| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gábor Maksay, Tímea Bíró, Bodo Laub. Hyperekplexia mutation of glycine receptors: decreased gating efficacy with altered binding thermodynamics. Biochemical pharmacology. vol 64. issue 2. 2002-08-16. PMID:12123749. |
the temperature dependence of displacement by the partial agonists taurine on alpha(1) glyrs and glycine on alpha(1)r271l glyrs was biphasic reflecting negative heat capacity changes, dehydration changes and/or a complex binding mechanism. |
2002-08-16 |
2023-08-12 |
human |
| Valerie B Caraiscos, S John Mihic, John F MacDonald, Beverley A Orse. Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human alpha(1)beta glycine receptors. The Journal of physiology. vol 539. issue Pt 2. 2002-06-04. PMID:11882681. |
glycine receptors (glyrs) are transmitter-gated channels that mediate fast inhibitory neurotransmission in the spinal cord and brain. |
2002-06-04 |
2023-08-12 |
human |
| Valerie B Caraiscos, S John Mihic, John F MacDonald, Beverley A Orse. Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human alpha(1)beta glycine receptors. The Journal of physiology. vol 539. issue Pt 2. 2002-06-04. PMID:11882681. |
to examine if protein tyrosine kinases (ptks) regulate the function of glyrs, we analysed whole-cell currents activated by applications of glycine to ca1 hippocampal neurons and spinal neurons. |
2002-06-04 |
2023-08-12 |
human |
| Y Grosskreutz, A Hermann, S Kins, J C Fuhrmann, H Betz, M Kneusse. Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin. Biological chemistry. vol 382. issue 10. 2002-05-23. PMID:11727829. |
in coexpression experiments, collybistin ii has been shown to induce the formation of submembraneous gephyrin aggregates which cluster with hetero-oligomeric glycine receptors (glyrs). |
2002-05-23 |
2023-08-12 |
Not clear |
| Siriporn C Chattipakorn, Lori L McMaho. Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices. Journal of neurophysiology. vol 87. issue 3. 2002-05-20. PMID:11877523. |
additionally, the inhibitory amino acid, taurine, which has been shown to activate glyrs in other systems, activated glyrs expressed by both pyramidal cells and interneurons, although with much less potency than glycine, having an ec(50) 10-fold higher. |
2002-05-20 |
2023-08-12 |
rat |
| Siriporn C Chattipakorn, Lori L McMaho. Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices. Journal of neurophysiology. vol 87. issue 3. 2002-05-20. PMID:11877523. |
to examine the potential subunit composition of hippocampal glyrs, we tested the effect of the gaba(a) receptor antagonist, picrotoxin, on i(gly) recorded from both cell types. |
2002-05-20 |
2023-08-12 |
rat |
| Siriporn C Chattipakorn, Lori L McMaho. Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices. Journal of neurophysiology. vol 87. issue 3. 2002-05-20. PMID:11877523. |
at low micromolar concentrations of picrotoxin (< or =100 microm), which selectively block alpha homomeric glyrs, i(gly) was partially attenuated in both cell types, indicating that alpha homomeric receptors are expressed by pyramidal cells and interneurons. |
2002-05-20 |
2023-08-12 |
rat |
| G S Findlay, M J Wick, M P Mascia, D Wallace, G W Miller, R A Harris, Y A Bledno. Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice. The Journal of pharmacology and experimental therapeutics. vol 300. issue 2. 2002-02-25. PMID:11805213. |
glycine receptors (glyrs) are pentameric ligand-gated ion channels that inhibit neurotransmission in the adult brainstem and spinal cord. |
2002-02-25 |
2023-08-12 |
mouse |
| Brigitte van Zundert, Francisco J Alvarez, Gonzalo E Yevenes, Juan G Cárcamo, Juan Carlos Vera, Luis G Aguay. Glycine receptors involved in synaptic transmission are selectively regulated by the cytoskeleton in mouse spinal neurons. Journal of neurophysiology. vol 87. issue 1. 2002-02-07. PMID:11784780. |
using whole cell patch-clamp recordings, we examined the effect of colchicine, a microtubule disrupter, on the properties of glycine receptors (glyrs) in cultured spinal cord neurons. |
2002-02-07 |
2023-08-12 |
mouse |
| N L Han, J L Haddrill, J W Lync. Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the beta-amino acid agonist, taurine. Journal of neurochemistry. vol 79. issue 3. 2001-12-07. PMID:11701767. |
thr112 is the only domain element in mammalian cell-expressed glyrs which was demonstrated to discriminate between glycine and taurine. |
2001-12-07 |
2023-08-12 |
human |
| D De Saint Jan, B David-Watine, H Korn, P Bregestovsk. Activation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABA. The Journal of physiology. vol 535. issue Pt 3. 2001-12-05. PMID:11559772. |
the ability of homomeric alphah1 and alphah2 glyrs to be activated by glycine, taurine and gaba was studied in xenopus oocytes or in the human embryonic kidney hek-293 cell line. |
2001-12-05 |
2023-08-12 |
human |
| D De Saint Jan, B David-Watine, H Korn, P Bregestovsk. Activation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABA. The Journal of physiology. vol 535. issue Pt 3. 2001-12-05. PMID:11559772. |
in outside-out patches from hek cells, glycine, taurine and gaba activated both glyrs with the same main unitary conductance, i.e. |
2001-12-05 |
2023-08-12 |
human |
| D De Saint Jan, B David-Watine, H Korn, P Bregestovsk. Activation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABA. The Journal of physiology. vol 535. issue Pt 3. 2001-12-05. PMID:11559772. |
the sensitivity of both alphah1 and alphah2 glyrs to glycine was highly variable. |
2001-12-05 |
2023-08-12 |
human |
| D De Saint Jan, B David-Watine, H Korn, P Bregestovsk. Activation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABA. The Journal of physiology. vol 535. issue Pt 3. 2001-12-05. PMID:11559772. |
the degree of desensitization, evaluated by fast application of saturating concentrations of agonist on outside-out patches from xenopus oocytes, was similar for glycine and taurine on both glyrs and did not exceed 50 %. |
2001-12-05 |
2023-08-12 |
human |
| G Maksay, B Laube, H Bet. Subunit-specific modulation of glycine receptors by neurosteroids. Neuropharmacology. vol 41. issue 3. 2001-12-04. PMID:11522328. |
the effects of pregnene and androstane steroids were studied on recombinant human glycine receptors (glyrs) by whole-cell voltage-clamp electrophysiology. |
2001-12-04 |
2023-08-12 |
human |
| G Maksay, B Laube, H Bet. Subunit-specific modulation of glycine receptors by neurosteroids. Neuropharmacology. vol 41. issue 3. 2001-12-04. PMID:11522328. |
pregs resulted in a parallel shift of the response curve of glycine for alpha(1) glyrs. |
2001-12-04 |
2023-08-12 |
human |
| M J Frech, J Pérez-León, H Wässle, K H Backu. Characterization of the spontaneous synaptic activity of amacrine cells in the mouse retina. Journal of neurophysiology. vol 86. issue 4. 2001-12-04. PMID:11600626. |
in addition to ionotropic glutamate receptors, amacrine cells express two types of inhibitory receptors, gaba(a) receptors (gaba(a)rs) and glycine receptors (glyrs). |
2001-12-04 |
2023-08-12 |
mouse |
| K Piechotta, F Weth, R J Harvey, E Friau. Localization of rat glycine receptor alpha1 and alpha2 subunit transcripts in the developing auditory brainstem. The Journal of comparative neurology. vol 438. issue 3. 2001-10-25. PMID:11550176. |
glycine receptors (glyrs), aside from gaba(a) receptors, mediate fast postsynaptic inhibition in the mammalian nervous system. |
2001-10-25 |
2023-08-12 |
rat |
| N Hussy, V Brès, M Rochette, A Duvoid, G Alonso, G Dayanithi, F C Moo. Osmoregulation of vasopressin secretion via activation of neurohypophysial nerve terminals glycine receptors by glial taurine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 18. 2001-10-04. PMID:11549721. |
osmotic regulation of supraoptic nucleus (son) neuron activity depends in part on activation of neuronal glycine receptors (glyrs), most probably by taurine released from adjacent astrocytes. |
2001-10-04 |
2023-08-12 |
Not clear |
| N Hussy, V Brès, M Rochette, A Duvoid, G Alonso, G Dayanithi, F C Moo. Osmoregulation of vasopressin secretion via activation of neurohypophysial nerve terminals glycine receptors by glial taurine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 18. 2001-10-04. PMID:11549721. |
on purified neurohypophysial nerve endings, activation of strychnine-sensitive glyrs by taurine or glycine primarily inhibits the high k(+)-induced rise in [ca(2+)](i) and subsequent release of vasopressin. |
2001-10-04 |
2023-08-12 |
Not clear |