| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongjuan Wang, Rong Wang, Zhiwei Zhao, Zhijuan Ji, Shiming Xu, Christian Holscher, Shuli Shen. Coexistences of insulin signaling-related proteins and choline acetyltransferase in neurons. Brain research. vol 1249. 2009-01-30. PMID:19013138. |
using immunohistochemistry, the insulin signaling-related proteins, such as insulin receptor (insr), insulin receptor substrate-1 (irs-1), protein kinase b (pkb, also named akt), glycogen synthase kinase-3beta (gsk-3beta) and insulin-degrading enzyme (ide) were analysed. |
2009-01-30 |
2023-08-12 |
mouse |
| Sunita Sharma, Jaya Prasanthi R P, Eric Schommer, Gwen Feist, Othman Ghrib. Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated with alteration in IGF-1 signaling. Neurobiology of disease. vol 32. issue 3. 2009-01-28. PMID:18775495. |
the insulin-like growth factor-1 (igf-1) regulates the glycogen-synthase kinase-3alpha (gsk-3alpha) and the insulin degrading enzyme (ide). |
2009-01-28 |
2023-08-12 |
rabbit |
| Eisuke Shimizu, Kohichi Kawahara, Makoto Kajizono, Makoto Sawada, Hitoshi Nakayam. IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 9. 2009-01-21. PMID:18941241. |
nep and ide also contributed to il-4-induced degradation of abeta(1-42), because their inhibitors, thiorphan and insulin, respectively, significantly suppressed this activity. |
2009-01-21 |
2023-08-12 |
rat |
| Vicki Betts, Malcolm A Leissring, Georgia Dolios, Rong Wang, Dennis J Selkoe, Dominic M Wals. Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiology of disease. vol 31. issue 3. 2008-12-15. PMID:18602473. |
neprilysin (nep), insulin degrading enzyme (ide) and plasmin play a major role in abeta catabolism, therefore we compared the ability of these enzymes to degrade wild type and mutant monomeric abeta peptides. |
2008-12-15 |
2023-08-12 |
Not clear |
| Heng Yan Qu, Ting Zhang, Xu Ling Li, Jian Ping Zhou, Bao Quan Zhao, Qian Li, Man Ji Su. Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice. European journal of pharmacology. vol 594. issue 1-3. 2008-11-25. PMID:18644361. |
neprilysin (nep), endothelin-converting enzyme 1 (ece-1) and insulin degrading enzyme (ide), increased in the p11-cntf treated dementia mice, accompanied by the proliferation of nestin- and choline acetyltransferase (chat)-positive cells in hippocampus. |
2008-11-25 |
2023-08-12 |
mouse |
| Christina Yfanti, Karin Mengele, Apostolos Gkazepis, Gregor Weirich, Cecylia Giersig, Wen-Liang Kuo, Wei-Jen Tang, Marsha Rosner, Manfred Schmit. Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues. International journal of molecular medicine. vol 22. issue 4. 2008-10-31. PMID:18813847. |
insulin-degrading enzyme (ide, insulysin, insulinase; ec 3.4.22.11), a thiol metalloendopeptidase, is involved in intracellular degradation of insulin, thereby inhibiting its translocation and accumulation to the nucleus. |
2008-10-31 |
2023-08-12 |
human |
| Saila Vepsäläinen, Mikko Hiltunen, Seppo Helisalmi, Jun Wang, Thomas van Groen, Heikki Tanila, Hilkka Soinine. Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimer's disease-like neuropathology. Neuroscience letters. vol 438. issue 2. 2008-09-19. PMID:18455870. |
expression levels of amyloid beta (abeta)-degrading enzymes, insulin degrading enzyme (ide) and neprilysin (nep), were examined in transgenic mice with alzheimer's disease-like neuropathology. |
2008-09-19 |
2023-08-12 |
mouse |
| b' Dragan M Pavlovi\\xc4\\x87, Aleksandra M Pavlovi\\xc4\\x8. [Dementia and diabetes mellitus]. Srpski arhiv za celokupno lekarstvo. vol 136. issue 3-4. 2008-09-18. PMID:18720754.' |
amyloid beta (abeta), the main pathogenic factor in ad development, is eliminated by advanced glycation end products (ages) and degraded by insulin degrading enzyme (ide) for which it competes with insulin. |
2008-09-18 |
2023-08-12 |
Not clear |
| Marie Neant-Fery, Rubén D Garcia-Ordoñez, Todd P Logan, Dennis J Selkoe, Lilin Li, Lael Reinstatler, Malcolm A Leissrin. Molecular basis for the thiol sensitivity of insulin-degrading enzyme. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 28. 2008-09-03. PMID:18621727. |
insulin-degrading enzyme (ide) is a ubiquitous zinc-metalloprotease that hydrolyzes several pathophysiologically relevant peptides, including insulin and the amyloid beta-protein (abeta). |
2008-09-03 |
2023-08-12 |
Not clear |
| Marie Neant-Fery, Rubén D Garcia-Ordoñez, Todd P Logan, Dennis J Selkoe, Lilin Li, Lael Reinstatler, Malcolm A Leissrin. Molecular basis for the thiol sensitivity of insulin-degrading enzyme. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 28. 2008-09-03. PMID:18621727. |
unexpectedly, alkylation of c590 was found to activate hydrolysis of abeta significantly, while having no effect on insulin, demonstrating that chemical modulation of ide can be both bidirectional and highly substrate selective. |
2008-09-03 |
2023-08-12 |
Not clear |
| Giuseppe Grasso, Enrico Rizzarelli, Giuseppe Spot. How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin. Biochimica et biophysica acta. vol 1784. issue 7-8. 2008-08-25. PMID:18489915. |
insulin degrading enzyme (ide) is known to play a pivotal role on amyloidogenic peptide degradation but little is known about the changes in the proteolytic activity of the enzyme upon modification of external factors. |
2008-08-25 |
2023-08-12 |
Not clear |
| Giuseppe Grasso, Enrico Rizzarelli, Giuseppe Spot. How the binding and degrading capabilities of insulin degrading enzyme are affected by ubiquitin. Biochimica et biophysica acta. vol 1784. issue 7-8. 2008-08-25. PMID:18489915. |
in this work, we study the role that ubiquitin plays on ide capability of binding and degrading insulin molecules and the obtained results indicate that ubiquitin has an allosteric role for ide and high ubiquitin levels impair ide activity. |
2008-08-25 |
2023-08-12 |
Not clear |
| Conrad L Epting, Frank W King, Anissa Pedersen, Jessica Zaman, Carissa Ritner, Harold S Bernstei. Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblasts. Journal of cellular physiology. vol 217. issue 1. 2008-08-19. PMID:18506847. |
we also demonstrate that sca-1 associates with insulin degrading enzyme (ide), a catalytic protein responsible for the cleavage of mitogenic peptides, in differentiating myoblasts. |
2008-08-19 |
2023-08-12 |
Not clear |
| Mun-Gwan Hong, Chandra Reynolds, Margaret Gatz, Boo Johansson, Jennifer C Palmer, Harvest F Gu, Kaj Blennow, Patrick G Kehoe, Ulf de Faire, Nancy L Pedersen, Jonathan A Princ. Evidence that the gene encoding insulin degrading enzyme influences human lifespan. Human molecular genetics. vol 17. issue 15. 2008-08-04. PMID:18448515. |
a tenable molecular basis of this is suggested by the observation of genetic association with both fasting plasma insulin levels and ide mrna expression. |
2008-08-04 |
2023-08-12 |
human |
| Mun-Gwan Hong, Chandra Reynolds, Margaret Gatz, Boo Johansson, Jennifer C Palmer, Harvest F Gu, Kaj Blennow, Patrick G Kehoe, Ulf de Faire, Nancy L Pedersen, Jonathan A Princ. Evidence that the gene encoding insulin degrading enzyme influences human lifespan. Human molecular genetics. vol 17. issue 15. 2008-08-04. PMID:18448515. |
across populations the emergent genetic model is indicative of over-dominance, where heterozygotes of critical markers have increased ide mrna expression and insulin levels, and this is reflected in diminished heterozygosity at advanced age. |
2008-08-04 |
2023-08-12 |
human |
| Mun-Gwan Hong, Chandra Reynolds, Margaret Gatz, Boo Johansson, Jennifer C Palmer, Harvest F Gu, Kaj Blennow, Patrick G Kehoe, Ulf de Faire, Nancy L Pedersen, Jonathan A Princ. Evidence that the gene encoding insulin degrading enzyme influences human lifespan. Human molecular genetics. vol 17. issue 15. 2008-08-04. PMID:18448515. |
a critical and replicating feature of this study is that change in ide genotype frequency with advancing age appears to be occurring only in men, and this is supported in that insulin levels are only associated with ide in men. |
2008-08-04 |
2023-08-12 |
human |
| Ramiro E Llovera, Matías de Tullio, Leonardo G Alonso, Malcolm A Leissring, Sergio B Kaufman, Alex E Roher, Gonzalo de Prat Gay, Laura Morelli, Eduardo M Castañ. The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis. The Journal of biological chemistry. vol 283. issue 25. 2008-07-25. PMID:18411275. |
insulin-degrading enzyme (ide) is central to the turnover of insulin and degrades amyloid beta (abeta) in the mammalian brain. |
2008-07-25 |
2023-08-12 |
rat |
| Ramiro E Llovera, Matías de Tullio, Leonardo G Alonso, Malcolm A Leissring, Sergio B Kaufman, Alex E Roher, Gonzalo de Prat Gay, Laura Morelli, Eduardo M Castañ. The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis. The Journal of biological chemistry. vol 283. issue 25. 2008-07-25. PMID:18411275. |
partial denaturation of ide as well as preincubation with a 10-fold molar excess of insulin prevented complex formation, suggesting that the irreversible interaction of abeta takes place with at least part of the substrate binding site of the protease. |
2008-07-25 |
2023-08-12 |
rat |
| S H Kwak, Y M Cho, M K Moon, J H Kim, B L Park, H S Cheong, H D Shin, H C Jang, S Y Kim, H K Lee, K S Par. Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population. Diabetes research and clinical practice. vol 79. issue 2. 2008-03-07. PMID:17913278. |
insulin-degrading enzyme (ide) is a metalloproteinase which degrades insulin and terminates its action. |
2008-03-07 |
2023-08-12 |
rat |
| Giuseppe Grasso, Enrico Rizzarelli, Giuseppe Spot. AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin. Journal of mass spectrometry : JMS. vol 42. issue 12. 2008-03-05. PMID:18085545. |
the prominent role that insulin degrading enzyme (ide) has in the clearance of insulin as well as of other molecules such as amyloid-beta has recently drawn much interest in the scientific community toward this protease. |
2008-03-05 |
2023-08-12 |
cattle |