| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seonil Kim, Andrea N Lapham, Christopher G K Freedman, Tiffany L Reed, Walter K Schmid. Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme. The Journal of biological chemistry. vol 280. issue 30. 2005-09-22. PMID:15944156. |
we have developed yeast as an expression and genetic system for functional studies of the insulin-degrading enzyme (ide), which cleaves and inactivates certain small peptide molecules, including insulin and the neurotoxic a beta peptide. |
2005-09-22 |
2023-08-12 |
rat |
| Seonil Kim, Andrea N Lapham, Christopher G K Freedman, Tiffany L Reed, Walter K Schmid. Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme. The Journal of biological chemistry. vol 280. issue 30. 2005-09-22. PMID:15944156. |
we show that heterologously expressed rat ide is enzymatically active, as judged by the ability of ide-containing yeast extracts to cleave insulin in vitro. |
2005-09-22 |
2023-08-12 |
rat |
| Hisae Hayashi, Michihisa Tohda, Hiroshi Watanabe, Yukihisa Murakami, Kinzo Matsumot. The effects of Choto-san on the mRNA expression of Alzheimer's disease related factors in the permanent ischemic rat brain. Biological & pharmaceutical bulletin. vol 28. issue 4. 2005-08-26. PMID:15802822. |
the expressions of beta-amyloid precursor protein, gamma-secretase, alpha7 nicotinic acetylcholine receptor, neprilysin, and insulin degrading enzyme (ide) were significantly increased on day 4 after permanent occlusion of the bilateral common carotid arteries (2vo). |
2005-08-26 |
2023-08-12 |
rat |
| Daniel P Udrisar, Maria I Wanderley, Regina C C Porto, Carla L P Cardoso, Maria C L Barbosa, Maria C Camberos, Juan C Crest. Androgen- and estrogen-dependent regulation of insulin-degrading enzyme in subcellular fractions of rat prostate and uterus. Experimental biology and medicine (Maywood, N.J.). vol 230. issue 7. 2005-07-27. PMID:15985623. |
innumerous data support the fact that insulin-degrading enzyme (ide) is the primary enzymatic mechanism for initiating and controlling cellular insulin degradation. |
2005-07-27 |
2023-08-12 |
rat |
| Daniel P Udrisar, Maria I Wanderley, Regina C C Porto, Carla L P Cardoso, Maria C L Barbosa, Maria C Camberos, Juan C Crest. Androgen- and estrogen-dependent regulation of insulin-degrading enzyme in subcellular fractions of rat prostate and uterus. Experimental biology and medicine (Maywood, N.J.). vol 230. issue 7. 2005-07-27. PMID:15985623. |
nevertheless, insulin degradation is unlikely to be the only cellular function of ide, because it appears that some cellular effects of insulin are mediated by ide as a regulatory protein. |
2005-07-27 |
2023-08-12 |
rat |
| Daniel P Udrisar, Maria I Wanderley, Regina C C Porto, Carla L P Cardoso, Maria C L Barbosa, Maria C Camberos, Juan C Crest. Androgen- and estrogen-dependent regulation of insulin-degrading enzyme in subcellular fractions of rat prostate and uterus. Experimental biology and medicine (Maywood, N.J.). vol 230. issue 7. 2005-07-27. PMID:15985623. |
besides insulin, other substrates are also degraded by ide, including various growth-promoting peptides. |
2005-07-27 |
2023-08-12 |
rat |
| Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P Lim, Surendra S Ambegaokar, Oliver J Ubeda, Sally A Frautschy, Greg M Col. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 49. 2005-07-07. PMID:15590928. |
because one of the main functions of ide is to degrade insulin, we hypothesized that there is a negative feedback mechanism whereby stimulation of insulin receptor-mediated signaling upregulates ide to prevent chronic activation of the pathway. |
2005-07-07 |
2023-08-12 |
mouse |
| Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P Lim, Surendra S Ambegaokar, Oliver J Ubeda, Sally A Frautschy, Greg M Col. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 49. 2005-07-07. PMID:15590928. |
we show that treatment of primary hippocampal neurons with insulin increased ide protein levels by approximately 25%. |
2005-07-07 |
2023-08-12 |
mouse |
| Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P Lim, Surendra S Ambegaokar, Oliver J Ubeda, Sally A Frautschy, Greg M Col. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 49. 2005-07-07. PMID:15590928. |
inhibition of pi3 kinase abolished the ide upregulation by insulin, indicating a cause-effect relationship between insulin signaling and ide upregulation. |
2005-07-07 |
2023-08-12 |
mouse |
| Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P Lim, Surendra S Ambegaokar, Oliver J Ubeda, Sally A Frautschy, Greg M Col. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 49. 2005-07-07. PMID:15590928. |
further support for this link was provided by the findings that deficient insulin signaling (decreased pi3 kinase subunit p85) was correlated with reduced ide in alzheimer's disease (ad) brains and in tg2576 swedish amyloid precursor protein transgenic mice fed a safflower oil-enriched ("bad") diet used to accelerate pathogenesis. |
2005-07-07 |
2023-08-12 |
mouse |
| Lixia Zhao, Bruce Teter, Takashi Morihara, Giselle P Lim, Surendra S Ambegaokar, Oliver J Ubeda, Sally A Frautschy, Greg M Col. Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 49. 2005-07-07. PMID:15590928. |
these in vitro and in vivo analyses validate the use of enhanced cns insulin signaling as a potential strategy for ad intervention to correct the ide defects occurring in ad. |
2005-07-07 |
2023-08-12 |
mouse |
| Malcolm A Leissring, Wesley Farris, Xining Wu, Danos C Christodoulou, Marcia C Haigis, Leonard Guarente, Dennis J Selko. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. The Biochemical journal. vol 383. issue Pt. 3. 2005-05-11. PMID:15285718. |
ide (insulin-degrading enzyme) is a widely expressed zinc-metallopeptidase that has been shown to regulate both cerebral amyloid beta-peptide and plasma insulin levels in vivo. |
2005-05-11 |
2023-08-12 |
Not clear |
| Mia E-L Blomqvist, Katy Chalmers, Niels Andreasen, Nenad Bogdanovic, Gordon K Wilcock, Nigel J Cairns, Lars Feuk, Anthony J Brookes, Seth Love, Kaj Blennow, Patrick G Kehoe, Jonathan A Princ. Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain. Neurobiology of aging. vol 26. issue 6. 2005-04-12. PMID:15718037. |
insulin degrading enzyme, encoded by ide, plays a primary role in the degradation of amyloid beta-protein (a beta), the deposition of which in senile plaques is one of the defining hallmarks of alzheimer's disease (ad). |
2005-04-12 |
2023-08-12 |
Not clear |
| J Jacob Kulstad, Pamela J McMillan, James B Leverenz, David G Cook, Pattie S Green, Elaine R Peskind, Charles W Wilkinson, Wesley Farris, Pankaj D Mehta, Suzanne Craf. Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque. Journal of neuropathology and experimental neurology. vol 64. issue 2. 2005-03-29. PMID:15751228. |
ide activity and binding to insulin are known to be inhibited by glucocorticoids in vitro. |
2005-03-29 |
2023-08-12 |
monkey |
| Ayumu Sakai, Hiroshi Ujike, Kenji Nakata, Yasushi Takehisa, Takaki Imamura, Naohiko Uchida, Akihiro Kanzaki, Mitsutoshi Yamamoto, Yoshikatsu Fujisawa, Kazuya Okumura, Shigetoshi Kurod. No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 125B. issue 1. 2005-03-21. PMID:14755451. |
recently, three independent studies have reported that loci on chromosome 10q are linked with ad, and the insulin degrading enzyme (ide; mim 146680) gene located on chromosome 10q23-q25; ide is located close to the maker d10s583, which exhibits a maximum lod score for late-onset ad. |
2005-03-21 |
2023-08-12 |
Not clear |
| Laura Morelli, Ramiro E Llovera, Irina Mathov, Lih-Fen Lue, Blas Frangione, Jorge Ghiso, Eduardo M Castañ. Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy. The Journal of biological chemistry. vol 279. issue 53. 2005-02-25. PMID:15489232. |
however, the activity of ide upon radiolabeled insulin was significantly reduced in caa as compared with age-matched controls. |
2005-02-25 |
2023-08-12 |
human |
| Wenwu Gao, Patricia B Eisenhauer, Kelly Conn, John A Lynch, John M Wells, M David Ullman, Ann McKee, Hamant S Thatte, Richard E Fin. Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells. Neuroscience letters. vol 371. issue 1. 2005-01-03. PMID:15500957. |
insulin degrading enzyme (ide) is found in the cytosol, peroxisomes and plasma membrane of many cells. |
2005-01-03 |
2023-08-12 |
human |
| Lap Ho, Weiping Qin, Patrick N Pompl, Zhongmin Xiang, Jun Wang, Zhong Zhao, Yuanzhen Peng, Gina Cambareri, Anne Rocher, Charles V Mobbs, Patrick R Hof, Giulio Maria Pasinett. Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 7. 2004-09-28. PMID:15033922. |
we found that diet-induced insulin resistance promoted amyloidogenic beta-amyloid (abeta) abeta1-40 and abeta1-42 peptide generation in the brain that corresponded with increased gamma-secretase activities and decreased insulin degrading enzyme (ide) activities. |
2004-09-28 |
2023-08-12 |
mouse |
| Harvest F Gu, Suad Efendic, Sofia Nordman, Claes-Göran Ostenson, Kerstin Brismar, Anthony J Brookes, Jonathan A Princ. Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277398. |
quantitative trait loci near the insulin-degrading enzyme (ide) gene contribute to variation in plasma insulin levels. |
2004-09-17 |
2023-08-12 |
human |
| Harvest F Gu, Suad Efendic, Sofia Nordman, Claes-Göran Ostenson, Kerstin Brismar, Anthony J Brookes, Jonathan A Princ. Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels. Diabetes. vol 53. issue 8. 2004-09-17. PMID:15277398. |
insulin-degrading enzyme (ide) plays a principal role in the proteolysis of several peptides in addition to insulin and is encoded by ide, which resides in a region of chromosome 10q that is linked to type 2 diabetes. |
2004-09-17 |
2023-08-12 |
human |