| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giuseppe Grasso, Enrico Rizzarelli, Giuseppe Spot. AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin. Journal of mass spectrometry : JMS. vol 42. issue 12. 2008-03-05. PMID:18085545. |
in this scenario, although the cleavage sites involved in the interaction of insulin with ide are known, a convenient experimental method that is able to identify in a complete and unambiguous way, all the peptide fragments generated by such interaction has yet to be found. |
2008-03-05 |
2023-08-12 |
cattle |
| Giuseppe Grasso, Enrico Rizzarelli, Giuseppe Spot. AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin. Journal of mass spectrometry : JMS. vol 42. issue 12. 2008-03-05. PMID:18085545. |
in this work, we report a new experimental procedure by which an unambiguous as well as complete assignment of all the peptide fragments generated by the interaction of insulin with ide is described. |
2008-03-05 |
2023-08-12 |
cattle |
| Giuseppe Grasso, Enrico Rizzarelli, Giuseppe Spot. AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin. Journal of mass spectrometry : JMS. vol 42. issue 12. 2008-03-05. PMID:18085545. |
atmospheric pressure/matrix-assisted laser desorption ionization (ap/maldi) mass spectra are reported and the data recorded, together with the introduction of a reduction/alkylation step, allows us to fully characterize the cleavage sites of the bovine insulin interacting with ide. |
2008-03-05 |
2023-08-12 |
cattle |
| Yoann Huet, Jochen Strassner, Andreas Schalle. Cloning, expression and characterization of insulin-degrading enzyme from tomato (Solanum lycopersicum). Biological chemistry. vol 389. issue 1. 2008-02-20. PMID:18095874. |
gst-slide was characterized as a neutral thiol-dependent metallopeptidase with insulinase activity: the recombinant enzyme cleaved the oxidized insulin b chain at eight peptide bonds, six of which are also targets of human ide. |
2008-02-20 |
2023-08-12 |
human |
| Janet Fawcett, Paska A Permana, Jennifer L Levy, William C Duckwort. Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing. Archives of biochemistry and biophysics. vol 468. issue 1. 2007-12-18. PMID:17964527. |
ide is responsible for the majority of cellular insulin degradation. |
2007-12-18 |
2023-08-12 |
human |
| Janet Fawcett, Paska A Permana, Jennifer L Levy, William C Duckwort. Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing. Archives of biochemistry and biophysics. vol 468. issue 1. 2007-12-18. PMID:17964527. |
we hypothesized that a reduction in ide would reduce insulin degradation and insulin's ability to inhibit protein degradation. |
2007-12-18 |
2023-08-12 |
human |
| Janet Fawcett, Paska A Permana, Jennifer L Levy, William C Duckwort. Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing. Archives of biochemistry and biophysics. vol 468. issue 1. 2007-12-18. PMID:17964527. |
hepg2 cells were transfected with sirna against human ide and insulin degradation and protein degradation measured. |
2007-12-18 |
2023-08-12 |
human |
| Janet Fawcett, Paska A Permana, Jennifer L Levy, William C Duckwort. Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing. Archives of biochemistry and biophysics. vol 468. issue 1. 2007-12-18. PMID:17964527. |
the inhibition of protein degradation by insulin was reduced 37-76% by a decreased expression of ide in hepg2 cells. |
2007-12-18 |
2023-08-12 |
human |
| Janet Fawcett, Paska A Permana, Jennifer L Levy, William C Duckwort. Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing. Archives of biochemistry and biophysics. vol 468. issue 1. 2007-12-18. PMID:17964527. |
this shows that ide is involved in cellular insulin metabolism and provides further evidence that insulin inhibits protein degradation via an interaction with ide. |
2007-12-18 |
2023-08-12 |
human |
| Razvan T Radulesc. One for all and all for one: RB defends the cell while IDE, PTEN and IGFBP-7 antagonize insulin and IGFs to protect RB. Medical hypotheses. vol 69. issue 5. 2007-12-13. PMID:17475416. |
one for all and all for one: rb defends the cell while ide, pten and igfbp-7 antagonize insulin and igfs to protect rb. |
2007-12-13 |
2023-08-12 |
Not clear |
| Razvan T Radulesc. One for all and all for one: RB defends the cell while IDE, PTEN and IGFBP-7 antagonize insulin and IGFs to protect RB. Medical hypotheses. vol 69. issue 5. 2007-12-13. PMID:17475416. |
a novel insight is now advanced to suggest that various inhibitors of insulin and insulin-like growth factor (igf) signalling such as the putative tumor suppressor insulin-degrading enzyme (ide) as well as the anti-oncogenic proteins pten and insulin-like growth factor-binding protein 7 (igfbp-7) serve the common goal of ensuring that rb remains active. |
2007-12-13 |
2023-08-12 |
Not clear |
| Razvan T Radulesc. One for all and all for one: RB defends the cell while IDE, PTEN and IGFBP-7 antagonize insulin and IGFs to protect RB. Medical hypotheses. vol 69. issue 5. 2007-12-13. PMID:17475416. |
since, moreover, ide and igfbp-7 each potentially achieves rb protection through preventing both binding and inactivation of rb by insulin, igf-1 or igf-2, the present perception also vindicates the importance of previous findings on the physical interaction of any of these growth factors with rb for cell fate. |
2007-12-13 |
2023-08-12 |
Not clear |
| Hookang Im, Marika Manolopoulou, Enrico Malito, Yuequan Shen, Ji Zhao, Marie Neant-Fery, Ching-Yu Sun, Stephen C Meredith, Sangram S Sisodia, Malcolm A Leissring, Wei-Jen Tan. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE. The Journal of biological chemistry. vol 282. issue 35. 2007-10-29. PMID:17613531. |
insulin-degrading enzyme (ide) is a zinc metalloprotease that hydrolyzes amyloid-beta (abeta) and insulin, which are peptides associated with alzheimer disease (ad) and diabetes, respectively. |
2007-10-29 |
2023-08-12 |
human |
| F G Hamel, J Fawcett, B T Tsui, R G Bennett, W C Duckwort. Effect of nelfinavir on insulin metabolism, proteasome activity and protein degradation in HepG2 cells. Diabetes, obesity & metabolism. vol 8. issue 6. 2007-09-28. PMID:17026490. |
we have previously demonstrated that insulin, through ide, can inhibit the proteasome, thus decreasing cytosolic protein degradation. |
2007-09-28 |
2023-08-12 |
Not clear |
| F G Hamel, J Fawcett, B T Tsui, R G Bennett, W C Duckwort. Effect of nelfinavir on insulin metabolism, proteasome activity and protein degradation in HepG2 cells. Diabetes, obesity & metabolism. vol 8. issue 6. 2007-09-28. PMID:17026490. |
these data show that nelfinavir inhibits ide, decreases insulin's ability to inhibit protein degradation via the proteasome and provides another possible mechanism for the insulin resistance seen in protease inhibitor-treated hiv patients. |
2007-09-28 |
2023-08-12 |
Not clear |
| Behnosh F Björk, Hagit Katzov, Patrick Kehoe, Laura Fratiglioni, Bengt Winblad, Jonathan A Prince, Caroline Graf. Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE. Neurobiology of aging. vol 28. issue 9. 2007-08-29. PMID:16876916. |
insulin degrading enzyme (ide) is one of the principal proteases involved in the degradation of the beta-amyloid peptide, which is the major constituent of senile plaques in alzheimer's disease (ad) brains. |
2007-08-29 |
2023-08-12 |
Not clear |
| Zhong Zhao, Zhongmin Xiang, Vahram Haroutunian, Joseph D Buxbaum, Breton Stetka, Giulio Maria Pasinett. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. Neurobiology of aging. vol 28. issue 6. 2007-05-17. PMID:16769157. |
in this study we report that the membrane-bound, but not cytosolic insulin degrading enzyme (ide) protein concentration and ide activity are significantly decreased in the hippocampal formation of cases affected by mild cognitive impairment (mci) which are at high risk to develop alzheimer's disease (ad), relative to normal neurological controls. |
2007-05-17 |
2023-08-12 |
Not clear |
| Minji Kim, Louis B Hersh, Malcolm A Leissring, Martin Ingelsson, Toshifumi Matsui, Wesley Farris, Alice Lu, Bradley T Hyman, Dennis J Selkoe, Lars Bertram, Rudolph E Tanz. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. The Journal of biological chemistry. vol 282. issue 11. 2007-04-24. PMID:17244626. |
we have shown that the catalytic activity of cytosolic ide to degrade insulin is reduced in affected versus unaffected subjects of these families. |
2007-04-24 |
2023-08-12 |
human |
| Dae Youn Hwang, Sujin Seo, Yongkyu Kim, Chuelkyu Kim, Sunbo Shim, Seungwan Jee, Suhae Lee, Jisoon Sin, Junyong Cho, Byeongchuel Kang, Insurk Jang, Jungsik Ch. Significant change in insulin production, glucose tolerance and ER stress signaling in transgenic mice coexpressing insulin-siRNA and human IDE. International journal of molecular medicine. vol 19. issue 1. 2007-03-19. PMID:17143549. |
significant change in insulin production, glucose tolerance and er stress signaling in transgenic mice coexpressing insulin-sirna and human ide. |
2007-03-19 |
2023-08-12 |
mouse |
| María Del Carmen Camberos, Juan C Crest. Insulin-degrading enzyme hydrolyzes ATP. Experimental biology and medicine (Maywood, N.J.). vol 232. issue 2. 2007-02-22. PMID:17259336. |
we reported in a previous work that insulin degradation by insulin-degrading enzyme (ide) was inhibited by atp (exp biol med 226:334-341, 2001). |
2007-02-22 |
2023-08-12 |
rat |