| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yusuke Nakatsu, Keiichi Mori, Yasuka Matsunaga, Takeshi Yamamotoya, Koji Ueda, Yuki Inoue, Keiko Mitsuzaki-Miyoshi, Hideyuki Sakoda, Midori Fujishiro, Suguru Yamaguchi, Akifumi Kushiyama, Hiraku Ono, Hisamitsu Ishihara, Tomoichiro Asan. The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion. The Journal of biological chemistry. vol 292. issue 28. 2017-08-03. PMID:28566287. |
we identified two independent factors underlying impaired insulin secretion in the βpin1 ko mice. |
2017-08-03 |
2023-08-13 |
mouse |
| Darline Garibay, Anne K McGavigan, Seon A Lee, James V Ficorilli, Amy L Cox, M Dodson Michael, Kyle W Sloop, Bethany P Cumming. β-Cell Glucagon-Like Peptide-1 Receptor Contributes to Improved Glucose Tolerance After Vertical Sleeve Gastrectomy. Endocrinology. vol 157. issue 9. 2017-06-27. PMID:27501183. |
augmentation of glucose-stimulated insulin secretion during the oral glucose tolerance test was blunted in vsg ko compared with vsg wt. |
2017-06-27 |
2023-08-13 |
mouse |
| Susana Rodriguez, Xia Lei, Pia S Petersen, Stefanie Y Tan, Hannah C Little, G William Won. Loss of CTRP1 disrupts glucose and lipid homeostasis. American journal of physiology. Endocrinology and metabolism. vol 311. issue 4. 2017-06-23. PMID:27555298. |
despite similar body weight, food intake, and energy expenditure, ctrp1 knockout (ko) mice fed a low-fat diet developed insulin resistance and hepatic steatosis. |
2017-06-23 |
2023-08-13 |
mouse |
| Zenobia B Mehta, Nicholas Fine, Timothy J Pullen, Matthew C Cane, Ming Hu, Pauline Chabosseau, Gargi Meur, Antonio Velayos-Baeza, Anthony P Monaco, Lorella Marselli, Piero Marchetti, Guy A Rutte. Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice. American journal of physiology. Endocrinology and metabolism. vol 311. issue 2. 2017-06-21. PMID:27329800. |
pancreatic histology revealed no significant change in β-cell mass in ko mice vs. controls, and glucose-stimulated insulin secretion from isolated islets was not altered in vitro between control and βvps13cko mice. |
2017-06-21 |
2023-08-13 |
mouse |
| Jacqueline Naylor, Arthur T Suckow, Asha Seth, David J Baker, Isabelle Sermadiras, Peter Ravn, Rob Howes, Jianliang Li, Mike R Snaith, Matthew P Coghlan, David C Hornigol. Use of CRISPR/Cas9-engineered INS-1 pancreatic β cells to define the pharmacology of dual GIPR/GLP-1R agonists. The Biochemical journal. vol 473. issue 18. 2017-06-20. PMID:27422784. |
camp production in response to gipr or glp-1r activation was abolished and gip- or glp-1-induced potentiation of glucose-stimulated insulin secretion (gsis) was attenuated in the cognate ko cell lines. |
2017-06-20 |
2023-08-13 |
mouse |
| Ali Yasrebi, Janelle A Rivera, Elizabeth A Krumm, Jennifer A Yang, Troy A Roepk. Activation of Estrogen Response Element-Independent ERα Signaling Protects Female Mice From Diet-Induced Obesity. Endocrinology. vol 158. issue 2. 2017-06-20. PMID:27901601. |
plasma insulin and interleukin 6 were elevated in kiko and ko female mice compared with lfd-fed wt female mice. |
2017-06-20 |
2023-08-13 |
mouse |
| Diana K Costa, Brydie R Huckestein, Lia R Edmunds, Max C Petersen, Ali Nasiri, Gina M Butrico, Abudukadier Abulizi, Daniel B Harmon, Canying Lu, Benjamin S Mantell, Douglas J Hartman, João-Paulo G Camporez, Robert M O'Doherty, Gary W Cline, Gerald I Shulman, Michael J Jurcza. Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice. American journal of physiology. Endocrinology and metabolism. vol 311. issue 1. 2017-06-12. PMID:27166280. |
surprisingly, park2 knockout (ko) mice are protected from nutritional stress and do not develop obesity, hepatic steatosis or insulin resistance when fed a high-fat diet (hfd). |
2017-06-12 |
2023-08-13 |
mouse |
| Diana K Costa, Brydie R Huckestein, Lia R Edmunds, Max C Petersen, Ali Nasiri, Gina M Butrico, Abudukadier Abulizi, Daniel B Harmon, Canying Lu, Benjamin S Mantell, Douglas J Hartman, João-Paulo G Camporez, Robert M O'Doherty, Gary W Cline, Gerald I Shulman, Michael J Jurcza. Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice. American journal of physiology. Endocrinology and metabolism. vol 311. issue 1. 2017-06-12. PMID:27166280. |
park2 ko mice showed reduced adiposity after 1-wk hfd, as well as improved hepatic and peripheral insulin sensitivity. |
2017-06-12 |
2023-08-13 |
mouse |
| Yong Hwan Han, Márcio Buffolo, Karla Maria Pires, Shaobo Pei, Philipp E Scherer, Sihem Boudin. Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects From Diet-Induced Obesity Through Increased Mitochondrial Uncoupling and Biogenesis. Diabetes. vol 65. issue 9. 2017-06-05. PMID:27284109. |
finally, hfd-fed adsod2 ko mice were protected from hepatic steatosis, adipose tissue inflammation, and glucose and insulin intolerance. |
2017-06-05 |
2023-08-13 |
mouse |
| Jiali Deng, Feixiang Yuan, Yajie Guo, Yuzhong Xiao, Yuguo Niu, Yalan Deng, Xiao Han, Youfei Guan, Shanghai Chen, Feifan Gu. Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure. Diabetes. vol 66. issue 3. 2017-06-05. PMID:27993927. |
here, we generated adult-onset agouti-related peptide neuron-specific atf4 knockout (agrp-atf4 ko) mice and found that these mice were lean, with improved insulin and leptin sensitivity and decreased hepatic lipid accumulation. |
2017-06-05 |
2023-08-13 |
mouse |
| Jiali Deng, Feixiang Yuan, Yajie Guo, Yuzhong Xiao, Yuguo Niu, Yalan Deng, Xiao Han, Youfei Guan, Shanghai Chen, Feifan Gu. Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure. Diabetes. vol 66. issue 3. 2017-06-05. PMID:27993927. |
moreover, agrp-atf4 ko mice were resistant to high-fat diet-induced obesity, insulin resistance, and liver steatosis and maintained at a higher body temperature under cold stress. |
2017-06-05 |
2023-08-13 |
mouse |
| Reema P Vazirani, Akanksha Verma, L Amanda Sadacca, Melanie S Buckman, Belen Picatoste, Muheeb Beg, Christopher Torsitano, Joanne H Bruno, Rajesh T Patel, Kotryna Simonyte, Joao P Camporez, Gabriela Moreira, Domenick J Falcone, Domenico Accili, Olivier Elemento, Gerald I Shulman, Barbara B Kahn, Timothy E McGra. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. vol 65. issue 6. 2017-06-01. PMID:27207531. |
in adipose-specific rab10 ko female mice, the partial inhibition of stimulated glucose uptake in adipocytes induces insulin resistance independent of diet challenge. |
2017-06-01 |
2023-08-13 |
mouse |
| Cory M Dungan, David L Williamso. Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis. Biochemical and biophysical research communications. vol 482. issue 4. 2017-06-01. PMID:27913296. |
in separate studies, redd1 ko mice were injected with 5 mg/kg bw of the mtor inhibitor, rapamycin, 3 h prior to acute insulin treatment. |
2017-06-01 |
2023-08-13 |
mouse |
| Cory M Dungan, David L Williamso. Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis. Biochemical and biophysical research communications. vol 482. issue 4. 2017-06-01. PMID:27913296. |
conversely, rapamycin inhibited s6k1 and rps6 activation, and significantly improved insulin -stimulated activation of irs-1 and mek1/2 in ko mice. |
2017-06-01 |
2023-08-13 |
mouse |
| Jibiao Li, David J Matye, Yifeng Wang, Tiangang L. Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice. FEBS letters. vol 591. issue 7. 2017-06-01. PMID:28236654. |
under the basal fasting state, chow-fed sort1 ko mice have decreased adipose glycolytic metabolites, but sort1 deletion does not affect insulin-stimulated tissue glucose uptake during the insulin clamp. |
2017-06-01 |
2023-08-13 |
mouse |
| Lance A Stechschulte, Bin Qiu, Manya Warrier, Terry D Hinds, Man Zhang, Hao Gu, Yuxue Xu, Saja S Khuder, Lucia Russo, Sonia M Najjar, Beata Lecka-Czernik, Weidong Yong, Edwin R Sanche. FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone. Endocrinology. vol 157. issue 10. 2017-05-29. PMID:27442117. |
under high-fat diet, ko mice were highly resistant to adiposity and exhibited reduced plasma lipids and elevated glucose and insulin tolerance. |
2017-05-29 |
2023-08-13 |
mouse |
| Changhwan Ahn, Dongoh Lee, Jae-Hwan Lee, Hyun Yang, Beum-Soo An, Eui-Bae Jeun. Calbindin-D9k Ablation Disrupt Glucose/Pancreatic Insulin Homeostasis. PloS one. vol 11. issue 10. 2017-05-16. PMID:27736926. |
using cabp-9k knock out (ko) mice, we demonstrated that ablation of cabp-9k causes reducing insulin secretion and increasing serum glucose. |
2017-05-16 |
2023-08-13 |
mouse |
| Jung Joo Yoon, Yun Jung Lee, Byung Hyuk Han, Eun Sik Choi, Min Chul Kho, Ji Hun Park, You Mee Ahn, Hye Yoom Kim, Dae Gill Kang, Ho Sub Le. Protective effect of betulinic acid on early atherosclerosis in diabetic apolipoprotein-E gene knockout mice. European journal of pharmacology. vol 796. 2017-04-28. PMID:27894808. |
male apoe ko mice and age-matched control group mice (c57bl/6jms) were used as experimental systems and their systolic blood pressure, insulin resistance, and vascular inflammation were measured. |
2017-04-28 |
2023-08-13 |
mouse |
| Jung Joo Yoon, Yun Jung Lee, Byung Hyuk Han, Eun Sik Choi, Min Chul Kho, Ji Hun Park, You Mee Ahn, Hye Yoom Kim, Dae Gill Kang, Ho Sub Le. Protective effect of betulinic acid on early atherosclerosis in diabetic apolipoprotein-E gene knockout mice. European journal of pharmacology. vol 796. 2017-04-28. PMID:27894808. |
blood glucose, insulin, glucose tolerance results, and the homeostasis model assessment of insulin resistance (homa-ir) index were found to be better in ba-treated apoe ko mice than untreated apoe ko mice. |
2017-04-28 |
2023-08-13 |
mouse |
| Yun Shi, Zhen-Ju Shu, Xiaoling Xue, Chih-Ko Yeh, Michael S Katz, Amrita Kama. β2-Adrenergic receptor ablation modulates hepatic lipid accumulation and glucose tolerance in aging mice. Experimental gerontology. vol 78. 2017-01-10. PMID:26952573. |
although no differences in plasma triglyceride, non-esterified fatty acids or insulin levels were detected between old wt and ko animals, an age-associated increase in hepatic expression of lipid homeostasis regulator cidea was significantly reduced in old ko mice. |
2017-01-10 |
2023-08-13 |
mouse |