| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satsuki Takashima, Eiichi Okamura, Yusuke Ichiyama, Kiyoto Nishi, Akio Shimizu, Chisato Watanabe, Masanaga Muto, Shoma Matsumoto, Setsuko Tsukiyama-Fujii, Tomoyuki Tsukiyama, Hisakazu Ogita, Eiichiro Nishi, Masahito Ohji, Fumihiro Sugiyama, Satoru Takahashi, Seiya Mizuno, Ken-Ichi Mizutani, Masatsugu Em. Null mutation of exocyst complex component 3-like does not affect vascular development in mice. Experimental animals. 2023-09-04. PMID:37661429. |
despite the implied roles, exoc3l ko mice exhibited no apparent phenotype in vascular development, cholesterol homeostasis, or insulin secretion. |
2023-09-04 |
2023-09-07 |
mouse |
| Emma J Buckels, Joey Tan, Huai-Ling Hsu, Yuting Zhu, Christina M Buchanan, Brya G Matthews, Kate L Le. Preptin Deficiency Does Not Protect against High-Fat Diet-Induced Metabolic Dysfunction or Bone Loss in Mice. JBMR plus. vol 7. issue 8. 2023-08-24. PMID:37614298. |
female wt mice had increased glucose-stimulated insulin secretion under hfd conditions that was absent in female ko mice. |
2023-08-24 |
2023-09-07 |
mouse |
| Anna L Lang, Nadee Nissanka, Ruy A Louzada, Alejandro Tamayo, Elizabeth Pereira, Carlos T Moraes, Alejandro Caiced. A DEFECT IN MITOCHONDRIAL COMPLEX III BUT NOT IN COMPLEXES I OR IV CAUSES EARLY BETA CELL DYSFUNCTION AND HYPERGLYCEMIA IN MICE. Diabetes. 2023-06-21. PMID:37343239. |
although all ko models had similar mitochondrial respiratory defects, complex iii caused early hyperglycemia, glucose intolerance, and loss of glucose-stimulated insulin secretion in vivo. |
2023-06-21 |
2023-08-14 |
mouse |
| Brenna Osborne, Lauren E Wright, Amanda E Brandon, Ella Stuart, Lewin Small, Joris Hoeks, Patrick Schrauwen, David A Sinclair, Magdalene K Montgomery, Gregory J Cooney, Nigel Turne. SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance. The Journal of endocrinology. 2023-06-19. PMID:37335200. |
thus, despite sirt3 ko mouse models indicating many beneficial metabolic roles for sirt3, our findings show that muscle-specific overexpression of sirt3 has only minor effects on the acute development of skeletal muscle insulin resistance in high fat fed rats. |
2023-06-19 |
2023-08-14 |
mouse |
| Simona Moffa, Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Chiara M A Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Gea Ciccarelli, Andrea Mari, Alfredo Pontecorvi, Andrea Giaccar. Effects of PCSK9 inhibition on glucose metabolism and β-cell function in humans: a pilot study. Frontiers in endocrinology. vol 14. 2023-06-16. PMID:37324254. |
pcsk9, however, is also expressed in tissues, including the pancreas, and studies on pcsk9 ko mice have shown impaired insulin secretion. |
2023-06-16 |
2023-08-14 |
mouse |
| Lenka Maletinska, Alena Karnošová, Veronika Strnadová, Blanka Zelezna, Jaroslav Kunes, Petr Kašpáre. NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose. Clinical science (London, England : 1979). 2023-05-16. PMID:37191311. |
in addition, reduced insulin pathway signaling proteins in npffr2 ko mice fed a hfd resulted in the development of hypothalamic insulin resistance. |
2023-05-16 |
2023-08-14 |
mouse |
| Charles J Kim, Chanpreet Singh, Christine Lee, Kevin DiMagno, Madison O'Donnell, Marina Kaczmarek, Arhum Ahmed, Jessica Salvo-Schaich, Alexis Perez, William Letsou, Maria-Alicia Carrillo Sepulveda, Raddy L Ramos, Michael Hadjiargyro. Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice. Physiological reports. vol 11. issue 9. 2023-05-11. PMID:37170065. |
these findings coincided with mrna changes in genes known to be involved in glucose metabolism, tolerance, and insulin sensitivity; 2-month-old male ko mice had significantly higher expression of glut1 and glut10 transporters, mup-1 while ostn expression was lower. |
2023-05-11 |
2023-08-14 |
mouse |
| Yuka Nozaki, Masaki Kobayashi, Hiroki Wakasawa, Shunsuke Hoshino, Fumika Suwa, Yuko Ose, Ryoma Tagawa, Yoshikazu Higam. Systemic depletion of WWP1 improves insulin sensitivity and lowers triglyceride content in the liver of obese mice. FEBS open bio. 2023-04-09. PMID:37032433. |
here, to determine which insulin-sensitive tissues contribute to this phenotype, we investigated the levels of several insulin signaling markers in white adipose tissue, liver and skeletal muscle of wwp1 ko mice, which were fed a normal or high-fat diet and transiently treated with insulin. |
2023-04-09 |
2023-08-14 |
mouse |
| Seul Gi Lee, Jongbeom Chae, Seon Min Woo, Seung Un Seo, Ha-Jeong Kim, Sang-Yeob Kim, David D Schlaepfer, In-San Kim, Hee-Sae Park, Taeg Kyu Kwon, Ju-Ock Na. TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway. Experimental & molecular medicine. 2023-02-28. PMID:36854775. |
tgfbi ko mice were resistant to adipose tissue hypertrophy, liver steatosis, and insulin resistance. |
2023-02-28 |
2023-08-14 |
mouse |
| Fusun Kili. The nature of the binding between insulin receptor and serotonin transporter in placenta (review). Placenta. vol 133. 2023-02-16. PMID:36796293. |
while insulin signaling is important for the modifications of sert proteins, the fact that phosphorylation of ir was significantly down-regulated in the placenta of sert knock out (ko) mice suggests that sert also regulates ir. |
2023-02-16 |
2023-08-14 |
mouse |
| Susheel K Gunasekar, John Heebink, Danielle H Carpenter, Ashutosh Kumar, Litao Xie, Haixia Zhang, Joel D Schilling, Rajan Sa. Adipose-targeted SWELL1 deletion exacerbates obesity and age-related non-alcoholic fatty liver disease. JCI insight. 2023-02-07. PMID:36749637. |
adipose-specific swell1 ablation (adipo ko) leads to insulin resistance and hyperglycemia during caloric excess, both of which are associated with nafld. |
2023-02-07 |
2023-08-14 |
mouse |
| Yumiko Okano Tamura, Jun Sugama, Shin-Ichi Abe, Yuji Shimizu, Hideki Hirose, Masanori Watanab. Selective somatostatin receptor 5 inhibition improves hepatic insulin sensitivity. Pharmacology research & perspectives. vol 11. issue 1. 2022-12-31. PMID:36585794. |
moreover, sstr5 knockout (ko) mice display enhanced insulin sensitivity; however, the underlying mechanism has not been clarified. |
2022-12-31 |
2023-08-14 |
mouse |
| Yumiko Okano Tamura, Jun Sugama, Shin-Ichi Abe, Yuji Shimizu, Hideki Hirose, Masanori Watanab. Selective somatostatin receptor 5 inhibition improves hepatic insulin sensitivity. Pharmacology research & perspectives. vol 11. issue 1. 2022-12-31. PMID:36585794. |
therefore, in this study, we investigate the effect of sstr5 blockade on insulin resistance and the target organ using sstr5 ko mice and a selective sstr5 antagonist (compound-1). |
2022-12-31 |
2023-08-14 |
mouse |
| Yumiko Okano Tamura, Jun Sugama, Shin-Ichi Abe, Yuji Shimizu, Hideki Hirose, Masanori Watanab. Selective somatostatin receptor 5 inhibition improves hepatic insulin sensitivity. Pharmacology research & perspectives. vol 11. issue 1. 2022-12-31. PMID:36585794. |
high-fat diet (hfd)-fed sstr5 ko mice exhibited significantly lower homeostasis model assessment of insulin resistance (homa-ir) than hfd-fed wild-type mice. |
2022-12-31 |
2023-08-14 |
mouse |
| Liming Wang, Yuping Tang, Mark A Herman, Robert F Spurne. Pharmacologic blockade of the natriuretic peptide clearance receptor promotes weight loss and enhances insulin sensitivity in type 2 diabetes. Translational research : the journal of laboratory and clinical medicine. 2022-12-23. PMID:36563959. |
knockout (ko) of nprc protects against diet induced obesity and improves insulin sensitivity in obese mice. |
2022-12-23 |
2023-08-14 |
mouse |
| Xiao-Huan Liu, Yupeng Zhang, Liao Chang, Yang Wei, Na Huang, Jin-Ting Zhou, Cheng Cheng, Jianbo Zhang, Jing Xu, Zongfang Li, Xiaoming L. Apolipoprotein A-IV reduced metabolic inflammation in white adipose tissue by inhibiting IKK and JNK signaling in adipocytes. Molecular and cellular endocrinology. vol 559. 2022-11-07. PMID:36341820. |
in diet-induced obesity (dio) c57bl/6j mice, apoa-iv deficiency induced in apoa-iv-/-knock-out (ko mice) resulted in increased bodyweight, insulin resistance (ir) and plasma free fatty acid (ffa), which was partially reversed by stable apoa-iv-green fluorescent protein (ko-a4-gfp) transfection in ko mice. |
2022-11-07 |
2023-08-14 |
mouse |
| Anzela Niraula, Rachael D Fasnacht, Kelly M Ness, Jeremy M Frey, Sophia A Cuschieri, Mauricio D Dorfman, Joshua P Thale. Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity. Diabetes. 2022-11-01. PMID:36318114. |
in correspondence with this lean phenotype, insulin sensitivity was also improved in the hfd-fed mg-ep4 ko mice though glucose tolerance remained surprisingly unaffected. |
2022-11-01 |
2023-08-14 |
mouse |
| Sara Carmo-Silva, Marisa Ferreira-Marques, Clévio Nóbrega, Mariana Botelho, Daniela Costa, Célia A Aveleira, Stefan M Pulst, Luís Pereira de Almeida, Claudia Cavada. Ataxin-2 in the hypothalamus at the crossroads between metabolism and clock genes. Journal of molecular endocrinology. 2022-09-14. PMID:36103139. |
atxn2 knockout (ko) mice are obese and insulin resistant, however the cause for this phenotype is still unknown. |
2022-09-14 |
2023-08-14 |
mouse |
| Camila O de Souza, Vivian A Paschoal, Xue-Nan Sun, Lavanya Vishvanath, Qianbin Zhang, Mengle Shao, Toshiharu Onodera, Shiuhwei Chen, Nolwenn Joffin, Lorena Ma Bueno, Rana K Gupta, Da Young O. GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model. The Journal of clinical investigation. 2022-09-06. PMID:36066975. |
alternatively, gpr92 agonist, farnesyl pyrophosphate (fpp) stimulation results in the inhibition of hfd-induced islet inflammation and increased insulin secretion in wt mice, but not in gpr92 ko mice. |
2022-09-06 |
2023-08-14 |
mouse |
| Ana M Fernandez, Laura Martinez-Rachadell, Marta Navarrete, Julia Pose-Utrilla, Jose Carlos Davila, Jaime Pignatelli, Sonia Diaz-Pacheco, Santiago Guerra-Cantera, Emilia Viedma-Moreno, Rocio Palenzuela, Samuel Ruiz de Martin Esteban, Ricardo Mostany, Cristina Garcia-Caceres, Matthias Tschöp, Teresa Iglesias, Maria L de Ceballos, Antonia Gutierrez, Ignacio Torres Alema. Insulin regulates neurovascular coupling through astrocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 29. 2022-07-20. PMID:35858325. |
mice with insulin receptor (ir)-deficient astrocytes (gfap-ir knockout [ko] mice) show blunted responses to insulin and reduced brain glucose uptake, whereas ir-deficient astrocytes show disturbed mitochondrial responses to glucose. |
2022-07-20 |
2023-08-14 |
mouse |