| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Du, Lang Zhang, Shubo Liu, Chi Zhang, Xiuqing Huang, Jian Li, Nanming Zhao, Zhao Wan. PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons. Biochemical and biophysical research communications. vol 383. issue 4. 2009-06-05. PMID:19383491. |
insulin-degrading enzyme (ide) is a protease that has been demonstrated to play a key role in degrading both abeta and insulin and deficient in ide function is associated with alzheimer's disease (ad) and type 2 diabetes mellitus (dm2) pathology. |
2009-06-05 |
2023-08-12 |
rat |
| Giuseppe Grasso, Ashley I Bush, Roberta D'Agata, Enrico Rizzarelli, Giuseppe Spot. Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme. European biophysics journal : EBJ. vol 38. issue 4. 2009-06-02. PMID:19048247. |
here, we propose a spr-ms combined experimental approach aimed at studying insulin degrading enzyme (ide) immobilized onto gold surfaces and its ability to interact with insulin. |
2009-06-02 |
2023-08-12 |
Not clear |
| Giuseppe Grasso, Ashley I Bush, Roberta D'Agata, Enrico Rizzarelli, Giuseppe Spot. Enzyme solid-state support assays: a surface plasmon resonance and mass spectrometry coupled study of immobilized insulin degrading enzyme. European biophysics journal : EBJ. vol 38. issue 4. 2009-06-02. PMID:19048247. |
the spr experiments allow the calculation of the kinetic constants involved for the interaction between immobilized ide and insulin molecules and evidence of ide conformational change upon insulin binding is also obtained. |
2009-06-02 |
2023-08-12 |
Not clear |
| Robert G Bennett, Dean G Heimann, Frederick G Hame. Degradation of relaxin family peptides by insulin-degrading enzyme. Annals of the New York Academy of Sciences. vol 1160. 2009-05-22. PMID:19416156. |
insulin-degrading enzyme (ide) is a ubiquitously expressed metalloproteinase responsible for the intracellular degradation of insulin. |
2009-05-22 |
2023-08-12 |
Not clear |
| Robert G Bennett, Dean G Heimann, Frederick G Hame. Degradation of relaxin family peptides by insulin-degrading enzyme. Annals of the New York Academy of Sciences. vol 1160. 2009-05-22. PMID:19416156. |
ide also interacts with other members of the insulin superfamily, including relaxin, but no studies have been reported regarding the interaction of other relaxin-like peptides with ide. |
2009-05-22 |
2023-08-12 |
Not clear |
| Robert G Bennett, Dean G Heimann, Frederick G Hame. Degradation of relaxin family peptides by insulin-degrading enzyme. Annals of the New York Academy of Sciences. vol 1160. 2009-05-22. PMID:19416156. |
in this study, we determined that relaxin, relaxin-3, and insl3 all competitively inhibited the degradation of insulin by ide to different degrees, and all inhibited covalent cross-linking of insulin to ide. |
2009-05-22 |
2023-08-12 |
Not clear |
| Robert G Bennett, Dean G Heimann, Frederick G Hame. Degradation of relaxin family peptides by insulin-degrading enzyme. Annals of the New York Academy of Sciences. vol 1160. 2009-05-22. PMID:19416156. |
each of the peptides was degraded by ide to various degrees (insulin > relaxin > insl3 = relaxin-3). |
2009-05-22 |
2023-08-12 |
Not clear |
| Robert G Bennett, Dean G Heimann, Frederick G Hame. Degradation of relaxin family peptides by insulin-degrading enzyme. Annals of the New York Academy of Sciences. vol 1160. 2009-05-22. PMID:19416156. |
in summary, relaxin, insl3, and relaxin-3 all bound to ide, competed for the binding and degradation of insulin, and were all substrates for the proteolytic activity of ide. |
2009-05-22 |
2023-08-12 |
Not clear |
| Robert G Bennett, Dean G Heimann, Frederick G Hame. Degradation of relaxin family peptides by insulin-degrading enzyme. Annals of the New York Academy of Sciences. vol 1160. 2009-05-22. PMID:19416156. |
therefore, it is possible that in addition to insulin, ide may be important for the cellular proteolysis of relaxin, insl3, and relaxin-3. |
2009-05-22 |
2023-08-12 |
Not clear |
| Benjamin J Alper, Walter K Schmid. A capillary electrophoresis method for evaluation of Abeta proteolysis in vitro. Journal of neuroscience methods. vol 178. issue 1. 2009-04-07. PMID:19071160. |
in the present analysis, we demonstrate that this ce-based method is amenable to kinetic analysis, and show that ide-mediated abeta proteolysis is significantly and disproportionately inhibited in the presence of insulin, an alternative ide substrate. |
2009-04-07 |
2023-08-12 |
Not clear |
| Mir A Ali, Qingxue Li, Elizabeth R Fischer, Jeffrey I Cohe. The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection. Virology. vol 386. issue 2. 2009-04-02. PMID:19233447. |
varicella-zoster virus (vzv) glycoprotein e (ge) interacts with glycoprotein i and with insulin degrading enzyme (ide), which is a receptor for the virus. |
2009-04-02 |
2023-08-12 |
Not clear |
| Crystal M Cordes, Robert G Bennett, Gerri L Siford, Frederick G Hame. Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation. Biochemical pharmacology. vol 77. issue 6. 2009-04-01. PMID:19154729. |
insulin-degrading enzyme (ide) is responsible for the degradation of a number of hormones and peptides, including insulin and amyloid beta (abeta). |
2009-04-01 |
2023-08-12 |
Not clear |
| Crystal M Cordes, Robert G Bennett, Gerri L Siford, Frederick G Hame. Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation. Biochemical pharmacology. vol 77. issue 6. 2009-04-01. PMID:19154729. |
no donors decreased both insulin and abeta degrading activities of ide. |
2009-04-01 |
2023-08-12 |
Not clear |
| Crystal M Cordes, Robert G Bennett, Gerri L Siford, Frederick G Hame. Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation. Biochemical pharmacology. vol 77. issue 6. 2009-04-01. PMID:19154729. |
s-nitrosylation of ide enzyme did not affect the insulin degradation products produced by the enzyme, nor did no affect insulin binding to ide as determined by cross-linking studies. |
2009-04-01 |
2023-08-12 |
Not clear |
| Matías B de Tullio, Laura Morelli, Eduardo M Castañ. The irreversible binding of amyloid peptide substrates to insulin-degrading enzyme: a biological perspective. Prion. vol 2. issue 2. 2009-03-19. PMID:19098445. |
insulin-degrading enzyme (ide) is a conserved zn(2+)metalloendopeptidase involved in insulin degradation and in the maintenance of brain steady-state levels of amyloid beta peptide (abeta) of alzheimer's disease (ad). |
2009-03-19 |
2023-08-12 |
Not clear |
| Enrico Malito, Luis A Ralat, Marika Manolopoulou, Julie L Tsay, Natasha L Wadlington, Wei-Jen Tan. Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme. Biochemistry. vol 47. issue 48. 2009-03-16. PMID:18986166. |
insulin degrading enzyme (ide) utilizes a large catalytic chamber to selectively bind and degrade peptide substrates such as insulin and amyloid beta (abeta). |
2009-03-16 |
2023-08-12 |
human |
| I Alafuzoff, L Aho, S Helisalmi, A Mannermaa, H Soinine. Beta-amyloid deposition in brains of subjects with diabetes. Neuropathology and applied neurobiology. vol 35. issue 1. 2009-03-09. PMID:18346114. |
one hypothesis is that the link between dm and ad is related to the function of insulin-degrading enzyme (ide), an enzyme that degrades not only insulin and pancreatic amylin but also beta-amyloid (abeta). |
2009-03-09 |
2023-08-12 |
human |
| I Alafuzoff, L Aho, S Helisalmi, A Mannermaa, H Soinine. Beta-amyloid deposition in brains of subjects with diabetes. Neuropathology and applied neurobiology. vol 35. issue 1. 2009-03-09. PMID:18346114. |
thus, in diabetics, insulin and abeta might compete for ide and this might lead to an increase in abeta. |
2009-03-09 |
2023-08-12 |
human |
| R P Jaya Prasanthi, Eric Schommer, Sarah Thomasson, Alex Thompson, Gwen Feist, Othman Ghrib. Regulation of beta-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's disease. Mechanisms of ageing and development. vol 129. issue 11. 2009-03-05. PMID:18845178. |
abeta levels in the brain are governed by its generation from amyloid precursor protein by beta-secretase (bace1), degradation by the insulin degrading enzyme (ide), clearance from the brain by the low density lipoprotein receptor-related protein (lrp-1), and transport from circulation into the brain by receptor for advanced glycation end products (rage). |
2009-03-05 |
2023-08-12 |
rabbit |
| Xiumei Zuo, Jianping Ji. Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease. Brain research. vol 1249. 2009-01-30. PMID:18996360. |
insulin degrading enzyme (ide) is involved in abeta degradation, therefore the gene encoding for insulin degrading enzyme is one of the candidate genes risky for ad. |
2009-01-30 |
2023-08-12 |
Not clear |