| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhening Zhang, Wenguang G Liang, Lucas J Bailey, Yong Zi Tan, Hui Wei, Andrew Wang, Mara Farcasanu, Virgil A Woods, Lauren A McCord, David Lee, Weifeng Shang, Rebecca Deprez-Poulain, Benoit Deprez, David R Liu, Akiko Koide, Shohei Koide, Anthony A Kossiakoff, Sheng Li, Bridget Carragher, Clinton S Potter, Wei-Jen Tan. Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. eLife. vol 7. 2019-06-03. PMID:29596046. |
furthermore, our insulin-bound ide structures explain how ide processively degrades insulin by stochastically cutting either chain without breaking disulfide bonds. |
2019-06-03 |
2023-08-13 |
human |
| Biswanath Dinda, Manikarna Dinda, Goutam Kulsi, Ankita Chakraborty, Subhajit Dind. Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review. European journal of medicinal chemistry. vol 169. 2019-05-28. PMID:30877973. |
these plant metabolites have been shown to ameliorate ad by increasing the expression of insulin degrading enzyme (ide), neprilysin (nep), ppar-γ, and α-secretase, and decreasing the expression of β-secretase (bace-1) to reduce the levels of aβ oligomers (aβ |
2019-05-28 |
2023-08-13 |
Not clear |
| Pablo Villa-Pérez, Beatriz Merino, Cristina M Fernández-Díaz, Pilar Cidad, Carmen D Lobatón, Alfredo Moreno, Harrison T Muturi, Hilda E Ghadieh, Sonia M Najjar, Malcolm A Leissring, Irene Cózar-Castellano, Germán Perdom. Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice. Metabolism: clinical and experimental. vol 88. 2019-05-08. PMID:30098324. |
the role of insulin-degrading enzyme (ide), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood. |
2019-05-08 |
2023-08-13 |
mouse |
| Melissa J Alldred, Helen M Chao, Sang Han Lee, Judah Beilin, Brian E Powers, Eva Petkova, Barbara J Strupp, Stephen D Ginsber. CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation. Hippocampus. vol 28. issue 4. 2019-04-15. PMID:29394516. |
specifically, normalized expression levels were found for endothelin converting enzyme-2 (ece2), insulin degrading enzyme (ide), dyrk1a, and calcium/calmodulin-dependent protein kinase ii (camk2a), among other relevant genes. |
2019-04-15 |
2023-08-13 |
mouse |
| Qing-Hua Yang, Ling Guo, Qing Chen, Kai-Hui Wu, Yan-Jun Wu, Yan Jia, Shu-Juan Zhu, Cheng-Lin Tang, Hua-Jun Shen. [Kidney-reinforcing and Governor Vessel-regulating EA Intervention May Improve Learningmemory Possibly by Suppressing Formation of Senile Plaques in Hippocampus in APP/PS 1 Double Transgenic Alzheimer's Disease Mice]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 4. 2019-04-03. PMID:29888573. |
to observe the effect of electroacupuncture (ea) intervention on learning-memory ability and the expression of senile plaques (sp), amyloid precursor protein (app), β-secretase 1(bace 1) and insulin degrading enzyme (ide) in the hippocampus in app/presenilin 1 (ps 1) double transgenic alzheimer's disease (ad) mice, so as to reveal its mechanisms underlying improvement of ad. |
2019-04-03 |
2023-08-13 |
mouse |
| Naoki Yamamoto, Ryo Ishikuro, Mamoru Tanida, Kenji Suzuki, Yuri Ikeda-Matsuo, Kazuya Sobu. Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes. Neuroscience. vol 385. 2019-02-21. PMID:29932983. |
here, we investigated whether insulin regulates the degradation of aβ by inducing expression of nep and ide in cultured astrocytes. |
2019-02-21 |
2023-08-13 |
Not clear |
| Naoki Yamamoto, Ryo Ishikuro, Mamoru Tanida, Kenji Suzuki, Yuri Ikeda-Matsuo, Kazuya Sobu. Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes. Neuroscience. vol 385. 2019-02-21. PMID:29932983. |
treatment of astrocytes with insulin significantly reduced cellular nep levels, but increased ide expression. |
2019-02-21 |
2023-08-13 |
Not clear |
| Naoki Yamamoto, Ryo Ishikuro, Mamoru Tanida, Kenji Suzuki, Yuri Ikeda-Matsuo, Kazuya Sobu. Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes. Neuroscience. vol 385. 2019-02-21. PMID:29932983. |
the effects of insulin on the expression of nep and ide involved activation of an extracellular signal-regulated kinase (erk)-mediated pathway. |
2019-02-21 |
2023-08-13 |
Not clear |
| Naoki Yamamoto, Ryo Ishikuro, Mamoru Tanida, Kenji Suzuki, Yuri Ikeda-Matsuo, Kazuya Sobu. Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes. Neuroscience. vol 385. 2019-02-21. PMID:29932983. |
these results suggest that insulin exposure enhanced aβ degradation via an increase in nep secretion and ide expression in astrocytes, via activation of the erk-mediated pathway. |
2019-02-21 |
2023-08-13 |
Not clear |
| Naoki Yamamoto, Ryo Ishikuro, Mamoru Tanida, Kenji Suzuki, Yuri Ikeda-Matsuo, Kazuya Sobu. Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes. Neuroscience. vol 385. 2019-02-21. PMID:29932983. |
the inhibition of insulin signaling pathways delayed aβ degradation by attenuating alterations in nep and ide levels and competition with insulin and aβ. |
2019-02-21 |
2023-08-13 |
Not clear |
| Kenta Arai, Toshiki Takei, Masaki Okumura, Satoshi Watanabe, Yuta Amagai, Yuya Asahina, Luis Moroder, Hironobu Hojo, Kenji Inaba, Michio Iwaok. Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue. Angewandte Chemie (International ed. in English). vol 56. issue 20. 2019-02-04. PMID:28394477. |
the replacement of the interchain disulfide with a diselenide bridge, which is more resistant to reduction and internal bond rotation, can enhance the lifetime of insulin in the presence of the insulin-degrading enzyme (ide) without impairing the hormonal function. |
2019-02-04 |
2023-08-13 |
Not clear |
| Cristina M Fernández-Díaz, Luis Escobar-Curbelo, J F López-Acosta, Carmen D Lobatón, Alfredo Moreno, Julián Sanz-Ortega, Germán Perdomo, Irene Cózar-Castellan. Insulin degrading enzyme is up-regulated in pancreatic β cells by insulin treatment. Histology and histopathology. vol 33. issue 11. 2019-01-28. PMID:29726577. |
insulin degrading enzyme (ide) is an endopeptidase that degrades insulin and glucagon. |
2019-01-28 |
2023-08-13 |
mouse |
| Cristina M Fernández-Díaz, Luis Escobar-Curbelo, J F López-Acosta, Carmen D Lobatón, Alfredo Moreno, Julián Sanz-Ortega, Germán Perdomo, Irene Cózar-Castellan. Insulin degrading enzyme is up-regulated in pancreatic β cells by insulin treatment. Histology and histopathology. vol 33. issue 11. 2019-01-28. PMID:29726577. |
to contribute in the understanding of ide's role in glucose metabolism, we analyzed ide protein level in pancreatic islets from two hyperinsulinemic mouse models, db/db and high-fat diet (hfd) mice, as well as in human islets from dm2 patients treated with oral hypoglycemic agents (ohas) or insulin. |
2019-01-28 |
2023-08-13 |
mouse |
| Cristina M Fernández-Díaz, Luis Escobar-Curbelo, J F López-Acosta, Carmen D Lobatón, Alfredo Moreno, Julián Sanz-Ortega, Germán Perdomo, Irene Cózar-Castellan. Insulin degrading enzyme is up-regulated in pancreatic β cells by insulin treatment. Histology and histopathology. vol 33. issue 11. 2019-01-28. PMID:29726577. |
ins1e cells, rat and human islets were treated with insulin and ide protein level was studied. |
2019-01-28 |
2023-08-13 |
mouse |
| Cristina M Fernández-Díaz, Luis Escobar-Curbelo, J F López-Acosta, Carmen D Lobatón, Alfredo Moreno, Julián Sanz-Ortega, Germán Perdomo, Irene Cózar-Castellan. Insulin degrading enzyme is up-regulated in pancreatic β cells by insulin treatment. Histology and histopathology. vol 33. issue 11. 2019-01-28. PMID:29726577. |
meanwhile, islets from insulin-treated dm2 patients showed augmented ide protein level compared to ohas patients, pointing to an upregulation of ide protein level stimulated by insulin. |
2019-01-28 |
2023-08-13 |
mouse |
| Cristina M Fernández-Díaz, Luis Escobar-Curbelo, J F López-Acosta, Carmen D Lobatón, Alfredo Moreno, Julián Sanz-Ortega, Germán Perdomo, Irene Cózar-Castellan. Insulin degrading enzyme is up-regulated in pancreatic β cells by insulin treatment. Histology and histopathology. vol 33. issue 11. 2019-01-28. PMID:29726577. |
furthermore, insulin stimulates ide protein level in pancreatic beta-cells. |
2019-01-28 |
2023-08-13 |
mouse |
| Eun Suk Song, David W Rodgers, Louis B Hers. Insulin-degrading enzyme is not secreted from cultured cells. Scientific reports. vol 8. issue 1. 2018-12-14. PMID:29402917. |
reports suggest that ide secreted by an unconventional pathway participates in extracellular hydrolysis of insulin and aβ. |
2018-12-14 |
2023-08-13 |
Not clear |
| Inci Kazkayasi, Nihan Burul-Bozkurt, Muhammad-Al-Mustafa Ismail, Paula Merino-Serrais, Can Pekiner, Angel Cedazo-Minguez, Serdar Um. Insulin deprivation decreases insulin degrading enzyme levels in primary cultured cortical neurons and in the cerebral cortex of rats with streptozotocin-induced diabetes. Pharmacological reports : PR. vol 70. issue 4. 2018-11-19. PMID:29940507. |
among several factors, insulin degrading enzyme (ide), which plays roles in the degradation of both insulin and amyloid β (aβ), has gained interest as a potential target in efforts to solve this puzzle. |
2018-11-19 |
2023-08-13 |
rat |
| Inci Kazkayasi, Nihan Burul-Bozkurt, Muhammad-Al-Mustafa Ismail, Paula Merino-Serrais, Can Pekiner, Angel Cedazo-Minguez, Serdar Um. Insulin deprivation decreases insulin degrading enzyme levels in primary cultured cortical neurons and in the cerebral cortex of rats with streptozotocin-induced diabetes. Pharmacological reports : PR. vol 70. issue 4. 2018-11-19. PMID:29940507. |
this study sought to examine the effects of varying insulin and/or glucose concentrations on ide expression. |
2018-11-19 |
2023-08-13 |
rat |
| Fengmin Li, Jian Yang, Van Anthony M Villar, Laureano D Asico, Xiaobo Ma, Ines Armando, Hironobu Sanada, Minoru Yoneda, Robin A Felder, Pedro A Jose, Xiaoyan Wan. Loss of renal SNX5 results in impaired IDE activity and insulin resistance in mice. Diabetologia. vol 61. issue 3. 2018-11-05. PMID:29080975. |
loss of renal snx5 results in impaired ide activity and insulin resistance in mice. |
2018-11-05 |
2023-08-13 |
human |