| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Veerle Lemmens, Bart Thevelein, Yana Vella, Svenja Kankowski, Julia Leonhard, Hideaki Mizuno, Susana Rocha, Bert Brône, Jochen C Meier, Jelle Hendri. Hetero-pentamerization determines mobility and conductance of Glycine receptor α3 splice variants. Cellular and molecular life sciences : CMLS. vol 79. issue 11. 2022-10-05. PMID:36197517. |
glycine receptors (glyrs) are ligand-gated pentameric chloride channels in the central nervous system. |
2022-10-05 |
2023-08-14 |
Not clear |
| Anibal Araya, Scarlet Gallegos, Adolfo Maldonado, Mario Rivera-Meza, Ramesh Chandra, Mary Kay Lobo, Luis G Aguay. Overexpression of wild type glycine alpha 1 subunit rescues ethanol sensitivity in accumbal receptors and reduces binge drinking in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-09-29. PMID:36175550. |
the presence of inhibitory α1 glycine receptor (glyrs) subunits, sensitive to ethanol, has been recently reported in accumbal neurons suggesting that they are protective against excessive binge consumption. |
2022-09-29 |
2023-08-14 |
mouse |
| Hongtao Zh. Structure and Mechanism of Glycine Receptor Elucidated by Cryo-Electron Microscopy. Frontiers in pharmacology. vol 13. 2022-08-26. PMID:36016557. |
glycine receptors (glyrs) are pentameric ion channels that mediate fast inhibitory neurotransmission. |
2022-08-26 |
2023-08-14 |
Not clear |
| Ricardo Valdés-Jorquera, Leticia Oviedo-Castro, Carolina A Oliva, Trinidad A Marique. Role of glycine and glycine receptors in vascular endothelium: a new perspective for the management of the post-ischemic injury. Current vascular pharmacology. 2022-07-22. PMID:35864795. |
glycine receptors (glyrs) are cell-surface transmembrane proteins that belong to the cys-loop ligand-gated ion channels superfamily (cys-loop lgics). |
2022-07-22 |
2023-08-14 |
Not clear |
| Yan Li, Xin-Yu Yang, Na Jin, Cheng Zhen, Su-Yue Zhu, Wan-Yu Chu, Huan-Huan Zhang, Ai-Ping Xu, Jie Wu, Meng-Ya Wang, Chao Zhen. Activation of M Neuroscience letters. 2022-05-22. PMID:35598692. |
activation of m our study aimed to determine the effects of pilocarpine and the mechanisms involving muscarinic acetylcholine receptors (machrs) on glycine receptors (glyrs) in neurons of the spinal cord ventral horn. |
2022-05-22 |
2023-08-13 |
Not clear |
| Xiumin Chen, Katie A Wilson, Natascha Schaefer, Lachlan De Hayr, Mark Windsor, Emmanuel Scalais, Germaine van Rijckevorsel, Katrien Stouffs, Carmen Villmann, Megan L O'Mara, Joseph W Lynch, Robert J Harve. Loss, Gain and Altered Function of GlyR α2 Subunit Mutations in Neurodevelopmental Disorders. Frontiers in molecular neuroscience. vol 15. 2022-05-16. PMID:35571374. |
glycine receptors (glyrs) containing the α2 subunit govern cell fate, neuronal migration and synaptogenesis in the developing cortex and spinal cord. |
2022-05-16 |
2023-08-13 |
Not clear |
| Teja Wolfgang Groemer, Antoine Triller, Hanns Ulrich Zeilhofer, Kristina Becker, Volker Eulenburg, Cord Michael Becke. Nociception in the Glycine Receptor Deficient Mutant Mouse Spastic. Frontiers in molecular neuroscience. vol 15. 2022-05-13. PMID:35548669. |
glycine receptors (glyrs) are the primary mediators of fast inhibitory transmission in the mammalian spinal cord, where they modulate sensory and motor signaling. |
2022-05-13 |
2023-08-13 |
mouse |
| Ghada I Aboheimed, Maha M AlRasheed, Sultan Almudimeegh, Karla A Peña-Guerra, Kelly J Cardona-Londoño, Mustafa A Salih, Mohammed Z Seidahmed, Futwan Al-Mohanna, Dilek Colak, Kirsten Harvey, Stefan T Arold, Namik Kaya, Arnaud J Rui. Clinical, genetic, and functional characterization of the glycine receptor β-subunit A455P variant in a family affected by hyperekplexia syndrome. The Journal of biological chemistry. 2022-05-08. PMID:35526563. |
the genetic causes of the disease can vary and several associated genes and mutations have been reported to affect glycine receptors (glyrs); however, the mechanistic links between glyrs and hyperekplexia are not yet understood. |
2022-05-08 |
2023-08-13 |
Not clear |
| Victoria P San Martín, Anggelo Sazo, Elías Utreras, Gustavo Moraga-Cid, Gonzalo E Yévene. Glycine Receptor Subtypes and Their Roles in Nociception and Chronic Pain. Frontiers in molecular neuroscience. vol 15. 2022-04-11. PMID:35401105. |
in line with this concept, recent studies have provided robust proof that pharmacological intervention of glycine receptors (glyrs) restores the inhibitory function and exerts anti-nociceptive effects on preclinical models of chronic pain. |
2022-04-11 |
2023-08-13 |
Not clear |
| Darius P Zlotos, Yasmine M Mandour, Anders A Jense. Strychnine and its mono- and dimeric analogues: a pharmaco-chemical perspective. Natural product reports. 2022-04-05. PMID:35380133. |
particular attention is given to its sars at glycine receptors (glyrs) in light of recently published high-resolution structures of strychnine-glyr complexes. |
2022-04-05 |
2023-08-13 |
Not clear |
| Hongtao Zhu, Eric Gouau. Architecture and assembly mechanism of native glycine receptors. Nature. vol 599. issue 7885. 2021-12-10. PMID:34555840. |
glycine receptors (glyrs) are pentameric, 'cys-loop' receptors that form chloride-permeable channels and mediate fast inhibitory signalling throughout the central nervous system |
2021-12-10 |
2023-08-13 |
Not clear |
| Josip Ivica, Remigijus Lape, Lucia G Sivilott. Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors. The Journal of physiology. 2021-12-08. PMID:34802146. |
glycine receptors (glyrs) share this property, but it is not well understood how they are affected by ph changes. |
2021-12-08 |
2023-08-13 |
rat |
| Josip Ivica, Remigijus Lape, Lucia G Sivilott. Acidic pH reduces agonist efficacy and responses to synaptic-like glycine applications in zebrafish α1 and rat α1β recombinant glycine receptors. The Journal of physiology. 2021-12-08. PMID:34802146. |
moderate acidic conditions (ph 6.4) reduce the maximum single channel open probability of recombinant homomeric glyrs produced by the neurotransmitter glycine or other agonists, such as β-alanine and taurine. |
2021-12-08 |
2023-08-13 |
rat |
| Stephanie Maynard, Philippe Rostaing, Natascha Schaefer, Olivier Gemin, Adrien Candat, Andréa Dumoulin, Carmen Villmann, Antoine Triller, Christian G Spech. Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses. eLife. vol 10. 2021-12-08. PMID:34878402. |
glycine receptors (glyrs) are the primary fast inhibitory neurotransmitter receptors in the spinal cord and brainstem. |
2021-12-08 |
2023-08-13 |
Not clear |
| Braulio Muñoz, Trinidad Mariqueo, Pablo Murath, Christian Peters, Gonzalo E Yevenes, Gustavo Moraga-Cid, Robert W Peoples, Luis G Aguay. Modulatory Actions of the Glycine Receptor β Subunit on the Positive Allosteric Modulation of Ethanol in α2 Containing Receptors. Frontiers in molecular neuroscience. vol 14. 2021-12-07. PMID:34867189. |
alpha1-containing glycine receptors (glyrs) are major mediators of synaptic inhibition in the spinal cord and brain stem. |
2021-12-07 |
2023-08-13 |
Not clear |
| Robert J Harvey, Robert J Vandenber. Glycine Transporters and Receptors as Targets for Analgesics. Biomolecules. vol 11. issue 11. 2021-11-30. PMID:34827674. |
the suitability of modulating glycinergic neurotransmission for the treatment of inflammatory and chronic pain has gained widespread recognition, with glycine receptors (glyrs) and glycine transporters (glyt1 and glyt2) now considered key therapeutic targets [...]. |
2021-11-30 |
2023-08-13 |
Not clear |
| A Carvajal-González, L Jacobson, L Clover, M Wickremaratchi, S Shields, B Lang, A Vincen. Systemic delivery of human GlyR IgG antibody induces GlyR internalization into motor neurons of brainstem and spinal cord with motor dysfunction in mice. Neuropathology and applied neurobiology. vol 47. issue 2. 2021-11-22. PMID:32910464. |
progressive encephalomyelitis with rigidity and myoclonus (perm) is a life-threatening condition often associated with highly raised serum antibodies to glycine receptors (glyrs); these bind to the surface of large neurons and interneurons in rodent brain and spinal cord sections and, in vitro, inhibit function and reduce surface expression of the glyrs. |
2021-11-22 |
2023-08-13 |
mouse |
| L M McCracken, M L McCracken, D H Gong, J R Trudell, R A Harri. Linking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues. ACS chemical neuroscience. vol 1. issue 7. 2021-10-20. PMID:21326622. |
glycine receptors (glyrs) are pentameric ligand-gated ion channels that mediate inhibitory neurotransmission in the brain and spinal cord and are targets of alcohols and anesthetics. |
2021-10-20 |
2023-08-12 |
xenopus_laevis |
| Arthur Macha, Filip Liebsch, Steffen Fricke, Florian Hetsch, Franziska Neuser, Lena Johannes, Vanessa Kress, Tania Djémié, Jose A Santamaria-Araujo, Catheline Vilain, Alec Aeby, Patrick Van Bogaert, Borislav Dejanovic, Sarah Weckhuysen, Jochen C Meier, Guenter Schwar. Bi-allelic gephyrin variants impair GABAergic inhibition in a patient with epileptic encephalopathy. Human molecular genetics. 2021-10-07. PMID:34617111. |
gephyrin (geph) is the principal scaffolding protein at inhibitory synapses and is essential for postsynaptic clustering of glycine (glyrs) and gaba type a receptors (gabaars). |
2021-10-07 |
2023-08-13 |
Not clear |
| Hanns Ulrich Zeilhofer, Karolina Werynska, Jacinthe Gingras, Gonzalo E Yévene. Glycine Receptors in Spinal Nociceptive Control-An Update. Biomolecules. vol 11. issue 6. 2021-09-23. PMID:34204137. |
selective targeting of the α3 subtype of glycine receptors (glyrs), which is highly enriched in the superficial layers of the spinal dorsal horn, a key site of nociceptive processing, may help to further narrow down pharmacological intervention on the nociceptive system and increase tolerability. |
2021-09-23 |
2023-08-13 |
Not clear |