| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wesley Farris, Stefan Mansourian, Yang Chang, Loren Lindsley, Elizabeth A Eckman, Matthew P Frosch, Christopher B Eckman, Rudolph E Tanzi, Dennis J Selkoe, Suzanne Guenett. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 7. 2003-05-22. PMID:12634421. |
two substrates of insulin-degrading enzyme (ide), amyloid beta-protein (abeta) and insulin, are critically important in the pathogenesis of alzheimer's disease (ad) and type 2 diabetes mellitus (dm2), respectively. |
2003-05-22 |
2023-08-12 |
mouse |
| Wesley Farris, Stefan Mansourian, Yang Chang, Loren Lindsley, Elizabeth A Eckman, Matthew P Frosch, Christopher B Eckman, Rudolph E Tanzi, Dennis J Selkoe, Suzanne Guenett. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 7. 2003-05-22. PMID:12634421. |
to establish whether ide hypofunction decreases abeta and insulin degradation in vivo and chronically increases their levels, we characterized mice with homozygous deletions of the ide gene (ide --). |
2003-05-22 |
2023-08-12 |
mouse |
| Wesley Farris, Stefan Mansourian, Yang Chang, Loren Lindsley, Elizabeth A Eckman, Matthew P Frosch, Christopher B Eckman, Rudolph E Tanzi, Dennis J Selkoe, Suzanne Guenett. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 7. 2003-05-22. PMID:12634421. |
ide deficiency resulted in a >50% decrease in abeta degradation in both brain membrane fractions and primary neuronal cultures and a similar deficit in insulin degradation in liver. |
2003-05-22 |
2023-08-12 |
mouse |
| Xie Ling, R N Martins, M Racchi, S Craft, E Helmerhors. Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor. Journal of Alzheimer's disease : JAD. vol 4. issue 5. 2003-04-04. PMID:12446969. |
the fact that insulin and abeta appear to share a common system for degradation and disposal as they are both substrates of the insulin degrading enzyme (ide) suggested the possibility of a reciprocal interference. |
2003-04-04 |
2023-08-12 |
Not clear |
| David G Cook, James B Leverenz, Pamela J McMillan, J Jacob Kulstad, Sasha Ericksen, Richard A Roth, Gerard D Schellenberg, Lee-Way Jin, Kristina S Kovacina, Suzanne Craf. Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele. The American journal of pathology. vol 162. issue 1. 2003-01-24. PMID:12507914. |
the possible association of ide with ad, as well as the link between apoe status and insulin metabolism, led us to examine the expression of ide in ad. |
2003-01-24 |
2023-08-12 |
human |
| Mekki Boussaha, Didier Hannequin, Patrice Verpillat, Alexis Brice, Thierry Frebourg, Dominique Campio. Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease. Neuroscience letters. vol 329. issue 1. 2002-11-15. PMID:12161276. |
the insulin degrading enzyme (ide) is an attractive candidate gene since: (i), previous studies have identified a possible role that ide plays in the degradation and clearance of human amyloid beta from migroglial cells and neurons; and (ii), this gene is located on chromosome 10q23-q24, a region in which a susceptibility locus for ad has recently been mapped. |
2002-11-15 |
2023-08-12 |
human |
| Chen-Zhong Li, Su-Hua Zhang, Chang-Da Shu, Wei Re. [Relationship between insulin-degrading enzyme activity and insulin sensitivity in cell model of insulin-resistance]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA. vol 22. issue 2. 2002-11-04. PMID:12390813. |
to investigate the relationship between insulin-degrading enzyme (ide) activity and the onset and development of insulin resistance (ir). |
2002-11-04 |
2023-08-12 |
Not clear |
| Dieter Edbauer, Michael Willem, Sven Lammich, Harald Steiner, Christian Haas. Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). The Journal of biological chemistry. vol 277. issue 16. 2002-06-07. PMID:11809755. |
when insulin, a well characterized substrate of ide, was added to the in vitro degradation assay, removal of aicd was efficiently blocked. |
2002-06-07 |
2023-08-12 |
Not clear |
| A S Balasubramania. Amyloid beta peptide processing, insulin degrading enzyme, and butyrylcholinesterase. Neurochemical research. vol 26. issue 4. 2002-01-02. PMID:11495357. |
amyloid beta peptide implicated in alzheimers disease is cleaved by insulin degrading enzyme (ide). |
2002-01-02 |
2023-08-12 |
Not clear |
| F G Hamel, R G Bennett, J L Upward, W C Duckwort. Insulin inhibits peroxisomal fatty acid oxidation in isolated rat hepatocytes. Endocrinology. vol 142. issue 6. 2001-06-21. PMID:11356722. |
since insulin degrading enzyme (ide) is an insulin-binding protein known to be in peroxisomes, we studied the effect of an inhibitory anti-ide antibody on the ability of insulin to inhibit the fatty acyl-coa oxidizing system. |
2001-06-21 |
2023-08-12 |
rat |
| F G Hamel, R G Bennett, J L Upward, W C Duckwort. Insulin inhibits peroxisomal fatty acid oxidation in isolated rat hepatocytes. Endocrinology. vol 142. issue 6. 2001-06-21. PMID:11356722. |
we conclude that insulin inhibits peroxisomal fatty acid oxidation by a mechanism requiring ide. |
2001-06-21 |
2023-08-12 |
rat |
| M Morita, I V Kurochkin, K Motojima, S Goto, T Takano, S Okamura, R Sato, S Yokota, T Imanak. Insulin-degrading enzyme exists inside of rat liver peroxisomes and degrades oxidized proteins. Cell structure and function. vol 25. issue 5. 2001-05-17. PMID:11235899. |
in addition, ide isolated from peroxisomes degraded insulin as well as oxidized lysozyme as a model substrate for oxidized proteins. |
2001-05-17 |
2023-08-12 |
rat |
| H Fakhrai-Rad, A Nikoshkov, A Kamel, M Fernström, J R Zierath, S Norgren, H Luthman, J Gall. Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. Human molecular genetics. vol 9. issue 14. 2000-11-21. PMID:10958757. |
congenic rats with the ide: gk allele displayed post-prandial hyperglycemia, reduced lipogenesis in fat cells, blunted insulin-stimulated glucose transmembrane uptake and reduced insulin degradation in isolated muscle. |
2000-11-21 |
2023-08-12 |
rat |
| V Chesneau, M R Rosne. Functional human insulin-degrading enzyme can be expressed in bacteria. Protein expression and purification. vol 19. issue 1. 2000-08-14. PMID:10833395. |
insulin-degrading enzyme (ide) has been shown to degrade a number of biologically important peptides, including insulin and the amyloid-beta protein implicated in alzheimer's disease. |
2000-08-14 |
2023-08-12 |
human |
| R G Bennett, F G Hamel, W C Duckwort. Insulin inhibits the ubiquitin-dependent degrading activity of the 26S proteasome. Endocrinology. vol 141. issue 7. 2000-07-20. PMID:10875252. |
the proteasome-associated ide was displaced when the samples were treated with insulin. |
2000-07-20 |
2023-08-12 |
Not clear |
| R G Bennett, F G Hamel, W C Duckwort. Insulin inhibits the ubiquitin-dependent degrading activity of the 26S proteasome. Endocrinology. vol 141. issue 7. 2000-07-20. PMID:10875252. |
the displacement of ide from the proteasome provides a mechanism for this insulin action. |
2000-07-20 |
2023-08-12 |
Not clear |
| A Pérez, L Morelli, J C Cresto, E M Castañ. Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. Neurochemical research. vol 25. issue 2. 2000-06-14. PMID:10786709. |
insulin degrading enzyme (ide) is a metalloprotease that has been involved in amyloid beta peptide (a(beta)) degradation in the brain. |
2000-06-14 |
2023-08-12 |
human |
| W Q Qiu, D M Walsh, Z Ye, K Vekrellis, J Zhang, M B Podlisny, M R Rosner, A Safavi, L B Hersh, D J Selko. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. The Journal of biological chemistry. vol 273. issue 49. 1999-01-08. PMID:9830016. |
we have now purified and characterized the protease and find that it is indistinguishable from insulin-degrading enzyme (ide), a thiol metalloendopeptidase that degrades small peptides such as insulin, glucagon, and atrial natriuretic peptide. |
1999-01-08 |
2023-08-12 |
human |
| W Q Qiu, D M Walsh, Z Ye, K Vekrellis, J Zhang, M B Podlisny, M R Rosner, A Safavi, L B Hersh, D J Selko. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. The Journal of biological chemistry. vol 273. issue 49. 1999-01-08. PMID:9830016. |
degradation of both endogenous and synthetic abeta at picomolar to nanomolar concentrations was completely inhibited by the competitive ide substrate, insulin, and by two other ide inhibitors. |
1999-01-08 |
2023-08-12 |
human |
| W C Duckworth, R G Bennett, F G Hame. Insulin degradation: progress and potential. Endocrine reviews. vol 19. issue 5. 1998-12-31. PMID:9793760. |
most evidence supports ide as the primary degradative mechanism, but other systems (pdi, lysosomes, and other enzymes) undoubtedly contribute to insulin metabolism. |
1998-12-31 |
2023-08-12 |
Not clear |