| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| César O Lara, Carlos F Burgos, Katherine Fariña-Oliva, Ana M Marileo, Victoria P San Martín, David Flaig, Paul Soto-Ortega, Omayra V Contreras, Anggelo Sazo, Krishna Gaete-Riquelme, Jeremías Corradi, Carola Muñoz-Montesino, Jorge Fuentealba, Patricio A Castro, Luis G Aguayo, Cecilia Bouzat, Gustavo Moraga-Cid, Gonzalo E Yévene. Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide. Scientific reports. vol 15. issue 1. 2025-02-14. PMID:39953280. |
ionotropic glycine receptors (glyrs) are chloride-permeable ligand-gated ion channels expressed in the nervous system. |
2025-02-14 |
2025-02-18 |
Not clear |
| Anna-Lena Wiessler, Fang Zheng, Christian Werner, Margarita Habib, Erdem Tuzun, Christian Alzheimer, Claudia Sommer, Carmen Villman. Impaired Presynaptic Function Contributes Significantly to the Pathology of Glycine Receptor Autoantibodies. Neurology(R) neuroimmunology & neuroinflammation. vol 12. issue 2. 2025-01-17. PMID:39819053. |
autoantibodies (aabs) against glycine receptors (glyrs) are mainly associated with the rare neurologic diseases stiff person syndrome (sps) and progressive encephalomyelitis with rigidity and myoclonus (perm). |
2025-01-17 |
2025-01-20 |
Not clear |
| Xu-Ke Pang, Si Chen, Xiang-Xian Ma, Yi-Nuo Xu, Wei-Jie Bai, Chong-Lei Fu, Gui-Chang Zo. [Advances in inhibitory ion channel glycine receptors]. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 6. 2025-01-09. PMID:39780567. |
glycine receptors (glyrs) belong to the ligand-gated ion channel receptor superfamily and are widely distributed throughout the central nervous system. |
2025-01-09 |
2025-01-13 |
Not clear |
| Kayla Kindig, Eric Gibbs, David Seiferth, Philip C Biggin, Sudha Chakrapan. Mechanisms underlying modulation of human GlyRα3 receptors by Zn Science advances. vol 10. issue 51. 2024-12-18. PMID:39693447. |
mechanisms underlying modulation of human glyrα3 receptors by zn glycine receptors (glyrs) regulate motor control and pain processing in the central nervous system through inhibitory synaptic signaling. |
2024-12-18 |
2024-12-21 |
human |
| Hailong Yu, Weiwei Wan. Modulation of heteromeric glycine receptor function through high concentration clustering. bioRxiv : the preprint server for biology. 2024-10-28. PMID:39464082. |
human heteromeric glycine receptors (glyrs) are the major inhibitory neurotransmitter receptors in the spinal cord and are active targets for developing chronic pain medications. |
2024-10-28 |
2024-10-30 |
human |
| Junfang Yan, Luonan Chen, Arieh Warshel, Chen Ba. Exploring the Activation Process of the Glycine Receptor. Journal of the American Chemical Society. 2024-09-16. PMID:39279763. |
in this study, we investigated the coupling of protein conformational changes and glycine binding events to elucidate the influence of binding patterns on the activation and desensitization processes of α1 glyrs. |
2024-09-16 |
2024-09-18 |
Not clear |
| Weiwei Wang, Xiaofen Li. Mechanism of human ⍺3β GlyR modulation in inflammatory pain and 2, 6-DTBP interaction. Research square. 2024-08-16. PMID:39149480. |
α3β glycine receptor (glyr) is a subtype of the glyrs that belongs to the cys-loop receptor superfamily. |
2024-08-16 |
2024-08-18 |
human |
| Xiaofen Liu, Weiwei Wan. Gating mechanism of the human α1β GlyR by glycine. Structure (London, England : 1993). 2024-08-15. PMID:39146932. |
glycine receptors (glyrs) are members of the cys-loop receptors that constitute a major portion of mammalian neurotransmitter receptors. |
2024-08-15 |
2024-08-18 |
human |
| Lorena Armijo Weingart, Loreto San Martin, Scarlet Gallegos, Anibal Araya, Macarena Konar Nie, Eduardo Fernandez-Pérez, Luis G Aguay. Loss of glycine receptors in the nucleus accumbens and ethanol reward in an Alzheimer´s Disease mouse model. Progress in neurobiology. 2024-05-09. PMID:38723884. |
accumbal neurons express high levels of inhibitory glycine receptors (glyrs) that are allosterically modulated by ethanol and have a role in controlling its intake. |
2024-05-09 |
2024-05-27 |
mouse |
| Loreto S San Martin, Lorena Armijo-Weingart, Scarlet Gallegos, Anibal Araya, Gregg E Homanics, Luis G Aguay. Changes in ethanol effects in knock-in mice expressing ethanol insensitive alpha1 and alpha2 glycine receptor subunits. Life sciences. 2024-04-28. PMID:38679193. |
glycine receptors (glyrs) are potentiated by physiologically relevant concentrations of ethanol, and mutations in the intracellular loop of α1 and α2 subunits reduced the effect of the drug. |
2024-04-28 |
2024-05-01 |
mouse |
| James R E Thompson, Christopher A Beaudoin, Sarah C R Lummi. Modelling and Molecular Dynamics Predict the Structure and Interactions of the Glycine Receptor Intracellular Domain. Biomolecules. vol 13. issue 12. 2023-12-23. PMID:38136628. |
glycine receptors (glyrs) are glycine-gated inhibitory pentameric ligand-gated ion channels composed of α or α + β subunits. |
2023-12-23 |
2023-12-25 |
Not clear |
| Anna Loftén, Louise Adermark, Mia Ericson, Bo Söderpal. Regulation of ethanol-mediated dopamine elevation by glycine receptors located on cholinergic interneurons in the nucleus accumbens. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017639. |
the rewarding and reinforcing properties of ethanol have been linked to activation of the mesolimbic dopamine system, an effect that appears to involve glycine receptors (glyrs) in the nucleus accumbens. |
2023-11-30 |
2023-12-07 |
rat |
| Anna Loftén, Louise Adermark, Mia Ericson, Bo Söderpal. Regulation of ethanol-mediated dopamine elevation by glycine receptors located on cholinergic interneurons in the nucleus accumbens. Addiction biology. vol 28. issue 12. 2023-11-29. PMID:38017639. |
the rewarding and reinforcing properties of ethanol have been linked to activation of the mesolimbic dopamine system, an effect that appears to involve glycine receptors (glyrs) in the nucleus accumbens. |
2023-11-29 |
2023-12-07 |
rat |
| Xiaofen Liu, Weiwei Wan. Gating mechanism of the human α1β GlyR by glycine. bioRxiv : the preprint server for biology. 2023-08-23. PMID:37609197. |
glycine receptors (glyrs) are members of the cys-loop receptors that constitute a major portion of neurotransmitter receptors in the human nervous system. |
2023-08-23 |
2023-09-07 |
human |
| Xiaofen Liu, Weiwei Wan. Gating mechanism of the human α1β GlyR by glycine. bioRxiv : the preprint server for biology. 2023-08-23. PMID:37609197. |
recent resolution of heteromeric glyrs structures in multiple functional states identified an invariable 4:1 α:β subunit stoichiometry and provided snapshots in the gating cycle, challenging previous beliefs and raising the fundamental questions of how α and β subunit functions in glycine binding and channel activation. |
2023-08-23 |
2023-09-07 |
human |
| Karolina Werynska, Elena Neumann, Teresa Cramer, Robert P Ganley, Jacinthe Gingras, Hanns Ulrich Zeilhofe. A phospho-deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons. The Journal of physiology. 2023-08-20. PMID:37598301. |
glycine receptors (glyrs), together with gaba |
2023-08-20 |
2023-09-07 |
mouse |
| Mohamed Darwish, Satoko Hattori, Hirofumi Nishizono, Tsuyoshi Miyakawa, Nozomu Yachie, Keizo Taka. Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency. Molecular brain. vol 16. issue 1. 2023-05-22. PMID:37217969. |
glycine receptors (glyrs) are ligand-gated chloride channels comprising alpha (α1-4) and β subunits. |
2023-05-22 |
2023-08-14 |
mouse |
| Eric Gibbs, Emily Klemm, David Seiferth, Arvind Kumar, Serban L Ilca, Philip C Biggin, Sudha Chakrapan. Conformational transitions and allosteric modulation in a heteromeric glycine receptor. Nature communications. vol 14. issue 1. 2023-03-14. PMID:36914669. |
glycine receptors (glyrs) provide inhibitory neuronal input in the spinal cord and brainstem, which is critical for muscle coordination and sensory perception. |
2023-03-14 |
2023-08-14 |
zebrafish |
| Hung-Chen Wang, Kuang-I Cheng, Kuang-Yi Tseng, Aij-Lie Kwan, Lin-Li Chan. AAV-glycine receptor α3 alleviates CFA-induced inflammatory pain by downregulating ERK phosphorylation and proinflammatory cytokine expression in SD rats. Molecular medicine (Cambridge, Mass.). vol 29. issue 1. 2023-02-16. PMID:36792984. |
glycine receptors (glyrs) play key roles in the processing of inflammatory pain. |
2023-02-16 |
2023-08-14 |
human |
| Adrien H Cerdan, Laurie Peverini, Jean-Pierre Changeux, Pierre-Jean Corringer, Marco Cecchin. Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway. Science advances. vol 8. issue 41. 2022-10-14. PMID:36240268. |
glycine receptors (glyrs) are ligand-gated ion channels mediating signal transduction at chemical synapses. |
2022-10-14 |
2023-08-14 |
human |