| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María Del Carmen Camberos, Juan C Crest. Insulin-degrading enzyme hydrolyzes ATP. Experimental biology and medicine (Maywood, N.J.). vol 232. issue 2. 2007-02-22. PMID:17259336. |
all results showed concordance between insulin degradation and atp hydrolysis, suggesting that ide has both functions. |
2007-02-22 |
2023-08-12 |
rat |
| María Del Carmen Camberos, Juan C Crest. Insulin-degrading enzyme hydrolyzes ATP. Experimental biology and medicine (Maywood, N.J.). vol 232. issue 2. 2007-02-22. PMID:17259336. |
we conclude that ides have atpase activity and that insulin-binding and degradation are dependent on atp concentration; however, insulin does not modify the atpase activity of ide. |
2007-02-22 |
2023-08-12 |
rat |
| Eun Suk Song, Clint Cady, Michael G Fried, Louis B Hers. Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation. Biochemistry. vol 45. issue 50. 2007-02-21. PMID:17154546. |
the approximately 76 and approximately 56 kda ide proteolytic fragments were active toward the physiological peptides beta-endorphin, insulin, and amyloid beta peptide 1-40. |
2007-02-21 |
2023-08-12 |
Not clear |
| Lauren Marlowe, Rita Peila, Kelly Suzanne Benke, John Hardy, Lon R White, Lenore J Launer, Amanda Myer. Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk. Neuro-degenerative diseases. vol 3. issue 6. 2007-02-15. PMID:17192720. |
insulin-degrading enzyme (ide) polymorphism is hypothesized to regulate insulin levels as well as processes involved in neuronal compromise found in dementia. |
2007-02-15 |
2023-08-12 |
Not clear |
| Razvan T Radulescu, Carla Hufnagel, Peter Luppa, Heide Hellebrand, Wen-Liang Kuo, Marsha Rich Rosner, Nadia Harbeck, Cecylia Giersig, Alfons Meindl, Manfred Schmitt, Gregor Weiric. Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels. International journal of oncology. vol 30. issue 1. 2007-01-31. PMID:17143514. |
we also performed immunohistochemistry for insulin-degrading enzyme (ide), a cytoplasmic zinc metalloprotease belonging to the inverzincin family and participating in insulin cleavage. |
2007-01-31 |
2023-08-12 |
human |
| Yuequan Shen, Andrzej Joachimiak, Marsha Rich Rosner, Wei-Jen Tan. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature. vol 443. issue 7113. 2006-11-27. PMID:17051221. |
insulin-degrading enzyme (ide), a zn2+-metalloprotease, is involved in the clearance of insulin and amyloid-beta (refs 1-3). |
2006-11-27 |
2023-08-12 |
human |
| Yuequan Shen, Andrzej Joachimiak, Marsha Rich Rosner, Wei-Jen Tan. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature. vol 443. issue 7113. 2006-11-27. PMID:17051221. |
here we report structures of human ide in complex with four substrates (insulin b chain, amyloid-beta peptide (1-40), amylin and glucagon). |
2006-11-27 |
2023-08-12 |
human |
| Yuequan Shen, Andrzej Joachimiak, Marsha Rich Rosner, Wei-Jen Tan. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature. vol 443. issue 7113. 2006-11-27. PMID:17051221. |
the amino- and carboxy-terminal domains of ide (ide-n and ide-c, respectively) form an enclosed cage just large enough to encapsulate insulin. |
2006-11-27 |
2023-08-12 |
human |
| Mark F McCart. Toward prevention of Alzheimers disease--potential nutraceutical strategies for suppressing the production of amyloid beta peptides. Medical hypotheses. vol 67. issue 4. 2006-10-05. PMID:16828233. |
good insulin sensitivity and efficient brain insulin function protect by inhibiting gamma-secretase activity and increasing expression of ide. |
2006-10-05 |
2023-08-12 |
Not clear |
| John A Lynch, Ana M George, Patricia B Eisenhauer, Kelly Conn, Wenwu Gao, Isabel Carreras, John M Wells, Ann McKee, M David Ullman, Richard E Fin. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures. Journal of neuroscience research. vol 83. issue 7. 2006-07-25. PMID:16511862. |
insulin degrading enzyme (ide) is expressed in the brain and may play an important role there in the degradation of the amyloid beta peptide (abeta). |
2006-07-25 |
2023-08-12 |
human |
| John A Lynch, Ana M George, Patricia B Eisenhauer, Kelly Conn, Wenwu Gao, Isabel Carreras, John M Wells, Ann McKee, M David Ullman, Richard E Fin. Insulin degrading enzyme is localized predominantly at the cell surface of polarized and unpolarized human cerebrovascular endothelial cell cultures. Journal of neuroscience research. vol 83. issue 7. 2006-07-25. PMID:16511862. |
we believe that this degradation is largely the result of the action of ide, as it can be substantially blocked by the presence of insulin in the medium, a competitive substrate of ide. |
2006-07-25 |
2023-08-12 |
human |
| Pengyun Li, Wen-Liang Kuo, Mohammed Yousef, Marsha Rich Rosner, Wei-Jen Tan. The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition. Biochemical and biophysical research communications. vol 343. issue 4. 2006-06-09. PMID:16574064. |
insulin degrading enzyme (ide), a zinc metalloprotease, can specifically recognize and degrade insulin, as well as several amyloidogenic peptides such as amyloid beta (abeta) and amylin. |
2006-06-09 |
2023-08-12 |
human |
| Pengyun Li, Wen-Liang Kuo, Mohammed Yousef, Marsha Rich Rosner, Wei-Jen Tan. The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition. Biochemical and biophysical research communications. vol 343. issue 4. 2006-06-09. PMID:16574064. |
fluorescence polarization assays using labeled insulin reveal that ide-n has reduced affinity to insulin relative to wild type ide. |
2006-06-09 |
2023-08-12 |
human |
| Jose C Florez, Steven Wiltshire, Christina M Agapakis, Noël P Burtt, Paul I W de Bakker, Peter Almgren, Kristina Bengtsson Boström, Tiinamaija Tuomi, Daniel Gaudet, Mark J Daly, Joel N Hirschhorn, Mark I McCarthy, David Altshuler, Leif Groo. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. Diabetes. vol 55. issue 1. 2006-03-29. PMID:16380485. |
various groups have explored the role of the common genetic variation of ide on insulin resistance and reported associations of various single nucleotide polymorphisms (snps) and haplotypes on both type 2 diabetes and glycemic traits. |
2006-03-29 |
2023-08-12 |
Not clear |
| Jose C Florez, Steven Wiltshire, Christina M Agapakis, Noël P Burtt, Paul I W de Bakker, Peter Almgren, Kristina Bengtsson Boström, Tiinamaija Tuomi, Daniel Gaudet, Mark J Daly, Joel N Hirschhorn, Mark I McCarthy, David Altshuler, Leif Groo. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. Diabetes. vol 55. issue 1. 2006-03-29. PMID:16380485. |
we sought to characterize the haplotype structure of ide in detail and replicate the association of common variants with type 2 diabetes, fasting insulin, fasting glucose, and insulin resistance. |
2006-03-29 |
2023-08-12 |
Not clear |
| Wei Qiao Qiu, Marshal F Folstei. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiology of aging. vol 27. issue 2. 2006-03-14. PMID:16399206. |
we review the current evidence, which suggests that hyperinsulinaemia may elevate abeta through insulin's competition with abeta for ide. |
2006-03-14 |
2023-08-12 |
Not clear |
| Wei Qiao Qiu, Marshal F Folstei. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiology of aging. vol 27. issue 2. 2006-03-14. PMID:16399206. |
the deficiency of ide can be caused by genetic variation or by the diversion of ide from the metabolism of abeta to the metabolism of insulin. |
2006-03-14 |
2023-08-12 |
Not clear |
| Dae Y Hwang, Jung S Cho, Chuel K Kim, Sun B Shim, Seung W Jee, Su H Lee, Su J Seo, Joon Y Cho, Seok H Lee, Yong K Ki. Aging-related correlation of insulin-degrading enzyme with gamma-secretase-generated products involving insulin and glucose levels in transgenic mice. Neurochemical research. vol 30. issue 9. 2006-02-06. PMID:16292511. |
the aim of this study was to examine aging-related correlation of ide with gamma-secretase-generated products involving insulin and glucose levels in transgenic brains expressing neuron-specific enolase (nse)-controlled human mutant presenilin-2 (hps2m). |
2006-02-06 |
2023-08-12 |
mouse |
| Dae Y Hwang, Jung S Cho, Chuel K Kim, Sun B Shim, Seung W Jee, Su H Lee, Su J Seo, Joon Y Cho, Seok H Lee, Yong K Ki. Aging-related correlation of insulin-degrading enzyme with gamma-secretase-generated products involving insulin and glucose levels in transgenic mice. Neurochemical research. vol 30. issue 9. 2006-02-06. PMID:16292511. |
in parallel, inhibition in the ide expression at this age underlies to the levels-up of abeta-42, aicd, gamma-secretase, and glucose with a level-down of insulin. |
2006-02-06 |
2023-08-12 |
mouse |
| Yinuo Pang, Masahiro Sakagami, Peter R Byro. The pharmacokinetics of pulmonary insulin in the in vitro isolated perfused rat lung: implications of metabolism and regional deposition. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 25. issue 4-5. 2005-10-18. PMID:15979534. |
indeed, bac, but neither nem nor anp, was found to decrease the value of k(nal), which suggested that bac-inhibitable lung ectopeptidases, and not insulin degrading enzyme (ide), were responsible for this pulmonary metabolism. |
2005-10-18 |
2023-08-12 |
rat |