mice. |
2021-01-15 |
2023-08-13 |
mouse |
| Yanyun Chen, Min Song, Jonathan P Riley, Charlie C Hu, Xianbu Peng, Donalyn Scheuner, Krister Bokvist, Pranab Maiti, Steven D Kahl, Chahrzad Montrose-Rafizadeh, Chafiq Hamdouchi, Anne Reifel Mille. A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes. Pharmacology research & perspectives. vol 4. issue 6. 2021-01-09. PMID:28097011. |
significant increases in insulin secretion were detected when ly2881835 was tested in primary islets from wt mice but not in islets from gpr40 ko mice. |
2021-01-09 |
2023-08-13 |
mouse |
| Huimin Pang, Jinwen Li, Hongyan Du, Yingtang Gao, Jili Lv, Yanxia Liu, Shu Jie L. Loss of voltage-gated proton channel Hv1 leads to diet-induced obesity in mice. BMJ open diabetes research & care. vol 8. issue 1. 2021-01-07. PMID:32049639. |
here, we investigated the role of hv1 in adipose tissue differentiation, metabolic homeostasis and insulin sensitivity using hv1 knockout (ko) mice. |
2021-01-07 |
2023-08-13 |
mouse |
| Ting Chen, Jonathon T Hill, Timothy M Moore, Eric C K Cheung, Zachary E Olsen, Ted B Piorczynski, Tanner D Marriott, Jeffery S Tessem, Chase M Walton, Benjamin T Bikman, Jason M Hansen, David M Thomso. Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 8. 2021-01-04. PMID:32339642. |
ko did not affect glucose or insulin tolerance. |
2021-01-04 |
2023-08-13 |
mouse |
| Ting Chen, Jonathon T Hill, Timothy M Moore, Eric C K Cheung, Zachary E Olsen, Ted B Piorczynski, Tanner D Marriott, Jeffery S Tessem, Chase M Walton, Benjamin T Bikman, Jason M Hansen, David M Thomso. Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 8. 2021-01-04. PMID:32339642. |
however, fasting serum insulin and skeletal muscle insulin signaling were higher in the ko mice. |
2021-01-04 |
2023-08-13 |
mouse |
| Frank K Huynh, Brett S Peterson, Kristin A Anderson, Zhihong Lin, Aeowynn J Coakley, Fiara M S Llaguno, Thi-Tina N Nguyen, Jonathan E Campbell, Samuel B Stephens, Christopher B Newgard, Matthew D Hirsche. β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice. American journal of physiology. Endocrinology and metabolism. vol 319. issue 4. 2020-12-31. PMID:32865009. |
we showed that mice with a global loss of sirt4 [sirt4-knockout (ko) mice] developed an increase in glucose- and leucine-stimulated insulin secretion, and this was followed by accelerated age-induced glucose intolerance and insulin resistance. |
2020-12-31 |
2023-08-13 |
mouse |
| Xunshan Ding, Rugmani Iyer, Christopher Novotny, Daniel Metzger, Heather H Zhou, Gordon I Smith, Mihoko Yoshino, Jun Yoshino, Samuel Klein, Gayathri Swaminath, Saswata Talukdar, Yingjiang Zho. Inhibition of Grb14, a negative modulator of insulin signaling, improves glucose homeostasis without causing cardiac dysfunction. Scientific reports. vol 10. issue 1. 2020-11-10. PMID:32099031. |
data from human genetic studies have shown that grb14 functions as a negative modulator of ir activity, and the germline grb14-knockout (ko) mice have improved insulin signaling in liver and skeletal muscle. |
2020-11-10 |
2023-08-13 |
mouse |
| Lili Song, Do-Sung Kim, Wenyu Gou, Jingjing Wang, Ping Wang, Zhiguo Wei, Bei Liu, Zihai Li, Kemian Gou, Hongjun Wan. GRP94 regulates M1 macrophage polarization and insulin resistance. American journal of physiology. Endocrinology and metabolism. vol 318. issue 6. 2020-10-26. PMID:32208002. |
to determine the role of grp94 in macrophage polarization and insulin resistance, macrophage-specific grp94 conditional knockout (ko) mice were challenged with a high-fat diet (hfd). |
2020-10-26 |
2023-08-13 |
mouse |
| Lili Song, Do-Sung Kim, Wenyu Gou, Jingjing Wang, Ping Wang, Zhiguo Wei, Bei Liu, Zihai Li, Kemian Gou, Hongjun Wan. GRP94 regulates M1 macrophage polarization and insulin resistance. American journal of physiology. Endocrinology and metabolism. vol 318. issue 6. 2020-10-26. PMID:32208002. |
ko mice showed better glucose tolerance and increased insulin sensitivity. |
2020-10-26 |
2023-08-13 |
mouse |
| Lili Song, Do-Sung Kim, Wenyu Gou, Jingjing Wang, Ping Wang, Zhiguo Wei, Bei Liu, Zihai Li, Kemian Gou, Hongjun Wan. GRP94 regulates M1 macrophage polarization and insulin resistance. American journal of physiology. Endocrinology and metabolism. vol 318. issue 6. 2020-10-26. PMID:32208002. |
in vitro, wt adipocytes cocultured with ko macrophages retained insulin sensitivity, whereas those cultured with wt macrophages did not. |
2020-10-26 |
2023-08-13 |
mouse |
| Michael L Blackburn, Kikumi D Ono-Moore, Hany F Sobhi, Sean H Adam. Carnitine palmitoyltransferase 2 knockout potentiates palmitate-induced insulin resistance in C American journal of physiology. Endocrinology and metabolism. vol 319. issue 2. 2020-10-26. PMID:32459525. |
growing cells in carnitine-free media abolished differences between wt and cpt2 ko, but this did not fully rescue pa-induced insulin resistance. |
2020-10-26 |
2023-08-13 |
Not clear |