| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janet Fawcett, Hairong Sang, Paska A Permana, Jennifer L Levy, William C Duckwort. Insulin metabolism in human adipocytes from subcutaneous and visceral depots. Biochemical and biophysical research communications. vol 402. issue 4. 2011-01-13. PMID:21036154. |
the majority of the clearance of insulin is due to the action of insulin-degrading enzyme (ide) and ide is present throughout all tissues. |
2011-01-13 |
2023-08-12 |
human |
| Janet Fawcett, Hairong Sang, Paska A Permana, Jennifer L Levy, William C Duckwort. Insulin metabolism in human adipocytes from subcutaneous and visceral depots. Biochemical and biophysical research communications. vol 402. issue 4. 2011-01-13. PMID:21036154. |
inhibitors of cathepsins b and d has no effect on the degradation of insulin, while bacitracin, an inhibitor of ide, inhibited degradation by approx. |
2011-01-13 |
2023-08-12 |
human |
| Janet Fawcett, Hairong Sang, Paska A Permana, Jennifer L Levy, William C Duckwort. Insulin metabolism in human adipocytes from subcutaneous and visceral depots. Biochemical and biophysical research communications. vol 402. issue 4. 2011-01-13. PMID:21036154. |
these data show that insulin metabolism is relatively greater in vis than in sq fat tissue and potentially due to ide. |
2011-01-13 |
2023-08-12 |
human |
| Eun Suk Song, David W Rodgers, Louis B Hers. A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties. PloS one. vol 5. issue 3. 2011-01-11. PMID:20300529. |
a monomeric variant of insulin degrading enzyme (ide) loses its regulatory properties. |
2011-01-11 |
2023-08-12 |
human |
| Eun Suk Song, David W Rodgers, Louis B Hers. A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties. PloS one. vol 5. issue 3. 2011-01-11. PMID:20300529. |
insulin degrading enzyme (ide) is a key enzyme in the metabolism of both insulin and amyloid beta peptides. |
2011-01-11 |
2023-08-12 |
human |
| Verónica Berta Dorfman, Laura Pasquini, Miguel Riudavets, Juan José López-Costa, Andrés Villegas, Juan Carlos Troncoso, Francisco Lopera, Eduardo Miguel Castaño, Laura Morell. Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease. Neurobiology of aging. vol 31. issue 10. 2010-12-23. PMID:19019493. |
evidences suggest that deficits in the brain expression of insulin degrading enzyme (ide) and neprilysin (nep), both proteases involved in amyloid degradation, may promote a beta deposition in sad. |
2010-12-23 |
2023-08-12 |
Not clear |
| Ram Prasad Bora, Arghya Barman, Xiaoxia Zhu, Mehmet Ozbil, Rajeev Prabhaka. Which one among aspartyl protease, metallopeptidase, and artificial metallopeptidase is the most efficient catalyst in peptide hydrolysis? The journal of physical chemistry. B. vol 114. issue 33. 2010-12-01. PMID:20669962. |
in this comparative dft study, the hydrolysis of a peptide bond (phe1-phe2) by the following three types of catalysts has been studied: (1) beta-secretase (bace2), (2) matrix metalloproteinase (mmp) and insulin degrading enzyme (ide), and (3) [pd(h(2)o)(4)](2+) (i(mpc)) and [pd(2)(mu-oh)([18]anen(6))](3+) (i(dpc)). |
2010-12-01 |
2023-08-12 |
Not clear |
| Erica Buoso, Cristina Lanni, Gennaro Schettini, Stefano Govoni, Marco Racch. beta-Amyloid precursor protein metabolism: focus on the functions and degradation of its intracellular domain. Pharmacological research. vol 62. issue 4. 2010-11-29. PMID:20561999. |
we critically reviewed literature concerning physiological function of this proteolitic fragment, mainly focusing on their degradation by the two best characterized systems, proteasome and ide (insulin degrading enzyme). |
2010-11-29 |
2023-08-12 |
Not clear |
| María Celeste Leal, Agata Fernandez Gamba, Laura Morelli, Eduardo M Castañ. [Cerebral proteolysis of amiloid-b peptide: relevance of insulin-degrading enzyme in Alzheimer's disease]. Medicina. vol 69. issue 4. 2010-10-12. PMID:19770104. |
biochemical and genetic data have shown that insulin-degrading enzyme (ide) participates in ab and insulin homeostasis. |
2010-10-12 |
2023-08-12 |
Not clear |
| María Celeste Leal, Agata Fernandez Gamba, Laura Morelli, Eduardo M Castañ. [Cerebral proteolysis of amiloid-b peptide: relevance of insulin-degrading enzyme in Alzheimer's disease]. Medicina. vol 69. issue 4. 2010-10-12. PMID:19770104. |
these alterations in ide distribution and activity may result in insufficient degradation of ab and insulin, promoting the formation of ab oligomers and hormone resistance. |
2010-10-12 |
2023-08-12 |
Not clear |
| Malcolm A Leissring, Enrico Malito, Sabrine Hedouin, Lael Reinstatler, Tomoko Sahara, Samer O Abdul-Hay, Shakeel Choudhry, Ghulam M Maharvi, Abdul H Fauq, Malwina Huzarska, Philip S May, Sungwoon Choi, Todd P Logan, Benjamin E Turk, Lewis C Cantley, Marika Manolopoulou, Wei-Jen Tang, Ross L Stein, Gregory D Cuny, Dennis J Selko. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PloS one. vol 5. issue 5. 2010-09-07. PMID:20498699. |
in principle, it should be possible to enhance the activity of insulin by inhibiting its catabolism, which is mediated primarily by insulin-degrading enzyme (ide), a structurally and evolutionarily distinctive zinc-metalloprotease. |
2010-09-07 |
2023-08-12 |
Not clear |
| S Kasturirangan, M Sierk. Targeted hydrolysis of Beta-amyloid with engineered antibody fragment. Current Alzheimer research. vol 7. issue 3. 2010-08-12. PMID:20088808. |
brain abeta levels are controlled by the action of several proteolytic enzymes such as neprilysin (nep), insulin degrading enzyme (ide) and plasmin. |
2010-08-12 |
2023-08-12 |
mouse |
| Manabu Tsuda, Toshikazu Kobayashi, Takashi Matsuo, Toshiro Aigak. Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila. FEBS letters. vol 584. issue 13. 2010-07-05. PMID:20493190. |
here we provide genetic evidence that drosophila ide (dide) antagonizes the insulin signaling pathway and human abeta-induced neurotoxicity in drosophila. |
2010-07-05 |
2023-08-12 |
human |
| Jelena Osmanovic, Konstanze Plaschke, Melita Salkovic-Petrisic, Edna Grünblatt, Peter Riederer, Siegfried Hoye. Chronic exogenous corticosterone administration generates an insulin-resistant brain state in rats. Stress (Amsterdam, Netherlands). vol 13. issue 2. 2010-06-18. PMID:19929311. |
gene expression analyzes were performed by rt-pcr in cerebral cortical tissue for insulin genes 1 and 2, insulin receptor (ir), insulin degrading enzyme (ide), and tau protein. |
2010-06-18 |
2023-08-12 |
rat |
| Jelena Osmanovic, Konstanze Plaschke, Melita Salkovic-Petrisic, Edna Grünblatt, Peter Riederer, Siegfried Hoye. Chronic exogenous corticosterone administration generates an insulin-resistant brain state in rats. Stress (Amsterdam, Netherlands). vol 13. issue 2. 2010-06-18. PMID:19929311. |
significantly reduced behavioral abilities in cst-treated rats were associated with reduced gene expression of insulin 1 ( - 20%), ide ( - 23%), and ir ( - 26%), indicating an insulin-resistant brain state, followed by increased tau protein (+28%) gene expression. |
2010-06-18 |
2023-08-12 |
rat |
| Wei-Jie Zhang, Xiao Luo, Zhan-Yun Gu. In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme. The protein journal. vol 29. issue 2. 2010-06-09. PMID:20082125. |
insulin-degrading enzyme (ide) is a zinc-metalloprotease, responsible for in vivo degradation of insulin, abeta, and other peptide hormones. |
2010-06-09 |
2023-08-12 |
human |
| Wei-Jie Zhang, Xiao Luo, Zhan-Yun Gu. In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme. The protein journal. vol 29. issue 2. 2010-06-09. PMID:20082125. |
recombinant human ide degraded human insl3, but its degradation rate for insl3 is more than a magnitude lower than that for insulin. |
2010-06-09 |
2023-08-12 |
human |
| Wei-Jie Zhang, Xiao Luo, Zhan-Yun Gu. In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme. The protein journal. vol 29. issue 2. 2010-06-09. PMID:20082125. |
however, ide bound insl3 and insulin with almost same affinity. |
2010-06-09 |
2023-08-12 |
human |
| Ram Prasad Bora, Rajeev Prabhaka. Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study. Biochemistry. vol 49. issue 18. 2010-05-25. PMID:20380468. |
in this study, interactions of the two full-length alzheimer amyloid beta peptides (abeta40 and abeta42) with the fully active form of insulin degrading enzyme (ide) through unrestrained, all-atom md simulations have been investigated. |
2010-05-25 |
2023-08-12 |
Not clear |
| Minerva M Carrasquillo, Olivia Belbin, Fanggeng Zou, Mariet Allen, Nilufer Ertekin-Taner, Morad Ansari, Samantha L Wilcox, Mariah R Kashino, Li Ma, Linda H Younkin, Samuel G Younkin, Curtis S Younkin, Toros A Dincman, Melissa E Howard, Chanley C Howell, Chloe M Stanton, Christopher M Watson, Michael Crump, Veronique Vitart, Caroline Hayward, Nicholas D Hastie, Igor Rudan, Harry Campbell, Ozren Polasek, Kristelle Brown, Peter Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Patrick G Kehoe, David M Mann, A David Smith, Helen Beaumont, Donald Warden, Clive Holmes, Reinhard Heun, Heike Kölsch, Noor Kalsheker, V Shane Pankratz, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Alan F Wright, Steven G Younkin, Kevin Morga. Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. PloS one. vol 5. issue 1. 2010-05-20. PMID:20098734. |
concordant association of insulin degrading enzyme gene (ide) variants with ide mrna, abeta, and alzheimer's disease. |
2010-05-20 |
2023-08-12 |
Not clear |