| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia Grigorova, Zhenya Ivanova, Bodil Bjørndal, Rolf Kristian Berge, Ekaterina Vachkova, Aneliya Milanova, Georgi Penchev, Ivan Penchev Georgie. Diet restriction alone improves glucose tolerance and insulin sensitivity than its coadministration with krill or fish oil in a rabbit model of castration-induced obesity. Journal of animal physiology and animal nutrition. 2022-07-19. PMID:35851693. |
this study investigated the effect of 50% diet restriction and its coadministration with krill oil (ko) or fish oil (fo) on glucose tolerance and insulin sensitivity in a rabbit model of obesity. |
2022-07-19 |
2023-08-14 |
rabbit |
| Natalia Grigorova, Zhenya Ivanova, Bodil Bjørndal, Rolf Kristian Berge, Ekaterina Vachkova, Aneliya Milanova, Georgi Penchev, Ivan Penchev Georgie. Diet restriction alone improves glucose tolerance and insulin sensitivity than its coadministration with krill or fish oil in a rabbit model of castration-induced obesity. Journal of animal physiology and animal nutrition. 2022-07-19. PMID:35851693. |
surprisingly, ko and fo administration downregulated acetyl-coenzyme a oxidase and carnitine palmitoyltransferase 2 messenger rna gene expression compared to the rg. in conclusion, we can assume that a better effect on insulin sensitivity and glucose tolerance was observed in the diet restriction alone than in the coadministration of ko or fo when animals are exposed to highly obesity predisposing factors. |
2022-07-19 |
2023-08-14 |
rabbit |
| Qianqian Li, Yutian Li, Wei Huang, Xiaohong Wang, Zhenling Liu, Jing Chen, Yanbo Fan, Tianqing Peng, Sakthivel Sadayappan, Yigang Wang, Guo-Chang Fa. Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy Frontiers in immunology. vol 13. 2022-06-27. PMID:35757735. |
next, using a global lcn10-knockout (ko) mouse model to induce type-2 diabetes (t2d), we observed that loss of lcn10 promoted more pro-inflammatory macrophage infiltration into the heart, compared to controls, leading to aggravated insulin resistance and impaired cardiac function. |
2022-06-27 |
2023-08-14 |
mouse |
| Dabin Lee, Kang-Hoon Lee, Dong Wook Kim, Sanghyuk Yoon, Je-Yoel Ch. CXCL5 inhibits excessive oxidative stress by regulating white adipocyte differentiation. Redox biology. vol 54. 2022-06-13. PMID:35696764. |
oxidative stress and insulin resistance occurred in cxcl5 ko mice due to decreased antioxidant enzymes and failure to remove ros. |
2022-06-13 |
2023-08-14 |
mouse |
| Chunqing Wang, Xing Zhang, Liping Luo, Yan Luo, Dandan Wu, Dianna Spilca, Que Le, Xin Yang, Katelyn Alvarez, William Curtis Hines, Xuexian O Yang, Meilian Li. COX-2 Deficiency Promotes White Adipogenesis via PGE2-Mediated Paracrine Mechanism and Exacerbates Diet-Induced Obesity. Cells. vol 11. issue 11. 2022-06-10. PMID:35681514. |
using adipocyte-specific cox-2 knockout (ko) mice, we showed that depleting cox-2 in adipocytes promoted white adipose tissue development accompanied with increased size and number of adipocytes and predisposed diet-induced adiposity, obesity, and insulin resistance. |
2022-06-10 |
2023-08-14 |
mouse |
| Ling Cui, Chunlu Tan, Lili Huang, Weihao Wang, Zhengxiang Huang, Fang Geng, Mengjun Wu, Xiaolin Chen, Michael Cowley, Ferdinand Roelfsema, Chen Che. Dapagliflozin partially restores reproductive function in MC4R KO obese female mice. The Journal of endocrinology. 2022-05-25. PMID:35612570. |
melanocortin-4-receptor knock-out (mc4r ko) mouse is an over-eating obese model with hyperphagia, hyperinsulinemia, reduced growth hormone (gh), and insulin resistance. |
2022-05-25 |
2023-08-13 |
mouse |
| Praghalathan Kanthakumar, Dieniffer Peixoto-Neves, Ravi Kumar, Hitesh Soni, Adebowale Adebiy. Urotensin II receptor knockout alleviates streptozotocin-induced hyperglucagonemia and diabetic kidney disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553154. |
stz-treated mice showed increased blood glucose levels, glucosuria, decreased plasma insulin levels, and diabetic kidney disease (dkd), which ut ko attenuated. |
2022-05-13 |
2023-08-13 |
mouse |
| Praghalathan Kanthakumar, Dieniffer Peixoto-Neves, Ravi Kumar, Hitesh Soni, Adebowale Adebiy. Urotensin II receptor knockout alleviates streptozotocin-induced hyperglucagonemia and diabetic kidney disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553154. |
however, ut ko failed to reverse stz-induced insulin deficiency. |
2022-05-13 |
2023-08-13 |
mouse |
| Praghalathan Kanthakumar, Dieniffer Peixoto-Neves, Ravi Kumar, Hitesh Soni, Adebowale Adebiy. Urotensin II receptor knockout alleviates streptozotocin-induced hyperglucagonemia and diabetic kidney disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35553154. |
to understand the underlying mechanism for alleviating hyperglycemia and dkd in ut ko despite the uncorrected insulin deficiency, we tested the role of the primary insulin counterregulatory hormone, glucagon. |
2022-05-13 |
2023-08-13 |
mouse |
| Adriana C Norris, Eugenia Yazlovitskaya, Lin Zhu, Bailey Rose, Sophia Yu, John A McLean, John Stafford, Todd R Graha. ATP10A has a protective and sex-specific role in lipid metabolism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555158. |
additionally, female atp10a ko mice exhibit elevated fasting blood glucose levels without compensatory elevation of insulin. |
2022-05-13 |
2023-08-13 |
mouse |
| Reddy S Sagabala, Avinash D Londhe, Krisann Marquart, Darryl Pappin, Benoit Boivi. Role of PTP1B in the Regulation of Cholesterol Homeostasis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555694. |
we also observed that proteins involved in retinoic acid homeostasis, which have also been involved in the regulation of insulin resistance and lipid homeostasis, were overexpressed in ptp1b ko mefs. |
2022-05-13 |
2023-08-13 |
mouse |
| Alessandra Gentile, Nunzia Magnacca, Rita de Matteis, Maria Moreno, Federica Cioffi, Antonia Giacco, Antonia Lanni, Pieter de Lange, Rosalba Senese, Fernando Goglia, Elena Silvestri, Assunta Lombard. Ablation of uncoupling protein 3 affects interrelated factors leading to lipolysis and insulin resistance in visceral white adipose tissue. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 5. 2022-04-22. PMID:35452152. |
the response of gwat to in vivo insulin administration, revealed by (ser473)-akt phosphorylation, was blunted in ko mice, with a putative role played by eif2a, jnk, and inflammation. |
2022-04-22 |
2023-08-13 |
mouse |
| Yang Yang, Xian Liu, Hui Chen, Pengjun Wang, Songhui Yao, Bin Zhou, Ronghua Yin, Changyan Li, Chutse Wu, Xiaoming Yang, Miao Y. HPS protects the liver against steatosis, cell death, inflammation and fibrosis in mice with steatohepatitis. The FEBS journal. 2022-03-14. PMID:35285180. |
in contrast, hps administration improved mcd- or hfd-induced liver phenotypes and insulin resistance in hps ko and wt mice. |
2022-03-14 |
2023-08-13 |
mouse |
| Dieniffer Peixoto-Neves, Praghalathan Kanthakumar, Ravi Kumar, Hitesh Soni, Adebowale Adebiy. Loss of urotensin II receptor diminishes hyperglycemia and kidney injury in streptozotocin-treated mice. Journal of molecular endocrinology. 2022-03-04. PMID:35244607. |
ut ko also ameliorated stz-induced increase in hba1c, but not stz-induced decrease in plasma insulin levels. |
2022-03-04 |
2023-08-13 |
mouse |
| Masashi Satoh, Misao Iizuka, Masataka Majima, Chizuru Ohwa, Akito Hattori, Luc Van Kaer, Kazuya Iwabuch. Adipose invariant NKT cells interact with CD1d-expressing macrophages to regulate obesity-related inflammation. Immunology. 2022-03-01. PMID:35137411. |
we previously reported that cd1d knockout (ko) mice are partially protected against the development of obesity-associated insulin resistance, and these findings were recapitulated in mice with an adipocyte-specific cd1d deficiency, suggesting that nkt cell-adipocyte interactions play a critical role in exacerbating disease. |
2022-03-01 |
2023-08-16 |
mouse |
| Mohsin Rahim, Arya Y Nakhe, Deveena R Banerjee, Emily M Overway, Karin J Bosma, Jonah C Rosch, James K Oeser, Bo Wang, Ethan S Lippmann, David A Jacobson, Richard M O'Brien, Jamey D Youn. Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells. The Journal of biological chemistry. 2022-02-17. PMID:35176280. |
at 5 mm glucose, pancreatic islets from g6pc2 knockout (ko) mice exhibit no glucose cycling, increased glycolytic flux, and enhanced glucose-stimulated insulin secretion (gsis). |
2022-02-17 |
2023-08-13 |
mouse |
| Amin Ardestani, Kathrin Maedle. MST1 deletion protects β-cells in a mouse model of diabetes. Nutrition & diabetes. vol 12. issue 1. 2022-02-09. PMID:35136036. |
importantly, the glucose-lowering effects in the mst1-knockout (ko) mice could be accounted to the enhanced β-cell mass and improved insulin secretion without changes in insulin sensitivity. |
2022-02-09 |
2023-08-13 |
mouse |
| Ru Chen, Xi Luo, Xiaoli Jiang, Shan Den. Vinexin β deficiency exacerbates diet-induced obesity, hepatosteatosis, insulin resistance and endoplasmic reticulum stress in mice. Biochemical and biophysical research communications. vol 596. 2022-02-01. PMID:35104662. |
furthermore, we confirmed the inhibited akt signaling and exacerbated insulin resistance which resulted in high fasting blood glucose in ko mice. |
2022-02-01 |
2023-08-13 |
mouse |
| Seongkyun Lim, J William Deaver, Megan E Rosa-Caldwell, David E Lee, Francielly Morena Da Silva, Ana Regina Cabrera, Eleanor R Schrems, Landen W Saling, Tyrone A Washington, James D Fluckey, Nicholas P Green. Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner. American journal of physiology. Endocrinology and metabolism. 2022-01-24. PMID:35068192. |
(2) we generated muscle-specific mir-16 knockout (ko) mice fed a high-fat diet (hfd) to assess how mir-16 content impacts metabolic and contractile properties including glucose tolerance, insulin sensitivity, muscle contractile function, protein anabolism, and mitochondrial network health. |
2022-01-24 |
2023-08-13 |
mouse |
| Seongkyun Lim, J William Deaver, Megan E Rosa-Caldwell, David E Lee, Francielly Morena Da Silva, Ana Regina Cabrera, Eleanor R Schrems, Landen W Saling, Tyrone A Washington, James D Fluckey, Nicholas P Green. Muscle miR-16 deletion results in impaired insulin sensitivity and contractile function in a sex-dependent manner. American journal of physiology. Endocrinology and metabolism. 2022-01-24. PMID:35068192. |
however, while males specifically exhibited impaired insulin sensitivity following mir-16 deletion (p=0.030), female ko mice showed pronounced glucose intolerance (p=0.046), corresponding with lower muscle weights (p=0.015), and protein hyperanabolism (p=0.023). |
2022-01-24 |
2023-08-13 |
mouse |