| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W C Duckworth, R G Bennett, F G Hame. Insulin degradation: progress and potential. Endocrine reviews. vol 19. issue 5. 1998-12-31. PMID:9793760. |
ide increases proteasome and steroid hormone receptor activity, and this activation is reversed by insulin. |
1998-12-31 |
2023-08-12 |
Not clear |
| W C Duckworth, R G Bennett, F G Hame. Insulin degradation: progress and potential. Endocrine reviews. vol 19. issue 5. 1998-12-31. PMID:9793760. |
this raises the possibility of a direct intracellular interaction of insulin with ide that could modulate protein and fat metabolism. |
1998-12-31 |
2023-08-12 |
Not clear |
| F G Hamel, R G Bennett, W C Duckwort. Regulation of multicatalytic enzyme activity by insulin and the insulin-degrading enzyme. Endocrinology. vol 139. issue 10. 1998-10-08. PMID:9751483. |
the insulin-degrading enzyme (ide) plays an important role in the cellular metabolism of insulin. |
1998-10-08 |
2023-08-12 |
Not clear |
| F G Hamel, R G Bennett, W C Duckwort. Regulation of multicatalytic enzyme activity by insulin and the insulin-degrading enzyme. Endocrinology. vol 139. issue 10. 1998-10-08. PMID:9751483. |
this provides a potential mechanism of action for internalized insulin and other ide substrates in the control of protein turnover. |
1998-10-08 |
2023-08-12 |
Not clear |
| F G Hamel, R G Bennett, W C Duckwort. Regulation of multicatalytic enzyme activity by insulin and the insulin-degrading enzyme. Endocrinology. vol 139. issue 10. 1998-10-08. PMID:9751483. |
inhibitors of ide also blocked the insulin effect on mcp activity, as did treatment with sds. |
1998-10-08 |
2023-08-12 |
Not clear |
| M C Hsu, J P Ba. Investigation into the presence of insulin-degrading enzyme in cultured type II alveolar cells and the effects of enzyme inhibitors on pulmonary bioavailability of insulin in rats. The Journal of pharmacy and pharmacology. vol 50. issue 5. 1998-09-21. PMID:9643444. |
the purpose of this study was to investigate the role of insulin-degrading enzyme (ide, ec 3.4.22.11) in insulin degradation in alveolar epithelium. |
1998-09-21 |
2023-08-12 |
rat |
| M C Hsu, J P Ba. Investigation into the presence of insulin-degrading enzyme in cultured type II alveolar cells and the effects of enzyme inhibitors on pulmonary bioavailability of insulin in rats. The Journal of pharmacy and pharmacology. vol 50. issue 5. 1998-09-21. PMID:9643444. |
these results suggest that ide is present in alveolar epithelium and might be involved in limiting insulin absorption in the lung. |
1998-09-21 |
2023-08-12 |
rat |
| W C Duckworth, R G Bennett, F G Hame. Insulin acts intracellularly on proteasomes through insulin-degrading enzyme. Biochemical and biophysical research communications. vol 244. issue 2. 1998-04-23. PMID:9514933. |
we have shown that insulin can have an inhibitory effect on the action of the proteasome in vitro, which requires the presence of insulin degrading enzyme (ide). |
1998-04-23 |
2023-08-12 |
Not clear |
| W C Duckworth, R G Bennett, F G Hame. Insulin acts intracellularly on proteasomes through insulin-degrading enzyme. Biochemical and biophysical research communications. vol 244. issue 2. 1998-04-23. PMID:9514933. |
in this study we have used an antibody which inhibits the activity of ide to show that ide is required for insulin inhibition of protein degradation in intact cells. |
1998-04-23 |
2023-08-12 |
Not clear |
| W C Duckworth, R G Bennett, F G Hame. Insulin acts intracellularly on proteasomes through insulin-degrading enzyme. Biochemical and biophysical research communications. vol 244. issue 2. 1998-04-23. PMID:9514933. |
these data suggest that insulin works intracellularly via ide to inhibit protein degradation by the proteasome. |
1998-04-23 |
2023-08-12 |
Not clear |
| W C Duckworth, R G Bennett, F G Hame. Insulin acts intracellularly on proteasomes through insulin-degrading enzyme. Biochemical and biophysical research communications. vol 244. issue 2. 1998-04-23. PMID:9514933. |
thus, ide may function as an intracellular mediator for insulin effects on protein degradation. |
1998-04-23 |
2023-08-12 |
Not clear |
| W C Duckworth, F G Hamel, D E Peav. Two pathways for insulin metabolism in adipocytes. Biochimica et biophysica acta. vol 1358. issue 2. 1997-11-05. PMID:9332452. |
cell mediated insulin degradation in the presence of combinations of inhibitors suggested two pathways in adipocytes, one affected by inhibitors of the insulin degrading enzyme (ide) (bacitracin and pcmbs) and the other altered by cell processing inhibitors (dc, cq and phenylarsenoxide). |
1997-11-05 |
2023-08-12 |
Not clear |
| V Chesneau, R K Perlman, W Li, G A Keller, M R Rosne. Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation. Endocrinology. vol 138. issue 8. 1997-08-15. PMID:9231799. |
although considerable evidence implicates insulin-degrading enzyme (ide) in the cellular metabolism of insulin in many cell types, its mechanism and site of action are not clear. |
1997-08-15 |
2023-08-12 |
human |
| L L Chang, L E Stout, W D Wong, J G Buls, D A Rothenberger, W T Shier, R L Sorenson, J P Ba. Immunohistochemical localization of insulin-degrading enzyme along the rat intestine, in the human colon adenocarcinoma cell line (Caco-2), and in human ileum. Journal of pharmaceutical sciences. vol 86. issue 1. 1997-04-01. PMID:9002470. |
insulin-degrading enzyme (ide) has been implicated in the intracellular degradation of insulin in insulin target cells. |
1997-04-01 |
2023-08-12 |
human |
| R G Bennett, F G Hamel, W C Duckwort. Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex. Diabetes. vol 46. issue 2. 1997-02-12. PMID:9000694. |
insulin, the primary substrate for ide, inhibits the proteolytic activity of the ide-mcp complex but not of purified mcp. |
1997-02-12 |
2023-08-12 |
Not clear |
| R G Bennett, F G Hamel, W C Duckwort. Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex. Diabetes. vol 46. issue 2. 1997-02-12. PMID:9000694. |
this provides a regulatory role for ide in cellular proteolysis and a potential mechanism for intracellular insulin action. |
1997-02-12 |
2023-08-12 |
Not clear |
| R G Bennett, F G Hamel, W C Duckwort. Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex. Diabetes. vol 46. issue 2. 1997-02-12. PMID:9000694. |
igf-ii, which (similar to insulin) is a good substrate for ide, had a substantial inhibitory effect, whereas igf-i, which is bound but poorly degraded, had little inhibitory activity on mcp. |
1997-02-12 |
2023-08-12 |
Not clear |
| R G Bennett, F G Hamel, W C Duckwort. Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex. Diabetes. vol 46. issue 2. 1997-02-12. PMID:9000694. |
proinsulin, another ligand of ide that is tightly bound but poorly degraded, had a partial effect on mcp activity, but inhibited the full insulin effect. |
1997-02-12 |
2023-08-12 |
Not clear |
| J L Zachayus, S Khan, C Pla. Sequential insulin degradation in cultured fetal hepatocytes in relation to chloroquine-dependent events. The American journal of physiology. vol 271. issue 3 Pt 1. 1996-12-05. PMID:8843733. |
thus cell-associated insulin degradation implied primarily two cleavages in b-chain near the cooh-terminus, the one sensitive to chloroquine and ide inhibitors occurring after endosomal segregation of insulin and its receptor. |
1996-12-05 |
2023-08-12 |
rat |
| F Authier, B I Posner, J J Bergero. Insulin-degrading enzyme. Clinical and investigative medicine. Medecine clinique et experimentale. vol 19. issue 3. 1996-10-23. PMID:8724818. |
it has been proposed that insulin-degrading enzyme (ide), an evolutionarily conserved, neutral thiol-metalloendopeptidase, plays a crucial role in the degradation of internalized insulin in many types of cells. |
1996-10-23 |
2023-08-12 |
Not clear |