| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R K Perlman, M R Rosne. Identification of zinc ligands of the insulin-degrading enzyme. The Journal of biological chemistry. vol 269. issue 52. 1995-01-30. PMID:7806544. |
vectors containing wild type or mutant ide genes were transfected into cos cells, and the enzymes were analyzed for insulin degradation, insulin cross-linking, and zinc binding. |
1995-01-30 |
2023-08-12 |
human |
| W C Duckworth, R G Bennett, F G Hame. A direct inhibitory effect of insulin on a cytosolic proteolytic complex containing insulin-degrading enzyme and multicatalytic proteinase. The Journal of biological chemistry. vol 269. issue 40. 1994-11-04. PMID:7929129. |
ide is the primary enzyme involved in cellular degradation of insulin, and insulin has been shown to interact with cytosolic ide. |
1994-11-04 |
2023-08-12 |
Not clear |
| W C Duckworth, R G Bennett, F G Hame. A direct inhibitory effect of insulin on a cytosolic proteolytic complex containing insulin-degrading enzyme and multicatalytic proteinase. The Journal of biological chemistry. vol 269. issue 40. 1994-11-04. PMID:7929129. |
after ion-exchange chromatography, which separates ide and mcp, insulin no longer has an inhibitory effect. |
1994-11-04 |
2023-08-12 |
Not clear |
| W C Duckworth, R G Bennett, F G Hame. A direct inhibitory effect of insulin on a cytosolic proteolytic complex containing insulin-degrading enzyme and multicatalytic proteinase. The Journal of biological chemistry. vol 269. issue 40. 1994-11-04. PMID:7929129. |
recombination of purified ide and mcp does not restore the effect of insulin, but inclusion of additional components from the ion-exchange column does. |
1994-11-04 |
2023-08-12 |
Not clear |
| W C Duckworth, R G Bennett, F G Hame. A direct inhibitory effect of insulin on a cytosolic proteolytic complex containing insulin-degrading enzyme and multicatalytic proteinase. The Journal of biological chemistry. vol 269. issue 40. 1994-11-04. PMID:7929129. |
insulin interacts with ide and alters the activity of mcp, suggesting a functional relationship between these two components and a mechanism for an intracellular action of insulin. |
1994-11-04 |
2023-08-12 |
Not clear |
| W L Kuo, B D Gehm, M R Rosner, W Li, G Kelle. Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line. The Journal of biological chemistry. vol 269. issue 36. 1994-10-04. PMID:8077210. |
insulin degrading enzyme (ide) is an evolutionarily conserved, nonlysosomal metalloprotease that has been implicated in the cellular degradation and processing of insulin. |
1994-10-04 |
2023-08-12 |
human |
| W L Kuo, B D Gehm, M R Rosner, W Li, G Kelle. Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line. The Journal of biological chemistry. vol 269. issue 36. 1994-10-04. PMID:8077210. |
these results demonstrate that stably transfected ide catalyzes a rate-limiting step in cellular insulin degradation and is localized predominantly in peroxisomes. |
1994-10-04 |
2023-08-12 |
human |
| S R Kupfer, E M Wilson, F S Frenc. Androgen and glucocorticoid receptors interact with insulin degrading enzyme. The Journal of biological chemistry. vol 269. issue 32. 1994-09-06. PMID:8051160. |
raf activity co-purified with a 110-kda protein, the partial amino acid sequence of which shares 97.5% identity with insulin degrading enzyme (ide), a metalloendoprotease implicated in the intracellular degradation of insulin. |
1994-09-06 |
2023-08-12 |
Not clear |
| S R Kupfer, E M Wilson, F S Frenc. Androgen and glucocorticoid receptors interact with insulin degrading enzyme. The Journal of biological chemistry. vol 269. issue 32. 1994-09-06. PMID:8051160. |
in addition, the interaction of ar or gr with raf was competed by insulin and bacitracin, a competitive inhibitor of ide. |
1994-09-06 |
2023-08-12 |
Not clear |
| R G Bennett, F G Hamel, W C Duckwort. Identification and isolation of a cytosolic proteolytic complex containing insulin degrading enzyme and the multicatalytic proteinase. Biochemical and biophysical research communications. vol 202. issue 2. 1994-09-01. PMID:8048917. |
the insulin degrading enzyme (ide) is the first recognized member of a new class of metalloproteinases. |
1994-09-01 |
2023-08-12 |
Not clear |
| I V Kurochkin, S Got. Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS letters. vol 345. issue 1. 1994-06-29. PMID:8194595. |
this protein was identified as insulin degrading enzyme (ide) since the labeling of the 110 kda protein was completely blocked by an excess of insulin, and anti-ide monoclonal antibodies precipitated the labeled protein. |
1994-06-29 |
2023-08-12 |
rat |
| C A Bondy, J Zhou, E Chin, R R Reinhardt, L Ding, R A Rot. Cellular distribution of insulin-degrading enzyme gene expression. Comparison with insulin and insulin-like growth factor receptors. The Journal of clinical investigation. vol 93. issue 3. 1994-04-21. PMID:8132782. |
insulin-degrading enzyme (ide) hydrolyzes both insulin and igfs and has been proposed to play a role in signal termination after binding of these peptides to their receptors. |
1994-04-21 |
2023-08-12 |
rat |
| C A Bondy, J Zhou, E Chin, R R Reinhardt, L Ding, R A Rot. Cellular distribution of insulin-degrading enzyme gene expression. Comparison with insulin and insulin-like growth factor receptors. The Journal of clinical investigation. vol 93. issue 3. 1994-04-21. PMID:8132782. |
ide mrna is highly abundant in kidney and liver, tissues known to play a role in insulin degradation. |
1994-04-21 |
2023-08-12 |
rat |
| C A Bondy, J Zhou, E Chin, R R Reinhardt, L Ding, R A Rot. Cellular distribution of insulin-degrading enzyme gene expression. Comparison with insulin and insulin-like growth factor receptors. The Journal of clinical investigation. vol 93. issue 3. 1994-04-21. PMID:8132782. |
these data are compatible with a role for ide in degrading insulin and igfs after they bind to and are internalized with their respective receptors and may also suggest a novel role for ide in germ cells. |
1994-04-21 |
2023-08-12 |
rat |
| F Authier, R A Rachubinski, B I Posner, J J Bergero. Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme. The Journal of biological chemistry. vol 269. issue 4. 1994-03-04. PMID:8300632. |
insulin degrading enzyme (ide; ec 3.4.22.11), a mainly cytosolic neutral thiol metalloendopeptidase of 110 kda, has been proposed to be the main cellular clearance mechanism. |
1994-03-04 |
2023-08-12 |
human |
| F Authier, R A Rachubinski, B I Posner, J J Bergero. Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme. The Journal of biological chemistry. vol 269. issue 4. 1994-03-04. PMID:8300632. |
however, endosomes concentrate and degrade internalized insulin demonstrating that ide is unlikely to be the relevant enzyme for endosomal proteolysis of internalized insulin in liver parenchyma. |
1994-03-04 |
2023-08-12 |
human |
| F Authier, R A Rachubinski, B I Posner, J J Bergero. Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme. The Journal of biological chemistry. vol 269. issue 4. 1994-03-04. PMID:8300632. |
in purified endosomal fractions insulin was actively degraded at acid ph and ide was undetectable as evaluated by immunoblotting, immunoprecipitation, or chemical cross-linking procedures. |
1994-03-04 |
2023-08-12 |
human |
| R K Perlman, B D Gehm, W L Kuo, M R Rosne. Functional analysis of conserved residues in the active site of insulin-degrading enzyme. The Journal of biological chemistry. vol 268. issue 29. 1993-11-18. PMID:8104941. |
insulin-degrading enzyme (ide), a nonlysosomal metalloprotease involved in metabolizing internalized insulin, has catalytic properties that have been strongly conserved through evolution. |
1993-11-18 |
2023-08-12 |
human |
| S Harada, R M Smith, J A Smith, L Jaret. Inhibition of insulin-degrading enzyme increases translocation of insulin to the nucleus in H35 rat hepatoma cells: evidence of a cytosolic pathway. Endocrinology. vol 132. issue 6. 1993-07-02. PMID:8504733. |
we examined the effects of inhibiting insulin degrading enzyme (ide) with 1,10-phenanthroline on the nuclear accumulation of insulin in h35 cells. |
1993-07-02 |
2023-08-12 |
rat |
| S Harada, R M Smith, J A Smith, L Jaret. Inhibition of insulin-degrading enzyme increases translocation of insulin to the nucleus in H35 rat hepatoma cells: evidence of a cytosolic pathway. Endocrinology. vol 132. issue 6. 1993-07-02. PMID:8504733. |
these results suggested that inhibition of cytosolic ide activity resulted in increased insulin translocation from the cytosol to the nucleus. |
1993-07-02 |
2023-08-12 |
rat |