| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Casey J Bauchle, Kristen E Rohli, Cierra K Boyer, Vidhant Pal, Jonathan V Rocheleau, Siming Liu, Yumi Imai, Eric B Taylor, Samuel B Stephen. Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function. Diabetes. vol 70. issue 8. 2021-09-21. PMID:34039628. |
here, we generated constitutive and adult cic β-cell knockout (ko) mice and demonstrate that these animals have normal glucose tolerance, similar responses to diet-induced obesity, and identical insulin secretion responses to various fuel secretagogues. |
2021-09-21 |
2023-08-13 |
mouse |
| Casey J Bauchle, Kristen E Rohli, Cierra K Boyer, Vidhant Pal, Jonathan V Rocheleau, Siming Liu, Yumi Imai, Eric B Taylor, Samuel B Stephen. Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function. Diabetes. vol 70. issue 8. 2021-09-21. PMID:34039628. |
furthermore, suppression of the downstream enzyme cytosolic isocitrate dehydrogenase (idh1) inhibited insulin secretion in wild-type islets but failed to impact β-cell function in β-cell cic ko islets. |
2021-09-21 |
2023-08-13 |
mouse |
| Guoqing Zhang, Ran Li, Wu Li, Sijia Yang, Qing Sun, Hongping Yin, Cui Wang, Biyu Hou, Huanhuan Wang, Liping Yu, Rucheng Chen, Liyun Shi, Kezhong Zhang, Chong Wee Liew, Guifen Qiang, Qinghua Sun, Cuiqing Li. Toll-like receptor 3 ablation prevented high-fat diet-induced obesity and metabolic disorder. The Journal of nutritional biochemistry. vol 95. 2021-09-16. PMID:33965533. |
body weight, glucose homeostasis and insulin sensitivity were evaluated in tlr3 wild-type and knockout (ko) mice on a chow diet (cd) or high-fat diet for 15 weeks. |
2021-09-16 |
2023-08-13 |
mouse |
| John M Dean, Anyuan He, Min Tan, Jun Wang, Dongliang Lu, Babak Razani, Irfan J Lodh. MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARγ-Dependent Gene Expression. Cell reports. vol 33. issue 1. 2021-09-15. PMID:33027649. |
adipose-specific med19 knockout (ko) in mice results in a striking loss of wat, whitening of brown fat, hepatic steatosis, and insulin resistance. |
2021-09-15 |
2023-08-13 |
Not clear |
| Marie-Line Peyot, Anna Roubtsova, Roxane Lussier, Ann Chamberland, Rachid Essalmani, S R Murthy Madiraju, Nabil G Seidah, Marc Prentki, Annik Pra. Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice. Biochimica et biophysica acta. Molecular and cell biology of lipids. vol 1866. issue 8. 2021-09-15. PMID:33992809. |
whole body ko and βko mice presented normal glucose tolerance, insulin release in response to glucose load and insulin sensitivity. |
2021-09-15 |
2023-08-13 |
mouse |
| Marie-Line Peyot, Anna Roubtsova, Roxane Lussier, Ann Chamberland, Rachid Essalmani, S R Murthy Madiraju, Nabil G Seidah, Marc Prentki, Annik Pra. Substantial PCSK9 inactivation in β-cells does not modify glucose homeostasis or insulin secretion in mice. Biochimica et biophysica acta. Molecular and cell biology of lipids. vol 1866. issue 8. 2021-09-15. PMID:33992809. |
ex vivo glucose-stimulated insulin secretion in presence or absence of fatty acids was similar in wt and ko islets. |
2021-09-15 |
2023-08-13 |
mouse |
| Vishwanie S Budhram-Mahadeo, Matthew R Solomons, Eeshan A O Mahadeo-Head. Linking metabolic dysfunction with cardiovascular diseases: Brn-3b/POU4F2 transcription factor in cardiometabolic tissues in health and disease. Cell death & disease. vol 12. issue 3. 2021-09-14. PMID:33712567. |
skeletal muscle and adipose tissue) and is important for normal function because constitutive brn-3b-knockout (ko) mice develop profound metabolic dysfunction (hyperglycaemia; insulin resistance). |
2021-09-14 |
2023-08-13 |
mouse |
| Valeria López-Salazar, Mónica Sánchez Tapia, Sandra Tobón-Cornejo, Daniel Díaz, Gabriela Alemán-Escondrillas, Omar Granados-Portillo, Lilia Noriega, Armando R Tovar, Nimbe Torre. Consumption of soybean or olive oil at recommended concentrations increased the intestinal microbiota diversity and insulin sensitivity and prevented fatty liver compared to the effects of coconut oil. The Journal of nutritional biochemistry. vol 94. 2021-09-13. PMID:33915261. |
therefore, the purpose of the present work was to study whether different types of oils rich in polyunsaturated (soybean oil, so), monounsaturated (olive oil, oo), or saturated fatty acids (coconut oil, co) can regulate the gut microbiota, insulin sensitivity, inflammation, mitochondrial function in wild type and pparα ko mice. |
2021-09-13 |
2023-08-13 |
mouse |
| Laura M Clart, Rebecca J Welly, Eric D Queathem, R Scott Rector, Jaume Padilla, Christopher P Baines, Jill A Kanaley, Dennis B Lubahn, Victoria J Vieira-Potte. Role of ERβ in adipocyte metabolic response to wheel running following ovariectomy. The Journal of endocrinology. vol 249. issue 3. 2021-09-07. PMID:33877054. |
the inability to upregulate ucp1 with exercise following ovx may have resulted in the increased insulin resistance observed in ko mice, a hypothesis requiring further investigation. |
2021-09-07 |
2023-08-13 |
mouse |
| Jiyoon Ryu, Jason T Hadley, Zhi Li, Feng Dong, Huan Xu, Xiaoban Xin, Ye Zhang, Cang Chen, Senlin Li, Xiaoning Guo, Jared L Zhao, Robin J Leach, Muhammad A Abdul-Ghani, Ralph A DeFronzo, Amrita Kamat, Feng Liu, Lily Q Don. Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration. Diabetes. vol 70. issue 6. 2021-09-02. PMID:34162682. |
here, we report that hepatocyte-specific knockout (ko) of the adaptor protein appl2 enhanced adiponectin sensitivity and prevented mice from developing high-fat diet-induced inflammation, insulin resistance, and glucose intolerance, although it caused fatty liver. |
2021-09-02 |
2023-08-13 |
mouse |
| Yu Zhe Li, Antonio Di Cristofano, Minna Wo. Metabolic Role of PTEN in Insulin Signaling and Resistance. Cold Spring Harbor perspectives in medicine. vol 10. issue 8. 2021-07-21. PMID:31964643. |
through the use of a variety of models, such as tissue-specific knockout (ko) mice and in vitro cell cultures, pten's role in regulating insulin action has been elucidated across many cell types. |
2021-07-21 |
2023-08-13 |
mouse |
| Taiji Sato, Chihiro Ishiwatari, Yukiko K Kaneko, Yoko Ishikawa, Yuki Kimura, Naoya Watanabe, Ikumi Aoshima, Yukari Matsuda, Takahiro Nakayama, Rina Chiba, Takahiro Fujinuki, Kai Iwata, Qiang Lu, Takako Usuki, Fumio Sakane, Tomohisa Ishikaw. Diacylglycerol kinase δ functions as a proliferation suppressor in pancreatic β-cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 5. 2021-07-19. PMID:33774855. |
we developed β-cell-specific dgkδ knockout (βdgkδ ko) mice, which showed lower blood glucose, higher plasma insulin levels, and better glucose tolerance compared to control mice. |
2021-07-19 |
2023-08-13 |
mouse |
| Shunsuke Hoshino, Masaki Kobayashi, Ryoma Tagawa, Ryutaro Konno, Takuro Abe, Kazuhiro Furuya, Kumi Miura, Hiroki Wakasawa, Naoyuki Okita, Yuka Sudo, Yuhei Mizunoe, Yoshimi Nakagawa, Takeshi Nakamura, Hiroshi Kawabe, Yoshikazu Higam. WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism. FEBS open bio. vol 10. issue 3. 2021-07-09. PMID:31965758. |
however, plasma insulin level was low and glucose level was unchanged in obese wwp1 ko mice. |
2021-07-09 |
2023-08-13 |
mouse |
| Shunsuke Hoshino, Masaki Kobayashi, Ryoma Tagawa, Ryutaro Konno, Takuro Abe, Kazuhiro Furuya, Kumi Miura, Hiroki Wakasawa, Naoyuki Okita, Yuka Sudo, Yuhei Mizunoe, Yoshimi Nakagawa, Takeshi Nakamura, Hiroshi Kawabe, Yoshikazu Higam. WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism. FEBS open bio. vol 10. issue 3. 2021-07-09. PMID:31965758. |
moreover, both glucose tolerance test and insulin tolerance test were improved in obese wwp1 ko mice. |
2021-07-09 |
2023-08-13 |
mouse |
| Hye-Na Cha, Chang-Hoon Woo, Hwa-Young Kim, So-Young Par. Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice. Redox biology. vol 38. 2021-06-18. PMID:33296856. |
to test this hypothesis, we examined the effect of msrb3 deficiency on hfd-induced insulin resistance using msrb3 knockout (ko) mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Hye-Na Cha, Chang-Hoon Woo, Hwa-Young Kim, So-Young Par. Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice. Redox biology. vol 38. 2021-06-18. PMID:33296856. |
the hfd increased oxidative stress and induced insulin resistance in the skeletal muscle of wild-type mice, but did not affect either in msrb3 ko mice. |
2021-06-18 |
2023-08-13 |
mouse |
| Troy A Roepke, Ali Yasrebi, Alejandra Villalobos, Elizabeth A Krumm, Jennifer A Yang, Kyle J Mamouni. The loss of ERE-dependent ERα signaling potentiates the effects of maternal high-fat diet on energy homeostasis in female offspring fed an obesogenic diet. Journal of developmental origins of health and disease. vol 11. issue 3. 2021-06-17. PMID:31543088. |
insulin and tumor necrosis factor α levels were higher in ko offspring from hfd-fed dams. |
2021-06-17 |
2023-08-13 |
mouse |
| Leonardo Velazco-Cruz, Madeleine M Goedegebuure, Kristina G Maxwell, Punn Augsornworawat, Nathaniel J Hogrebe, Jeffrey R Millma. SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro. Cell reports. vol 31. issue 8. 2021-05-21. PMID:32460030. |
knockdown (kd) or knockout (ko) of six2 in sc-β cells drastically limits glucose-stimulated insulin secretion in both static and dynamic assays, along with the upstream processes of cytoplasmic calcium flux and mitochondrial respiration. |
2021-05-21 |
2023-08-13 |
human |
| Ashley S Williams, Timothy R Koves, Michael T Davidson, Scott B Crown, Kelsey H Fisher-Wellman, Maria J Torres, James A Draper, Tara M Narowski, Dorothy H Slentz, Louise Lantier, David H Wasserman, Paul A Grimsrud, Deborah M Muoi. Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction. Cell metabolism. vol 31. issue 1. 2021-05-12. PMID:31813822. |
dko mice are highly susceptible to extreme hyperacetylation of the mitochondrial proteome and develop a more severe form of diet-induced insulin resistance than either single ko mouse line. |
2021-05-12 |
2023-08-13 |
mouse |
| Miao Chen, Caoyu Ji, Qingchen Yang, Shuya Gao, Yue Peng, Zhe Li, Xingyu Gao, Yaoting Li, Nan Jiang, Yubin Zhang, Xiaohong Bian, Caiping Chen, Kaidi Zhang, Daniel Sanchis, Fangrong Yan, Junmei Y. AKT2 regulates development and metabolic homeostasis via AMPK-depedent pathway in skeletal muscle. Clinical science (London, England : 1979). vol 134. issue 17. 2021-03-23. PMID:32880392. |
moreover, akt2 ko mice exhibited impaired ampk signaling in response to insulin stimulation compared with wt mice. |
2021-03-23 |
2023-08-13 |
mouse |