| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samer O Abdul-Hay, Dongcheul Kang, Melinda McBride, Lilin Li, Ji Zhao, Malcolm A Leissrin. Deletion of insulin-degrading enzyme elicits antipodal, age-dependent effects on glucose and insulin tolerance. PloS one. vol 6. issue 6. 2011-11-02. PMID:21695259. |
insulin-degrading enzyme (ide) is widely recognized as the principal protease responsible for the clearance and inactivation of insulin, but its role in glycemic control in vivo is poorly understood. |
2011-11-02 |
2023-08-12 |
mouse |
| Nicholas Noinaj, Sonia K Bhasin, Eun Suk Song, Kirsten E Scoggin, Maria A Juliano, Luiz Juliano, Louis B Hersh, David W Rodger. Identification of the allosteric regulatory site of insulysin. PloS one. vol 6. issue 6. 2011-11-02. PMID:21731629. |
insulin degrading enzyme (ide) is responsible for the metabolism of insulin and plays a role in clearance of the aβ peptide associated with alzheimer's disease. |
2011-11-02 |
2023-08-12 |
Not clear |
| Olivia Belbin, Michael Crump, Gina D Bisceglio, Minerva M Carrasquillo, Kevin Morgan, Steven G Younki. Multiple insulin degrading enzyme variants alter in vitro reporter gene expression. PloS one. vol 6. issue 6. 2011-11-02. PMID:21731745. |
the insulin degrading enzyme (ide) variant, v311 (rs6583817), is associated with increased post-mortem cerebellar ide mrna, decreased plasma β-amyloid (aβ), decreased risk for alzheimer's disease (ad) and increased reporter gene expression, suggesting that it is a functional variant driving increased ide expression. |
2011-11-02 |
2023-08-12 |
Not clear |
| Dingzhen Luo, Xunyao Hou, Liang Hou, Meixia Wang, Song Xu, Chuanfang Dong, Xueping Li. Effect of pioglitazone on altered expression of Aβ metabolism-associated molecules in the brain of fructose-drinking rats, a rodent model of insulin resistance. European journal of pharmacology. vol 664. issue 1-3. 2011-10-06. PMID:21549699. |
we found that diet-induced insulin resistance induced aβ overproduction with altered expression of aβ metabolism-associated molecules, which corresponded with increased β-secretase-1 (bace1), γ-secretase (ps-1) activities and decreased insulin degrading enzyme (ide) activities, but not neprilysin in the cortex and hippocampus. |
2011-10-06 |
2023-08-12 |
rat |
| J-P Lee, K-C Cheng, H-H Chung, H-T Wu, C-T Chen, J-T Chen. Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 43. issue 7. 2011-09-28. PMID:21557151. |
additionally, brain homogenates were co-incubated with racecadotril or thiorphan to evaluate insulin degrading enzyme (ide) activity. |
2011-09-28 |
2023-08-12 |
rat |
| J-P Lee, K-C Cheng, H-H Chung, H-T Wu, C-T Chen, J-T Chen. Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 43. issue 7. 2011-09-28. PMID:21557151. |
in rat brain homogenates, racecadotril and thiorphan inhibited ide activity and increased the cerebral insulin level. |
2011-09-28 |
2023-08-12 |
rat |
| J-P Lee, K-C Cheng, H-H Chung, H-T Wu, C-T Chen, J-T Chen. Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 43. issue 7. 2011-09-28. PMID:21557151. |
our results suggest that racecadotril lowers blood glucose mainly through inhibition of ide activity and increases endogenous insulin in the brain. |
2011-09-28 |
2023-08-12 |
rat |
| Konstantin Glebov, Sebastian Schütze, Jochen Walte. Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme. The Journal of biological chemistry. vol 286. issue 26. 2011-09-09. PMID:21576244. |
ide is ubiquitously expressed and degrades peptide substrates including insulin, endorphin, and the amyloid-β peptide. |
2011-09-09 |
2023-08-12 |
Not clear |
| Juliany S B César Vieira, Karina L A Saraiva, Maria C L Barbosa, Regina C C Porto, Juan C Cresto, Christina A Peixoto, Maria I Wanderley, Daniel P Udrisa. Effect of dexamethasone and testosterone treatment on the regulation of insulin-degrading enzyme and cellular changes in ventral rat prostate after castration. International journal of experimental pathology. vol 92. issue 4. 2011-09-08. PMID:21507087. |
in conclusion, the present study reports that dexamethasone-induced hyperinsulinaemic condition plus exogenous testosterone treatment leads to synergistic effects of insulin and testosterone in the prostatic growth and in the amount of ide in the nucleus and whole epithelial cell. |
2011-09-08 |
2023-08-12 |
rat |
| Zong-Zheng Sun, Zhi-Bin Chen, Hui Jiang, Ling-Ling Li, Er-Guang Li, Yun X. Alteration of Aβ metabolism-related molecules in predementia induced by AlCl3 and D-galactose. Age (Dordrecht, Netherlands). vol 31. issue 4. 2011-08-09. PMID:19468866. |
protein expression of β-amyloid (aβ), β-secretase (bace1), neprilysin (nep), insulin degrading enzyme (ide) and receptor for advanced glycation end products (rage) in the brain was measured. |
2011-08-09 |
2023-08-12 |
mouse |
| Ayelén Bulloj, María C Leal, Ezequiel I Surace, Xue Zhang, Huaxi Xu, Maria D Ledesma, Eduardo M Castaño, Laura Morell. Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation. Molecular neurodegeneration. vol 3. 2011-07-14. PMID:19117523. |
detergent resistant membrane-associated ide in brain tissue and cultured cells: relevance to abeta and insulin degradation. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ayelén Bulloj, María C Leal, Ezequiel I Surace, Xue Zhang, Huaxi Xu, Maria D Ledesma, Eduardo M Castaño, Laura Morell. Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Abeta and insulin degradation. Molecular neurodegeneration. vol 3. 2011-07-14. PMID:19117523. |
insulin degrading enzyme (ide) is implicated in the regulation of amyloid beta (abeta) steady-state levels in the brain, and its deficient expression and/or activity may be a risk factor in sporadic alzheimer's disease (ad). |
2011-07-14 |
2023-08-12 |
Not clear |
| Noriko Sato, Akinori Ueki, Hideo Ueno, Hidetaka Shinjo, Yoshio Morit. IDE Gene Polymorphism Influences on BPSD in Mild Dementia of Alzheimer's Type. Current gerontology and geriatrics research. 2011-07-14. PMID:19415148. |
insulin degrading enzyme (ide) degrades amyloid beta (abeta), which may inhibit the accumulation of abeta in a brain affected with dementia of alzheimer's type (dat). |
2011-07-14 |
2023-08-12 |
Not clear |
| Razvan T Radulesc. Intracellular insulin in human tumors: examples and implications. Diabetology & metabolic syndrome. vol 3. issue 1. 2011-07-14. PMID:21457557. |
a potential mechanism for such involvement is insulin's binding and inactivation of the retinoblastoma tumor suppressor protein (rb) which in turn is likely controlled by insulin-degrading enzyme (ide). |
2011-07-14 |
2023-08-12 |
human |
| Crystal M Cordes, Robert G Bennett, Gerri L Siford, Frederick G Hame. Redox regulation of insulin degradation by insulin-degrading enzyme. PloS one. vol 6. issue 3. 2011-07-05. PMID:21448434. |
insulin-degrading enzyme (ide) is a thiol sensitive peptidase that degrades insulin and amyloid β, and has been linked to type 2 diabetes mellitus and alzheimer's disease. |
2011-07-05 |
2023-08-12 |
rat |
| Crystal M Cordes, Robert G Bennett, Gerri L Siford, Frederick G Hame. Redox regulation of insulin degradation by insulin-degrading enzyme. PloS one. vol 6. issue 3. 2011-07-05. PMID:21448434. |
reduced glutathione had no effect on ide, but reacted with partially degraded insulin to disrupt its disulfide bonds and accelerate its breakdown to trichloroacetic acid soluble fragments. |
2011-07-05 |
2023-08-12 |
rat |
| Crystal M Cordes, Robert G Bennett, Gerri L Siford, Frederick G Hame. Redox regulation of insulin degradation by insulin-degrading enzyme. PloS one. vol 6. issue 3. 2011-07-05. PMID:21448434. |
our results demonstrate the sensitivity of insulin degradation by ide to the redox environment and suggest another mechanism by which the cell's oxidation state may contribute to the development of, and the link between, type 2 diabetes and alzheimer's disease. |
2011-07-05 |
2023-08-12 |
rat |
| Luis A Ralat, Vasilios Kalas, Zhongzhou Zheng, Robert D Goldman, Tobin R Sosnick, Wei-Jen Tan. Ubiquitin is a novel substrate for human insulin-degrading enzyme. Journal of molecular biology. vol 406. issue 3. 2011-06-09. PMID:21185309. |
insulin-degrading enzyme (ide) can degrade insulin and amyloid-β, peptides involved in diabetes and alzheimer's disease, respectively. |
2011-06-09 |
2023-08-12 |
human |
| Joogyung Hyun, Carl Hashimot. Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila. Fly. vol 5. issue 1. 2011-06-03. PMID:21212741. |
insulin-degrading enzyme (ide) degrades insulin and other peptides, including the aβ peptide of alzheimer's disease. |
2011-06-03 |
2023-08-12 |
drosophila_melanogaster |
| Joogyung Hyun, Carl Hashimot. Physiological effects of manipulating the level of insulin-degrading enzyme in insulin-producing cells of Drosophila. Fly. vol 5. issue 1. 2011-06-03. PMID:21212741. |
as mis-regulated insulin signaling in peripheral tissues is known to cause similar phenotypes, our data suggest a role for drosophila ide in determining the level of insulin-like peptides made by ipcs that systemically activate insulin signaling. |
2011-06-03 |
2023-08-12 |
drosophila_melanogaster |