| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joanne C McNelis, Yun Sok Lee, Rafael Mayoral, Rik van der Kant, Andrew M F Johnson, Joshua Wollam, Jerrold M Olefsk. GPR43 Potentiates β-Cell Function in Obesity. Diabetes. vol 64. issue 9. 2015-11-17. PMID:26023106. |
hfd-fed gpr43 knockout (ko) mice develop glucose intolerance due to a defect in insulin secretion. |
2015-11-17 |
2023-08-13 |
mouse |
| Eunjung Lee, Dae Young Jung, Jong Hun Kim, Payal R Patel, Xiaodi Hu, Yongjin Lee, Yoshihiro Azuma, Hsun-Fan Wang, Nicholas Tsitsilianos, Umber Shafiq, Jung Yeon Kwon, Hyong Joo Lee, Ki Won Lee, Jason K Ki. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 8. 2015-10-19. PMID:25888600. |
in this study, trpv1 knockout (ko) and wild-type (wt) mice (as controls) were fed a high-fat diet (hfd), and metabolic studies were performed to measure insulin and leptin action. |
2015-10-19 |
2023-08-13 |
mouse |
| Eunjung Lee, Dae Young Jung, Jong Hun Kim, Payal R Patel, Xiaodi Hu, Yongjin Lee, Yoshihiro Azuma, Hsun-Fan Wang, Nicholas Tsitsilianos, Umber Shafiq, Jung Yeon Kwon, Hyong Joo Lee, Ki Won Lee, Jason K Ki. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 8. 2015-10-19. PMID:25888600. |
the hyperinsulinemic-euglycemic clamp experiment showed that the trpv1 ko mice were more insulin resistant after hfd because of the ∼40% reduction in glucose metabolism in the white and brown adipose tissue, compared with that in the wt mice. |
2015-10-19 |
2023-08-13 |
mouse |
| Eunjung Lee, Dae Young Jung, Jong Hun Kim, Payal R Patel, Xiaodi Hu, Yongjin Lee, Yoshihiro Azuma, Hsun-Fan Wang, Nicholas Tsitsilianos, Umber Shafiq, Jung Yeon Kwon, Hyong Joo Lee, Ki Won Lee, Jason K Ki. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 8. 2015-10-19. PMID:25888600. |
we also found that the trpv1 ko mice were more obese and insulin resistant than the wt mice at 9 mo of age. |
2015-10-19 |
2023-08-13 |
mouse |
| Lisa M DiPilato, Faiyaz Ahmad, Matthew Harms, Patrick Seale, Vincent Manganiello, Morris J Birnbau. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin. Molecular and cellular biology. vol 35. issue 16. 2015-10-05. PMID:26031333. |
in pde3b knockout (ko) adipocytes, insulin was unable to suppress β-adrenergic receptor-stimulated glycerol release. |
2015-10-05 |
2023-08-13 |
Not clear |
| Lisa M DiPilato, Faiyaz Ahmad, Matthew Harms, Patrick Seale, Vincent Manganiello, Morris J Birnbau. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin. Molecular and cellular biology. vol 35. issue 16. 2015-10-05. PMID:26031333. |
reexpressing wild-type pde3b in ko adipocytes fully rescued the action of insulin against lipolysis. |
2015-10-05 |
2023-08-13 |
Not clear |
| Juan C Alvarez-Perez, Taylor C Rosa, Gabriella P Casinelli, Shelley R Valle, Jayalakshmi Lakshmipathi, Carolina Rosselot, Francisco Rausell-Palamos, Rupangi C Vasavada, Adolfo García-Ocañ. Hepatocyte growth factor ameliorates hyperglycemia and corrects β-cell mass in IRS2-deficient mice. Molecular endocrinology (Baltimore, Md.). vol 28. issue 12. 2015-09-01. PMID:25361392. |
glucose homeostasis analysis revealed significantly reduced hyperglycemia, compensatory hyperinsulinemia, and improved glucose tolerance in tg/ko mice compared with those in ko mice in the context of similar insulin resistance. |
2015-09-01 |
2023-08-13 |
mouse |
| Martha L Wall, Lynley D Pound, Irina Trenary, Richard M O'Brien, Jamey D Youn. Novel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets. Diabetes. vol 64. issue 6. 2015-08-19. PMID:25552595. |
studies of g6pc2 knockout (ko) mice suggest that g6pc2 represents a negative regulator of basal glucose-stimulated insulin secretion (gsis) that acts by hydrolyzing glucose-6-phosphate (g6p), thereby reducing glycolytic flux. |
2015-08-19 |
2023-08-13 |
mouse |
| Jaideep Behari, Huanan Li, Shiguang Liu, Maja Stefanovic-Racic, Laura Alonso, Christopher P O'Donnell, Sruti Shiva, Srikanth Singamsetty, Yoshio Watanabe, Vijay P Singh, Qing Li. β-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice. The American journal of pathology. vol 184. issue 12. 2015-08-12. PMID:25300578. |
hfd-fed tg mice rapidly developed diet-induced obesity and systemic insulin resistance, but ko mice were resistant to diet-induced obesity. |
2015-08-12 |
2023-08-13 |
mouse |
| Junlan Zhou, Min Cheng, Chan Boriboun, Mariam M Ardehali, Changfei Jiang, Qinghua Liu, Shuling Han, David A Goukassian, Yao-Liang Tang, Ting C Zhao, Ming Zhao, Lu Cai, Stéphane Richard, Raj Kishore, Gangjian Qi. Inhibition of Sam68 triggers adipose tissue browning. The Journal of endocrinology. vol 225. issue 3. 2015-08-11. PMID:25934704. |
when they were fed a high-fat diet, sam68 ko mice gained much less body weight and fat mass than their wt littermates did, and they displayed an improved glucose and insulin tolerance. |
2015-08-11 |
2023-08-13 |
mouse |
| David R Powell, Jason P Gay, Nathaniel Wilganowski, Deon Doree, Katerina V Savelieva, Thomas H Lanthorn, Robert Read, Peter Vogel, Gwenn M Hansen, Robert Brommage, Zhi-Ming Ding, Urvi Desai, Brian Zambrowic. Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice. Frontiers in endocrinology. vol 6. 2015-06-17. PMID:26082754. |
our dagla and cnr1 ko mice also had low fasting insulin, triglyceride, and total cholesterol levels, and after glucose challenge had normal glucose but very low insulin levels. |
2015-06-17 |
2023-08-13 |
mouse |
| Niclas Franck, Michael Maris, Sarah Nalbandian, Saswata Talukdar, Simon Schenk, Hans-Peter Hofmann, David Bullough, Olivia Osbor. Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity. PloS one. vol 9. issue 9. 2015-06-16. PMID:25244011. |
a similar effect was observed in il1-r1 ko mice, suggesting that at high concentrations of il-1ra typically observed in obesity, il-1ra can contribute to the development of insulin resistance in a mechanism independent of il-1ra binding to il-1r1. |
2015-06-16 |
2023-08-13 |
mouse |
| Zhanguo Gao, Jin Zhang, Tara M Henagan, Jong Han Lee, Xin Ye, Hui Wang, Jianping Y. P65 inactivation in adipocytes and macrophages attenuates adipose inflammatory response in lean but not in obese mice. American journal of physiology. Endocrinology and metabolism. vol 308. issue 6. 2015-06-15. PMID:25564477. |
body weight, glucose metabolism, and insulin sensitivity were not significantly altered in ko mice under the lean and obese conditions. |
2015-06-15 |
2023-08-13 |
mouse |
| Chithra Keembiyehetty, Dona C Love, Katryn R Harwood, Oksana Gavrilova, Marcella E Comly, John A Hanove. Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis. The Journal of biological chemistry. vol 290. issue 11. 2015-05-29. PMID:25596529. |
reduced insulin sensitivity, glucose tolerance, and hyperleptinemia were also observed in het and ko female mice. |
2015-05-29 |
2023-08-13 |
mouse |
| Camila O Souza, Alexandre A S Teixeira, Edson A Lima, Helena A P Batatinha, Lara M Gomes, Milena Carvalho-Silva, Isabella T Mota, Emilio L Streck, Sandro M Hirabara, José C Rosa Net. Palmitoleic acid (n-7) attenuates the immunometabolic disturbances caused by a high-fat diet independently of PPARα. Mediators of inflammation. vol 2014. 2015-05-15. PMID:25147439. |
treatment with palmitoleate markedly attenuated the insulin resistance induced by the hfd, increased glucose uptake and incorporation into muscle in vitro, reduced the serum levels of ast in wt mice, decreased the hepatic levels of il1-beta and il-12 in ko mice, reduced the expression of tlr-4 and increased the expression of il-1ra in wt mice, and reduced the phosphorylation of nf ����b (p65) in the livers of ko mice. |
2015-05-15 |
2023-08-13 |
mouse |
| David L Williamson, Zhuyun Li, Rubin M Tuder, Elena Feinstein, Scot R Kimball, Cory M Dunga. Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency. Journal of applied physiology (Bethesda, Md. : 1985). vol 117. issue 3. 2015-04-16. PMID:24876363. |
similarly, the redd1 ko mouse muscle displayed blunted mtorc1 signaling responses (s6k1 and 4e-bp1, raptor-mtor binding) and circulating insulin under fed conditions vs. the robust responses (p < 0.05) in the wt fed mouse muscle. |
2015-04-16 |
2023-08-13 |
mouse |
| Mini P Sajan, Robert A Ivey, Mackenzie Lee, Stephen Mastorides, Michael J Jurczak, Varman T Samuels, Gerald I Shulman, Ursula Braun, Michael Leitges, Robert V Fares. PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. Molecular endocrinology (Baltimore, Md.). vol 28. issue 7. 2015-04-16. PMID:24877563. |
thus, whereas muscle ko of pkc-λ impairs glucose transport and causes glucose intolerance, insulin resistance, and liver-dependent lipid abnormalities, liver ko and adipocyte ko of pkc-λ increase insulin sensitivity through salutary alterations in hepatic enzymes. |
2015-04-16 |
2023-08-13 |
mouse |
| Kyuho Kim, Chang-Myung Oh, Mica Ohara-Imaizumi, Sangkyu Park, Jun Namkung, Vijay K Yadav, Natalia A Tamarina, Michael W Roe, Louis H Philipson, Gerard Karsenty, Shinya Nagamatsu, Michael S German, Hail Ki. Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. vol 156. issue 2. 2015-03-24. PMID:25426873. |
pancreas perfusion assays revealed defective first-phase insulin secretion in htr3a ko mice. |
2015-03-24 |
2023-08-13 |
mouse |
| Kyuho Kim, Chang-Myung Oh, Mica Ohara-Imaizumi, Sangkyu Park, Jun Namkung, Vijay K Yadav, Natalia A Tamarina, Michael W Roe, Louis H Philipson, Gerard Karsenty, Shinya Nagamatsu, Michael S German, Hail Ki. Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. vol 156. issue 2. 2015-03-24. PMID:25426873. |
gsis was impaired in islets isolated from hfd-fed htr3a ko and tph1 βko mice, and 5-ht treatment improved insulin secretion from tph1 βko islets but not from htr3a ko islets. |
2015-03-24 |
2023-08-13 |
mouse |
| Gautam K Bandyopadhyay, Minh Lu, Ennio Avolio, Jawed A Siddiqui, Jiaur R Gayen, Joshua Wollam, Christine U Vu, Nai-Wen Chi, Daniel T O'Connor, Sushil K Mahat. Pancreastatin-dependent inflammatory signaling mediates obesity-induced insulin resistance. Diabetes. vol 64. issue 1. 2015-03-11. PMID:25048197. |
conversely, a pst variant peptide pstv1 (pst-nΔ3: chga(276-301)), lacking pst activity, simulated the ko phenotype by sensitizing wt-dio mice to insulin. |
2015-03-11 |
2023-08-13 |
mouse |