| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Monica Hoang, Emelien Jentz, Sarah M Janssen, Daniela Nasteska, Federica Cuozzo, David J Hodson, A Russell Tupling, Guo-Hua Fong, Jamie W Josep. Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function. Endocrinology. vol 163. issue 1. 2021-12-11. PMID:34718519. |
none of the β-phd ko mice showed any significant in vivo defects associated with glucose tolerance and insulin resistance except for β-phd2 ko mice which had significantly increased plasma insulin during a glucose challenge. |
2021-12-11 |
2023-08-13 |
mouse |
| Monica Hoang, Emelien Jentz, Sarah M Janssen, Daniela Nasteska, Federica Cuozzo, David J Hodson, A Russell Tupling, Guo-Hua Fong, Jamie W Josep. Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function. Endocrinology. vol 163. issue 1. 2021-12-11. PMID:34718519. |
isolated islets from β-phd1 ko and β-phd3 ko had impaired glucose-stimulated insulin secretion and glucose-stimulated increases in the atp/adp and nadph/nadp+ ratio. |
2021-12-11 |
2023-08-13 |
mouse |
| Monica Hoang, Emelien Jentz, Sarah M Janssen, Daniela Nasteska, Federica Cuozzo, David J Hodson, A Russell Tupling, Guo-Hua Fong, Jamie W Josep. Isoform-specific Roles of Prolyl Hydroxylases in the Regulation of Pancreatic β-Cell Function. Endocrinology. vol 163. issue 1. 2021-12-11. PMID:34718519. |
however, β-phd1 ko and β-phd3 ko mice had defective β-cell mass and islet insulin secretion, suggesting that these mice may be predisposed to developing diabetes. |
2021-12-11 |
2023-08-13 |
mouse |
| Yaojing Jiang, Lu Zhu, Di Wu, Yunzhi Ni, Chuxin Huang, Hongying Ye, Yehong Yang, Rui Liu, Yiming L. Type IIB PKA is highly expressed in β cells and controls cell proliferation via regulating Cyclin D1 expression. The FEBS journal. 2021-12-07. PMID:34839588. |
riib ko mice also showed increased insulin levels and improved glucose tolerance. |
2021-12-07 |
2023-08-13 |
mouse |
| Jing Gao, Akiko Mizokami, Hiroshi Takeuchi, Aonan Li, Fei Huang, Haruki Nagano, Takashi Kanematsu, Eijiro Jimi, Masato Hirat. Phospholipase C-related catalytically inactive protein acts as a positive regulator for insulin signalling in adipocytes. Journal of cell science. 2021-12-03. PMID:34859819. |
we found that insulin signalling including insulin-stimulated phosphorylation of the insulin receptor (ir), insulin receptor substrate-1 (irs-1), akt, and glucose uptake, were impaired in adipocytes from prip-knockout (ko) mice compared with those from wild-type (wt) mice. |
2021-12-03 |
2023-08-13 |
mouse |
| Huimin Pang, Jinzhi Li, Yuzhou Wang, Xiaomin Su, Yingtang Gao, Shu Jie L. Mice lacking the proton channel Hv1 exhibit sex-specific differences in glucose homeostasis. The Journal of biological chemistry. vol 297. issue 4. 2021-11-23. PMID:34547291. |
here, we investigated the differences in glucose metabolism and insulin sensitivity between male and female ko mice and how sex steroids contribute to these differences. |
2021-11-23 |
2023-08-13 |
mouse |
| Huimin Pang, Jinzhi Li, Yuzhou Wang, Xiaomin Su, Yingtang Gao, Shu Jie L. Mice lacking the proton channel Hv1 exhibit sex-specific differences in glucose homeostasis. The Journal of biological chemistry. vol 297. issue 4. 2021-11-23. PMID:34547291. |
furthermore, exogenous testosterone supplementation decreased blood glucose levels in male ko mice, as well as enhancing insulin signaling. |
2021-11-23 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122340. |
we show that gip receptor ko mice exhibit glucose intolerance in the presence of impaired insulin response after 100 and 125 mg glucose, but not after lower doses of glucose. |
2021-11-10 |
2023-08-13 |
mouse |
| Bo Ahrén, Yuichiro Yamada, Yutaka Sein. The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122340. |
in contrast, glp-1 receptor ko mice have normal glucose tolerance after all glucose loads, in the presence of a compensatory increase in the insulin response. |
2021-11-10 |
2023-08-13 |
mouse |
| Vivian A Paschoal, Evelyn Walenta, Saswata Talukdar, Ariane R Pessentheiner, Olivia Osborn, Nasun Hah, Tyler J Chi, George L Tye, Aaron M Armando, Ronald M Evans, Nai-Wen Chi, Oswald Quehenberger, Jerrold M Olefsky, Da Young O. Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity. Cell metabolism. vol 31. issue 6. 2021-11-09. PMID:32413335. |
further, we used macrophage- (mko) or adipocyte-specific gpr120 ko (ako) mice to show that grp120 has anti-inflammatory effects via macrophages while working with pparγ in adipocytes to increase insulin sensitivity. |
2021-11-09 |
2023-08-13 |
mouse |
| Peng Tang, Sam Virtue, Jian Yi Gerald Goie, Chin Wen Png, Jing Guo, Ying Li, Huipeng Jiao, Yen Leong Chua, Mark Campbell, José Maria Moreno-Navarrete, Asim Shabbir, José-Manuel Fernández-Real, Stephan Gasser, David Michael Kemeny, Henry Yang, Antonio Vidal-Puig, Yongliang Zhan. Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3. Cell death and differentiation. vol 28. issue 11. 2021-11-05. PMID:34091599. |
the irf3 knockout (ko) mice develop obesity, insulin resistance, glucose intolerance, and eventually type 2 diabetes with aging, which is associated with the development of white adipose tissue (wat) inflammation. |
2021-11-05 |
2023-08-13 |
mouse |
| Erika Harno, Charlotte Sefton, Jonathan R Wray, Tiffany-Jayne Allen, Alison Davies, Anthony P Coll, Anne Whit. Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons. Scientific reports. vol 11. issue 1. 2021-11-02. PMID:34215821. |
additionally, cort treatment led to hyperinsulinaemia, but compared to controls, cort-treated agrp-gr ko mice had both lower fasting insulin levels and lower insulin levels during a glucose tolerance test. |
2021-11-02 |
2023-08-13 |
mouse |
| Shuaishuai Xing, Qi Li, Baichen Xiong, Yao Chen, Feng Feng, Wenyuan Liu, Haopeng Su. Structure and therapeutic uses of butyrylcholinesterase: Application in detoxification, Alzheimer's disease, and fat metabolism. Medicinal research reviews. vol 41. issue 2. 2021-10-28. PMID:33103262. |
bche could influence the weight and insulin secretion and resistance of bche knockout (ko) mice through hydrolyzing ghrelin. |
2021-10-28 |
2023-08-13 |
mouse |
| Andrea K Anderson, Johana M Lambert, David J Montefusco, Bao Ngan Tran, Patrick Roddy, William L Holland, L Ashley Cowar. Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease. Journal of lipid research. vol 61. issue 10. 2021-10-22. PMID:32690594. |
previous studies by us and others have demonstrated that global sphingosine kinase 1 ko mice are protected from diet-induced obesity, insulin resistance, systemic inflammation, and nafld, suggesting that sphk1 may mediate pathological outcomes of obesity. |
2021-10-22 |
2023-08-13 |
mouse |
| Erica L Schoeller, Karen J Tonsfeldt, McKenna Sinkovich, Rujing Shi, Pamela L Mello. Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1. Endocrinology. vol 162. issue 4. 2021-10-18. PMID:33539533. |
we also found disrupted serum insulin growth factor 1 (igf-1) and liver igf1 messenger rna in the bmal1 ko mice, which may underlie the disrupted gh release. |
2021-10-18 |
2023-08-13 |
mouse |
| Songhua Zhang, Aryanna Sousa, Mengqui Lin, Ayako Iwano, Rishubh Jain, Bing Ma, Chang Min Lee, Jin Wook Park, Suchitra Kamle, Rolf Carlson, Ghun Geun Lee, Jack A Elias, Jack R Wand. Role of Chitinase 3-Like 1 Protein in the Pathogenesis of Hepatic Insulin Resistance in Nonalcoholic Fatty Liver Disease. Cells. vol 10. issue 2. 2021-10-12. PMID:33498326. |
we hypothesize that chi3l1 gene expression is important in the development of hepatic insulin resistance characterized by the generation of pakt, pgsk, and perk in wild type and chi3l1 knockout (ko) murine liver following insulin stimulation. |
2021-10-12 |
2023-08-13 |
mouse |
| Songhua Zhang, Aryanna Sousa, Mengqui Lin, Ayako Iwano, Rishubh Jain, Bing Ma, Chang Min Lee, Jin Wook Park, Suchitra Kamle, Rolf Carlson, Ghun Geun Lee, Jack A Elias, Jack R Wand. Role of Chitinase 3-Like 1 Protein in the Pathogenesis of Hepatic Insulin Resistance in Nonalcoholic Fatty Liver Disease. Cells. vol 10. issue 2. 2021-10-12. PMID:33498326. |
transmission of the hepatic insulin signal was substantially improved following ko of the chi3l1 gene and there was reduced lipid deposition produced by a hfd. |
2021-10-12 |
2023-08-13 |
mouse |
| Songhua Zhang, Aryanna Sousa, Mengqui Lin, Ayako Iwano, Rishubh Jain, Bing Ma, Chang Min Lee, Jin Wook Park, Suchitra Kamle, Rolf Carlson, Ghun Geun Lee, Jack A Elias, Jack R Wand. Role of Chitinase 3-Like 1 Protein in the Pathogenesis of Hepatic Insulin Resistance in Nonalcoholic Fatty Liver Disease. Cells. vol 10. issue 2. 2021-10-12. PMID:33498326. |
a ko of the chi3l1 gene reduced lipid accumulation and improved insulin signaling. |
2021-10-12 |
2023-08-13 |
mouse |
| Fiona L Roberts, Nabil A Rashdan, Kanchan Phadwal, Greg R Markby, Scott Dillon, Janna Zoll, Julian Berger, Elspeth Milne, Isabel R Orriss, Gerard Karsenty, Olivier Le Saux, Nicholas M Morton, Colin Farquharson, Vicky E MacRa. Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice. Journal of cellular physiology. vol 236. issue 6. 2021-10-04. PMID:33305372. |
male osteoblast-specific ko and fl/fl mice showed comparable glucose and insulin tolerance despite increased levels of insulin-sensitizing under-carboxylated osteocalcin (195% increase; p < .05). |
2021-10-04 |
2023-08-13 |
mouse |
| Fiona L Roberts, Nabil A Rashdan, Kanchan Phadwal, Greg R Markby, Scott Dillon, Janna Zoll, Julian Berger, Elspeth Milne, Isabel R Orriss, Gerard Karsenty, Olivier Le Saux, Nicholas M Morton, Colin Farquharson, Vicky E MacRa. Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice. Journal of cellular physiology. vol 236. issue 6. 2021-10-04. PMID:33305372. |
however, following high-fat-diet challenge, osteoblast-specific ko mice showed impaired glucose and insulin tolerance compared with fl/fl mice. |
2021-10-04 |
2023-08-13 |
mouse |