| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Timothy B Durham, James L Toth, Valentine J Klimkowski, Julia X C Cao, Angela M Siesky, Jesline Alexander-Chacko, Ginger Y Wu, Jeffrey T Dixon, James E McGee, Yong Wang, Sherry Y Guo, Rachel Nicole Cavitt, John Schindler, Stefan J Thibodeaux, Nathan A Calvert, Michael J Coghlan, Dana K Sindelar, Michael Christe, Vladislav V Kiselyov, M Dodson Michael, Kyle W Sloo. Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. The Journal of biological chemistry. vol 290. issue 33. 2015-12-08. PMID:26085101. |
however, ide(-/-) mice display variable phenotypes relating to fasting plasma insulin levels, glucose tolerance, and insulin sensitivity depending on the cohort and age of animals. |
2015-12-08 |
2023-08-13 |
mouse |
| Timothy B Durham, James L Toth, Valentine J Klimkowski, Julia X C Cao, Angela M Siesky, Jesline Alexander-Chacko, Ginger Y Wu, Jeffrey T Dixon, James E McGee, Yong Wang, Sherry Y Guo, Rachel Nicole Cavitt, John Schindler, Stefan J Thibodeaux, Nathan A Calvert, Michael J Coghlan, Dana K Sindelar, Michael Christe, Vladislav V Kiselyov, M Dodson Michael, Kyle W Sloo. Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. The Journal of biological chemistry. vol 290. issue 33. 2015-12-08. PMID:26085101. |
importantly, ide inhibition with nte-1 did result in elevated plasma amylin levels, suggesting the in vivo role of ide action on amylin may be more significant than an effect on insulin. |
2015-12-08 |
2023-08-13 |
mouse |
| Timothy B Durham, James L Toth, Valentine J Klimkowski, Julia X C Cao, Angela M Siesky, Jesline Alexander-Chacko, Ginger Y Wu, Jeffrey T Dixon, James E McGee, Yong Wang, Sherry Y Guo, Rachel Nicole Cavitt, John Schindler, Stefan J Thibodeaux, Nathan A Calvert, Michael J Coghlan, Dana K Sindelar, Michael Christe, Vladislav V Kiselyov, M Dodson Michael, Kyle W Sloo. Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. The Journal of biological chemistry. vol 290. issue 33. 2015-12-08. PMID:26085101. |
furthermore, using the inhibitors described in this report, we demonstrate that in hek cells ide has little impact on insulin clearance. |
2015-12-08 |
2023-08-13 |
mouse |
| Timothy B Durham, James L Toth, Valentine J Klimkowski, Julia X C Cao, Angela M Siesky, Jesline Alexander-Chacko, Ginger Y Wu, Jeffrey T Dixon, James E McGee, Yong Wang, Sherry Y Guo, Rachel Nicole Cavitt, John Schindler, Stefan J Thibodeaux, Nathan A Calvert, Michael J Coghlan, Dana K Sindelar, Michael Christe, Vladislav V Kiselyov, M Dodson Michael, Kyle W Sloo. Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. The Journal of biological chemistry. vol 290. issue 33. 2015-12-08. PMID:26085101. |
in total, evidence from our studies supports a minimal role for ide in insulin metabolism in vivo and suggests ide may be more important in helping regulate amylin clearance. |
2015-12-08 |
2023-08-13 |
mouse |
| Gargi Chatterjee, Debashree Roy, Vineet Kumar Khemka, Mrittika Chattopadhyay, Sasanka Chakrabart. Genistein, the Isoflavone in Soybean, Causes Amyloid Beta Peptide Accumulation in Human Neuroblastoma Cell Line: Implications in Alzheimer's Disease. Aging and disease. vol 6. issue 6. 2015-11-30. PMID:26618047. |
our data, however, show that in shsy5y cells genistein causes increased expression (mrna and protein) of amyloid precursor protein (app), increased mrna expression and activity of β-secretase and diminished level of insulin degrading enzyme (ide) which also degrades amyloid beta peptide. |
2015-11-30 |
2023-08-13 |
human |
| Doaa A Ghareeb, Sofia Khalil, Hani S Hafez, Jürgen Bajorath, Hany E A Ahmed, Eman Sarhan, Eiman Elwakeel, Maha A El-Demellaw. Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-11-20. PMID:26576191. |
these changes were significantly correlated with decreased insulin degrading enzyme (ide) and beta-amyloid40 (aβ 40) and increased beta-amyloid42 (aβ 42) in the hippocampal region. |
2015-11-20 |
2023-08-13 |
rat |
| Julie Charton, Marion Gauriot, Jane Totobenazara, Nathalie Hennuyer, Julie Dumont, Damien Bosc, Xavier Marechal, Jamal Elbakali, Adrien Herledan, Xiaoan Wen, Cyril Ronco, Helene Gras-Masse, Antoine Heninot, Virginie Pottiez, Valerie Landry, Bart Staels, Wenguang G Liang, Florence Leroux, Wei-Jen Tang, Benoit Deprez, Rebecca Deprez-Poulai. Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. European journal of medicinal chemistry. vol 90. 2015-10-09. PMID:25489670. |
insulin degrading enzyme (ide) is a zinc metalloprotease that degrades small amyloid peptides such as amyloid-â and insulin. |
2015-10-09 |
2023-08-13 |
human |
| Tingting Zhang, Mehmet Ozbil, Arghya Barman, Thomas J Paul, Ram Prasad Bora, Rajeev Prabhaka. Theoretical insights into the functioning of metallopeptidases and their synthetic analogues. Accounts of chemical research. vol 48. issue 2. 2015-09-14. PMID:25607542. |
in particular, the role of the metal ions, ligands, and microenvironment in the functioning of mono- and binuclear metal center containing enzymes such as insulin degrading enzyme (ide) and bovine lens leucine aminopeptidase (bilap), respectively, and their synthetic analogues have been investigated. |
2015-09-14 |
2023-08-13 |
cattle |
| M Del Campo, A Stargardt, R Veerhuis, E Reits, C E Teunisse. Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer's disease. Neuroscience letters. vol 589. 2015-08-27. PMID:25597881. |
accumulation of bri2-brichos ectodomain correlates with a decreased clearance of aβ by insulin degrading enzyme (ide) in alzheimer's disease. |
2015-08-27 |
2023-08-13 |
human |
| M Del Campo, A Stargardt, R Veerhuis, E Reits, C E Teunisse. Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer's disease. Neuroscience letters. vol 589. 2015-08-27. PMID:25597881. |
the precursor protein bri2 that in its mutated form is associated with british and danish dementia, can regulate critical processes involved in ad pathogenesis including not only the metabolism of amyloid precursor protein (app) and formation of aβ, but also the levels of secreted insulin degrading enzyme (ide), an enzyme involved in aβ clearance. |
2015-08-27 |
2023-08-13 |
human |
| Hongwei Wang, Qing Ye, Yan Huang, Huiying Liao, Haifen Huang, Yong Yo. [Effect of rehabilitation training on insulin-resistance and hippocampus amyloid-beta peptide in rats with vascular dementia]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 38. issue 11. 2015-07-17. PMID:24316935. |
to investigate the effect of rehabilitation training on insulin-resistance and insulin degrading enzyme (ide) in the hippocampus in rats with vascular dementia. |
2015-07-17 |
2023-08-12 |
rat |
| María Del Carmen Camberos, Gabriel Cao, María I Wanderley, Daniel P Udrisar, Juan C Crest. I - insulin transfer to mitochondria. Journal of bioenergetics and biomembranes. vol 46. issue 5. 2015-06-04. PMID:25104045. |
the aim of this study was to determine if insulin is transferred to mitoplasts by insulin-degrading enzyme (ide).hepatic mitochondria were isolated and controlled by electron microscopy. |
2015-06-04 |
2023-08-13 |
rat |
| María Del Carmen Camberos, Gabriel Cao, María I Wanderley, Daniel P Udrisar, Juan C Crest. I - insulin transfer to mitochondria. Journal of bioenergetics and biomembranes. vol 46. issue 5. 2015-06-04. PMID:25104045. |
insulin accumulation was studied at 25 °c at different times, without or with ide, bacitracin, 2,4-dinitrophenol, apyrase or sodium succinate + adenosine diphosphate. |
2015-06-04 |
2023-08-13 |
rat |
| María Del Carmen Camberos, Gabriel Cao, María I Wanderley, Daniel P Udrisar, Juan C Crest. I - insulin transfer to mitochondria. Journal of bioenergetics and biomembranes. vol 46. issue 5. 2015-06-04. PMID:25104045. |
insulin accumulation in mitoplasts and om + ims after mitochondrial cross-linking was studied with electrophoresis in sds-page, immunoblots of ide, insulin or tim23 (inner mitochondrial transporter) and autoradiography.the studies showed that addition of ide increased insulin transfer from om + ims to mitoplasts, and the insulin accumulation in mitoplast was ide dependent. |
2015-06-04 |
2023-08-13 |
rat |
| María Del Carmen Camberos, Gabriel Cao, María I Wanderley, Daniel P Udrisar, Juan C Crest. I - insulin transfer to mitochondria. Journal of bioenergetics and biomembranes. vol 46. issue 5. 2015-06-04. PMID:25104045. |
the constant "k" (liter.mol⁻¹ s⁻¹) showed that ide increased and bacitracin or 2,4-dinitrophenol decreased the velocity of insulin transfer. |
2015-06-04 |
2023-08-13 |
rat |
| María Del Carmen Camberos, Gabriel Cao, María I Wanderley, Daniel P Udrisar, Juan C Crest. I - insulin transfer to mitochondria. Journal of bioenergetics and biomembranes. vol 46. issue 5. 2015-06-04. PMID:25104045. |
sds-page and immunoblots studies showed bands and radioactivity coincident with ide, insulin and tim23. |
2015-06-04 |
2023-08-13 |
rat |
| María Del Carmen Camberos, Gabriel Cao, María I Wanderley, Daniel P Udrisar, Juan C Crest. I - insulin transfer to mitochondria. Journal of bioenergetics and biomembranes. vol 46. issue 5. 2015-06-04. PMID:25104045. |
non degraded insulin was demonstrated in immunoblot after ide immunoprecipitation from mitoplasts. |
2015-06-04 |
2023-08-13 |
rat |
| María Del Carmen Camberos, Gabriel Cao, María I Wanderley, Daniel P Udrisar, Juan C Crest. I - insulin transfer to mitochondria. Journal of bioenergetics and biomembranes. vol 46. issue 5. 2015-06-04. PMID:25104045. |
confocal studies showed mitochondrial colocalization of ide and insulin.the results showed that insulin at 25 °c were transferred from om + ims to mitoplasts by ide or that the enzyme facilitates this transfer, and they reach the matrix together. |
2015-06-04 |
2023-08-13 |
rat |
| Xiuqing Wei, Bilun Ke, Zhiyun Zhao, Xin Ye, Zhanguo Gao, Jianping Y. Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice. PloS one. vol 9. issue 4. 2015-06-01. PMID:24740421. |
insulin degrading enzyme (ide) is a potential drug target in the treatment of type 2 diabetes (t2d). |
2015-06-01 |
2023-08-13 |
mouse |
| Xiuqing Wei, Bilun Ke, Zhiyun Zhao, Xin Ye, Zhanguo Gao, Jianping Y. Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice. PloS one. vol 9. issue 4. 2015-06-01. PMID:24740421. |
ide controls circulating insulin through a degradation-dependent clearance mechanism in multiple tissues. |
2015-06-01 |
2023-08-13 |
mouse |