| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria P San Martín, Carlos F Burgos, Ana M Marileo, Cesar O Lara, Anggelo Sazo, Jorge Fuentealba, Leonardo Guzmán, Patricio A Castro, Luis G Aguayo, Gustavo Moraga-Cid, Gonzalo E Yévene. Inhibitory Actions of Tropeines on the α3 Glycine Receptor Function. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31024303. |
glycine receptors (glyrs) are chloride-permeable pentameric ligand-gated ion channels. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xiaojuan Yang, Christian G Spech. Subsynaptic Domains in Super-Resolution Microscopy: The Treachery of Images. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31312120. |
in particular, we discuss the possible regulation of co-transmission at mixed inhibitory synapses as a consequence of the subsynaptic distribution of glycine receptors (glyrs) and gaba |
2020-10-01 |
2023-08-13 |
Not clear |
| Svetlana M Molchanova, Joris Comhair, Deniz Karadurmus, Elisabeth Piccart, Robert J Harvey, Jean-Michel Rigo, Serge N Schiffmann, Bert Brône, David Gal. Tonically Active α2 Subunit-Containing Glycine Receptors Regulate the Excitability of Striatal Medium Spiny Neurons. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29375305. |
however, msns also express chloride-permeable glycine receptors (glyrs) although their subunit composition and functional significance in the striatum is unknown. |
2020-09-30 |
2023-08-13 |
mouse |
| Elena Petukhova, Daria Ponomareva, Marat Mukhamedyarov, Galyna Maleeva, Piotr Bregestovsk. Developmental Changes in the Inhibition of Glycinergic Synaptic Currents by Niflumic Acid in Hypoglossal Motoneurons. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:30483054. |
during the early postnatal development, subunit composition of chloride-permeable glycine receptors (glyrs) changes leading to a decrease of "fetal" alpha2 and elevation of "adult" alpha1 glyr subunits. |
2020-09-30 |
2023-08-13 |
mouse |
| Cora Lau, Prajwal P Thakre, Mark C Bellingha. Alfaxalone Causes Reduction of Glycinergic IPSCs, but Not Glutamatergic EPSCs, and Activates a Depolarizing Current in Rat Hypoglossal Motor Neurons. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:30967762. |
these results suggest that alfaxalone modulates glycine receptors (glyrs), causing a delayed and prolonged channel opening, as well as causing presynaptic reduction of glycine release, and activates a membrane current, which remains to be identified. |
2020-09-30 |
2023-08-13 |
rat |
| Galyna Maleeva, Franck Peiretti, Boris S Zhorov, Piotr Bregestovsk. Voltage-Dependent Inhibition of Glycine Receptor Channels by Niflumic Acid. Frontiers in molecular neuroscience. vol 10. 2020-09-29. PMID:28559795. |
here we present evidence that nfa is an efficient blocker of chloride-permeable glycine receptors (glyrs) with subunit heterogeneity of action. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yan Zhang, Thi Nhu Thao Ho, Robert J Harvey, Joseph W Lynch, Angelo Keramida. Structure-Function Analysis of the GlyR α2 Subunit Autism Mutation p.R323L Reveals a Gain-of-Function. Frontiers in molecular neuroscience. vol 10. 2020-09-29. PMID:28588452. |
glycine receptors (glyrs) containing the α2 subunit regulate cortical interneuron migration. |
2020-09-29 |
2023-08-13 |
Not clear |
| Guichang Zou, Qi Chen, Kai Chen, Xin Zuo, Yushu Ge, Yiwen Hou, Tao Pan, Huilin Pan, Dan Liu, Li Zhang, Wei Xion. Human Hyperekplexic Mutations in Glycine Receptors Disinhibit the Brainstem by Hijacking GABA iScience. vol 19. 2020-09-28. PMID:31450193. |
human hyperekplexic mutations in glycine receptors disinhibit the brainstem by hijacking gaba hyperekplexia disease is usually caused by naturally occurring point mutations in glycine receptors (glyrs). |
2020-09-28 |
2023-08-13 |
human |
| Carola Muñoz-Montesino, Carlos F Burgos, Cesar O Lara, Camila R Riquelme, David Flaig, Victoria P San Martin, Luis G Aguayo, Jorge Fuentealba, Patricio A Castro, Leonardo Guzmán, Gonzalo E Yévenes, Gustavo Moraga-Ci. Inhibition of the Glycine Receptor alpha 3 Function by Colchicine. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32903667. |
colchicine is able to modify the function of several pentameric ligand-gated ion channels, including glycine receptors (glyrs). |
2020-09-28 |
2023-08-13 |
Not clear |
| Arvind Kumar, Sandip Basak, Shanlin Rao, Yvonne Gicheru, Megan L Mayer, Mark S P Sansom, Sudha Chakrapan. Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs. Nature communications. vol 11. issue 1. 2020-09-08. PMID:32719334. |
glycine receptors (glyrs) are key players in mediating fast inhibitory neurotransmission at these synapses. |
2020-09-08 |
2023-08-13 |
Not clear |
| Wenting Li, Wanhong Zuo, Wei Wu, Qi Kang Zuo, Rao Fu, Liangzhi Wu, Haifeng Zhang, Michael Ndukwe, Jiang-Hong Y. Activation of glycine receptors in the lateral habenula rescues anxiety- and depression-like behaviors associated with alcohol withdrawal and reduces alcohol intake in rats. Neuropharmacology. vol 157. 2020-07-21. PMID:31254534. |
the lateral habenula (lhb) is activated by a range of aversive states including those related to alcohol withdrawal and has glycine receptors (glyrs), a sensitive target of alcohol. |
2020-07-21 |
2023-08-13 |
rat |
| Wenting Li, Wanhong Zuo, Wei Wu, Qi Kang Zuo, Rao Fu, Liangzhi Wu, Haifeng Zhang, Michael Ndukwe, Jiang-Hong Y. Activation of glycine receptors in the lateral habenula rescues anxiety- and depression-like behaviors associated with alcohol withdrawal and reduces alcohol intake in rats. Neuropharmacology. vol 157. 2020-07-21. PMID:31254534. |
glycine's effect was blocked by strychnine, a glyr antagonist, indicating that it was mediated by strychnine-sensitive glyrs. |
2020-07-21 |
2023-08-13 |
rat |
| S Gallegos, B Muñoz, A Araya, L G Aguay. High ethanol sensitive glycine receptors regulate firing in D1 medium spiny neurons in the nucleus accumbens. Neuropharmacology. vol 160. 2020-07-08. PMID:31521620. |
inhibitory glycine receptors (glyrs) are widely expressed in spinal cord and brain stem. |
2020-07-08 |
2023-08-13 |
Not clear |
| Cesar O Lara, Carlos F Burgos, Tiare Silva-Grecchi, Carola Muñoz-Montesino, Luis G Aguayo, Jorge Fuentealba, Patricio A Castro, Jose L Guzmán, Pierre-Jean Corringer, Gonzalo E Yévenes, Gustavo Moraga-Ci. Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors. ACS chemical neuroscience. vol 10. issue 5. 2020-05-29. PMID:30893555. |
glycine receptors (glyrs) are members of the pentameric ligand-gated ionic channel family (plgics) and mediate fast inhibitory neurotransmission in the brain stem and spinal cord. |
2020-05-29 |
2023-08-13 |
human |
| Zi-Yang Zhang, Hu-Hu Bai, Zhen Guo, Hu-Ling Li, Yong-Tao He, Xing-Lian Duan, Zhan-Wei Suo, Xian Yang, Yong-Xing He, Xiao-Dong H. mGluR5/ERK signaling regulated the phosphorylation and function of glycine receptor α1ins subunit in spinal dorsal horn of mice. PLoS biology. vol 17. issue 8. 2020-02-27. PMID:31433808. |
inhibitory glycinergic transmission in adult spinal cord is primarily mediated by glycine receptors (glyrs) containing the α1 subunit. |
2020-02-27 |
2023-08-13 |
mouse |
| Eric Samarut, Domitille Chalopin, Raphaëlle Riché, Marc Allard, Meijiang Liao, Pierre Drapea. Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish. PloS one. vol 14. issue 5. 2020-02-20. PMID:31048868. |
glycine receptors (glyrs) are ligand-gated chloride channels mediating inhibitory neurotransmission in the brain stem and spinal cord. |
2020-02-20 |
2023-08-13 |
human |
| Lautaro D Alvarez, Adali Pecc. Mapping the neurosteroid binding sites on glycine receptors. The Journal of steroid biochemistry and molecular biology. vol 192. 2020-01-21. PMID:31176751. |
glycine is a major inhibitory neurotransmitter in the cns, where it modulates both sensory and motor transduction throughout its binding to glycine receptors (glyrs), pentameric chloride channels that share structural and functional properties with type a γ-aminobutyric acid receptors (gaba |
2020-01-21 |
2023-08-13 |
Not clear |
| Zi-Yang Zhang, Zhen Guo, Hu-Ling Li, Yong-Tao He, Xing-Lian Duan, Zhan-Wei Suo, Xian Yang, Xiao-Dong H. Ubiquitination and inhibition of glycine receptor by HUWE1 in spinal cord dorsal horn. Neuropharmacology. vol 148. 2019-12-27. PMID:30721695. |
glycine receptors (glyrs) are pentameric proteins that consist of α (α1-α4) subunits and/or β subunit. |
2019-12-27 |
2023-08-13 |
mouse |
| Hung-Chen Wang, Kuang-I Cheng, Pei-Ru Chen, Kuang-Yi Tseng, Aij-Lie Kwan, Lin-Li Chan. Glycine receptors expression in rat spinal cord and dorsal root ganglion in prostaglandin E2 intrathecal injection models. BMC neuroscience. vol 19. issue 1. 2019-08-19. PMID:30413143. |
glycine receptors (glyrs) are involved in the development of spinal pain sensitization. |
2019-08-19 |
2023-08-13 |
rat |
| Chen-Hung Wang, Ciria C Hernandez, Junyi Wu, Ning Zhou, Hsin-Yu Hsu, Mei-Lin Shen, Yi-Ching Wang, Robert L Macdonald, Dong Chuan W. A Missense Mutation A384P Associated with Human Hyperekplexia Reveals a Desensitization Site of Glycine Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 11. 2019-07-05. PMID:29440552. |
from analysis of newly identified human hyperekplexia mutations in the glycine receptor (glyr) α1 subunit, we found that an alanine-to-proline missense mutation (a384p) resulted in substantially higher desensitization level and lower agonist sensitivity of homomeric α1 glyrs when expressed in hek cells. |
2019-07-05 |
2023-08-13 |
human |