| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bolanle M Famakin, Yongshan Mou, Kory Johnson, Maria Spatz, John Hallenbec. A new role for downstream Toll-like receptor signaling in mediating immediate early gene expression during focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 2. 2014-03-25. PMID:24301291. |
we used real-time polymerase chain reaction to confirm the expression of four immediate early genes; egr1, egr2, arc, nurr77, in this pathway, and insulin degrading enzyme (ide). |
2014-03-25 |
2023-08-12 |
mouse |
| Yue-E Shen, Yan Wang, Gui-Chun Yu, Chao Liu, Zhen-Yu Zhang, Li-Ming Zhan. Effects of edaravone on amyloid-β precursor protein processing in SY5Y-APP695 cells. Neurotoxicity research. vol 24. issue 2. 2014-03-03. PMID:23325603. |
in addition, the mrna and protein levels of insulin degrading enzyme (ide) and neprilysin (nep), two key aβ degrading enzymes, were not changed after edaravone administration. |
2014-03-03 |
2023-08-12 |
human |
| Clémentine Beuzelin, Irini Evnouchidou, Pascal Rigolet, Anne Cauvet-Burgevin, Pierre-Marie Girard, Delphine Dardalhon, Slobodan Culina, Abdelaziz Gdoura, Peter van Endert, Stefania Francescon. Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress. PloS one. vol 8. issue 6. 2014-02-04. PMID:23826334. |
insulin degrading enzyme (ide) is a protease conserved through evolution with a role in diabetes and alzheimer's disease. |
2014-02-04 |
2023-08-12 |
human |
| Clémentine Beuzelin, Irini Evnouchidou, Pascal Rigolet, Anne Cauvet-Burgevin, Pierre-Marie Girard, Delphine Dardalhon, Slobodan Culina, Abdelaziz Gdoura, Peter van Endert, Stefania Francescon. Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress. PloS one. vol 8. issue 6. 2014-02-04. PMID:23826334. |
although iph1 cleaved hallmark ide substrates including insulin efficiently, its role in the er stress response was independent of its catalytic activity since expression of inactive iph1 restored normal sensitivity. |
2014-02-04 |
2023-08-12 |
human |
| G Peggy McFall, Sandra A Wiebe, David Vergote, David Westaway, Jack Jhamandas, Roger A Dixo. IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults. Neurobiology of aging. vol 34. issue 9. 2014-01-17. PMID:23597493. |
we tested independent and interactive contributions of a recently noted and promising insulin degrading enzyme polymorphism (ide; rs6583817) and type 2 diabetes (t2d) to executive function performance, concurrently and longitudinally. |
2014-01-17 |
2023-08-12 |
Not clear |
| Vincent Kwok Lim Lam, Ronald Ching Wan Ma, Heung Man Lee, Cheng Hu, Kyong Soo Park, Hiroto Furuta, Ying Wang, Claudia Ha Ting Tam, Xueling Sim, Daniel Peng-Keat Ng, Jianjun Liu, Tien-Yin Wong, E Shyong Tai, Andrew P Morris, Nelson Leung Sang Tang, Jean Woo, Ping Chung Leung, Alice Pik Shan Kong, Risa Ozaki, Wei Ping Jia, Hong Kyu Lee, Kishio Nanjo, Gang Xu, Maggie Chor Yin Ng, Wing-Yee So, Juliana Chung Ngor Cha. Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations. PloS one. vol 8. issue 6. 2014-01-16. PMID:23776430. |
amongst the tag snps, rs1583645 in carboxypeptidase e (cpe) and rs6583813 in insulin degrading enzyme (ide) were associated with 1.09 to 1.28 fold increased risk of t2d (p meta = 9.4×10(-3) and 0.02 respectively) in a meta-analysis of east asians. |
2014-01-16 |
2023-08-12 |
human |
| P Brandimarti, J M Costa-Júnior, S M Ferreira, A O Protzek, G J Santos, E M Carneiro, A C Boschero, L F Rezend. Cafeteria diet inhibits insulin clearance by reduced insulin-degrading enzyme expression and mRNA splicing. The Journal of endocrinology. vol 219. issue 2. 2013-12-03. PMID:23959080. |
more importantly, mice that were fed a cafeteria diet demonstrated reduced insulin clearance and decay rate as well as reduced insulin-degrading enzyme (ide) protein and mrna levels in liver and skeletal muscle compared with the control animals. |
2013-12-03 |
2023-08-12 |
mouse |
| P Brandimarti, J M Costa-Júnior, S M Ferreira, A O Protzek, G J Santos, E M Carneiro, A C Boschero, L F Rezend. Cafeteria diet inhibits insulin clearance by reduced insulin-degrading enzyme expression and mRNA splicing. The Journal of endocrinology. vol 219. issue 2. 2013-12-03. PMID:23959080. |
in conclusion, a cafeteria diet impairs glucose homeostasis by reducing insulin sensitivity, but it also reduces insulin clearance by reducing ide expression and alternative splicing in mouse liver; however, whether this mechanism contributes to the glucose intolerance or helps to ameliorate it remains unclear. |
2013-12-03 |
2023-08-12 |
mouse |
| Nikisha Carty, Kevin R Nash, Milene Brownlow, Dana Cruite, Donna Wilcock, Maj-Linda B Selenica, Daniel C Lee, Marcia N Gordon, Dave Morga. Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice. PloS one. vol 8. issue 3. 2013-09-30. PMID:23555730. |
several proteases, including neprilysin (nep), endothelin converting enzyme (ece), and insulin degrading enzyme (ide), have been shown to cleave β-amyloid peptides (aβ). |
2013-09-30 |
2023-08-12 |
mouse |
| Giuseppe Grasso, Fabrizio Salomone, Grazia R Tundo, Giuseppe Pappalardo, Chiara Ciaccio, Giuseppe Spoto, Adriana Pietropaolo, Massimo Coletta, Enrico Rizzarell. Metal ions affect insulin-degrading enzyme activity. Journal of inorganic biochemistry. vol 117. 2013-09-24. PMID:22819648. |
insulin degradation is a finely tuned process that plays a major role in controlling insulin action and most evidence supports ide (insulin-degrading enzyme) as the primary degradative agent. |
2013-09-24 |
2023-08-12 |
human |
| Giuseppe Grasso, Fabrizio Salomone, Grazia R Tundo, Giuseppe Pappalardo, Chiara Ciaccio, Giuseppe Spoto, Adriana Pietropaolo, Massimo Coletta, Enrico Rizzarell. Metal ions affect insulin-degrading enzyme activity. Journal of inorganic biochemistry. vol 117. 2013-09-24. PMID:22819648. |
here, we have investigated the effects of different metal ions on the ide proteolytic activity toward insulin as well as a designed peptide comprising a portion of the insulin b chain (b20-30), which has a very low affinity for metal ions. |
2013-09-24 |
2023-08-12 |
human |
| Yunyun Zhang, Bin Wang, Heming Wan, Qida Zhou, Tianjie L. Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease. Neuroscience letters. vol 541. 2013-09-03. PMID:23416320. |
the association between insulin degrading enzyme (ide) gene polymorphisms and alzheimer's disease (ad) risk has been widely reported, but results were somewhat controversial. |
2013-09-03 |
2023-08-12 |
Not clear |
| Abhishek Tripathi, Vikas Saini, Adriano Marchese, Brian F Volkman, Wei-Jen Tang, Matthias Majetscha. Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification. Biochemistry. vol 52. issue 24. 2013-09-03. PMID:23697661. |
reduction of cell surface expression of insulin degrading enzyme (ide), which cleaves the c-terminal di-gly of ubiquitin, enhances ubiquitin induced reduction of camp levels in bv2 and thp-1 cells, but does not influence changes in camp levels in response to sdf-1α. |
2013-09-03 |
2023-08-12 |
Not clear |
| Pär Steneberg, Lisandro Bernardo, Sara Edfalk, Lisa Lundberg, Fredrik Backlund, Claes-Göran Ostenson, Helena Edlun. The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of α-synuclein levels in β-cells. Diabetes. vol 62. issue 6. 2013-08-02. PMID:23349488. |
the type 2 diabetes-associated gene ide is required for insulin secretion and suppression of α-synuclein levels in β-cells. |
2013-08-02 |
2023-08-12 |
mouse |
| Pär Steneberg, Lisandro Bernardo, Sara Edfalk, Lisa Lundberg, Fredrik Backlund, Claes-Göran Ostenson, Helena Edlun. The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of α-synuclein levels in β-cells. Diabetes. vol 62. issue 6. 2013-08-02. PMID:23349488. |
we find that glucose-stimulated insulin secretion (gsis) is decreased in ide ko mice due to impaired replenishment of the releasable pool of granules and that the ide gene is haploinsufficient. |
2013-08-02 |
2023-08-12 |
mouse |
| Akiko Sheala Shingo, Tomomichi Kanabayashi, Shozo Kito, Toshio Muras. Intracerebroventricular administration of an insulin analogue recovers STZ-induced cognitive decline in rats. Behavioural brain research. vol 241. 2013-07-01. PMID:23238038. |
we previously demonstrated that intracerebroventricular streptozotocin (stz-icv) injection induced cognitive dysfunction and led to decreased expression levels of phospho-cyclic amp responsive element binding protein (pcreb), akt, and insulin degrading enzyme (ide) and increased amyloid beta (ab) deposition in the hippocampus. |
2013-07-01 |
2023-08-12 |
rat |
| Francesco Bellia, Adriana Pietropaolo, Giuseppe Grass. Formation of insulin fragments by insulin-degrading enzyme: the role of zinc(II) and cystine bridges. Journal of mass spectrometry : JMS. vol 48. issue 2. 2013-07-01. PMID:23378084. |
insulin-degrading enzyme (ide) has been identified as the main factor of insulin degradation, but it is still unknown the exact way and location at which ide action toward insulin occurs and how metal ions can modulate this interaction. |
2013-07-01 |
2023-08-12 |
Not clear |
| Francesco Bellia, Adriana Pietropaolo, Giuseppe Grass. Formation of insulin fragments by insulin-degrading enzyme: the role of zinc(II) and cystine bridges. Journal of mass spectrometry : JMS. vol 48. issue 2. 2013-07-01. PMID:23378084. |
in this work, the role of zinc(ii) and cystine bridges in the degradation of insulin by ide are investigated by high-performance liquid chromatography-mass spectrometry (hplc-ms), and the experimental conditions at which peculiar insulin fragments having biological activity are formed by the action of ide are found and discussed. |
2013-07-01 |
2023-08-12 |
Not clear |
| Samer O Abdul-Hay, Amy L Lane, Thomas R Caulfield, Clémence Claussin, Juliette Bertrand, Amandine Masson, Shakeel Choudhry, Abdul H Fauq, Guhlam M Maharvi, Malcolm A Leissrin. Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity. Journal of medicinal chemistry. vol 56. issue 6. 2013-05-23. PMID:23437776. |
insulin-degrading enzyme (ide) is an atypical zinc-metallopeptidase that degrades insulin and the amyloid ß-protein and is strongly implicated in the pathogenesis of diabetes and alzheimer's disease. |
2013-05-23 |
2023-08-12 |
Not clear |
| Anna Castell-Auví, Lídia Cedó, Victor Pallarès, M Teresa Blay, Montserrat Pinent, M José Motilva, Santiago Garcia-Vallvé, Gerard Pujadas, Pierre Maechler, Anna Ardévo. Procyanidins modify insulinemia by affecting insulin production and degradation. The Journal of nutritional biochemistry. vol 23. issue 12. 2013-04-30. PMID:22444499. |
gspe also modified glut2, glucokinase and ucp2 gene expression as well as altered the expression of hepatic insulin-degrading enzyme (ide), thereby altering insulin degradation. |
2013-04-30 |
2023-08-12 |
rat |