| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| María Del Carmen Camberos, Adriana A Pérez, Gisel A Passicot, Lucía C Martucci, María I Wanderley, Daniel P Udrisar, Juan C Crest. II - Insulin processing in mitochondria. Journal of bioenergetics and biomembranes. vol 48. issue 5. 2017-04-10. PMID:27796771. |
our objective was to know how insulin is processing in mitochondria; if ide is the only participant in mitochondrial insulin degradation and the role of insulin degradation on ide accumulation in mitoplasts. |
2017-04-10 |
2023-08-13 |
human |
| María Del Carmen Camberos, Adriana A Pérez, Gisel A Passicot, Lucía C Martucci, María I Wanderley, Daniel P Udrisar, Juan C Crest. II - Insulin processing in mitochondria. Journal of bioenergetics and biomembranes. vol 48. issue 5. 2017-04-10. PMID:27796771. |
mitochondrial incubation with insulin increased ide in matrix as observed in immunoblot. |
2017-04-10 |
2023-08-13 |
human |
| María Del Carmen Camberos, Adriana A Pérez, Gisel A Passicot, Lucía C Martucci, María I Wanderley, Daniel P Udrisar, Juan C Crest. II - Insulin processing in mitochondria. Journal of bioenergetics and biomembranes. vol 48. issue 5. 2017-04-10. PMID:27796771. |
mitochondrial incubation with insulin increased ide in matrix. |
2017-04-10 |
2023-08-13 |
human |
| Nadia Neyazi, Taiebeh Mohammadi Farsani, Zahra Nouri, Mohammad Hossein Ghahremani, Mohammad Reza Khorramizadeh, Roksana Tajerian, Elahe Motevasel. Potential efficacy of Lactobacillus casei IBRC_M10711 on expression and activity of insulin degrading enzyme but not insulin degradation. In vitro cellular & developmental biology. Animal. vol 53. issue 1. 2017-03-06. PMID:27573410. |
insulin-degrading enzyme (ide) is responsible for insulin breakdown in various tissues and is known as a potential drug target for t2d. |
2017-03-06 |
2023-08-13 |
Not clear |
| Nadia Neyazi, Taiebeh Mohammadi Farsani, Zahra Nouri, Mohammad Hossein Ghahremani, Mohammad Reza Khorramizadeh, Roksana Tajerian, Elahe Motevasel. Potential efficacy of Lactobacillus casei IBRC_M10711 on expression and activity of insulin degrading enzyme but not insulin degradation. In vitro cellular & developmental biology. Animal. vol 53. issue 1. 2017-03-06. PMID:27573410. |
here, we assessed the effects of cell-free supernatant (cfs) and uv-killed lactobacillus casei ibrc_m10711 on ide expression, ide activity, and insulin degradation in caco-2 cell line. |
2017-03-06 |
2023-08-13 |
Not clear |
| Nadia Neyazi, Taiebeh Mohammadi Farsani, Zahra Nouri, Mohammad Hossein Ghahremani, Mohammad Reza Khorramizadeh, Roksana Tajerian, Elahe Motevasel. Potential efficacy of Lactobacillus casei IBRC_M10711 on expression and activity of insulin degrading enzyme but not insulin degradation. In vitro cellular & developmental biology. Animal. vol 53. issue 1. 2017-03-06. PMID:27573410. |
in conclusion, l. casei ibrc_m10711 is effective on ide expression and its activity, but not on insulin degradation. |
2017-03-06 |
2023-08-13 |
Not clear |
| Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Al. Vitamin D3 intake as regulator of insulin degrading enzyme and insulin receptor phosphorylation in diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 85. 2017-02-22. PMID:27930980. |
insulin-degrading enzyme (ide, insulysin) is a rate-limiting enzyme in the insulin degradation process. |
2017-02-22 |
2023-08-13 |
rat |
| Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Al. Vitamin D3 intake as regulator of insulin degrading enzyme and insulin receptor phosphorylation in diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 85. 2017-02-22. PMID:27930980. |
ide catalyzes degradation of several small proteins including insulin, amylin and β-amyloid protein. |
2017-02-22 |
2023-08-13 |
rat |
| Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Al. Vitamin D3 intake as regulator of insulin degrading enzyme and insulin receptor phosphorylation in diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 85. 2017-02-22. PMID:27930980. |
vitamin d alleviated also insulin resistance, where both ide, glucagon levels showed significant decrease along with activation of insulin receptor phosphorylation. |
2017-02-22 |
2023-08-13 |
rat |
| Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Al. Vitamin D3 intake as regulator of insulin degrading enzyme and insulin receptor phosphorylation in diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 85. 2017-02-22. PMID:27930980. |
we concluded that vitamin d3 ameliorated insulin resistance and hyperinsulinemia in diabetic rat model received hfw through reduction of ide and activation of insulin receptor phosphorylation. |
2017-02-22 |
2023-08-13 |
rat |
| Melissa A Schillin. Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease1. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26967215. |
for example, some studies have concluded that insulin deficiency is primarily at fault, suggesting that intranasal insulin or inhibiting the insulin-degrading enzyme (ide) could be beneficial. |
2016-12-29 |
2023-08-13 |
Not clear |
| Melissa A Schillin. Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease1. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26967215. |
other research has concluded that hyperinsulinemia is to blame, which implies that intranasal insulin or the inhibition of ide would exacerbate the disease. |
2016-12-29 |
2023-08-13 |
Not clear |
| Melissa A Schillin. Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease1. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26967215. |
this integration suggests that there is an important relationship between insulin, ide, and ad that yields multiple pathways to ad depending on the where deficiency or excess in the cycle occurs. |
2016-12-29 |
2023-08-13 |
Not clear |
| Melissa A Schillin. Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease1. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26967215. |
the results suggest that avoiding excess insulin, and supporting robust ide levels, could be important ways of preventing and lessening the impact of ad. |
2016-12-29 |
2023-08-13 |
Not clear |
| Wei-Jen Tan. Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus. Trends in endocrinology and metabolism: TEM. vol 27. issue 1. 2016-09-30. PMID:26651592. |
insulin-degrading enzyme (ide) selectively degrades peptides, such as insulin, amylin, and amyloid β (aβ) that form toxic aggregates, to maintain proteostasis. |
2016-09-30 |
2023-08-13 |
human |
| Sung Min Son, Seokjo Kang, Heesun Choi, Inhee Mook-Jun. Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway. Molecular neurodegeneration. vol 10. 2016-08-24. PMID:26520569. |
insulin degrading enzyme (ide) is a major protease of amyloid beta peptide (aβ), a prominent toxic protein in alzheimer's disease (ad) pathogenesis. |
2016-08-24 |
2023-08-13 |
Not clear |
| Sherilyn Thibeau, G Peggy McFall, Sandra A Wiebe, Kaarin J Anstey, Roger A Dixo. Genetic factors moderate everyday physical activity effects on executive functions in aging: Evidence from the Victoria Longitudinal Study. Neuropsychology. vol 30. issue 1. 2016-08-15. PMID:26710092. |
we tested independent and interactive effects of brain-derived neurotrophic factor (bdnf rs6265) and insulin degrading enzyme (ide rs6583817) on ef and epa-ef relationships. |
2016-08-15 |
2023-08-13 |
Not clear |
| Golnaz Bahramali, Bahram Goliaei, Zarrin Minuchehr, Ali Salar. Chameleon sequences in neurodegenerative diseases. Biochemical and biophysical research communications. vol 472. issue 1. 2016-08-08. PMID:26920059. |
we also found that there are proteins such as insulin degrading enzyme ide and gtp-binding nuclear protein ran (ran) with the most number of chameleons (640 and 405 respectively). |
2016-08-08 |
2023-08-13 |
Not clear |
| Niraj Kumar Jha, Saurabh Kumar Jha, Dhiraj Kumar, Noopur Kejriwal, Renu Sharma, Rashmi K Ambasta, Pravir Kuma. Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications. Journal of Alzheimer's disease : JAD. vol 48. issue 4. 2016-08-03. PMID:26444774. |
this purpose is expertly fulfilled by the potential role of aβ degrading enzymes such as insulin degrading enzyme (ide) and neprilysin (nep). |
2016-08-03 |
2023-08-13 |
Not clear |
| Rebecca Deprez-Poulain, Nathalie Hennuyer, Damien Bosc, Wenguang G Liang, Emmanuelle Enée, Xavier Marechal, Julie Charton, Jane Totobenazara, Gonzague Berte, Jouda Jahklal, Tristan Verdelet, Julie Dumont, Sandrine Dassonneville, Eloise Woitrain, Marion Gauriot, Charlotte Paquet, Isabelle Duplan, Paul Hermant, François-Xavier Cantrelle, Emmanuel Sevin, Maxime Culot, Valerie Landry, Adrien Herledan, Catherine Piveteau, Guy Lippens, Florence Leroux, Wei-Jen Tang, Peter van Endert, Bart Staels, Benoit Depre. Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nature communications. vol 6. 2016-05-24. PMID:26394692. |
insulin-degrading enzyme (ide) is a protease that cleaves insulin and other bioactive peptides such as amyloid-β. |
2016-05-24 |
2023-08-13 |
mouse |