| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaozhe Lu, Yanyan Huang, Yun Liu, Xiaoyan Wu, Xiaomei Sh. Variants in the insulin-degrading enzyme gene are associated with metabolic syndrome in Chinese elders. Metabolism: clinical and experimental. vol 58. issue 10. 2009-10-09. PMID:19592050. |
insulin-degrading enzyme (ide) plays a primary role in insulin degradation and cellular insulin processing and therefore affects glucose and lipid metabolism. |
2009-10-09 |
2023-08-12 |
Not clear |
| Jianjia Fan, James Donkin, Cheryl Wellingto. Greasing the wheels of Abeta clearance in Alzheimer's disease: the role of lipids and apolipoprotein E. BioFactors (Oxford, England). vol 35. issue 3. 2009-08-25. PMID:19472365. |
a second effect is to facilitate the proteolytic degradation of abeta by neprilysin and insulin degrading enzyme (ide), which is enhanced when apoe is lipidated. |
2009-08-25 |
2023-08-12 |
mouse |
| Dorothea Strozyk, Lenore J Launer, Paul A Adlard, Robert A Cherny, Andrew Tsatsanis, Irene Volitakis, Kaj Blennow, Helen Petrovitch, Lon R White, Ashley I Bus. Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid. Neurobiology of aging. vol 30. issue 7. 2009-08-21. PMID:18068270. |
however, in health, abeta degradation is mediated by extracellular metalloproteinases, neprilysin, insulin degrading enzyme (ide) and matrix metalloproteinases. |
2009-08-21 |
2023-08-12 |
human |
| Yun Luo, Fengnan Niu, Zongzheng Sun, Wangsen Cao, Xin Zhang, Dening Guan, Zhimai Lv, Bing Zhang, Yun X. Altered expression of Abeta metabolism-associated molecules from D-galactose/AlCl(3) induced mouse brain. Mechanisms of ageing and development. vol 130. issue 4. 2009-08-14. PMID:19150622. |
furthermore, al/d-gal reduced the expression of neprilysin (nep), but not the insulin degrading enzyme (ide). |
2009-08-14 |
2023-08-12 |
mouse |
| Giuseppe Grasso, Enrico Rizzarelli, Giuseppe Spot. The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study. Journal of mass spectrometry : JMS. vol 44. issue 5. 2009-07-28. PMID:19127548. |
in a previous work we have already shown the great potentiality of atmospheric pressure/laser desorption ionization-mass spectrometry (ap/maldi-ms) for studying the interaction between ide and insulin. |
2009-07-28 |
2023-08-12 |
Not clear |
| Giuseppe Grasso, Enrico Rizzarelli, Giuseppe Spot. The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study. Journal of mass spectrometry : JMS. vol 44. issue 5. 2009-07-28. PMID:19127548. |
the roles that ide/insulin concentration ratio, reaction time, adenosine 5'-triphosphate (atp) and metal ions (zn and cu) have on the insulin cleavage pattern produced by ide are investigated and a plausible interpretation involving the proteolytic action of the different ide oligomeric forms is proposed. |
2009-07-28 |
2023-08-12 |
Not clear |
| Jarbas S Roriz-Filho, Ticiana M Sá-Roriz, Idiane Rosset, Ana L Camozzato, Antonio C Santos, Márcia L F Chaves, Júlio César Moriguti, Matheus Roriz-Cru. (Pre)diabetes, brain aging, and cognition. Biochimica et biophysica acta. vol 1792. issue 5. 2009-07-07. PMID:19135149. |
whereas insulin is clearly neurothrophic at moderate concentrations, too much insulin in the brain may be associated with reduced amyloid-beta (abeta) clearance due to competition for their common and main depurative mechanism - the insulin-degrading enzyme (ide). |
2009-07-07 |
2023-08-12 |
human |
| Jarbas S Roriz-Filho, Ticiana M Sá-Roriz, Idiane Rosset, Ana L Camozzato, Antonio C Santos, Márcia L F Chaves, Júlio César Moriguti, Matheus Roriz-Cru. (Pre)diabetes, brain aging, and cognition. Biochimica et biophysica acta. vol 1792. issue 5. 2009-07-07. PMID:19135149. |
since ide is much more selective for insulin than for abeta, brain hyperinsulinism may deprive abeta of its main clearance mechanism. |
2009-07-07 |
2023-08-12 |
human |
| Marika Manolopoulou, Qing Guo, Enrico Malito, Alexander B Schilling, Wei-Jen Tan. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. The Journal of biological chemistry. vol 284. issue 21. 2009-07-07. PMID:19321446. |
insulin is a hormone vital for glucose homeostasis, and insulin-degrading enzyme (ide) plays a key role in its clearance. |
2009-07-07 |
2023-08-12 |
human |
| Marika Manolopoulou, Qing Guo, Enrico Malito, Alexander B Schilling, Wei-Jen Tan. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. The Journal of biological chemistry. vol 284. issue 21. 2009-07-07. PMID:19321446. |
ide exhibits a remarkable specificity to degrade insulin without breaking the disulfide bonds that hold the insulin a and b chains together. |
2009-07-07 |
2023-08-12 |
human |
| Marika Manolopoulou, Qing Guo, Enrico Malito, Alexander B Schilling, Wei-Jen Tan. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. The Journal of biological chemistry. vol 284. issue 21. 2009-07-07. PMID:19321446. |
using fourier transform ion cyclotron resonance (fticr) mass spectrometry to obtain high mass accuracy, and electron capture dissociation (ecd) to selectively break the disulfide bonds in gas phase fragmentation, we determined the cleavage sites and composition of human insulin fragments generated by human ide. |
2009-07-07 |
2023-08-12 |
human |
| Marika Manolopoulou, Qing Guo, Enrico Malito, Alexander B Schilling, Wei-Jen Tan. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. The Journal of biological chemistry. vol 284. issue 21. 2009-07-07. PMID:19321446. |
our time-dependent analysis of ide-digested insulin fragments reveals that ide is highly processive in its initial cleavage at the middle of both the insulin a and b chains. |
2009-07-07 |
2023-08-12 |
human |
| Marika Manolopoulou, Qing Guo, Enrico Malito, Alexander B Schilling, Wei-Jen Tan. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. The Journal of biological chemistry. vol 284. issue 21. 2009-07-07. PMID:19321446. |
this ensures that ide effectively splits insulin into inactive n- and c-terminal halves without breaking the disulfide bonds. |
2009-07-07 |
2023-08-12 |
human |
| Marika Manolopoulou, Qing Guo, Enrico Malito, Alexander B Schilling, Wei-Jen Tan. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. The Journal of biological chemistry. vol 284. issue 21. 2009-07-07. PMID:19321446. |
to understand the molecular basis of the recognition and unfolding of insulin by ide, we determined a 2.6-a resolution insulin-bound ide structure. |
2009-07-07 |
2023-08-12 |
human |
| Marika Manolopoulou, Qing Guo, Enrico Malito, Alexander B Schilling, Wei-Jen Tan. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. The Journal of biological chemistry. vol 284. issue 21. 2009-07-07. PMID:19321446. |
our structure reveals that ide forms an enclosed catalytic chamber that completely engulfs and intimately interacts with a partially unfolded insulin molecule. |
2009-07-07 |
2023-08-12 |
human |
| Marika Manolopoulou, Qing Guo, Enrico Malito, Alexander B Schilling, Wei-Jen Tan. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. The Journal of biological chemistry. vol 284. issue 21. 2009-07-07. PMID:19321446. |
this structure also highlights how the unique size, shape, charge distribution, and exosite of the ide catalytic chamber contribute to its high affinity ( approximately 100 nm) for insulin. |
2009-07-07 |
2023-08-12 |
human |
| Marika Manolopoulou, Qing Guo, Enrico Malito, Alexander B Schilling, Wei-Jen Tan. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme. The Journal of biological chemistry. vol 284. issue 21. 2009-07-07. PMID:19321446. |
in addition, this structure shows how ide utilizes the interaction of its exosite with the n terminus of the insulin a chain as well as other properties of the catalytic chamber to guide the unfolding of insulin and allowing for the processive cleavages. |
2009-07-07 |
2023-08-12 |
human |
| Raymond E Hulse, Luis A Ralat, Tang Wei-Je. Structure, function, and regulation of insulin-degrading enzyme. Vitamins and hormones. vol 80. 2009-06-23. PMID:19251053. |
the short half-life of insulin in the human body (4-6 min) prompted the search and discovery of insulin-degrading enzyme (ide), a 110-kda metalloprotease that can rapidly degrade insulin into inactive fragments. |
2009-06-23 |
2023-08-12 |
human |
| Raymond E Hulse, Luis A Ralat, Tang Wei-Je. Structure, function, and regulation of insulin-degrading enzyme. Vitamins and hormones. vol 80. 2009-06-23. PMID:19251053. |
genetic and biochemical evidence accumulated in the last sixty years has implicated ide as an important physiological contributor in the maintenance of insulin levels. |
2009-06-23 |
2023-08-12 |
human |
| Raymond E Hulse, Luis A Ralat, Tang Wei-Je. Structure, function, and regulation of insulin-degrading enzyme. Vitamins and hormones. vol 80. 2009-06-23. PMID:19251053. |
recent structural and biochemical analyses reveal the molecular basis of how ide uses size and charge distribution of the catalytic chamber and structural flexibility of substrates to selectively recognize and degrade insulin, as well as the regulatory mechanisms of this enzyme. |
2009-06-23 |
2023-08-12 |
human |