| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael L Blackburn, Kikumi D Ono-Moore, Hany F Sobhi, Sean H Adam. Carnitine palmitoyltransferase 2 knockout potentiates palmitate-induced insulin resistance in C American journal of physiology. Endocrinology and metabolism. vol 319. issue 2. 2020-10-26. PMID:32459525. |
since carnitine-free conditions could not fully rescue insulin signaling, and cpt2 ko did not alter cell stress responses, the majority of pa-induced "lipotoxicity" in c2c12 myotubes cannot be attributed to palmitoylcarnitine alone. |
2020-10-26 |
2023-08-13 |
Not clear |
| Yong Zhang, Lili Song, Huansheng Dong, Do-Sung Kim, Zhen Sun, Heather Boger, Qin Wang, Hongjun Wan. Spinophilin-deficient mice are protected from diet-induced obesity and insulin resistance. American journal of physiology. Endocrinology and metabolism. vol 319. issue 2. 2020-10-26. PMID:32603260. |
male spl knockout (ko) mice fed a chow diet were significantly leaner, had lower body weights, and exhibited better glucose tolerance and insulin sensitivity than wild-type (wt) littermate controls. |
2020-10-26 |
2023-08-13 |
mouse |
| Yong Zhang, Lili Song, Huansheng Dong, Do-Sung Kim, Zhen Sun, Heather Boger, Qin Wang, Hongjun Wan. Spinophilin-deficient mice are protected from diet-induced obesity and insulin resistance. American journal of physiology. Endocrinology and metabolism. vol 319. issue 2. 2020-10-26. PMID:32603260. |
when fed an hfd, spl ko mice were protected from increased body fat, weight gain, hepatic steatosis, hyperinsulinemia, and insulin resistance. |
2020-10-26 |
2023-08-13 |
mouse |
| Zsuzsanna Winkler, Dániel Kuti, Ágnes Polyák, Balázs Juhász, Krisztina Gulyás, Nikolett Lénárt, Ádám Dénes, Szilamér Ferenczi, Krisztina J Kovác. Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses. Scientific reports. vol 9. issue 1. 2020-10-20. PMID:30996341. |
fractalkine-cx3cr1 signaling plays a role in control of microglia during hypoglycemia, because density and solidity of iba1-ir profiles was attenuated in fasted, insulin-treated, cx3cr1 ko mice, which was parallel with exaggerated neuropeptide responses and higher blood glucose levels following insulin administration. |
2020-10-20 |
2023-08-13 |
mouse |
| Miljenko Valentin Panajatovic, François Singh, Stephan Krähenbühl, Jamal Bouitbi. Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle Expression. Biomedicines. vol 8. issue 9. 2020-10-20. PMID:32942550. |
in conclusion, simvastatin impaired skeletal muscle insulin sensitivity in wt mice, while ko mice exhibited impaired skeletal muscle insulin sensitivity already in the absence of simvastatin. |
2020-10-20 |
2023-08-13 |
mouse |
| Xi Fang, Jaegwon Chung, Erik Olsen, Isabelle Snider, Rachael H Earls, Julie Jeon, Hea Jin Park, Jae-Kyung Le. Depletion of regulator-of-G-protein signaling-10 in mice exaggerates high-fat diet-induced insulin resistance and inflammation, and this effect is mitigated by dietary green tea extract. Nutrition research (New York, N.Y.). vol 70. 2020-10-19. PMID:30032988. |
our results showed that rgs10 knockout (ko) mice fed a hfd gained significantly more weight and developed severe insulin resistance compared to wild-type (wt) mice fed hfd. |
2020-10-19 |
2023-08-13 |
mouse |
| Minji Woo, Hyun-Il Choi, So-Hyun Park, Jiyun Ahn, Young-Jin Jang, Tae-Youl Ha, Dae-Hee Lee, Hyo-Deok Seo, Chang Hwa Jun. The unc-51 like autophagy activating kinase 1-autophagy related 13 complex has distinct functions in tunicamycin-treated cells. Biochemical and biophysical research communications. vol 524. issue 3. 2020-10-14. PMID:32035621. |
notably, atg13 and ulk1 deficiency ameliorated tunicamycin-induced insulin resistance, with enhanced rps6kb1 and akt1 phosphorylation in ko cells compared to wt cells. |
2020-10-14 |
2023-08-13 |
Not clear |
| Christinna V Jørgensen, Sylvia J Gasparini, Jinwen Tu, Hong Zhou, Markus J Seibel, Hans Bräuner-Osborn. Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice. Scientific reports. vol 9. issue 1. 2020-10-07. PMID:30979912. |
compared to wt, vehicle-treated ko mice presented with normal body composition, unaltered insulin sensitivity and basal serum insulin and glucose levels. |
2020-10-07 |
2023-08-13 |
mouse |
| Evangelia Kalaitzoglou, Erika Barboza Prado Lopes, Yao Fu, Jacquelyn C Herron, Josiah M Flaming, Elise L Donovan, Yanqing Hu, Adrian Filiberti, Timothy M Griffin, Mary Beth Humphre. TLR4 Promotes and DAP12 Limits Obesity-Induced Osteoarthritis in Aged Female Mice. JBMR plus. vol 3. issue 4. 2020-09-30. PMID:31044181. |
we fed 13- to 15-month-old female wt, tlr4 ko, and dap12 ko mice a high-fat diet (hfd) or a control diet for 12 weeks, and changes in body composition, glucose tolerance, serum cytokines, and insulin levels were compared. |
2020-09-30 |
2023-08-13 |
mouse |
| Yoichi Nozato, Yoichi Takami, Koichi Yamamoto, Motonori Nagasawa, Satoko Nozato, Yuki Imaizumi, Hikari Takeshita, Cheng Wang, Yuki Ito, Shuko Takeda, Yasushi Takeya, Ken Sugimoto, Hironori Nakagami, Rikinari Hanayama, Hiromi Rakug. Novel properties of myoferlin in glucose metabolism via pathways involving modulation of adipose functions. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 2. 2020-09-29. PMID:31912559. |
whereas young myof knockout (ko) mice on a normal diet showed aggravated glucose tolerance and insulin sensitivity, those on a high-fat diet (hfd) showed preserved glucose tolerance with an attenuated gain of body weight, reduced visceral fat deposits, and less severe fatty liver. |
2020-09-29 |
2023-08-13 |
mouse |
| Lia R Edmunds, Brydie R Huckestein, Mario Kahn, Dongyan Zhang, Yanxia Chu, Yingze Zhang, Stacy G Wendell, Gerald I Shulman, Michael J Jurcza. Hepatic insulin sensitivity is improved in high-fat diet-fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis. Physiological reports. vol 7. issue 21. 2020-08-27. PMID:31724300. |
park2 ko mice are protected from diet-induced obesity and hepatic insulin sensitivity is improved in high-fat diet (hfd)-fed park2 ko mice even under body weight-matched conditions. |
2020-08-27 |
2023-08-13 |
mouse |
| Lia R Edmunds, Brydie R Huckestein, Mario Kahn, Dongyan Zhang, Yanxia Chu, Yingze Zhang, Stacy G Wendell, Gerald I Shulman, Michael J Jurcza. Hepatic insulin sensitivity is improved in high-fat diet-fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis. Physiological reports. vol 7. issue 21. 2020-08-27. PMID:31724300. |
in order to better understand the cellular mechanism by which park2 ko mice are protected from diet-induced hepatic insulin resistance, we determined changes in multiple pathways commonly associated with the pathogenesis of insulin resistance, namely levels of bioactive lipid species, activation of the endoplasmic reticulum (er) stress response and changes in cytokine levels and signaling. |
2020-08-27 |
2023-08-13 |
mouse |
| Lia R Edmunds, Brydie R Huckestein, Mario Kahn, Dongyan Zhang, Yanxia Chu, Yingze Zhang, Stacy G Wendell, Gerald I Shulman, Michael J Jurcza. Hepatic insulin sensitivity is improved in high-fat diet-fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis. Physiological reports. vol 7. issue 21. 2020-08-27. PMID:31724300. |
we report for the first time that whole-body insulin sensitivity is unchanged in regular chow (rc)-fed park2 ko mice, and that liver diacylglycerol levels are reduced and very-long-chain ceramides are increased in park2 ko mice fed hfd for 1 week. |
2020-08-27 |
2023-08-13 |
mouse |
| Jian Ma, Xin He, Yan Cao, Kienan O'Dwyer, Katherine M Szigety, Yuan Wu, Buddha Gurung, Zijie Feng, Bryson W Katona, Xianxin Hu. Islet-specific Prmt5 excision leads to reduced insulin expression and glucose intolerance in mice. The Journal of endocrinology. vol 244. issue 1. 2020-07-13. PMID:31539871. |
the results show that islet-specific ko of prmt5 reduced expression of the insulin gene and impaired glucose tolerance and gsis in vivo. |
2020-07-13 |
2023-08-13 |
mouse |
| Jian Ma, Xin He, Yan Cao, Kienan O'Dwyer, Katherine M Szigety, Yuan Wu, Buddha Gurung, Zijie Feng, Bryson W Katona, Xianxin Hu. Islet-specific Prmt5 excision leads to reduced insulin expression and glucose intolerance in mice. The Journal of endocrinology. vol 244. issue 1. 2020-07-13. PMID:31539871. |
the reduced expression of insulin in beta cells in the prmt5 ko mice may contribute to impaired glucose tolerance (igt) and deficient gsis in the mouse model. |
2020-07-13 |
2023-08-13 |
mouse |
| Stephanie L Clookey, Rebecca J Welly, Terese M Zidon, MIchelle L Gastecki, Makenzie L Woodford, Zachary I Grunewald, Nathan C Winn, Dusti Eaton, Natalia G Karasseva, Harrold S Sacks, Jaume Padilla, Victoria Vieira-Potte. Increased susceptibility to OVX-associated metabolic dysfunction in UCP1-null mice. The Journal of endocrinology. 2020-07-08. PMID:30089681. |
whereas ovx-induced weight gain was not synergistically greater for ko compared to wt (gxo, ns), ovx-induced insulin resistance was significantly exacerbated in ko compared to wt (gxo for homa-ir, p<0.05). |
2020-07-08 |
2023-08-13 |
mouse |
| Md Razaul Karim, Cody R Fisher, Rebecca J Kapphahn, Jorge R Polanco, Deborah A Ferringto. Investigating AKT activation and autophagy in immunoproteasome-deficient retinal cells. PloS one. vol 15. issue 4. 2020-07-08. PMID:32275682. |
wt and lmp2 ko cells were monitored after treatment with ebss to stimulate autophagy, insulin to stimulate akt, or an akt inhibitor (trehalose or mk-2206). |
2020-07-08 |
2023-08-13 |
mouse |
| Lin-Juan Li, Jun-Chen Zheng, Rui Kang, Jian-Qun Ya. Targeting Trim69 alleviates high fat diet (HFD)-induced hippocampal injury in mice by inhibiting apoptosis and inflammation through ASK1 inactivation. Biochemical and biophysical research communications. vol 515. issue 4. 2020-07-06. PMID:31178136. |
trim69 knockout (ko) mice exhibited an exaggerated version of the metabolic disorder after hfd challenge, as evidenced by their increased body weight and elevated insulin resistance. |
2020-07-06 |
2023-08-13 |
mouse |
| Kripa Shankar, Deepali Gupta, Bharath K Mani, Brianna G Findley, Caleb C Lord, Sherri Osborne-Lawrence, Nathan P Metzger, Claudio Pietra, Chen Liu, Eric D Berglund, Jeffrey M Zigma. Acyl-ghrelin Is Permissive for the Normal Counterregulatory Response to Insulin-Induced Hypoglycemia. Diabetes. vol 69. issue 2. 2020-07-02. PMID:31685528. |
ghrelin knockout (ko) mice and wild-type (wt) littermates underwent an insulin bolus-induced hypoglycemia test and a low-dose hyperinsulinemic-hypoglycemic clamp procedure. |
2020-07-02 |
2023-08-13 |
mouse |
| Huimeng Qi, Li Yao, Qiang Li. MicroRNA-96 regulates pancreatic β cell function under the pathological condition of diabetes mellitus through targeting Foxo1 and Sox6. Biochemical and biophysical research communications. vol 519. issue 2. 2020-06-29. PMID:31506178. |
insulin functions, including fasting blood glucose, plasma insulin, homa-ir, homa-%b, glucose tolerance and insulin tolerance, were assessed in microrna-96 ko mice and wild-type mice fed with normal diet or high-fat diet. |
2020-06-29 |
2023-08-13 |
mouse |