| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karolina Werynska, Jacinthe Gingras, Dietmar Benke, Louis Scheurer, Elena Neumann, Hanns Ulrich Zeilhofe. A Glra3 phosphodeficient mouse mutant establishes the critical role of protein kinase A-dependent phosphorylation and inhibition of glycine receptors in spinal inflammatory hyperalgesia. Pain. vol 162. issue 9. 2021-09-13. PMID:34264571. |
glycinergic neurons and glycine receptors (glyrs) exert a critical control over spinal nociception. |
2021-09-13 |
2023-08-13 |
mouse |
| Josip Ivica, Remigijus Lape, Vid Jazbec, Jie Yu, Hongtao Zhu, Eric Gouaux, Matthew G Gold, Lucia G Sivilott. The intracellular domain of homomeric glycine receptors modulates agonist efficacy. The Journal of biological chemistry. vol 296. 2021-09-09. PMID:33617876. |
like other pentameric ligand-gated channels, glycine receptors (glyrs) contain long intracellular domains (icds) between transmembrane helices 3 and 4. |
2021-09-09 |
2023-08-13 |
zebrafish |
| David Stroebel, Laetitia Mony, Pierre Paolett. Glycine agonism in ionotropic glutamate receptors. Neuropharmacology. vol 193. 2021-07-21. PMID:34058193. |
surprisingly however, five out of the eighteen vertebrate iglur subunits do not bind glutamate but glycine, a neurotransmitter known to mediate inhibitory neurotransmission through its action on pentameric glycine receptors (glyrs). |
2021-07-21 |
2023-08-13 |
Not clear |
| Alexandre M J Gomila, Karin Rustler, Galyna Maleeva, Alba Nin-Hill, Daniel Wutz, Antoni Bautista-Barrufet, Xavier Rovira, Miquel Bosch, Elvira Mukhametova, Elena Petukhova, Daria Ponomareva, Marat Mukhamedyarov, Franck Peiretti, Mercedes Alfonso-Prieto, Carme Rovira, Burkhard König, Piotr Bregestovski, Pau Gorostiz. Photocontrol of Endogenous Glycine Receptors In Vivo. Cell chemical biology. vol 27. issue 11. 2021-07-08. PMID:32846115. |
glycine receptors (glyrs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. |
2021-07-08 |
2023-08-13 |
Not clear |
| Loreto San Martin, Scarlet Gallegos, Anibal Araya, Nicol Romero, Giovanni Morelli, Joris Comhair, Robert J Harvey, Jean-Michel Rigo, Bert Brone, Luis G Aguay. Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit. British journal of pharmacology. vol 177. issue 17. 2021-06-21. PMID:32436225. |
it has been shown that glycine receptors (glyrs) present in the nac are potentiated by clinically relevant concentrations of ethanol, where α1 and α2 are the predominant subunits expressed. |
2021-06-21 |
2023-08-13 |
mouse |
| Thomas Chapdelaine, Vincent Hakim, Antoine Triller, Jonas Ranft, Christian G Spech. Reciprocal stabilization of glycine receptors and gephyrin scaffold proteins at inhibitory synapses. Biophysical journal. vol 120. issue 5. 2021-05-31. PMID:33539789. |
at inhibitory synapses in the spinal cord, the main scaffold protein gephyrin assembles in dense molecule clusters that provide binding sites for glycine receptors (glyrs). |
2021-05-31 |
2023-08-13 |
Not clear |
| Lei Yao, Marta Wells, Xiongwu Wu, Yan Xu, Li Zhang, Wei Xion. Membrane cholesterol dependence of cannabinoid modulation of glycine receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-03-01. PMID:32608538. |
cannabinoids exert therapeutic effects on several diseases such as chronic pain and startle disease by targeting glycine receptors (glyrs). |
2021-03-01 |
2023-08-13 |
Not clear |
| Braulio Muñoz, Scarlet Gallegos, Christian Peters, Pablo Murath, David M Lovinger, Gregg E Homanics, Luis G Aguay. Influence of nonsynaptic α1 glycine receptors on ethanol consumption and place preference. Addiction biology. vol 25. issue 2. 2021-02-16. PMID:30884072. |
here, we used knock-in (ki) mice that have ethanol-insensitive alpha 1 glycine receptors (glyrs) (kk385/386aa) to examine how alpha 1 glyrs might affect binge drinking and conditioned place preference. |
2021-02-16 |
2023-08-13 |
mouse |
| Zhiyi Wu, Remigijus Lape, Lea Jopp-Saile, Benjamin J O'Callaghan, Timo Greiner, Lucia G Sivilott. The startle disease mutation α1S270T predicts shortening of glycinergic synaptic currents. The Journal of physiology. vol 598. issue 16. 2021-02-15. PMID:32445491. |
recombinant heteromeric glyrs were less impaired than homomers by this mutation when we measured their response to equilibrium applications of glycine. |
2021-02-15 |
2023-08-13 |
Not clear |
| Casey I Gallagher, Diba Sheipouri, Susan Shimmon, Tristan Rawling, Robert J Vandenber. Identification of N-acyl amino acids that are positive allosteric modulators of glycine receptors. Biochemical pharmacology. vol 180. 2021-01-11. PMID:32579961. |
glycine receptors (glyrs) mediate inhibitory neurotransmission within the spinal cord and play a crucial role in nociceptive signalling. |
2021-01-11 |
2023-08-13 |
Not clear |
| Daishi Ito, Yoshinori Kawazoe, Ayato Sato, Motonari Uesugi, Hiromi Hirat. Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor. Scientific reports. vol 10. issue 1. 2020-12-23. PMID:32814817. |
glycine binds to and activates glycine receptors (glyrs), increasing cl |
2020-12-23 |
2023-08-13 |
Not clear |
| Gustavo Moraga-Cid, Victoria P San Martín, Cesar O Lara, Braulio Muñoz, Ana M Marileo, Anggelo Sazo, Carola Muñoz-Montesino, Jorge Fuentealba, Patricio A Castro, Leonardo Guzmán, Carlos F Burgos, Hanns U Zeilhofer, Luis G Aguayo, Pierre-Jean Corringer, Gonzalo E Yévene. Modulation of glycine receptor single-channel conductance by intracellular phosphorylation. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32179786. |
glycine receptors (glyrs) are anion-permeable pentameric ligand-gated ion channels (plgics). |
2020-12-08 |
2023-08-13 |
Not clear |
| Zheng Chen, Xiang Wang, Haikang Liao, Tao Sheng, Panhong Chen, Hongchang Zhou, Yongliang Pan, Weiqin Liu, Hua Ya. Glycine attenuates cerebrovascular remodeling via glycine receptor alpha 2 and vascular endothelial growth factor receptor 2 after stroke. American journal of translational research. vol 12. issue 10. 2020-11-17. PMID:33194080. |
as a dual-acting neurotransmitter, glycine plays critical roles in cerebral ischemia by activating both glycine receptors (glyrs) and n-methyl-d-aspartate acid receptors (nmdars). |
2020-11-17 |
2023-08-13 |
rat |
| Adrien H Cerdan, Marion Sisquellas, Gilberto Pereira, Diego E Barreto Gomes, Jean-Pierre Changeux, Marco Cecchin. The Glycine Receptor Allosteric Ligands Library (GRALL). Bioinformatics (Oxford, England). vol 36. issue 11. 2020-10-29. PMID:32163115. |
glycine receptors (glyrs) mediate fast inhibitory neurotransmission in the brain and have been recognized as key pharmacological targets for pain. |
2020-10-29 |
2023-08-13 |
Not clear |
| Georg Langlhofer, Natascha Schaefer, Hans M Maric, Angelo Keramidas, Yan Zhang, Peter Baumann, Robert Blum, Ulrike Breitinger, Kristian Strømgaard, Andreas Schlosser, Michael M Kessels, Dennis Koch, Britta Qualmann, Hans-Georg Breitinger, Joseph W Lynch, Carmen Villman. A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 25. 2020-10-26. PMID:32354853. |
glycine receptors (glyrs) are the major mediators of fast synaptic inhibition in the adult human spinal cord and brainstem. |
2020-10-26 |
2023-08-13 |
human |
| Sophie Leacock, Parnayan Syed, Victoria M James, Anna Bode, Koichi Kawakami, Angelo Keramidas, Maximiliano Suster, Joseph W Lynch, Robert J Harve. Structure/Function Studies of the α4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29445326. |
inhibitory glycine receptors (glyrs) are pentameric ligand-gated anion channels with major roles in startle disease/hyperekplexia (glyr α1), cortical neuronal migration/autism spectrum disorder (glyr α2), and inflammatory pain sensitization/rhythmic breathing (glyr α3). |
2020-10-01 |
2023-08-13 |
human |
| Ulrike Breitinger, Lamiaa M Bahnassawy, Dieter Janzen, Vera Roemer, Cord-Michael Becker, Carmen Villmann, Hans-Georg Breitinge. PKA and PKC Modulators Affect Ion Channel Function and Internalization of Recombinant Alpha1 and Alpha1-Beta Glycine Receptors. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29867346. |
glycine receptors (glyrs) are important mediators of fast inhibitory neurotransmission in the mammalian central nervous system. |
2020-10-01 |
2023-08-13 |
human |
| Ulrike Breitinger, Lamiaa M Bahnassawy, Dieter Janzen, Vera Roemer, Cord-Michael Becker, Carmen Villmann, Hans-Georg Breitinge. PKA and PKC Modulators Affect Ion Channel Function and Internalization of Recombinant Alpha1 and Alpha1-Beta Glycine Receptors. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29867346. |
here, we studied the effects of protein kinase c (pkc) and camp-dependent protein kinase a (pka) on glycine induced currents in hek293 cells expressing human homomeric α1 and heteromeric α1-β glyrs using whole-cell patch clamp techniques as well as internalization assays. |
2020-10-01 |
2023-08-13 |
human |
| Natascha Schaefer, Vera Roemer, Dieter Janzen, Carmen Villman. Impaired Glycine Receptor Trafficking in Neurological Diseases. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:30186111. |
ionotropic glycine receptors (glyrs) enable fast synaptic neurotransmission in the adult spinal cord and brainstem. |
2020-10-01 |
2023-08-13 |
Not clear |
| Joris Comhair, Jens Devoght, Giovanni Morelli, Robert J Harvey, Victor Briz, Sarah C Borrie, Claudia Bagni, Jean-Michel Rigo, Serge N Schiffmann, David Gall, Bert Brône, Svetlana M Molchanov. Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:30374290. |
glycine receptors (glyrs) containing the α2 subunit are highly expressed in the developing brain, where they regulate neuronal migration and maturation, promote spontaneous network activity and subsequent development of synaptic connections. |
2020-10-01 |
2023-08-13 |
Not clear |