| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Haobin Cai, Yijie Wang, Jiayang He, Tiantian Cai, Jun Wu, Jiansong Fang, Rong Zhang, Zhouke Guo, Li Guan, Qinkai Zhan, Li Lin, Yao Xiao, Huafeng Pan, Qi Wan. Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice. Oncotarget. vol 8. issue 54. 2019-11-20. PMID:29190943. |
bjjs treatment increased the level of insulin degradation enzyme (ide) and neprilysin (nep) and decreased the level of β-site app cleaving enzyme 1(bace1) in the brain of app/ps1 mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Soren Hayrabedyan, Krassimira Todorova, Marialuigia Spinelli, Eytan R Barnea, Martin Muelle. The core sequence of PIF competes for insulin/amyloid β in insulin degrading enzyme: potential treatment for Alzheimer's disease. Oncotarget. vol 9. issue 74. 2019-11-20. PMID:30338033. |
the clearance of aβ may be induced by the large zinc-binding protease insulin degrading enzyme (ide). |
2019-11-20 |
2023-08-13 |
Not clear |
| Soren Hayrabedyan, Krassimira Todorova, Marialuigia Spinelli, Eytan R Barnea, Martin Muelle. The core sequence of PIF competes for insulin/amyloid β in insulin degrading enzyme: potential treatment for Alzheimer's disease. Oncotarget. vol 9. issue 74. 2019-11-20. PMID:30338033. |
ide is the common link between ad and type ii diabetes as insulin is an ide target as well. |
2019-11-20 |
2023-08-13 |
Not clear |
| Rui Lai, Wei-Jen Tang, Hui L. Catalytic Mechanism of Amyloid-β Peptide Degradation by Insulin Degrading Enzyme: Insights from Quantum Mechanics and Molecular Mechanics Style Møller-Plesset Second Order Perturbation Theory Calculation. Journal of chemical information and modeling. vol 58. issue 9. 2019-10-21. PMID:30133282. |
insulin degrading enzyme (ide), a metalloprotease that degrades amyloid-β (aβ) peptides and insulin, is associated with alzheimer's disease and diabetes. |
2019-10-21 |
2023-08-13 |
human |
| Florence Leroux, Damien Bosc, Terence Beghyn, Paul Hermant, Sandrine Warenghem, Valérie Landry, Virginie Pottiez, Valentin Guillaume, Julie Charton, Adrien Herledan, Sarah Urata, Wenguang Liang, Li Sheng, Wei-Jen Tang, Benoit Deprez, Rebecca Deprez-Poulai. Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening. European journal of medicinal chemistry. vol 179. 2019-10-17. PMID:31276900. |
insulin-degrading enzyme, ide, is a metalloprotease implicated in the metabolism of key peptides such as insulin, glucagon, β-amyloid peptide. |
2019-10-17 |
2023-08-13 |
Not clear |
| Dan Yang, Weirong Qin, Xiaodong Shi, Bili Zhu, Mingsheng Xie, Hui Zhao, Bin Teng, Yujie Wu, Rongtong Zhao, Feng Yin, Peigen Ren, Lizhong Liu, Zigang L. Stabilized β-Hairpin Peptide Inhibits Insulin Degrading Enzyme. Journal of medicinal chemistry. vol 61. issue 18. 2019-10-14. PMID:30148634. |
insulin-degrading enzyme (ide) plays a critical role in both the proteolytic degradation and inactivation of insulin. |
2019-10-14 |
2023-08-13 |
Not clear |
| Yasumasa Ohyagi, Katsue Miyoshi, Norimichi Nakamur. Therapeutic Strategies for Alzheimer's Disease in the View of Diabetes Mellitus. Advances in experimental medicine and biology. vol 1128. 2019-08-07. PMID:31062332. |
while we identified apomorphine (apo) as a novel drug that promoted intracellular aβ degradation and improved memory function in an ad mouse model, more recently, we have revealed that apo treatment improves neuronal insulin resistance and activates insulin-degrading enzyme (ide), a major aβ-degrading enzyme. |
2019-08-07 |
2023-08-13 |
mouse |
| Juan Pablo Maianti, Grace A Tan, Amedeo Vetere, Amie J Welsh, Bridget K Wagner, Markus A Seeliger, David R Li. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nature chemical biology. vol 15. issue 6. 2019-07-29. PMID:31086331. |
the metalloprotease insulin-degrading enzyme (ide) modulates blood glucose levels by cleaving insulin, a hormone that promotes glucose clearance. |
2019-07-29 |
2023-08-13 |
Not clear |
| Juan Pablo Maianti, Grace A Tan, Amedeo Vetere, Amie J Welsh, Bridget K Wagner, Markus A Seeliger, David R Li. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nature chemical biology. vol 15. issue 6. 2019-07-29. PMID:31086331. |
however, ide also degrades glucagon, a hormone that elevates glucose levels and opposes the effect of insulin. |
2019-07-29 |
2023-08-13 |
Not clear |
| Juan Pablo Maianti, Grace A Tan, Amedeo Vetere, Amie J Welsh, Bridget K Wagner, Markus A Seeliger, David R Li. Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nature chemical biology. vol 15. issue 6. 2019-07-29. PMID:31086331. |
ide inhibitors to treat diabetes, therefore, should prevent ide-mediated insulin degradation, but not glucagon degradation, in contrast with traditional modes of enzyme inhibition. |
2019-07-29 |
2023-08-13 |
Not clear |
| Mirian A Kurauti, José M Costa-Júnior, Sandra M Ferreira, Gustavo J Santos, Carlos H G Sponton, Everardo M Carneiro, Guilherme D Telles, Mara P T Chacon-Mikahil, Cláudia R Cavaglieri, Luiz F Rezende, Antonio C Boscher. Interleukin-6 increases the expression and activity of insulin-degrading enzyme. Scientific reports. vol 7. 2019-07-22. PMID:28429777. |
il-6 ko mice displayed lower insulin clearance in the liver and skeletal muscle, compared with wild type (wt), due to reduced ide expression and activity. |
2019-07-22 |
2023-08-13 |
mouse |
| Valerie A Ivancic, Claire A Krasinski, Qiuchen Zheng, Rebecca J Meservier, Donald E Spratt, Noel D Laz. Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme. Bioscience reports. vol 38. issue 6. 2019-07-22. PMID:30305381. |
a major requirement is an understanding of how other molecules present in cells regulate the activity of the enzyme toward insulin, ide's most important physiologically relevant substrate. |
2019-07-22 |
2023-08-13 |
Not clear |
| Jean Franciesco Vettorazzi, Mirian Ayumi Kurauti, Gabriela Moreira Soares, Patricia Cristine Borck, Sandra Mara Ferreira, Renato Chaves Souto Branco, Luciana de Souza Lima Michelone, Antonio Carlos Boschero, Jose Maria Costa Junior, Everardo Magalhães Carneir. Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice. Scientific reports. vol 7. issue 1. 2019-07-17. PMID:29093479. |
the liver is the major site for insulin degradation, a process mainly coordinated by the insulin-degrading enzyme (ide). |
2019-07-17 |
2023-08-13 |
mouse |
| Jean Franciesco Vettorazzi, Mirian Ayumi Kurauti, Gabriela Moreira Soares, Patricia Cristine Borck, Sandra Mara Ferreira, Renato Chaves Souto Branco, Luciana de Souza Lima Michelone, Antonio Carlos Boschero, Jose Maria Costa Junior, Everardo Magalhães Carneir. Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice. Scientific reports. vol 7. issue 1. 2019-07-17. PMID:29093479. |
here, we demonstrated that 15 days treatment with tudca reestablished plasma insulin to physiological concentrations in high fat diet (hfd) mice, a phenomenon associated with increased insulin clearance and liver ide expression. |
2019-07-17 |
2023-08-13 |
mouse |
| Jean Franciesco Vettorazzi, Mirian Ayumi Kurauti, Gabriela Moreira Soares, Patricia Cristine Borck, Sandra Mara Ferreira, Renato Chaves Souto Branco, Luciana de Souza Lima Michelone, Antonio Carlos Boschero, Jose Maria Costa Junior, Everardo Magalhães Carneir. Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice. Scientific reports. vol 7. issue 1. 2019-07-17. PMID:29093479. |
these results indicate that treatment with tudca may be helpful to counteract obesity-induced hyperinsulinemia through increasing insulin clearance, likely through enhanced liver ide expression in a mechanism dependent on s1pr2-insulin pathway activation. |
2019-07-17 |
2023-08-13 |
mouse |
| Lazaros Stefanidis, Nicholas D Fusco, Samantha E Cooper, Jillian E Smith-Carpenter, Benjamin J Alpe. Molecular Determinants of Substrate Specificity in Human Insulin-Degrading Enzyme. Biochemistry. vol 57. issue 32. 2019-06-05. PMID:30004674. |
insulin-degrading enzyme (ide) is a 110 kda chambered zinc metalloendopeptidase that degrades insulin, amyloid β, and other intermediate-sized aggregation prone peptides that adopt β-structures. |
2019-06-05 |
2023-08-13 |
human |
| Lazaros Stefanidis, Nicholas D Fusco, Samantha E Cooper, Jillian E Smith-Carpenter, Benjamin J Alpe. Molecular Determinants of Substrate Specificity in Human Insulin-Degrading Enzyme. Biochemistry. vol 57. issue 32. 2019-06-05. PMID:30004674. |
here, we examine functional requirements for conserved hydrophobic and aromatic ide active site residues that are positioned within 4.5 Å of ide-bound insulin b chain and amyloid β peptides in the reported crystal structures for the respective enzyme-substrate complexes. |
2019-06-05 |
2023-08-13 |
human |
| Lazaros Stefanidis, Nicholas D Fusco, Samantha E Cooper, Jillian E Smith-Carpenter, Benjamin J Alpe. Molecular Determinants of Substrate Specificity in Human Insulin-Degrading Enzyme. Biochemistry. vol 57. issue 32. 2019-06-05. PMID:30004674. |
charge, size, hydrophobicity, aromaticity, and other functional group requirements for substrate binding ide active site residues were examined through mutational analysis of the recombinant human enzyme and enzyme kinetic studies conducted using native and fluorogenic derivatives of human insulin and amyloid β peptides. |
2019-06-05 |
2023-08-13 |
human |
| Lazaros Stefanidis, Nicholas D Fusco, Samantha E Cooper, Jillian E Smith-Carpenter, Benjamin J Alpe. Molecular Determinants of Substrate Specificity in Human Insulin-Degrading Enzyme. Biochemistry. vol 57. issue 32. 2019-06-05. PMID:30004674. |
ide mutant alleles that exhibited enhanced or diminished proteolytic activity toward insulin or amyloid β peptides and derivative substrates were identified. |
2019-06-05 |
2023-08-13 |
human |
| Zhening Zhang, Wenguang G Liang, Lucas J Bailey, Yong Zi Tan, Hui Wei, Andrew Wang, Mara Farcasanu, Virgil A Woods, Lauren A McCord, David Lee, Weifeng Shang, Rebecca Deprez-Poulain, Benoit Deprez, David R Liu, Akiko Koide, Shohei Koide, Anthony A Kossiakoff, Sheng Li, Bridget Carragher, Clinton S Potter, Wei-Jen Tan. Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. eLife. vol 7. 2019-06-03. PMID:29596046. |
insulin degrading enzyme (ide) plays key roles in degrading peptides vital in type two diabetes, alzheimer's, inflammation, and other human diseases. |
2019-06-03 |
2023-08-13 |
human |