| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Megan E Wilkins, Alex Caley, Marc C Gielen, Robert J Harvey, Trevor G Smar. Murine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation. The Journal of physiology. vol 594. issue 13. 2017-08-14. PMID:27028707. |
glycine receptors (glyrs) are major mediators of inhibition in the spinal cord and brainstem. |
2017-08-14 |
2023-08-13 |
Not clear |
| Megan E Wilkins, Alex Caley, Marc C Gielen, Robert J Harvey, Trevor G Smar. Murine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation. The Journal of physiology. vol 594. issue 13. 2017-08-14. PMID:27028707. |
a missense mutation, replacing asparagine (n) with lysine (k), at position 46 in the glyr α1 subunit induced hyperekplexia following a reduction in the potency of the transmitter glycine; this resulted from a rapid deactivation of the agonist current at mutant glyrs. |
2017-08-14 |
2023-08-13 |
Not clear |
| Georg Langlhofer, Carmen Villman. The role of charged residues in independent glycine receptor folding domains for intermolecular interactions and ion channel function. Journal of neurochemistry. vol 142. issue 1. 2017-08-14. PMID:28429370. |
glycine receptor (glyr) truncations in the intracellular tm3-4 loop, documented in patients suffering from hyperekplexia and in the mouse mutant oscillator, lead to non-functionality of glyrs. |
2017-08-14 |
2023-08-13 |
mouse |
| Howard Bregman, Jeffrey R Simard, Kristin L Andrews, Shawn Ayube, Hao Chen, Hakan Gunaydin, Angel Guzman-Perez, Jiali Hu, Liyue Huang, Xin Huang, Paul H Krolikowski, Sonya G Lehto, Richard T Lewis, Klaus Michelsen, Pamela Pegman, Matthew H Plant, Paul L Shaffer, Yohannes Teffera, Shuyan Yi, Maosheng Zhang, Jacinthe Gingras, Erin F DiMaur. The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors. Journal of medicinal chemistry. vol 60. issue 3. 2017-07-06. PMID:28001399. |
glycine receptors (glyrs) are inhibitory ligand-gated ion channels expressed in nerves of the spinal dorsal horn, where their activation is believed to reduce transmission of painful stimuli. |
2017-07-06 |
2023-08-13 |
mouse |
| Xin Huang, Paul L Shaffer, Shawn Ayube, Howard Bregman, Hao Chen, Sonya G Lehto, Jason A Luther, David J Matson, Stefan I McDonough, Klaus Michelsen, Matthew H Plant, Stephen Schneider, Jeffrey R Simard, Yohannes Teffera, Shuyan Yi, Maosheng Zhang, Erin F DiMauro, Jacinthe Gingra. Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators. Nature structural & molecular biology. vol 24. issue 2. 2017-07-03. PMID:27991902. |
here, we present a novel class of potent selective, central nervous system (cns)-penetrant potentiators of glycine receptors (glyrs), ligand-gated ion channels expressed in the cns. |
2017-07-03 |
2023-08-13 |
mouse |
| Xiangjing Qin, Xiangyu Deng, Lei Chen, Wei Xi. Crystal Structure of the Wild-Type Human GlyRS Bound with tRNA(Gly) in a Productive Conformation. Journal of molecular biology. vol 428. issue 18. 2017-06-23. PMID:27261259. |
crystal structure of the wild-type human glyrs bound with trna(gly) in a productive conformation. |
2017-06-23 |
2023-08-13 |
human |
| Giovanni Morelli, Ariel Avila, Stylianos Ravanidis, Najat Aourz, Rachael L Neve, Ilse Smolders, Robert J Harvey, Jean-Michel Rigo, Laurent Nguyen, Bert Brôn. Cerebral Cortical Circuitry Formation Requires Functional Glycine Receptors. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 3. 2017-05-02. PMID:26891984. |
among them, α2 subunit-containing glycine receptors (glyrs) regulate cortical neurogenesis and the present work demonstrates the long-term consequences of their genetic disruption on neuronal connectivity in the postnatal cerebral cortex. |
2017-05-02 |
2023-08-13 |
mouse |
| Chrysovalandis Schwale, Stefanie Schumacher, Claus Bruehl, Stefan Titz, Andrea Schlicksupp, Mirka Kokocinska, Joachim Kirsch, Andreas Draguhn, Jochen Kuhs. KCC2 knockdown impairs glycinergic synapse maturation in cultured spinal cord neurons. Histochemistry and cell biology. vol 145. issue 6. 2017-04-05. PMID:26780567. |
synaptic inhibition in the spinal cord is mediated mainly by strychnine-sensitive glycine (glyrs) and by γ-aminobutyric acid type a receptors (gabaar). |
2017-04-05 |
2023-08-13 |
Not clear |
| Marco Igor Valencia-Sánchez, Annia Rodríguez-Hernández, Ruben Ferreira, Hugo Aníbal Santamaría-Suárez, Marcelino Arciniega, Anne-Catherine Dock-Bregeon, Dino Moras, Brice Beinsteiner, Haydyn Mertens, Dmitri Svergun, Luis G Brieba, Morten Grøtli, Alfredo Torres-Lario. Structural Insights into the Polyphyletic Origins of Glycyl tRNA Synthetases. The Journal of biological chemistry. vol 291. issue 28. 2017-01-09. PMID:27226617. |
this work shows that glycine is recognized by a subset of different residues in the two types of glyrs. |
2017-01-09 |
2023-08-13 |
Not clear |
| Bin Luo, Lingli Hu, Chunhua Liu, Yiping Guo, Haitao Wan. Activation of 5-HT2A/C receptor reduces glycine receptor-mediated currents in cultured auditory cortical neurons. Amino acids. vol 48. issue 2. 2016-12-13. PMID:26371055. |
glycine receptors (glyrs) permeable to chloride only mediate tonic inhibition in the cerebral cortex where glycinergic projection is completely absent. |
2016-12-13 |
2023-08-13 |
Not clear |
| Y-Z Guan, J-H Y. Glycine blocks long-term potentiation of GABAergic synapses in the ventral tegmental area. Neuroscience. vol 318. 2016-12-13. PMID:26806277. |
thus, the blockade of ltpgaba by glycine is probably resulted from suppressing glutamate release by activating the glyrs on the glutamatergic terminals. |
2016-12-13 |
2023-08-13 |
rat |
| Xiangyu Deng, Xiangjing Qin, Lei Chen, Qian Jia, Yonghui Zhang, Zhiyong Zhang, Dongsheng Lei, Gang Ren, Zhihong Zhou, Zhong Wang, Qing Li, Wei Xi. Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis. The Journal of biological chemistry. vol 291. issue 11. 2016-08-08. PMID:26797133. |
glycyl-trna synthetase (glyrs) is the enzyme that covalently links glycine to cognate trna for translation. |
2016-08-08 |
2023-08-13 |
human |
| Xiangyu Deng, Xiangjing Qin, Lei Chen, Qian Jia, Yonghui Zhang, Zhiyong Zhang, Dongsheng Lei, Gang Ren, Zhihong Zhou, Zhong Wang, Qing Li, Wei Xi. Large Conformational Changes of Insertion 3 in Human Glycyl-tRNA Synthetase (hGlyRS) during Catalysis. The Journal of biological chemistry. vol 291. issue 11. 2016-08-08. PMID:26797133. |
we report two crystal structures of human glyrs variants, in the free form and in complex with trna(gly) respectively, and reveal new aspects of the glycylation mechanism. |
2016-08-08 |
2023-08-13 |
human |
| Roshan Puthenkalam, Marcel Hieckel, Xenia Simeone, Chonticha Suwattanasophon, Roman V Feldbauer, Gerhard F Ecker, Margot Erns. Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What? Frontiers in molecular neuroscience. vol 9. 2016-07-06. PMID:27378845. |
a comprehensive analysis of conserved structural features in gabaa and glycine receptors (glyrs), the glutamate gated ion channel, the bacterial homologs erwinia chrysanthemi (elic) and gloeobacter violaceus glic, and the serotonin type 3 (5-ht3) receptor was performed. |
2016-07-06 |
2023-08-13 |
Not clear |
| Mandy L McCracken, Giorgio Gorini, Lindsay M McCracken, R Dayne Mayfield, R Adron Harris, James R Trudel. Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor. Frontiers in molecular neuroscience. vol 9. 2016-07-06. PMID:27378846. |
glycine receptors (glyrs) mediate inhibitory neurotransmission and are targets for alcohols and anesthetics in brain. |
2016-07-06 |
2023-08-13 |
human |
| Nancy Dekki Shalaly, Eduardo Aneiros, Michael Blank, Johan Mueller, Eva Nyman, Michael Blind, Michael A Dabrowski, Christin V Andersson, Kristian Sandber. Positive Modulation of the Glycine Receptor by Means of Glycine Receptor-Binding Aptamers. Journal of biomolecular screening. vol 20. issue 9. 2016-06-28. PMID:26071243. |
according to the gate control theory of pain, the glycine receptors (glyrs) are putative targets for development of therapeutic analgesics. |
2016-06-28 |
2023-08-13 |
Not clear |
| Georg Langlhofer, Carmen Villman. The Intracellular Loop of the Glycine Receptor: It's not all about the Size. Frontiers in molecular neuroscience. vol 9. 2016-06-22. PMID:27330534. |
therefore, no structural information about the large tm3-4 loop of clrs including the glycine receptors (glyrs) is available except for some basic stretches close to tm3 and tm4. |
2016-06-22 |
2023-08-13 |
Not clear |
| Borislav Dejanovic, Tania Djémié, Nora Grünewald, Arvid Suls, Vanessa Kress, Florian Hetsch, Dana Craiu, Matthew Zemel, Padhraig Gormley, Dennis Lal, Candace T Myers, Heather C Mefford, Aarno Palotie, Ingo Helbig, Jochen C Meier, Peter De Jonghe, Sarah Weckhuysen, Guenter Schwar. Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy. EMBO molecular medicine. vol 7. issue 12. 2016-06-20. PMID:26613940. |
gephyrin is a central player at inhibitory postsynapses, directly binds and organizes gabaa and glycine receptors (gabaars and glyrs), and is thereby indispensable for normal inhibitory neurotransmission. |
2016-06-20 |
2023-08-13 |
Not clear |
| Marc Gielen, Philip Thomas, Trevor G Smar. The desensitization gate of inhibitory Cys-loop receptors. Nature communications. vol 6. 2016-02-29. PMID:25891813. |
here we present a generic mechanism for the desensitization of cys-loop gabaa (gabaars) and glycine receptors (glyrs), which both mediate fast inhibitory synaptic transmission. |
2016-02-29 |
2023-08-13 |
Not clear |
| A Naito, K H Muchhala, J Trang, L Asatryan, J R Trudell, G E Homanics, R L Alkana, D L Davie. Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol. Neuroscience. vol 297. 2016-01-27. PMID:25827497. |
to this end, we found that mutations within the extracellular loop 2 region of glycine receptors (glyrs) and γ-aminobutyric acid type a receptors (gabaars) can significantly increase receptor sensitivity to micro-molar concentrations of ethanol resulting in up to a 100-fold increase in ethanol sensitivity relative to wild-type (wt) receptors. |
2016-01-27 |
2023-08-13 |
xenopus_laevis |