| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miguel Chin-Chan, Juliana Navarro-Yepes, Betzabet Quintanilla-Veg. Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases. Frontiers in cellular neuroscience. vol 9. 2015-04-27. PMID:25914621. |
common mechanisms of environmental pollutants to increase aβ, p-tau, α-syn and neuronal death have been reported, including the oxidative stress mainly involved in the increase of aβ and α-syn, and the reduced activity/protein levels of aβ degrading enzyme (ide)s such as neprilysin or insulin ide. |
2015-04-27 |
2023-08-13 |
Not clear |
| G Peggy McFall, Sandra A Wiebe, David Vergote, Jack Jhamandas, David Westaway, Roger A Dixo. IDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults. Psychology and aging. vol 29. issue 2. 2015-03-18. PMID:24660790. |
specifically, we tested the independent and interactive effects of a recently identified insulin degrading enzyme genetic polymorphism (ide rs6583817) and pulse pressure (pp; one prominent aging-related vascular health indicator) across up to 9 years of ef data in a sample of older adults from the victoria longitudinal study. |
2015-03-18 |
2023-08-12 |
Not clear |
| Julie Charton, Marion Gauriot, Qing Guo, Nathalie Hennuyer, Xavier Marechal, Julie Dumont, Malika Hamdane, Virginie Pottiez, Valerie Landry, Olivier Sperandio, Marion Flipo, Luc Buee, Bart Staels, Florence Leroux, Wei-Jen Tang, Benoit Deprez, Rebecca Deprez-Poulai. Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis. European journal of medicinal chemistry. vol 79. 2015-01-12. PMID:24735644. |
insulin degrading enzyme (ide) is a highly conserved zinc metalloprotease that is involved in the clearance of various physiologically peptides like amyloid-beta and insulin. |
2015-01-12 |
2023-08-13 |
Not clear |
| Noor A Shaik, Mohammed Kaleemuddin, Babajan Banaganapalli, Fazal Khan, Nazia S Shaik, Ghada Ajabnoor, Sameer E Al-Harthi, Nabeel Bondagji, Jumana Y Al-Aama, Ramu Elang. Structural and functional characterization of pathogenic non- synonymous genetic mutations of human insulin-degrading enzyme by in silico methods. CNS & neurological disorders drug targets. vol 13. issue 3. 2015-01-07. PMID:24059301. |
insulin-degrading enzyme (ide) is a key protease involved in degrading insulin and amyloid peptides in human body. |
2015-01-07 |
2023-08-12 |
human |
| Janet Fawcet. Biologically active insulin-derived peptides. Protein and peptide letters. vol 21. issue 6. 2014-12-17. PMID:24559166. |
many actions have been related to insulin binding to its receptor and subsequent phosphorylation cascades, but insulin action on protein degradation has been shown to be linked to insulin degradation, specifically insulin degradation by the insulin-degrading enzyme (ide). |
2014-12-17 |
2023-08-12 |
Not clear |
| Janet Fawcet. Biologically active insulin-derived peptides. Protein and peptide letters. vol 21. issue 6. 2014-12-17. PMID:24559166. |
smaller fragments of insulin that are produced by the action of ide that do not bind to the insulin receptor show a small effect on protein degradation and a modest effect on mitogenesis. |
2014-12-17 |
2023-08-12 |
Not clear |
| Luiz F Rezende, Rafael L Camargo, Renato C S Branco, Ana P G Cappelli, Antonio C Boschero, Everardo M Carneir. Reduced insulin clearance and lower insulin-degrading enzyme expression in the liver might contribute to the thrifty phenotype of protein-restricted mice. The British journal of nutrition. vol 112. issue 6. 2014-11-24. PMID:25036874. |
the improved glucose tolerance could partially be explained by an increase in insulin sensitivity through the phosphorylation of the insulin receptor/protein kinase b and amp-activated protein kinase/acetyl-coa carboxylase in the liver, whereas the changes in insulin dynamics could be attributed to reduced insulin secretion coupled with reduced insulin clearance and lower insulin-degrading enzyme (ide) expression in the liver and gck. |
2014-11-24 |
2023-08-13 |
mouse |
| Luiz F Rezende, Rafael L Camargo, Renato C S Branco, Ana P G Cappelli, Antonio C Boschero, Everardo M Carneir. Reduced insulin clearance and lower insulin-degrading enzyme expression in the liver might contribute to the thrifty phenotype of protein-restricted mice. The British journal of nutrition. vol 112. issue 6. 2014-11-24. PMID:25036874. |
this phenomenon has the double benefit of sparing insulin while prolonging and potentiating its effects, probably due to the lower expression of ide in the liver, possibly with long-term consequences. |
2014-11-24 |
2023-08-13 |
mouse |
| Diego Galagovsky, Maximiliano J Katz, Julieta M Acevedo, Eleonora Sorianello, Alvaro Glavic, Pablo Wappne. The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner. Molecular biology of the cell. vol 25. issue 6. 2014-11-04. PMID:24430872. |
mammalian insulin-degrading enzyme (ide) cleaves insulin, among other peptidic substrates, but its function in insulin signaling is elusive. |
2014-11-04 |
2023-08-12 |
drosophila_melanogaster |
| Juan Pablo Maianti, Amanda McFedries, Zachariah H Foda, Ralph E Kleiner, Xiu Quan Du, Malcolm A Leissring, Wei-Jen Tang, Maureen J Charron, Markus A Seeliger, Alan Saghatelian, David R Li. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. vol 511. issue 7507. 2014-08-15. PMID:24847884. |
despite decades of speculation that inhibiting endogenous insulin degradation might treat type-2 diabetes, and the identification of ide (insulin-degrading enzyme) as a diabetes susceptibility gene, the relationship between the activity of the zinc metalloprotein ide and glucose homeostasis remains unclear. |
2014-08-15 |
2023-08-13 |
mouse |
| Juan Pablo Maianti, Amanda McFedries, Zachariah H Foda, Ralph E Kleiner, Xiu Quan Du, Malcolm A Leissring, Wei-Jen Tang, Maureen J Charron, Markus A Seeliger, Alan Saghatelian, David R Li. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. vol 511. issue 7507. 2014-08-15. PMID:24847884. |
although ide(-/-) mice have elevated insulin levels, they exhibit impaired, rather than improved, glucose tolerance that may arise from compensatory insulin signalling dysfunction. |
2014-08-15 |
2023-08-13 |
mouse |
| Juan Pablo Maianti, Amanda McFedries, Zachariah H Foda, Ralph E Kleiner, Xiu Quan Du, Malcolm A Leissring, Wei-Jen Tang, Maureen J Charron, Markus A Seeliger, Alan Saghatelian, David R Li. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. vol 511. issue 7507. 2014-08-15. PMID:24847884. |
treatment of lean and obese mice with this inhibitor shows that ide regulates the abundance and signalling of glucagon and amylin, in addition to that of insulin. |
2014-08-15 |
2023-08-13 |
mouse |
| Juan Pablo Maianti, Amanda McFedries, Zachariah H Foda, Ralph E Kleiner, Xiu Quan Du, Malcolm A Leissring, Wei-Jen Tang, Maureen J Charron, Markus A Seeliger, Alan Saghatelian, David R Li. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature. vol 511. issue 7507. 2014-08-15. PMID:24847884. |
under physiological conditions that augment insulin and amylin levels, such as oral glucose administration, acute ide inhibition leads to substantially improved glucose tolerance and slower gastric emptying. |
2014-08-15 |
2023-08-13 |
mouse |
| Wei Qiao Qiu, Haihao Zh. Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease? Frontiers in aging neuroscience. vol 6. 2014-08-14. PMID:25120481. |
amylin, a gut-brain axis hormone, and amyloid-beta peptides (aβ), a major component of the alzheimer's disease (ad) brain, share several features, including similar β-sheet secondary structures, binding to the same receptor and being degraded by the same protease, insulin degrading enzyme (ide). |
2014-08-14 |
2023-08-13 |
human |
| Zhong Q Wang, Yongmei Yu, Xian H Zhang, James Komorowsk. Chromium-Insulin Reduces Insulin Clearance and Enhances Insulin Signaling by Suppressing Hepatic Insulin-Degrading Enzyme and Proteasome Protein Expression in KKAy Mice. Frontiers in endocrinology. vol 5. 2014-07-29. PMID:25071716. |
our hypothesis was that cri enhances insulin's effects by altering insulin-degrading enzyme (ide) and proteasome enzymes. |
2014-07-29 |
2023-08-13 |
mouse |
| Zhong Q Wang, Yongmei Yu, Xian H Zhang, James Komorowsk. Chromium-Insulin Reduces Insulin Clearance and Enhances Insulin Signaling by Suppressing Hepatic Insulin-Degrading Enzyme and Proteasome Protein Expression in KKAy Mice. Frontiers in endocrinology. vol 5. 2014-07-29. PMID:25071716. |
hepatic ide, proteasome, and insulin signaling proteins were determined by western blotting. |
2014-07-29 |
2023-08-13 |
mouse |
| Zhong Q Wang, Yongmei Yu, Xian H Zhang, James Komorowsk. Chromium-Insulin Reduces Insulin Clearance and Enhances Insulin Signaling by Suppressing Hepatic Insulin-Degrading Enzyme and Proteasome Protein Expression in KKAy Mice. Frontiers in endocrinology. vol 5. 2014-07-29. PMID:25071716. |
this study, for the first time, demonstrates that cri reduces plasma insulin clearance by inhibition of hepatic ide protein expression and enhances insulin signaling as well as prevents degradation of irs-1 and irs-2 by suppressing ubiquitin-proteasome pathway in diabetic mice. |
2014-07-29 |
2023-08-13 |
mouse |
| Shingo Ito, Sumio Ohtsuki, Sho Murata, Yuki Katsukura, Hiroya Suzuki, Miho Funaki, Masanori Tachikawa, Tetsuya Terasak. Involvement of insulin-degrading enzyme in insulin- and atrial natriuretic peptide-sensitive internalization of amyloid-β peptide in mouse brain capillary endothelial cells. Journal of Alzheimer's disease : JAD. vol 38. issue 1. 2014-06-17. PMID:23948938. |
internalization of [125i]haβ1-40 into cultured mouse brain capillary endothelial cells (tm-bbb4) was significantly inhibited by either insulin, hanp, other natriuretic peptides or insulin-degrading enzyme (ide) inhibitors, but was not inhibited by phosphoramidon or thiorphan. |
2014-06-17 |
2023-08-12 |
mouse |
| Kuan-Chung Chen, Su-Sen Chang, Fuu-Jen Tsai, Calvin Yu-Chian Che. Han ethnicity-specific type 2 diabetic treatment from traditional Chinese medicine? Journal of biomolecular structure & dynamics. vol 31. issue 11. 2014-04-09. PMID:23146021. |
ide, a zinc-metalloendopeptidase, is a potential target for controlling insulin degradation. |
2014-04-09 |
2023-08-12 |
Not clear |
| Kuan-Chung Chen, Su-Sen Chang, Fuu-Jen Tsai, Calvin Yu-Chian Che. Han ethnicity-specific type 2 diabetic treatment from traditional Chinese medicine? Journal of biomolecular structure & dynamics. vol 31. issue 11. 2014-04-09. PMID:23146021. |
hence, we suggest the top three tcm compounds as potential inhibitor leads against ide protein to control insulin degradation for type 2 diabetes mellitus. |
2014-04-09 |
2023-08-12 |
Not clear |