| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alonso Sánchez-Cruz, María D Hernández-Fuentes, Cayetana Murillo-Gómez, Enrique J de la Rosa, Catalina Hernández-Sánche. Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa. Cells. vol 11. issue 10. 2022-05-28. PMID:35626658. |
insulin-degrading enzyme (ide) was named after its role as a proteolytic enzyme of insulin. |
2022-05-28 |
2023-08-13 |
mouse |
| Alessia Distefano, Gabriele Antonio Zingale, Giuseppe Grass. An SPR-based method for Hill coefficient measurements: the case of insulin-degrading enzyme. Analytical and bioanalytical chemistry. 2022-05-16. PMID:35577931. |
insulin-degrading enzyme (ide) is a highly conserved zinc metallopeptidase and is capable to catalytically cleave several substrates besides insulin, playing a pivotal role in several different biochemical pathways. |
2022-05-16 |
2023-08-13 |
Not clear |
| Alessia Distefano, Gabriele Antonio Zingale, Giuseppe Grass. An SPR-based method for Hill coefficient measurements: the case of insulin-degrading enzyme. Analytical and bioanalytical chemistry. 2022-05-16. PMID:35577931. |
in this scenario, we have developed a novel surface plasmon resonance (spr) method which allows for directly measuring the enzyme cooperativity for the binding of insulin in the presence of different ide activity modulators: carnosine, atp, and edta. |
2022-05-16 |
2023-08-13 |
Not clear |
| Laetitia Lesire, Florence Leroux, Rebecca Deprez-Poulain, Benoit Depre. Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer? Cells. vol 11. issue 7. 2022-04-12. PMID:35406791. |
known as the main enzyme responsible for the degradation of insulin, an essential growth factor for healthy cells and cancer cells, ide has also been shown to behave like a chaperone and interact with the proteasome. |
2022-04-12 |
2023-08-13 |
Not clear |
| Ofir Fursht, Mirit Liran, Yuval Nash, Vijay Krishna Medala, Dor Ini, Tabitha Grace Royal, Guy Goldsmith, Limor Nahary, Itai Benhar, Dan Frenke. Antibody-Mediated Inhibition of Insulin-Degrading Enzyme Improves Insulin Activity in a Diabetic Mouse Model. Frontiers in immunology. vol 13. 2022-03-30. PMID:35350789. |
small molecule inhibitors to insulin-degrading enzyme (ide) have been previously suggested as a potential treatment for diabetes through their ability to reduce insulin degradation and thus increase insulin activity. |
2022-03-30 |
2023-08-13 |
mouse |
| Ofir Fursht, Mirit Liran, Yuval Nash, Vijay Krishna Medala, Dor Ini, Tabitha Grace Royal, Guy Goldsmith, Limor Nahary, Itai Benhar, Dan Frenke. Antibody-Mediated Inhibition of Insulin-Degrading Enzyme Improves Insulin Activity in a Diabetic Mouse Model. Frontiers in immunology. vol 13. 2022-03-30. PMID:35350789. |
here, we describe the isolation of an ide-specific antibody that specifically inhibits insulin degradation by ide. |
2022-03-30 |
2023-08-13 |
mouse |
| Mariem Ghoula, Nathalie Janel, Anne-Claude Camproux, Gautier Moro. Exploring the Structural Rearrangements of the Human Insulin-Degrading Enzyme through Molecular Dynamics Simulations. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163673. |
insulin-degrading enzyme (ide) is a ubiquitously expressed metallopeptidase that degrades insulin and a large panel of amyloidogenic peptides. |
2022-02-15 |
2023-08-13 |
human |
| Nicolas Kraupner, Chau Phi Dinh, Xiaoan Wen, Valérie Landry, Adrien Herledan, Florence Leroux, Damien Bosc, Julie Charton, Clara Maillard, Sandrine Warenghem, Isabelle Duplan, Catherine Piveteau, Nathalie Hennuyer, Bart Staels, Benoit Deprez, Rebecca Deprez-Poulai. Identification of indole-based activators of insulin degrading enzyme. European journal of medicinal chemistry. 2021-11-24. PMID:34815130. |
insulin degrading enzyme (ide) is a zinc metalloprotease that cleaves numerous substrates among which amyloid-β and insulin. |
2021-11-24 |
2023-08-13 |
Not clear |
| Nicolas Kraupner, Chau Phi Dinh, Xiaoan Wen, Valérie Landry, Adrien Herledan, Florence Leroux, Damien Bosc, Julie Charton, Clara Maillard, Sandrine Warenghem, Isabelle Duplan, Catherine Piveteau, Nathalie Hennuyer, Bart Staels, Benoit Deprez, Rebecca Deprez-Poulai. Identification of indole-based activators of insulin degrading enzyme. European journal of medicinal chemistry. 2021-11-24. PMID:34815130. |
these indole-based pharmacological tools are activators of both aβ and insulin hydrolysis by ide and could be helpful to explore the multiple roles of ide. |
2021-11-24 |
2023-08-13 |
Not clear |
| Luís Sousa, Mariana Guarda, Maria João Meneses, M Paula Macedo, Hugo Vicente Mirand. Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases. The Journal of pathology. vol 255. issue 4. 2021-11-17. PMID:34396529. |
insulin-degrading enzyme (ide) function goes far beyond its known proteolytic role as a regulator of insulin levels. |
2021-11-17 |
2023-08-13 |
Not clear |
| Malcolm A Leissrin. Insulin-Degrading Enzyme: Paradoxes and Possibilities. Cells. vol 10. issue 9. 2021-11-15. PMID:34572094. |
for instance, where does ide, a predominantly cytosolic protein with no signal peptide or clearly identified secretion mechanism, interact with insulin and other extracellular substrates? |
2021-11-15 |
2023-08-13 |
Not clear |
| Ansab Akhtar, Mahendra Bishnoi, Sangeeta Pilkhwal Sa. Sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of Alzheimer's disease through modulation of brain insulin resistance induced tau pathology. Brain research bulletin. vol 164. 2021-10-29. PMID:32784004. |
estimation of oxidative stress, mitochondrial dysfunction as complex i, ii, iii, iv activity, cholinergic function as acetylcholinesterase activity, elisa for phosphorylated tau protein and insulin degrading enzyme (ide), neuroinflammation as nf-κb gene expression and insulin signaling functioning as q-rt-pcr for ir, irs-1, pi3k, akt, gsk-3β gene expression were performed. |
2021-10-29 |
2023-08-13 |
rat |
| Ansab Akhtar, Mahendra Bishnoi, Sangeeta Pilkhwal Sa. Sodium orthovanadate improves learning and memory in intracerebroventricular-streptozotocin rat model of Alzheimer's disease through modulation of brain insulin resistance induced tau pathology. Brain research bulletin. vol 164. 2021-10-29. PMID:32784004. |
however, the primary mechanism of sov remained attenuation of tau pathology by the upregulation of irs-1/pi3k/akt/gsk-3β pathway and reversal of insulin resistance in terms of ide. |
2021-10-29 |
2023-08-13 |
rat |
| Qiuchen Zheng, Micheal T Kebede, Bethany Lee, Claire A Krasinski, Saadman Islam, Liliana A Wurfl, Merc M Kemeh, Valerie A Ivancic, Charles E Jakobsche, Donald E Spratt, Noel D Laz. Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme. Antioxidants (Basel, Switzerland). vol 10. issue 9. 2021-10-01. PMID:34572974. |
the insulin-degrading enzyme (ide) possesses a strong ability to degrade insulin and aβ42 that has been linked to the neurodegeneration in alzheimer's disease (ad). |
2021-10-01 |
2023-08-13 |
Not clear |
| Qiuchen Zheng, Micheal T Kebede, Bethany Lee, Claire A Krasinski, Saadman Islam, Liliana A Wurfl, Merc M Kemeh, Valerie A Ivancic, Charles E Jakobsche, Donald E Spratt, Noel D Laz. Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme. Antioxidants (Basel, Switzerland). vol 10. issue 9. 2021-10-01. PMID:34572974. |
given this, an attractive ide-centric strategy for the development of therapeutics for ad is to boost ide's activity for the clearance of aβ42 without offsetting insulin proteostasis. |
2021-10-01 |
2023-08-13 |
Not clear |
| Qiuchen Zheng, Micheal T Kebede, Bethany Lee, Claire A Krasinski, Saadman Islam, Liliana A Wurfl, Merc M Kemeh, Valerie A Ivancic, Charles E Jakobsche, Donald E Spratt, Noel D Laz. Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme. Antioxidants (Basel, Switzerland). vol 10. issue 9. 2021-10-01. PMID:34572974. |
in this work, we used a combination of chromatographic and spectroscopic techniques to investigate the effects of resveratrol on ide's activity toward insulin. |
2021-10-01 |
2023-08-13 |
Not clear |
| Qiuchen Zheng, Micheal T Kebede, Bethany Lee, Claire A Krasinski, Saadman Islam, Liliana A Wurfl, Merc M Kemeh, Valerie A Ivancic, Charles E Jakobsche, Donald E Spratt, Noel D Laz. Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme. Antioxidants (Basel, Switzerland). vol 10. issue 9. 2021-10-01. PMID:34572974. |
our results show that the two polyphenols affect the ide-dependent degradation of insulin in different ways: egcg inhibits ide while resveratrol has no effect. |
2021-10-01 |
2023-08-13 |
Not clear |
| Miriam Ries, Helena Watts, Bibiana C Mota, Maria Yanez Lopez, Cornelius K Donat, Nicoleta Baxan, James A Pickering, Tsz Wing Chau, Annika Semmler, Brinda Gurung, Robertas Aleksynas, Laura Abelleira-Hervas, Soha Jamshed Iqbal, Carmen Romero-Molina, Gerard Hernandez-Mir, Antonio d'Amati, Chris Reutelingsperger, Marc H Goldfinger, Steve M Gentleman, Fred Van Leuven, Egle Solito, Magdalena Sastr. Annexin A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology. Brain : a journal of neurology. vol 144. issue 5. 2021-09-23. PMID:34148071. |
interestingly, the ameliorated blood-brain barrier permeability in young 5xfad mice by hranxa1 correlated with reduced brain amyloid-β load, due to increased clearance and degradation of amyloid-β by insulin degrading enzyme (ide). |
2021-09-23 |
2023-08-13 |
mouse |
| Dorota Wacławczyk, Jerzy Silberring, Giuseppe Grass. The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism. Journal of enzyme inhibition and medicinal chemistry. vol 36. issue 1. 2021-09-10. PMID:33401948. |
as ide is also responsible for the processing of many other peptides in the brain (amyloid beta protein among the others), we have also performed competitive degradation assays using mixtures of insulin and the above mentioned nps. |
2021-09-10 |
2023-08-13 |
Not clear |
| Dorota Wacławczyk, Jerzy Silberring, Giuseppe Grass. The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism. Journal of enzyme inhibition and medicinal chemistry. vol 36. issue 1. 2021-09-10. PMID:33401948. |
data show that insulin is able to slow down the degradation of both nps tested, whereas, surprisingly, npaf is able to accelerate insulin degradation, hinting ide as the possible link responsible of the mutual influence between insulin and nps metabolism. |
2021-09-10 |
2023-08-13 |
Not clear |