| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia Rudovich, Olga Pivovarova, Eva Fisher, Antje Fischer-Rosinsky, Joachim Spranger, Matthias Möhlig, Matthias B Schulze, Heiner Boeing, Andreas F H Pfeiffe. Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes. Journal of molecular medicine (Berlin, Germany). vol 87. issue 11. 2010-03-25. PMID:19809796. |
polymorphisms within insulin-degrading enzyme (ide) gene determine insulin metabolism and risk of type 2 diabetes. |
2010-03-25 |
2023-08-12 |
human |
| Natalia Rudovich, Olga Pivovarova, Eva Fisher, Antje Fischer-Rosinsky, Joachim Spranger, Matthias Möhlig, Matthias B Schulze, Heiner Boeing, Andreas F H Pfeiffe. Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes. Journal of molecular medicine (Berlin, Germany). vol 87. issue 11. 2010-03-25. PMID:19809796. |
insulin-degrading enzyme (ide) is the ubiquitously expressed major enzyme responsible for insulin degradation. |
2010-03-25 |
2023-08-12 |
human |
| Natalia Rudovich, Olga Pivovarova, Eva Fisher, Antje Fischer-Rosinsky, Joachim Spranger, Matthias Möhlig, Matthias B Schulze, Heiner Boeing, Andreas F H Pfeiffe. Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes. Journal of molecular medicine (Berlin, Germany). vol 87. issue 11. 2010-03-25. PMID:19809796. |
we verified associations of two ide polymorphisms (rs1887922 and rs2149632) with t2dm risk in two independent german cohorts and evaluated in detail the association of common variants with insulin metabolism and glycemic traits. |
2010-03-25 |
2023-08-12 |
human |
| Natalia Rudovich, Olga Pivovarova, Eva Fisher, Antje Fischer-Rosinsky, Joachim Spranger, Matthias Möhlig, Matthias B Schulze, Heiner Boeing, Andreas F H Pfeiffe. Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes. Journal of molecular medicine (Berlin, Germany). vol 87. issue 11. 2010-03-25. PMID:19809796. |
this study validates and confirms the association of ide polymorphisms with t2dm risk in the prospective german cohort and provides novel evidence of influences of ide genetic variants on insulin metabolism. |
2010-03-25 |
2023-08-12 |
human |
| Qing Guo, Marika Manolopoulou, Yao Bian, Alexander B Schilling, Wei-Jen Tan. Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme. Journal of molecular biology. vol 395. issue 2. 2010-03-03. PMID:19896952. |
insulin-degrading enzyme (ide) is involved in the clearance of many bioactive peptide substrates, including insulin and amyloid-beta, peptides vital to the development of diabetes and alzheimer's disease, respectively. |
2010-03-03 |
2023-08-12 |
human |
| Josiane Faganello, Valéria Dutra, Augusto Schrank, Wieland Meyer, Irene S Schrank, Marilene H Vainstei. Identification of genomic differences between Cryptococcus neoformans and Cryptococcus gattii by Representational Difference Analysis (RDA). Medical mycology. vol 47. issue 6. 2010-03-01. PMID:18668420. |
southern blot experiments using five selected clones confirmed the presence of polymorphisms for three sequences (a putative insulin degrading enzyme (ide), a chitin synthase and an endoplasmic reticulum protein). |
2010-03-01 |
2023-08-12 |
Not clear |
| A Fernández-Gamba, M C Leal, L Morelli, E M Castañ. Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease. Current pharmaceutical design. vol 15. issue 31. 2010-01-26. PMID:19925417. |
in vivo, ide contributes to regulate the steady state levels of peripheral insulin and cerebral amyloid beta peptide (abeta) of alzheimer's disease. |
2010-01-26 |
2023-08-12 |
human |
| J E Carpenter, W Jackson, G A de Souza, L Haarr, C Gros. Insulin-degrading enzyme binds to the nonglycosylated precursor of varicella-zoster virus gE protein found in the endoplasmic reticulum. Journal of virology. vol 84. issue 2. 2010-01-12. PMID:19864391. |
insulin degradation enzyme (ide) is a 110-kda zinc metalloprotease found in the cytosol of all cells. |
2010-01-12 |
2023-08-12 |
Not clear |
| J E Carpenter, W Jackson, G A de Souza, L Haarr, C Gros. Insulin-degrading enzyme binds to the nonglycosylated precursor of varicella-zoster virus gE protein found in the endoplasmic reticulum. Journal of virology. vol 84. issue 2. 2010-01-12. PMID:19864391. |
ide degrades insulin and a variety of small proteins including amyloid-beta. |
2010-01-12 |
2023-08-12 |
Not clear |
| Orazio Amata, Tiziana Marino, Nino Russo, Marirosa Toscan. Human insulin-degrading enzyme working mechanism. Journal of the American Chemical Society. vol 131. issue 41. 2010-01-11. PMID:19785409. |
the possible mechanism by which the insulin-degrading enzyme (ide) zinc-binding protease carries out its catalytic function toward two peptides of different length, simulating a portion of b chain of insulin, was investigated on an enzymatic model consisting of 130 /159 atoms, using the density functional theory method and the hybrid exchange-correlation functional b3lyp in gas phase and in the protein environment. |
2010-01-11 |
2023-08-12 |
human |
| Luis A Ralat, Min Ren, Alexander B Schilling, Wei-Jen Tan. Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation. The Journal of biological chemistry. vol 284. issue 49. 2009-12-22. PMID:19808678. |
insulin-degrading enzyme (ide), a 110-kda metalloendopeptidase, hydrolyzes several physiologically relevant peptides, including insulin and amyloid-beta (abeta). |
2009-12-22 |
2023-08-12 |
human |
| Rui Wang, Suqing Wang, James S Malter, Deng-Shun Wan. Effects of 4-hydroxy-nonenal and Amyloid-beta on expression and activity of endothelin converting enzyme and insulin degrading enzyme in SH-SY5Y cells. Journal of Alzheimer's disease : JAD. vol 17. issue 3. 2009-12-15. PMID:19363254. |
although endothelin converting enzyme (ece) and insulin degrading enzyme (ide) degrade and thus contribute to regulating the steady-state levels of abeta, how these enzymes are regulated remain poorly understood. |
2009-12-15 |
2023-08-12 |
human |
| Ying-Hao Chou, Wen-Liang Kuo, Marsha Rich Rosner, Wei-Jen Tang, Robert D Goldma. Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 11. 2009-11-30. PMID:19584300. |
in this study, we report that these disassembled vimentin/nestin complexes interact with insulin degrading enzyme (ide). |
2009-11-30 |
2023-08-12 |
Not clear |
| Ying-Hao Chou, Wen-Liang Kuo, Marsha Rich Rosner, Wei-Jen Tang, Robert D Goldma. Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 11. 2009-11-30. PMID:19584300. |
the insulin degradation activity of ide is suppressed approximately 50% by either nestin or phosphorylated vimentin, while the cleavage of bradykinin-mimetic peptide by ide is increased 2- to 3-fold. |
2009-11-30 |
2023-08-12 |
Not clear |
| Hans-Gert Bernstein, Theresia Ernst, Uwe Lendeckel, Alicja Bukowska, Siegfried Ansorge, Renate Stauch, Sara Ten Have, Johann Steiner, Henrik Dobrowolny, Bernhard Bogert. Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia. Journal of psychiatric research. vol 43. issue 13. 2009-11-09. PMID:19394958. |
insulin-degrading enzyme (ide) is a neutral thiol metalloprotease, which cleaves insulin with high specificity. |
2009-11-09 |
2023-08-12 |
rat |
| Hans-Gert Bernstein, Theresia Ernst, Uwe Lendeckel, Alicja Bukowska, Siegfried Ansorge, Renate Stauch, Sara Ten Have, Johann Steiner, Henrik Dobrowolny, Bernhard Bogert. Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia. Journal of psychiatric research. vol 43. issue 13. 2009-11-09. PMID:19394958. |
we studied the expression of ide protein in postmortem brains of patients with schizophrenia and controls because: (1) the gene encoding ide is located on chromosome 10q23-q25, a gene locus linked to schizophrenia; (2) insulin resistance with brain insulin receptor deficits/receptor dysfunction was reported in schizophrenia; (3) the enzyme cleaves igf-i and igf-ii which are implicated in the pathophysiology of the disease; and (4) brain gamma-endorphin levels, liberated from beta-endorphin exclusively by ide, have been reported to be altered in schizophrenia. |
2009-11-09 |
2023-08-12 |
rat |
| Hans-Gert Bernstein, Theresia Ernst, Uwe Lendeckel, Alicja Bukowska, Siegfried Ansorge, Renate Stauch, Sara Ten Have, Johann Steiner, Henrik Dobrowolny, Bernhard Bogert. Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia. Journal of psychiatric research. vol 43. issue 13. 2009-11-09. PMID:19394958. |
haloperidol however, might exert some effect on ide, through changes of the expression levels of its substrates igf-i and ii, insulin and beta-endorphin. |
2009-11-09 |
2023-08-12 |
rat |
| Hans-Gert Bernstein, Theresia Ernst, Uwe Lendeckel, Alicja Bukowska, Siegfried Ansorge, Renate Stauch, Sara Ten Have, Johann Steiner, Henrik Dobrowolny, Bernhard Bogert. Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia. Journal of psychiatric research. vol 43. issue 13. 2009-11-09. PMID:19394958. |
reduced cortical ide expression might be part of the disturbed insulin signaling cascades found in schizophrenia. |
2009-11-09 |
2023-08-12 |
rat |
| O Pivovarova, O Gögebakan, A F H Pfeiffer, N Rudovic. Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells. Diabetologia. vol 52. issue 8. 2009-10-23. PMID:19396426. |
insulin-degrading enzyme (ide) plays a key role in insulin degradation and its gene is located in a diabetes-associated chromosomal region. |
2009-10-23 |
2023-08-12 |
human |
| O Pivovarova, O Gögebakan, A F H Pfeiffer, N Rudovic. Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells. Diabetologia. vol 52. issue 8. 2009-10-23. PMID:19396426. |
we hypothesised that ide may be regulated by insulin and/or glucose in a liver cell model. |
2009-10-23 |
2023-08-12 |
human |