| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Laube, J Kuhse, N Rundström, J Kirsch, V Schmieden, H Bet. Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors. The Journal of physiology. vol 483 ( Pt 3). 1995-07-11. PMID:7776247. |
the effect of the divalent cation zn2+ on inhibitory glycine receptor (glyr) currents was investigated in rat embryonic spinal cord neurons and xenopus oocytes expressing recombinant glyrs. |
1995-07-11 |
2023-08-12 |
rat |
| J Williams, S Osvath, T F Khong, M Pearse, D Powe. Cloning, sequencing and bacterial expression of human glycine tRNA synthetase. Nucleic acids research. vol 23. issue 8. 1995-06-20. PMID:7753621. |
the human glycine trna synthetase gene (glyrs) has been cloned and sequenced. |
1995-06-20 |
2023-08-12 |
rabbit |
| M Koch, E Friau. Glycine receptors in the caudal pontine reticular formation: are they important for the inhibition of the acoustic startle response? Brain research. vol 671. issue 1. 1995-06-01. PMID:7728534. |
the present paper sought to test the hypothesis that inhibitory glycine receptors (glyrs) on giant neurons of the caudal pontine reticular formation (pnc) are involved in the inhibition of the acoustic startle response (asr) in rats. |
1995-06-01 |
2023-08-12 |
human |
| S Rajendra, J W Lynch, K D Pierce, C R French, P H Barry, P R Schofiel. Mutation of an arginine residue in the human glycine receptor transforms beta-alanine and taurine from agonists into competitive antagonists. Neuron. vol 14. issue 1. 1995-02-22. PMID:7826634. |
additionally, the binding of the glycinergic agonists beta-alanine and taurine to mutated glyrs does not initiate a chloride current, but instead competitively antagonizes currents activated by glycine. |
1995-02-22 |
2023-08-12 |
human |
| M Sassoè-Pognetto, H Wässle, U Grüner. Glycinergic synapses in the rod pathway of the rat retina: cone bipolar cells express the alpha 1 subunit of the glycine receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 8. 1994-08-30. PMID:8046473. |
glycine receptors (glyrs) and their role in retinal circuitry were analyzed immunocytochemically in the rat retina. |
1994-08-30 |
2023-08-12 |
rat |
| S Rajendra, J W Lynch, K D Pierce, C R French, P H Barry, P R Schofiel. Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor. The Journal of biological chemistry. vol 269. issue 29. 1994-08-15. PMID:7518444. |
additionally, we report corresponding 56- and 120-fold reductions in the apparent binding affinity (ki) of glycine to the mutant glyrs, but no change in the binding affinity of the competitive antagonist, strychnine. |
1994-08-15 |
2023-08-12 |
human |
| A Morales, Q T Nguyen, R Miled. Electrophysiological properties of newborn and adult rat spinal cord glycine receptors expressed in Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 91. issue 8. 1994-05-16. PMID:8159710. |
the properties of glycine receptors (glyrs) from newborn and adult rat spinal cord were studied in xenopus oocytes injected with whole mrna or the heavy (h) or light (l) mrna fractions encoding their respective glyrs. |
1994-05-16 |
2023-08-12 |
rat |
| R J Vandenberg, S Rajendra, C R French, P H Barry, P R Schofiel. The extracellular disulfide loop motif of the inhibitory glycine receptor does not form the agonist binding site. Molecular pharmacology. vol 44. issue 1. 1993-08-27. PMID:8393521. |
mutation of the lysine at position 143 to alanine resulted in essentially unaltered glyrs, showing only modest decreases in strychnine affinity (kd, 8.1 +/- 1.4 nm versus 13.4 +/- 1.3 nm), glycine displacement of strychnine binding (ki, 25 +/- 5 microm versus 49 +/- 9 microm), and glycine activation of chloride currents (ec50, 27 +/- 6 microm versus 114 +/- 14 microm). |
1993-08-27 |
2023-08-12 |
Not clear |
| R J Vandenberg, S Rajendra, C R French, P H Barry, P R Schofiel. The extracellular disulfide loop motif of the inhibitory glycine receptor does not form the agonist binding site. Molecular pharmacology. vol 44. issue 1. 1993-08-27. PMID:8393521. |
the d148e glyrs showed a 1 order of magnitude decrease in strychnine affinity (kd, 8.1 +/- 1.4 nm versus 82 +/- 21 nm), without any change in the glycine displacement of strychnine binding (ki, 25 +/- 5 microm versus 29 +/- 8 microm) or glycine activation of chloride currents (ec50, 27 +/- 6 microm versus 20 +/- 1 microm). |
1993-08-27 |
2023-08-12 |
Not clear |
| P A St John, S L Stephen. Adult-type glycine receptors form clusters on embryonic rat spinal cord neurons developing in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 7. 1993-08-13. PMID:7687278. |
the time course of development and the cellular and subcellular distributions of adult-type, strychnine-binding glycine receptors (glyrs) were examined on rat spinal cord neurons in vitro using both the glyr antagonist strychnine and a specific antibody against the receptor. |
1993-08-13 |
2023-08-12 |
rat |
| Y Srinivasan, A P Guzikowski, R P Haugland, K J Angelide. Distribution and lateral mobility of glycine receptors on cultured spinal cord neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 3. 1990-04-30. PMID:2156968. |
in order to examine the distribution of glycine receptors (glyrs) on neuronal cells, 2 novel fluorescent strychnine derivatives were synthesized and characterized chemically, spectroscopically, and biologically. |
1990-04-30 |
2023-08-11 |
rat |
| H Akagi, R Miled. Heterogeneity of glycine receptors and their messenger RNAs in rat brain and spinal cord. Science (New York, N.Y.). vol 242. issue 4876. 1988-11-17. PMID:2845580. |
the fractions were injected into xenopus oocytes to determine their potencies for expression of glycine receptors (glyrs), which were then examined electrophysiologically. |
1988-11-17 |
2023-08-11 |
rat |