| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohd Waseem Akhtar, Sara Sanz-Blasco, Nima Dolatabadi, James Parker, Kevin Chon, Michelle S Lee, Walid Soussou, Scott R McKercher, Rajesh Ambasudhan, Tomohiro Nakamura, Stuart A Lipto. Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation. Nature communications. vol 7. 2016-05-17. PMID:26743041. |
the increase in no results in s-nitrosylation of insulin-degrading enzyme (ide) and dynamin-related protein 1 (drp1), thus inhibiting insulin and aβ catabolism as well as hyperactivating mitochondrial fission machinery. |
2016-05-17 |
2023-08-13 |
human |
| Eun Suk Song, Mehmet Ozbil, Tingting Zhang, Michael Sheetz, David Lee, Danny Tran, Sheng Li, Rajeev Prabhakar, Louis B Hersh, David W Rodger. An Extended Polyanion Activation Surface in Insulin Degrading Enzyme. PloS one. vol 10. issue 7. 2016-05-05. PMID:26186535. |
insulin degrading enzyme (ide) is believed to be the major enzyme that metabolizes insulin and has been implicated in the degradation of a number of other bioactive peptides, including amyloid beta peptide (aβ), glucagon, amylin, and atrial natriuretic peptide. |
2016-05-05 |
2023-08-13 |
Not clear |
| André Otávio Peres Protzek, Luiz Fernando Rezende, José Maria Costa-Júnior, Sandra Mara Ferreira, Ana Paula Gameiro Cappelli, Flávia Maria Moura de Paula, Jane Cristina de Souza, Mirian Ayumi Kurauti, Everardo Magalhães Carneiro, Alex Rafacho, Antonio Carlos Boscher. Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme. The Journal of steroid biochemistry and molecular biology. vol 155. issue Pt A. 2016-05-03. PMID:26386462. |
there is evidence for also reduced hepatic insulin clearance, but whether this correlates with altered activity of insulin-degrading enzyme (ide) in the liver, is not fully understood. |
2016-05-03 |
2023-08-13 |
Not clear |
| André Otávio Peres Protzek, Luiz Fernando Rezende, José Maria Costa-Júnior, Sandra Mara Ferreira, Ana Paula Gameiro Cappelli, Flávia Maria Moura de Paula, Jane Cristina de Souza, Mirian Ayumi Kurauti, Everardo Magalhães Carneiro, Alex Rafacho, Antonio Carlos Boscher. Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme. The Journal of steroid biochemistry and molecular biology. vol 155. issue Pt A. 2016-05-03. PMID:26386462. |
here, we investigated whether hyperinsulinemia, in glucocorticoid-treated rodents, is associated with any alteration in the insulin clearance and activity of the ide in the liver. |
2016-05-03 |
2023-08-13 |
Not clear |
| Olga Pivovarova, Christian von Loeffelholz, Iryna Ilkavets, Carsten Sticht, Sergei Zhuk, Veronica Murahovschi, Sonja Lukowski, Stephanie Döcke, Jennifer Kriebel, Tonia de las Heras Gala, Anna Malashicheva, Anna Kostareva, Johan F Lock, Martin Stockmann, Harald Grallert, Norbert Gretz, Steven Dooley, Andreas F H Pfeiffer, Natalia Rudovic. Modulation of insulin degrading enzyme activity and liver cell proliferation. Cell cycle (Georgetown, Tex.). vol 14. issue 14. 2016-04-21. PMID:25945652. |
recently, the use of a novel inhibitor of insulin degrading enzyme (ide) was proposed as a new therapeutic strategy in t2dm. |
2016-04-21 |
2023-08-13 |
human |
| Olga Pivovarova, Christian von Loeffelholz, Iryna Ilkavets, Carsten Sticht, Sergei Zhuk, Veronica Murahovschi, Sonja Lukowski, Stephanie Döcke, Jennifer Kriebel, Tonia de las Heras Gala, Anna Malashicheva, Anna Kostareva, Johan F Lock, Martin Stockmann, Harald Grallert, Norbert Gretz, Steven Dooley, Andreas F H Pfeiffer, Natalia Rudovic. Modulation of insulin degrading enzyme activity and liver cell proliferation. Cell cycle (Georgetown, Tex.). vol 14. issue 14. 2016-04-21. PMID:25945652. |
however, ide inhibition might stimulate liver cell proliferation via increased intracellular insulin concentration. |
2016-04-21 |
2023-08-13 |
human |
| Olga Pivovarova, Christian von Loeffelholz, Iryna Ilkavets, Carsten Sticht, Sergei Zhuk, Veronica Murahovschi, Sonja Lukowski, Stephanie Döcke, Jennifer Kriebel, Tonia de las Heras Gala, Anna Malashicheva, Anna Kostareva, Johan F Lock, Martin Stockmann, Harald Grallert, Norbert Gretz, Steven Dooley, Andreas F H Pfeiffer, Natalia Rudovic. Modulation of insulin degrading enzyme activity and liver cell proliferation. Cell cycle (Georgetown, Tex.). vol 14. issue 14. 2016-04-21. PMID:25945652. |
hepg2 cells were treated with 10 nm insulin for 24 h with or without inhibition of ide activity using ide rnai, and cell transcriptome and proliferation rate were analyzed. |
2016-04-21 |
2023-08-13 |
human |
| Giuseppe Grasso, Cristina Satriano, Danilo Milard. A neglected modulator of insulin-degrading enzyme activity and conformation: The pH. Biophysical chemistry. vol 203-204. 2016-03-14. PMID:26025789. |
insulin-degrading enzyme (ide), a ubiquitously expressed zinc metalloprotease, has multiple activities in addition to insulin degradation and its malfunction is believed to connect type 2 diabetes with alzheimer's disease. |
2016-03-14 |
2023-08-13 |
Not clear |
| Giuseppe Grasso, Cristina Satriano, Danilo Milard. A neglected modulator of insulin-degrading enzyme activity and conformation: The pH. Biophysical chemistry. vol 203-204. 2016-03-14. PMID:26025789. |
our results clearly indicate a ph dependent coupling among enzyme conformation, assembly and stability and suggest that cellular acidosis can have a large effect on ide oligomerization state, inducing an enzyme inactivation and an altered insulin degradation that could have an impact on insulin signaling. |
2016-03-14 |
2023-08-13 |
Not clear |
| Sonali Gopichand Chavan, Deepti Dileep Deobagka. An in silico insight into novel therapeutic interaction of LTNF peptide-LT10 and design of structure based peptidomimetics for putative anti-diabetic activity. PloS one. vol 10. issue 3. 2016-03-11. PMID:25816209. |
in our in silico study, we identified insulin degrading enzyme (ide) as a potential target of lt10 peptide followed by molecular docking and molecular dynamic (md) simulation studies which revealed relatively stable interaction of lt10 peptide with ide. |
2016-03-11 |
2023-08-13 |
Not clear |
| Huawei Cheng, Lin Wang, Tianlu Shi, Yuping Shang, Ling Jian. Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis. The International journal of neuroscience. vol 125. issue 5. 2016-03-07. PMID:25105907. |
the association of insulin degrading enzyme (ide) genotypes rs4646953, rs2251101 and rs1544210 with ad has been detected, but the findings were conflicted, however, apolipoprotein-e (apoe)-ε4 allele has been observed as a genetic risk factor for ad. |
2016-03-07 |
2023-08-13 |
Not clear |
| José M Costa-Júnior, Sandra M Ferreira, André O Protzek, Gustavo J Santos, Ana P Cappelli, Leonardo R Silveira, Cláudio Zoppi, Camila A M de Oliveira, Antonio C Boschero, Everardo M Carneiro, Luiz F Rezend. Endurance training inhibits insulin clearance and IDE expression in Swiss mice. PloS one. vol 10. issue 3. 2016-02-23. PMID:25822220. |
endurance training inhibits insulin clearance and ide expression in swiss mice. |
2016-02-23 |
2023-08-13 |
mouse |
| Miren Ettcheto, Dmitry Petrov, Ignacio Pedrós, Luisa de Lemos, Mercè Pallàs, Marta Alegret, Juan Carlos Laguna, Jaume Folch, Antoni Camin. Hypercholesterolemia and neurodegeneration. Comparison of hippocampal phenotypes in LDLr knockout and APPswe/PS1dE9 mice. Experimental gerontology. vol 65. 2016-01-25. PMID:25797218. |
several proteins like insulin degrading enzyme (ide), pgc-1α, oxphos 1, nmdar1 and cyclic amp response element binding protein (creb) are up-regulated in the ldlr -/- mice, while in the app/ps1 mouse model only oxphos complexes 2, 3 and 5 are slightly downregulated. |
2016-01-25 |
2023-08-13 |
mouse |
| Kole D Meeker, James S Meabon, David G Coo. Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 45. issue 2. 2016-01-14. PMID:25589729. |
we found that partial glt-1 loss chronically increased akt activation (reflected by increased phosphorylation at serine 473), impaired insulin signaling (reflected by decreased irβ phosphorylation of tyrosines 1150/1151 and increased irs-1 phosphorylation at serines 632/635 - denoted as 636/639 in humans), and reduced insulin degrading enzyme (ide) activity in brains of mice expressing familial aβppswe/ps1Δe9 ad mutations. |
2016-01-14 |
2023-08-13 |
mouse |
| Sandeep K Sharma, Erik Chorell, Pernilla Wittung-Stafshed. Insulin-degrading enzyme is activated by the C-terminus of α-synuclein. Biochemical and biophysical research communications. vol 466. issue 2. 2016-01-08. PMID:26343304. |
the insulin-degrading enzyme (ide) plays a key role in type-2 diabetes and typically degrades small peptides such as insulin, amyloid β and islet amyloid polypeptide. |
2016-01-08 |
2023-08-13 |
Not clear |
| Yoshio Hamada, Naoko Miyamoto, Yoshiaki Kis. Novel β-amyloid aggregation inhibitors possessing a turn mimic. Bioorganic & medicinal chemistry letters. vol 25. issue 7. 2015-12-21. PMID:25736996. |
a number of potential ad therapeutics have been reported, including inhibitors of β-secretase, γ-secretase, and aβ aggregation, and anti-amyloid agents, such as neprilysin, insulin degrading enzyme (ide), and aβ antibodies. |
2015-12-21 |
2023-08-13 |
Not clear |
| J Osmanovic Barilar, A Knezovic, E Grünblatt, P Riederer, M Salkovic-Petrisi. Nine-month follow-up of the insulin receptor signalling cascade in the brain of streptozotocin rat model of sporadic Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 4. 2015-12-16. PMID:25503661. |
insulin-1 (ins-1), ir, phospho- and total (p/t)-glycogen synthase kinase 3-β (gsk-3β), p/t-tau and insulin degrading enzyme (ide) mrna and/or protein were measured. |
2015-12-16 |
2023-08-13 |
rat |
| Shraddha D Rege, Thangiah Geetha, Tom L Broderick, Jeganathan Ramesh Bab. Resveratrol protects β amyloid-induced oxidative damage and memory associated proteins in H19-7 hippocampal neuronal cells. Current Alzheimer research. vol 12. issue 2. 2015-12-15. PMID:25654502. |
aβ treatment also increased the expression of total tau as well as phosphorylated forms of tau (cp13, s202/205; phf1, s396/404) and decreased the expression of insulin degrading enzyme (ide), phosphoglycogen synthase kinase 3β involved in aβ degradation and tau hyper phosphorylation. |
2015-12-15 |
2023-08-13 |
rat |
| Timothy B Durham, James L Toth, Valentine J Klimkowski, Julia X C Cao, Angela M Siesky, Jesline Alexander-Chacko, Ginger Y Wu, Jeffrey T Dixon, James E McGee, Yong Wang, Sherry Y Guo, Rachel Nicole Cavitt, John Schindler, Stefan J Thibodeaux, Nathan A Calvert, Michael J Coghlan, Dana K Sindelar, Michael Christe, Vladislav V Kiselyov, M Dodson Michael, Kyle W Sloo. Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. The Journal of biological chemistry. vol 290. issue 33. 2015-12-08. PMID:26085101. |
insulin-degrading enzyme (ide, insulysin) is the best characterized catabolic enzyme implicated in proteolysis of insulin. |
2015-12-08 |
2023-08-13 |
mouse |
| Timothy B Durham, James L Toth, Valentine J Klimkowski, Julia X C Cao, Angela M Siesky, Jesline Alexander-Chacko, Ginger Y Wu, Jeffrey T Dixon, James E McGee, Yong Wang, Sherry Y Guo, Rachel Nicole Cavitt, John Schindler, Stefan J Thibodeaux, Nathan A Calvert, Michael J Coghlan, Dana K Sindelar, Michael Christe, Vladislav V Kiselyov, M Dodson Michael, Kyle W Sloo. Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. The Journal of biological chemistry. vol 290. issue 33. 2015-12-08. PMID:26085101. |
recently, a peptide inhibitor of ide has been shown to affect levels of insulin, amylin, and glucagon in vivo. |
2015-12-08 |
2023-08-13 |
mouse |