| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fengmin Li, Jian Yang, Van Anthony M Villar, Laureano D Asico, Xiaobo Ma, Ines Armando, Hironobu Sanada, Minoru Yoneda, Robin A Felder, Pedro A Jose, Xiaoyan Wan. Loss of renal SNX5 results in impaired IDE activity and insulin resistance in mice. Diabetologia. vol 61. issue 3. 2018-11-05. PMID:29080975. |
we hypothesised that renal sorting nexin 5 (snx5) regulates the insulin-degrading enzyme (ide) and, thus, circulating insulin levels. |
2018-11-05 |
2023-08-13 |
human |
| Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Al. Nigella sativa Oil and Chromium Picolinate Ameliorate Fructose-Induced Hyperinsulinemia by Enhancing Insulin Signaling and Suppressing Insulin-Degrading Enzyme in Male Rats. Biological trace element research. vol 184. issue 1. 2018-10-09. PMID:28975521. |
we, therefore, hypothesized that chromium picolinate may alter insulin clearance by modulating insulin-degrading enzyme (ide) in insulin-resistant rats. |
2018-10-09 |
2023-08-13 |
rat |
| Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Al. Nigella sativa Oil and Chromium Picolinate Ameliorate Fructose-Induced Hyperinsulinemia by Enhancing Insulin Signaling and Suppressing Insulin-Degrading Enzyme in Male Rats. Biological trace element research. vol 184. issue 1. 2018-10-09. PMID:28975521. |
nigella sativa oil or chromium picolinate concurrent administration with hfw significantly decreased body weight, serum lipids, glucagon, insulin resistance, and hepatic ide level but increased its mrna expression and insulin receptor phosphorlyation as well as high-density lipoprotein cholesterol (hdl-c) level as compared to control group values, suggesting their potential as modulators for insulin signaling and clearance. |
2018-10-09 |
2023-08-13 |
rat |
| Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Al. Nigella sativa Oil and Chromium Picolinate Ameliorate Fructose-Induced Hyperinsulinemia by Enhancing Insulin Signaling and Suppressing Insulin-Degrading Enzyme in Male Rats. Biological trace element research. vol 184. issue 1. 2018-10-09. PMID:28975521. |
however, nigella sativa oil exerted better improvement in feeding efficacy ratio as well as the levels of glucagon, insulin, insulin resistance, hepatic ide level and insulin receptor phosphorylation than chromium picolinate, suggesting its greater insulin sensitizing capacity. |
2018-10-09 |
2023-08-13 |
rat |
| Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Al. Nigella sativa Oil and Chromium Picolinate Ameliorate Fructose-Induced Hyperinsulinemia by Enhancing Insulin Signaling and Suppressing Insulin-Degrading Enzyme in Male Rats. Biological trace element research. vol 184. issue 1. 2018-10-09. PMID:28975521. |
our data, for the first time, prove that nigella sativa oil and chromium picolinate monotherapy can reduce fructose-induced insulin resistance by reduction of hepatic ide protein and activation of insulin receptor signaling. |
2018-10-09 |
2023-08-13 |
rat |
| Yi Zhang, Peichang Wan. Age-Related Increase of Insulin-Degrading Enzyme Is Inversely Correlated with Cognitive Function in APPswe/PS1dE9 Mice. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-09-28. PMID:29680859. |
although it is indispensable in removing plaques related to onset alzheimer's disease (ad) and in degrading insulin related to diabetes, there have been few studies on the dynamic level of ide in different stages of ad. |
2018-09-28 |
2023-08-13 |
mouse |
| Huajie Li, Jian Wu, Linfeng Zhu, Luolin Sha, Song Yang, Jiang Wei, Lei Ji, Xiaochun Tang, Keshi Mao, Liping Cao, Ning Wei, Wei Xie, Zhilong Yan. Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD. Bioscience reports. vol 38. issue 1. 2018-08-16. PMID:29222348. |
insulin degrading enzyme contributes to the pathology in a mixed model of type 2 diabetes and alzheimer's disease: possible mechanisms of ide in t2d and ad. |
2018-08-16 |
2023-08-13 |
mouse |
| Huajie Li, Jian Wu, Linfeng Zhu, Luolin Sha, Song Yang, Jiang Wei, Lei Ji, Xiaochun Tang, Keshi Mao, Liping Cao, Ning Wei, Wei Xie, Zhilong Yan. Insulin degrading enzyme contributes to the pathology in a mixed model of Type 2 diabetes and Alzheimer's disease: possible mechanisms of IDE in T2D and AD. Bioscience reports. vol 38. issue 1. 2018-08-16. PMID:29222348. |
insulin degrading enzyme (ide) is believed to act as a junction point of type 2 diabetes (t2d) and alzheimer's disease (ad); however, the underlying mechanism was not completely clear yet. |
2018-08-16 |
2023-08-13 |
mouse |
| Kelly A Hamilton, Yue Wang, Sophia M Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N Suire, Simonetta Camandola, Robert H Lipsky, Mark P Mattso. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus. PloS one. vol 13. issue 5. 2018-07-30. PMID:29715265. |
of the validated genes identified from mrna expression analysis, insulin degrading enzyme (ide) had the most significantly altered expression in hippocampus and was significantly downregulated on the rna and protein levels; although bhlhe40 did not occupy the ide gene by chip-seq. |
2018-07-30 |
2023-08-13 |
mouse |
| Camila Lubaczeuski, Luciana Mateus Gonçalves, Jean Franciesco Vettorazzi, Mirian Ayumi Kurauti, Junia Carolina Santos-Silva, Maria Lúcia Bonfleur, Antonio Carlos Boschero, José Maria Costa-Júnior, Everardo Magalhães Carneir. Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence. Neural plasticity. vol 2017. 2018-06-22. PMID:28951790. |
glucose-stimulated insulin secretion (gsis) in isolated islets, ipgtt, ipitt, in vivo insulin clearance, and liver expression of the insulin-degrading enzyme (ide) was accessed. |
2018-06-22 |
2023-08-13 |
mouse |
| Camila Lubaczeuski, Luciana Mateus Gonçalves, Jean Franciesco Vettorazzi, Mirian Ayumi Kurauti, Junia Carolina Santos-Silva, Maria Lúcia Bonfleur, Antonio Carlos Boschero, José Maria Costa-Júnior, Everardo Magalhães Carneir. Vagotomy Reduces Insulin Clearance in Obese Mice Programmed by Low-Protein Diet in the Adolescence. Neural plasticity. vol 2017. 2018-06-22. PMID:28951790. |
in conclusion, when submitted to vagotomy, the metabolic programmed mice showed improved glucose tolerance, associated with an increase of plasma insulin concentration as a result of insulin clearance reduction, a phenomenon probably due to diminished liver ide expression. |
2018-06-22 |
2023-08-13 |
mouse |
| Norsharina Ismail, Maznah Ismail, Nur Hanisah Azmi, Muhammad Firdaus Abu Bakar, Zhang Yida, Maizaton Atmadini Abdullah, Hamidon Basr. Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high fat/cholesterol diet-induced rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 95. 2018-06-11. PMID:28892789. |
particularly, the aβ generation; app processing, β-secretase 1 (bace1), γ-secretases of presenilin 1 (psen1) and presenilin 2 (psen2), aβ degradation; insulin degrading enzyme (ide), aβ transportation; low density lipoprotein receptor-related protein 1 (lrp1) and receptor for advanced glycation end products (rage) were measured in brain tissues. |
2018-06-11 |
2023-08-13 |
rat |
| Caitlin N Suire, Sarah Nainar, Michael Fazio, Adam G Kreutzer, Tara Paymozd-Yazdi, Caitlyn L Topper, Caroline R Thompson, Malcolm A Leissrin. Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display. PloS one. vol 13. issue 2. 2018-05-23. PMID:29447281. |
insulin-degrading enzyme (ide) is an atypical zinc-metalloendopeptidase that hydrolyzes insulin and other intermediate-sized peptide hormones, many of which are implicated in skin health and wound healing. |
2018-05-23 |
2023-08-13 |
Not clear |
| Caitlin N Suire, Sarah Nainar, Michael Fazio, Adam G Kreutzer, Tara Paymozd-Yazdi, Caitlyn L Topper, Caroline R Thompson, Malcolm A Leissrin. Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display. PloS one. vol 13. issue 2. 2018-05-23. PMID:29447281. |
pharmacological inhibitors of ide administered internally have been shown to slow the breakdown of insulin and thereby potentiate insulin action. |
2018-05-23 |
2023-08-13 |
Not clear |
| Caitlin N Suire, Sarah Nainar, Michael Fazio, Adam G Kreutzer, Tara Paymozd-Yazdi, Caitlyn L Topper, Caroline R Thompson, Malcolm A Leissrin. Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display. PloS one. vol 13. issue 2. 2018-05-23. PMID:29447281. |
given the importance of insulin and other ide substrates for a variety of dermatological processes, pharmacological inhibitors of ide suitable for topical applications would be expected to hold significant therapeutic and cosmetic potential. |
2018-05-23 |
2023-08-13 |
Not clear |
| Caitlin N Suire, Sarah Nainar, Michael Fazio, Adam G Kreutzer, Tara Paymozd-Yazdi, Caitlyn L Topper, Caroline R Thompson, Malcolm A Leissrin. Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display. PloS one. vol 13. issue 2. 2018-05-23. PMID:29447281. |
among several peptide sequences tested, a cyclic dodecapeptide dubbed p12-3a was found to potently inhibit the degradation of insulin (ki = 2.5 ± 0.31 μm) and other substrates by ide, while also being resistant to degradation, stable in biological milieu, and highly selective for ide. |
2018-05-23 |
2023-08-13 |
Not clear |
| Norimichi Nakamura, Yasumasa Ohyagi, Tomohiro Imamura, Yuki T Yanagihara, Kyoko M Iinuma, Naoko Soejima, Hiroyuki Murai, Ryo Yamasaki, Jun-Ichi Kir. Apomorphine Therapy for Neuronal Insulin Resistance in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 4. 2018-05-22. PMID:28550243. |
protein levels of insulin-degrading enzyme (ide), which is linked to insulin signaling and degrades aβ, significantly increased in the 3xtg-ad mice brain compared with non-transgenic mice, and were further increased by apo. |
2018-05-22 |
2023-08-13 |
mouse |
| Eun Suk Song, HyeIn Jang, Hou-Fu Guo, Maria A Juliano, Luiz Juliano, Andrew J Morris, Emilia Galperin, David W Rodgers, Louis B Hers. Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 14. 2018-05-15. PMID:28325868. |
insulin-degrading enzyme (ide) hydrolyzes bioactive peptides, including insulin, amylin, and the amyloid β peptides. |
2018-05-15 |
2023-08-13 |
Not clear |
| Khyati Mittal, Ruchi Jakhmola Mani, Deepshikha Pande Katar. Type 3 Diabetes: Cross Talk between Differentially Regulated Proteins of Type 2 Diabetes Mellitus and Alzheimer's Disease. Scientific reports. vol 6. 2018-03-26. PMID:27151376. |
the current study also suggests that insulin degrading enzyme (ide) could be the major player which holds the capacity to shift t2dm to t3d by altering metabolic pathways like regulation of beta-cell development, negative regulation of pi3k/akt pathways and amyloid beta degradation. |
2018-03-26 |
2023-08-13 |
Not clear |
| Zhi-Qi Wu, Ju Lu, Huanhuan Chen, Wensen Chen, Hua-Guo X. Individualized correction of insulin measurement in hemolyzed serum samples. Immunologic research. vol 65. issue 3. 2018-03-12. PMID:27817149. |
however, even slight hemolysis can negatively affect insulin measurement due to rbc insulin-degrading enzyme (ide). |
2018-03-12 |
2023-08-13 |
Not clear |