| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sayali S Kukday, Surya P Manandhar, Marissa C Ludley, Mary E Burriss, Benjamin J Alper, Walter K Schmid. Cell-permeable, small-molecule activators of the insulin-degrading enzyme. Journal of biomolecular screening. vol 17. issue 10. 2013-04-19. PMID:22740246. |
four compounds activate ide in the presence of the competing substrate insulin, which disproportionately inhibits ide activity. |
2013-04-19 |
2023-08-12 |
human |
| Grazia Raffaella Tundo, Diego Sbardella, Chiara Ciaccio, Antonio Bianculli, Augusto Orlandi, Maria Giovanna Desimio, Gaetano Arcuri, Massimiliano Coletta, Stefano Marin. Insulin-degrading enzyme (IDE): a novel heat shock-like protein. The Journal of biological chemistry. vol 288. issue 4. 2013-04-02. PMID:23188819. |
ide activity has been historically associated with insulin and β-amyloid catabolism. |
2013-04-02 |
2023-08-12 |
human |
| Eun Suk Song, Manana Melikishvili, Michael G Fried, Maria A Juliano, Luiz Juliano, David W Rodgers, Louis B Hers. Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation. PloS one. vol 7. issue 10. 2013-03-28. PMID:23077523. |
we found that converting the twelve cysteine residues in rat insulin degrading enzyme (ide) to serines resulted in a cysteine-free form of the enzyme with reduced activity and decreased activation by polyanions. |
2013-03-28 |
2023-08-12 |
rat |
| Anna Castell-Auví, Lídia Cedó, Victor Pallarès, Mayte Blay, Anna Ardévol, Montserrat Pinen. The effects of a cafeteria diet on insulin production and clearance in rats. The British journal of nutrition. vol 108. issue 7. 2012-12-10. PMID:22152054. |
to assay whether insulin clearance was also modified, we checked the activity of the ide, one of the enzymes responsible for insulin clearance. |
2012-12-10 |
2023-08-12 |
rat |
| Anna Castell-Auví, Lídia Cedó, Victor Pallarès, Mayte Blay, Anna Ardévol, Montserrat Pinen. The effects of a cafeteria diet on insulin production and clearance in rats. The British journal of nutrition. vol 108. issue 7. 2012-12-10. PMID:22152054. |
conversely, ide gene expression was unmodified in the kidney and adipose tissue; although when the adipose tissue weight was considered, the insulin clearance potential was higher in the cafeteria diet-treated rats. |
2012-12-10 |
2023-08-12 |
rat |
| Fen Wang, Chang Shu, Longfei Jia, Xiumei Zuo, Yongbiao Zhang, Aihong Zhou, Wei Qin, Haiqing Song, Cuibai Wei, Feng Zhang, Zhen Hong, Muni Tang, Duen-Mei Wang, Jianping Ji. Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese. Neurobiology of aging. vol 33. issue 5. 2012-11-23. PMID:20880607. |
a single nucleotide polymorphism (snp) in the insulin degrading enzyme gene (ide), rs3781239, showed a significant association with ad. |
2012-11-23 |
2023-08-12 |
human |
| Ji Zhao, Lilin Li, Malcolm A Leissrin. Insulin-degrading enzyme is exported via an unconventional protein secretion pathway. Molecular neurodegeneration. vol 4. 2012-10-02. PMID:19144176. |
insulin-degrading enzyme (ide) is a ubiquitously expressed zinc-metalloprotease that degrades several pathophysiologically significant extracellular substrates, including insulin and the amyloid beta-protein (abeta), and accumulating evidence suggests that ide dysfunction may be operative in both type 2 diabetes mellitus and alzheimer disease (ad). |
2012-10-02 |
2023-08-12 |
Not clear |
| Aline Borges, Siu Mui Tsai, Danielle Gregorio Gomes Calda. Validation of reference genes for RT-qPCR normalization in common bean during biotic and abiotic stresses. Plant cell reports. vol 31. issue 5. 2012-10-01. PMID:22193338. |
high stability was obtained for insulin degrading enzyme (ide), actin-11 (act11), unknown 1 (ukn1) and unknown 2 (ukn2) genes during biotic stress, and for skp1/ask-interacting protein 16 (skip16), act11, tubulin beta-8 (β-tub8) and unk1 genes under abiotic stresses. |
2012-10-01 |
2023-08-12 |
Not clear |
| Artur F Schuh, Carlos M Rieder, Liara Rizzi, Márcia Chaves, Matheus Roriz-Cru. Mechanisms of brain aging regulation by insulin: implications for neurodegeneration in late-onset Alzheimer's disease. ISRN neurology. vol 2011. 2012-08-23. PMID:22389813. |
hyperinsulinemic states may deviate ide utilization towards insulin processing, decreasing β-amyloid degradation. |
2012-08-23 |
2023-08-12 |
human |
| Yun-Lian Lin, Huey-Jen Tsay, Yung-Feng Liao, Mine-Fong Wu, Chuen-Neu Wang, Young-Ji Shia. The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-08-23. PMID:22719789. |
western blots assay was employed to measure the levels of soluble amyloid precursor protein and insulin degrading enzyme (ide). |
2012-08-23 |
2023-08-12 |
mouse |
| Zhiheng Liu, Haihao Zhu, Guang Guang Fang, Kathryn Walsh, Mkaya Mwamburi, Benjamin Wolozin, Samer O Abdul-Hay, Tsuneya Ikezu, Malcolm A Leissring, Wei Qiao Qi. Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease? Journal of Alzheimer's disease : JAD. vol 29. issue 2. 2012-07-26. PMID:22232014. |
we aimed to study the aβ degrading proteases including insulin degrading enzyme (ide), angiotensin converting enzyme (ace) and others in blood. |
2012-07-26 |
2023-08-12 |
human |
| Zhiheng Liu, Haihao Zhu, Guang Guang Fang, Kathryn Walsh, Mkaya Mwamburi, Benjamin Wolozin, Samer O Abdul-Hay, Tsuneya Ikezu, Malcolm A Leissring, Wei Qiao Qi. Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease? Journal of Alzheimer's disease : JAD. vol 29. issue 2. 2012-07-26. PMID:22232014. |
the existence of ide activity was demonstrated by the inhibition of insulin, amylin, or edta, and further confirmed by immunocapture of ide using monoclonal antibodies. |
2012-07-26 |
2023-08-12 |
human |
| Yue Zhao, Ying Zhang, Mengyi Zhou, Shiming Wang, Zichun Hua, Jianfa Zhan. Loss of mPer2 increases plasma insulin levels by enhanced glucose-stimulated insulin secretion and impaired insulin clearance in mice. FEBS letters. vol 586. issue 9. 2012-06-25. PMID:22504074. |
hepatic insulin degrading enzyme (ide) displayed an obvious day and night rhythm, which was impaired in mper2-deficient mice, leading to a decrease in insulin clearance. |
2012-06-25 |
2023-08-12 |
mouse |
| Bilal Çakir, Onur Dağliyan, Ezgi Dağyildiz, İbrahim Bariş, Ibrahim Halil Kavakli, Seda Kizilel, Metin Türka. Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme. PloS one. vol 7. issue 2. 2012-06-18. PMID:22355395. |
insulin-degrading enzyme (ide) is an allosteric zn(+2) metalloprotease involved in the degradation of many peptides including amyloid-β, and insulin that play key roles in alzheimer's disease (ad) and type 2 diabetes mellitus (t2dm), respectively. |
2012-06-18 |
2023-08-12 |
human |
| María C Leal, Ezequiel I Surace, María P Holgado, Carina C Ferrari, Rodolfo Tarelli, Fernando Pitossi, Thomas Wisniewski, Eduardo M Castaño, Laura Morell. Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: implications for cellular Aβ metabolism. Biochimica et biophysica acta. vol 1823. issue 2. 2012-05-10. PMID:22036964. |
notch signaling proteins hes-1 and hey-1 bind to insulin degrading enzyme (ide) proximal promoter and repress its transcription and activity: implications for cellular aβ metabolism. |
2012-05-10 |
2023-08-12 |
mouse |
| Nicholas Noinaj, Eun Suk Song, Sonia Bhasin, Benjamin J Alper, Walter K Schmidt, Louis B Hersh, David W Rodger. Anion activation site of insulin-degrading enzyme. The Journal of biological chemistry. vol 287. issue 1. 2012-05-08. PMID:22049080. |
insulin-degrading enzyme (ide) (insulysin) is a zinc metallopeptidase that metabolizes several bioactive peptides, including insulin and the amyloid β peptide. |
2012-05-08 |
2023-08-12 |
Not clear |
| Jasmin Bartl, Claus-Jürgen Scholz, Margareta Hinterberger, Susanne Jungwirth, Ildiko Wichart, Michael K Rainer, Susanne Kneitz, Walter Danielczyk, Karl H Tragl, Peter Fischer, Peter Riederer, Edna Grünblat. Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene. BMC medical genetics. vol 12. 2012-03-12. PMID:22107728. |
insulin-degrading enzyme (ide) is the ubiquitously expressed enzyme responsible for insulin and amyloid beta (aβ) degradation. |
2012-03-12 |
2023-08-12 |
Not clear |
| Liqin Zhao, Jia Yao, Zisu Mao, Shuhua Chen, Yan Wang, Roberta Diaz Brinto. 17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. Neurobiology of aging. vol 32. issue 11. 2012-01-18. PMID:20053478. |
insulin-degrading enzyme (ide), an enzyme that primarily degrades insulin, has recently been demonstrated to play a significant role in the catabolism of amyloid β (aβ) protein in the brain. |
2012-01-18 |
2023-08-12 |
mouse |
| Min Sun Kim, Jun Seo Goo, Ji Eun Kim, So Hee Nam, Sun Il Choi, Hye Ryun Lee, In Sik Hwang, Sun Bo Shim, Seung Wan Jee, Su Hae Lee, Chang Joon Bae, Jung Sik Cho, Jun Yong Cho, Dae Youn Hwan. Overexpression of Insulin Degrading Enzyme could Greatly Contribute to Insulin Down-regulation Induced by Short-Term Swimming Exercise. Laboratory animal research. vol 27. issue 1. 2011-11-10. PMID:21826157. |
to identify the other cause for exercise-induced insulin down-regulation, the changes in the levels of key factors involved in insulin production (c-peptide) and clearance (insulin-degrading enzyme; ide) were measured in w/s and gk rats. |
2011-11-10 |
2023-08-12 |
rat |
| Min Sun Kim, Jun Seo Goo, Ji Eun Kim, So Hee Nam, Sun Il Choi, Hye Ryun Lee, In Sik Hwang, Sun Bo Shim, Seung Wan Jee, Su Hae Lee, Chang Joon Bae, Jung Sik Cho, Jun Yong Cho, Dae Youn Hwan. Overexpression of Insulin Degrading Enzyme could Greatly Contribute to Insulin Down-regulation Induced by Short-Term Swimming Exercise. Laboratory animal research. vol 27. issue 1. 2011-11-10. PMID:21826157. |
therefore, these results showed that insulin down-regulation induced by short-term swimming exercise likely attributes to enhanced insulin clearance via ide over-expression than by altered insulin production. |
2011-11-10 |
2023-08-12 |
rat |