| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bijun Tang, Sarah C R Lummi. Multiple regions in the extracellular domain of the glycine receptor determine receptor activity. The Journal of biological chemistry. vol 293. issue 36. 2019-02-25. PMID:29941455. |
glycine receptors (glyrs) are cys-loop receptors that mediate fast synaptic inhibition in the brain stem and spinal cord. |
2019-02-25 |
2023-08-13 |
Not clear |
| Kohji Sat. Why does a steep caudal-rostral gradient exist in glycine content in the brain? Medical hypotheses. vol 120. 2019-01-14. PMID:30220327. |
glycine has dual roles as a neurotransmitter, one is the agonist for inhibitory glycine receptors (glyrs), and the other is a co-agonist for excitatory nmda receptors (nmdars). |
2019-01-14 |
2023-08-13 |
Not clear |
| Kohji Sat. Why does a steep caudal-rostral gradient exist in glycine content in the brain? Medical hypotheses. vol 120. 2019-01-14. PMID:30220327. |
inhibitory glyrs are concentrated in the lower brain and the affinity of glycine to glyrs is low, leading to the high content of glycine in the lower brain. |
2019-01-14 |
2023-08-13 |
Not clear |
| Nora Grünewald, Audric Jan, Charlotte Salvatico, Vanessa Kress, Marianne Renner, Antoine Triller, Christian G Specht, Guenter Schwar. Sequences Flanking the Gephyrin-Binding Site of GlyRβ Tune Receptor Stabilization at Synapses. eNeuro. vol 5. issue 1. 2019-01-09. PMID:29464196. |
at inhibitory synapses, gephyrin is the major scaffold protein that mediates the accumulation of heteromeric glycine receptors (glyrs) via the cytoplasmic loop in the β-subunit (β-loop). |
2019-01-09 |
2023-08-13 |
rat |
| Jieping Lu, Sijia Fan, Guichang Zou, Yiwen Hou, Tao Pan, Weiwei Guo, Lei Yao, Feng Du, Gregg E Homanics, Dan Liu, Li Zhang, Wei Xion. Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia. Neuropharmacology. vol 133. 2018-11-05. PMID:29407767. |
some cannabinoids have been shown to suppress chronic pain by targeting glycine receptors (glyrs). |
2018-11-05 |
2023-08-13 |
Not clear |
| Jieping Lu, Sijia Fan, Guichang Zou, Yiwen Hou, Tao Pan, Weiwei Guo, Lei Yao, Feng Du, Gregg E Homanics, Dan Liu, Li Zhang, Wei Xion. Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia. Neuropharmacology. vol 133. 2018-11-05. PMID:29407767. |
a point-mutation of s296a in tm3 of α1 glyrs significantly inhibits dh-cbd potentiation of glycine currents (i |
2018-11-05 |
2023-08-13 |
Not clear |
| Iryna Lushnikova, Galyna Maleeva, Galyna Skib. Glycine receptors are involved in hippocampal neuronal damage caused by oxygen-glucose deficiency. Cell biology international. vol 42. issue 10. 2018-10-30. PMID:30022566. |
glycine receptors (glyrs) belong to the family of ligand-gated cys-loop receptors and effectuate fast inhibitory neurotransmission in central nervous system (cns). |
2018-10-30 |
2023-08-13 |
Not clear |
| Lindsay M McCracken, Daniel C Lowes, Michael C Salling, Cyndel Carreau-Vollmer, Naomi N Odean, Yuri A Blednov, Heinrich Betz, R Adron Harris, Neil L Harriso. Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 34. 2018-07-26. PMID:28784756. |
in spinal cord, glycine mediates synaptic inhibition through the activation of heteromeric glycine receptors (glyrs) composed primarily of α1 and β subunits. |
2018-07-26 |
2023-08-13 |
mouse |
| Lindsay M McCracken, Daniel C Lowes, Michael C Salling, Cyndel Carreau-Vollmer, Naomi N Odean, Yuri A Blednov, Heinrich Betz, R Adron Harris, Neil L Harriso. Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 34. 2018-07-26. PMID:28784756. |
our results show ubiquitous expression of glyrs that mediate large-amplitude currents in response to exogenously applied glycine in these forebrain structures. |
2018-07-26 |
2023-08-13 |
mouse |
| Hu-Hu Bai, Jiang-Ping Liu, Li Yang, Ji-Yuan Zhao, Zhan-Wei Suo, Xian Yang, Xiao-Dong H. Adenosine A1 receptor potentiated glycinergic transmission in spinal cord dorsal horn of rats after peripheral inflammation. Neuropharmacology. vol 126. 2018-06-12. PMID:28882563. |
in spinal cord slices from intact rats, adenosine increased the inhibitory postsynaptic currents mediated by glycine receptors (glyrs). |
2018-06-12 |
2023-08-13 |
rat |
| B Förstera, B Muñoz, M K Lobo, R Chandra, D M Lovinger, L G Aguay. Presence of ethanol-sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens. The Journal of physiology. vol 595. issue 15. 2018-04-19. PMID:28524260. |
glycine receptors (glyrs) are potentiated by ethanol and they have been implicated in the regulation of accumbal dopamine levels. |
2018-04-19 |
2023-08-13 |
mouse |
| Mengwen Qi, Chunfeng Wu, Zhouqing Wang, Li Zhou, Chen Men, Yimei Du, Songming Huang, Lei Chen, Ling Che. Transient Receptor Potential Vanilloid 4 Activation-Induced Increase in Glycine-Activated Current in Mouse Hippocampal Pyramidal Neurons. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 45. issue 3. 2018-03-19. PMID:29439248. |
glycine plays an important role in regulating hippocampal inhibitory/ excitatory neurotransmission through activating glycine receptors (glyrs) and acting as a co-agonist of n-methyl-d-aspartate-type glutamate receptors. |
2018-03-19 |
2023-08-13 |
mouse |
| Katharina Kuenzel, Sepideh Abolpour Mofrad, Daniel F Gilber. Phenotyping Cellular Viability by Functional Analysis of Ion Channels: GlyR-Targeted Screening in NT2-N Cells. Methods in molecular biology (Clifton, N.J.). vol 1601. 2018-02-19. PMID:28470528. |
glycine receptor chloride channels (glyrs) are attractive drug targets for therapeutic intervention and are also more and more recognized in the context of in vitro neurotoxicity and developmental neurotoxicity testing. |
2018-02-19 |
2023-08-13 |
human |
| Joseph W Lynch, Yan Zhang, Sahil Talwar, Argel Estrada-Mondrago. Glycine Receptor Drug Discovery. Advances in pharmacology (San Diego, Calif.). vol 79. 2017-12-20. PMID:28528670. |
postsynaptic glycine receptor (glyr) chloride channels mediate inhibitory neurotransmission in the spinal cord and brain stem, although presynaptic and extrasynaptic glyrs are expressed more widely throughout the brain. |
2017-12-20 |
2023-08-13 |
Not clear |
| Dean Kirson, Jelena Todorovic, S John Mihi. Single Channel Analysis of Isoflurane and Ethanol Enhancement of Taurine-Activated Glycine Receptors. The Journal of pharmacology and experimental therapeutics. vol 364. issue 1. 2017-12-20. PMID:29118035. |
the amino acid taurine is an endogenous ligand acting on glycine receptors (glyrs), which is released by astrocytes in many brain regions, such as the nucleus accumbens and prefrontal cortex. |
2017-12-20 |
2023-08-13 |
Not clear |
| Ulrike Breitinger, Heinrich Sticht, Hans-Georg Breitinge. Modulation of Recombinant Human α1 Glycine Receptors by Mono- and Disaccharides: A Kinetic Study. ACS chemical neuroscience. vol 7. issue 8. 2017-10-30. PMID:27227552. |
glycine receptors (glyrs) mediate fast synaptic inhibition in spinal cord, brainstem, and higher brain centers. |
2017-10-30 |
2023-08-13 |
human |
| Mario A Acuña, Gonzalo E Yévenes, William T Ralvenius, Dietmar Benke, Alessandra Di Lio, Cesar O Lara, Braulio Muñoz, Carlos F Burgos, Gustavo Moraga-Cid, Pierre-Jean Corringer, Hanns Ulrich Zeilhofe. Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain. The Journal of clinical investigation. vol 126. issue 7. 2017-09-26. PMID:27270175. |
in inflammatory pain, reductions in synaptic inhibition occur partially through prostaglandin e2- (pge2-) and pka-dependent phosphorylation of a specific subtype of glycine receptors (glyrs) that contain α3 subunits. |
2017-09-26 |
2023-08-13 |
Not clear |
| M Pilorge, C Fassier, H Le Corronc, A Potey, J Bai, S De Gois, E Delaby, B Assouline, V Guinchat, F Devillard, R Delorme, G Nygren, M Råstam, J C Meier, S Otani, H Cheval, V M James, M Topf, T N Dear, C Gillberg, M Leboyer, B Giros, S Gautron, J Hazan, R J Harvey, P Legendre, C Betancu. Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism. Molecular psychiatry. vol 21. issue 7. 2017-09-25. PMID:26370147. |
glycine receptors (glyrs) are ligand-gated chloride channels that mediate inhibitory neurotransmission in the adult nervous system but exert an excitatory action in immature neurons. |
2017-09-25 |
2023-08-13 |
mouse |
| Nagasree Chakka, Kristin L Andrews, Loren M Berry, Howard Bregman, Hakan Gunaydin, Liyue Huang, Angel Guzman-Perez, Matthew H Plant, Jeffrey R Simard, Jacinthe Gingras, Erin F DiMaur. Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators. European journal of medicinal chemistry. vol 137. 2017-09-20. PMID:28575722. |
glycine receptors (glyrs) are pentameric glycine-gated chloride ion channels that are enriched in the brainstem and spinal cord where they have been demonstrated to play a role in central nervous system (cns) inhibition. |
2017-09-20 |
2023-08-13 |
Not clear |
| Natascha Schaefer, Alexandra Berger, Johannes van Brederode, Fang Zheng, Yan Zhang, Sophie Leacock, Laura Littau, Sibylle Jablonka, Sony Malhotra, Maya Topf, Friederike Winter, Daria Davydova, Joseph W Lynch, Christopher J Paige, Christian Alzheimer, Robert J Harvey, Carmen Villman. Disruption of a Structurally Important Extracellular Element in the Glycine Receptor Leads to Decreased Synaptic Integration and Signaling Resulting in Severe Startle Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 33. 2017-09-11. PMID:28724750. |
functional impairments or trafficking defects of inhibitory glycine receptors (glyrs) have been linked to human hyperekplexia/startle disease and autism spectrum disorders. |
2017-09-11 |
2023-08-13 |
mouse |