| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bikash R Sahoo, Pritam Kumar Panda, Wenguang Liang, Wei-Jen Tang, Rajeev Ahuja, Ayyalusamy Ramamoorth. Degradation of Alzheimer's Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme. Journal of molecular biology. vol 433. issue 13. 2021-08-30. PMID:33865867. |
the cysteine-free ide mutant (cf-e111q-ide) is catalytically inactive against insulin, but its effect on aβ degradation is unknown that would help in the allosteric modulation of the enzyme activity. |
2021-08-30 |
2023-08-13 |
Not clear |
| Zenghui Wei, Jagadish Koya, Sandra E Rezni. Insulin Resistance Exacerbates Alzheimer Disease via Multiple Mechanisms. Frontiers in neuroscience. vol 15. 2021-08-06. PMID:34349617. |
both insulin and amyloid β-protein are metabolized by insulin degrading enzyme (ide). |
2021-08-06 |
2023-08-13 |
Not clear |
| Chien-Ning Huang, Chau-Jong Wang, Chih-Li Lin, Hsin-Hua Li, An-Ting Yen, Chiung-Huei Pen. Abelmoschus esculentus subfractions attenuate Aβ and tau by regulating DPP-4 and insulin resistance signals. BMC complementary medicine and therapies. vol 20. issue 1. 2021-07-21. PMID:33267804. |
the neuropathological hallmarks of ad are beta amyloid (aβ) produced from sequential cleavage initiated by β-secretase and degraded by insulin degradation enzyme (ide), as well as hyperphosphorylation of tau (p-tau). |
2021-07-21 |
2023-08-13 |
Not clear |
| Y Sofer, Y Nash, E Osher, O Fursht, G Goldsmith, L Nahary, S Shaklai, K M Tordjman, M Serebro, E B Touati, M Yacobi Bach, Y Marcus, B Tal, J Sack, G Shefer, M Margaliot, N Landis, I Goldiner, W Abu Ahmad, N Stern, I Benhar, D Frenke. Insulin-degrading enzyme higher in subjects with metabolic syndrome. Endocrine. vol 71. issue 2. 2021-07-08. PMID:33398768. |
insulin-degrading enzyme (ide) is one of the mechanisms through which insulin blood levels are maintained. |
2021-07-08 |
2023-08-13 |
human |
| Y Sofer, Y Nash, E Osher, O Fursht, G Goldsmith, L Nahary, S Shaklai, K M Tordjman, M Serebro, E B Touati, M Yacobi Bach, Y Marcus, B Tal, J Sack, G Shefer, M Margaliot, N Landis, I Goldiner, W Abu Ahmad, N Stern, I Benhar, D Frenke. Insulin-degrading enzyme higher in subjects with metabolic syndrome. Endocrine. vol 71. issue 2. 2021-07-08. PMID:33398768. |
using a highly sensitive elisa assay of active ide in human serum, we found a strong correlation between circulating ide levels and circulating levels of triglycerides, insulin, and c-peptide and an inverse correlation with hdl cholesterol (hdlc). |
2021-07-08 |
2023-08-13 |
human |
| Y Sofer, Y Nash, E Osher, O Fursht, G Goldsmith, L Nahary, S Shaklai, K M Tordjman, M Serebro, E B Touati, M Yacobi Bach, Y Marcus, B Tal, J Sack, G Shefer, M Margaliot, N Landis, I Goldiner, W Abu Ahmad, N Stern, I Benhar, D Frenke. Insulin-degrading enzyme higher in subjects with metabolic syndrome. Endocrine. vol 71. issue 2. 2021-07-08. PMID:33398768. |
hence, circulating ide may serve as a tool to identify subjects with abnormal insulin metabolism, possibly those with ms that are at risk to develop diabetes. |
2021-07-08 |
2023-08-13 |
human |
| Andrew P Demidowich, Jordan A Levine, Sheila M Brady, Cheryl D Johnson, Steven J Soldin, Jack A Yanovsk. Bacitracin attenuates haemolysis-induced insulin degradation during insulin sensitivity testing: Repurposing an old drug for use in metabolic research. Diabetes, obesity & metabolism. vol 22. issue 8. 2021-06-24. PMID:32227616. |
haemolysis of serially collected insulin serum samples frequently causes falsely-low measured concentrations because of the release of intracellular insulin degrading enzyme (ide). |
2021-06-24 |
2023-08-13 |
Not clear |
| Andrew P Demidowich, Jordan A Levine, Sheila M Brady, Cheryl D Johnson, Steven J Soldin, Jack A Yanovsk. Bacitracin attenuates haemolysis-induced insulin degradation during insulin sensitivity testing: Repurposing an old drug for use in metabolic research. Diabetes, obesity & metabolism. vol 22. issue 8. 2021-06-24. PMID:32227616. |
we investigated if bacitracin, an in vitro ide inhibitor, could prevent haemolysis-induced insulin degradation during insulin sensitivity testing. |
2021-06-24 |
2023-08-13 |
Not clear |
| Yudai Nonaka, Reo Takeda, Yutaka Kano, Daisuke Hoshin. Short-Term Calorie Restriction Maintains Plasma Insulin Concentrations along with a Reduction in Hepatic Insulin-Degrading Enzyme Levels in db/db Mice. Nutrients. vol 13. issue 4. 2021-06-04. PMID:33916828. |
cr significantly reduced insulin-degrading enzyme (ide) levels in the liver, and hepatic ide levels were significantly positively and negatively correlated with plasma glucose concentrations (area under the curve) after glucose administration and after fasting insulin concentrations, respectively. |
2021-06-04 |
2023-08-13 |
mouse |
| Yudai Nonaka, Reo Takeda, Yutaka Kano, Daisuke Hoshin. Short-Term Calorie Restriction Maintains Plasma Insulin Concentrations along with a Reduction in Hepatic Insulin-Degrading Enzyme Levels in db/db Mice. Nutrients. vol 13. issue 4. 2021-06-04. PMID:33916828. |
therefore, 3-week cr maintained blood insulin levels and improved glucose tolerance with decreased hepatic ide levels in an animal model of late-stage diabetes. |
2021-06-04 |
2023-08-13 |
mouse |
| Dmytro O Minchenko, Olena O Khita, Dariia O Tsymbal, Serhij V Danilovskyi, Olha V Rudnytska, Oleh V Halkin, Iryna V Kryvdiuk, Maria V Smeshkova, Mykhailo M Yakymchuk, Borys H Bezrodnyi, Oleksandr H Minchenk. Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation. Endocrine regulations. vol 54. issue 3. 2021-05-31. PMID:32857715. |
the aim of the present investigation was to study the expression of genes encoding polyfunctional proteins insulinase (insulin degrading enzyme, ide) and pitrilysin metallopeptidase 1 (pitrm1) in u87 glioma cells in response to inhibition of endoplasmic reticulum stress signaling mediated by ern1/ire1 (endoplasmic reticulum to nucleus signaling 1) for evaluation of their possible significance in the control of metabolism through ern1 signaling as well as hypoxia, glucose and glutamine deprivations. |
2021-05-31 |
2023-08-13 |
Not clear |
| Carlos M González-Casimiro, Beatriz Merino, Elena Casanueva-Álvarez, Tamara Postigo-Casado, Patricia Cámara-Torres, Cristina M Fernández-Díaz, Malcolm A Leissring, Irene Cózar-Castellano, Germán Perdom. Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme. Biomedicines. vol 9. issue 1. 2021-02-18. PMID:33477364. |
insulin-degrading enzyme (ide) is a highly conserved and ubiquitously expressed metalloprotease that degrades insulin and several other intermediate-size peptides. |
2021-02-18 |
2023-08-13 |
mouse |
| Carlos M González-Casimiro, Beatriz Merino, Elena Casanueva-Álvarez, Tamara Postigo-Casado, Patricia Cámara-Torres, Cristina M Fernández-Díaz, Malcolm A Leissring, Irene Cózar-Castellano, Germán Perdom. Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme. Biomedicines. vol 9. issue 1. 2021-02-18. PMID:33477364. |
for many decades, ide had been assumed to be involved primarily in hepatic insulin clearance, a key process that regulates availability of circulating insulin levels for peripheral tissues. |
2021-02-18 |
2023-08-13 |
mouse |
| Carlos M González-Casimiro, Beatriz Merino, Elena Casanueva-Álvarez, Tamara Postigo-Casado, Patricia Cámara-Torres, Cristina M Fernández-Díaz, Malcolm A Leissring, Irene Cózar-Castellano, Germán Perdom. Modulation of Insulin Sensitivity by Insulin-Degrading Enzyme. Biomedicines. vol 9. issue 1. 2021-02-18. PMID:33477364. |
emerging evidence, however, suggests that ide has several other important physiological functions relevant to glucose and insulin homeostasis, including the regulation of insulin secretion from pancreatic β-cells. |
2021-02-18 |
2023-08-13 |
mouse |
| Muhammad Imran Khan, Jin Hyuk Shin, Min Yong Kim, Tai Sun Shin, Jong Deog Ki. Green Tea Seed Isolated Theasaponin E1 Ameliorates AD Promoting Neurotoxic Pathogenesis by Attenuating Aβ Peptide Levels in SweAPP N2a Cells. Molecules (Basel, Switzerland). vol 25. issue 10. 2021-02-12. PMID:32429462. |
additionally, theasaponin e1 effects on aβ degrading and clearing proteins neprilysin and insulin degrading enzyme (ide). |
2021-02-12 |
2023-08-13 |
mouse |
| Salina Louie, Jayanthi Lakkyreddy, Brian M Castellano, Benjamin Haley, Anh Nguyen Dang, Cynthia Lam, Danming Tang, Steven Lang, Brad Snedecor, Shahram Misagh. Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture media. Journal of biotechnology. vol 320. 2021-02-08. PMID:32526262. |
insulin degrading enzyme (ide) expressed by chinese hamster ovary (cho) cells is responsible for degradation of insulin in culture media. |
2021-02-08 |
2023-08-13 |
Not clear |
| Salina Louie, Jayanthi Lakkyreddy, Brian M Castellano, Benjamin Haley, Anh Nguyen Dang, Cynthia Lam, Danming Tang, Steven Lang, Brad Snedecor, Shahram Misagh. Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture media. Journal of biotechnology. vol 320. 2021-02-08. PMID:32526262. |
here we report that insulin is degraded in the culture media over time mainly due to the activity of the insulin degrading enzyme (ide). |
2021-02-08 |
2023-08-13 |
Not clear |
| Salina Louie, Jayanthi Lakkyreddy, Brian M Castellano, Benjamin Haley, Anh Nguyen Dang, Cynthia Lam, Danming Tang, Steven Lang, Brad Snedecor, Shahram Misagh. Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture media. Journal of biotechnology. vol 320. 2021-02-08. PMID:32526262. |
insulin degradation was faster in cell lines that released more ide, which negatively impacted cell growth and in turn, production titers. |
2021-02-08 |
2023-08-13 |
Not clear |
| Salina Louie, Jayanthi Lakkyreddy, Brian M Castellano, Benjamin Haley, Anh Nguyen Dang, Cynthia Lam, Danming Tang, Steven Lang, Brad Snedecor, Shahram Misagh. Insulin degrading enzyme (IDE) expressed by Chinese hamster ovary (CHO) cells is responsible for degradation of insulin in culture media. Journal of biotechnology. vol 320. 2021-02-08. PMID:32526262. |
deletion of the ide gene in a representative cho cell line nearly abolished insulin degradation in seed train and end-of-production media. |
2021-02-08 |
2023-08-13 |
Not clear |
| Xiao-Qi Liu, Ya-Xiang Deng, Zhao Dai, Tian Hu, Wei-Wu Cai, Hao-Fei Liu, Han Li, Wen-Li Zhu, Ben-Yue Li, Qi Wang, Shi-Jie Zhan. Sodium tanshinone IIA sulfonate protects against Aβ International journal of biological macromolecules. vol 151. 2021-02-04. PMID:32035959. |
in addition, the levels of insulin degrading enzymes (ide) and nepterrilysin (nep) (or call it cd10) were significantly increased after sts treatment. |
2021-02-04 |
2023-08-13 |
mouse |