| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Yan Zhang, Fang Ji, Ning Wang, Lin-Lin Chen, Tian Tian, Wei L. Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons. The Journal of biological chemistry. vol 289. issue 45. 2015-01-17. PMID:25231980. |
in addition, the induction of gly-ltp(nmda) requires binding of glycine with nmdars, whereas gly-ltd(nmda) requires that glycine bind with both sites on nmdars and glyrs. |
2015-01-17 |
2023-08-13 |
Not clear |
| Susanne Jonsson, Louise Adermark, Mia Ericson, Bo Söderpal. The involvement of accumbal glycine receptors in the dopamine-elevating effects of addictive drugs. Neuropharmacology. vol 82. 2015-01-09. PMID:24686030. |
our previous work in rats has demonstrated that accumbal glycine receptors (glyrs) are involved in mediating the dopamine-activating effects of ethanol, and in modulating ethanol intake. |
2015-01-09 |
2023-08-12 |
rat |
| Trinidad A Mariqueo, Adolfo Agurto, Braulio Muñoz, Loreto San Martin, Cesar Coronado, Eduardo J Fernández-Pérez, Pablo Murath, Andrea Sánchez, Gregg E Homanics, Luis G Aguay. Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons. Journal of neurophysiology. vol 111. issue 10. 2014-12-31. PMID:24572089. |
on the other hand, the currents activated by exogenously applied glycine were consistently potentiated (55 ± 10% above control, n = 11/12 cells), which suggests that ethanol modulates synaptic and nonsynaptic glycine receptors (glyrs) in a different fashion. |
2014-12-31 |
2023-08-12 |
mouse |
| James N Sleigh, Stuart J Grice, Robert W Burgess, Kevin Talbot, M Zameel Cade. Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot-Marie-Tooth type 2D mice. Human molecular genetics. vol 23. issue 10. 2014-12-03. PMID:24368416. |
glyrs charges the amino acid glycine with its cognate trna and is therefore essential for protein translation. |
2014-12-03 |
2023-08-12 |
mouse |
| Richard W Olsen, Guo-Dong Li, Martin Wallner, James R Trudell, Edward J Bertaccini, Erik Lindahl, Keith W Miller, Ronald L Alkana, Daryl L Davie. Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol. Alcoholism, clinical and experimental research. vol 38. issue 3. 2014-11-18. PMID:24164436. |
recent physiological, genetic, and biochemical studies have pin-pointed molecular targets for anesthetics and etoh in the brain as ligand-gated ion channel (lgic) membrane proteins, especially the pentameric (5 subunit) cys-loop superfamily of neurotransmitter receptors including nicotinic acetylcholine (nachrs), gabaa (gabaa rs), and glycine receptors (glyrs). |
2014-11-18 |
2023-08-12 |
Not clear |
| Matthew J Fischl, R Michael Burge. Glycinergic transmission modulates GABAergic inhibition in the avian auditory pathway. Frontiers in neural circuits. vol 8. 2014-09-24. PMID:24672432. |
studies of co-release in other brain regions suggest that gaba and glycine receptors (glyrs) interact via cross-suppressive modulation of receptor conductance. |
2014-09-24 |
2023-08-12 |
chicken |
| Sampsa T Sipilä, Albert Spoljaric, Mari A Virtanen, Inkeri Hiironniemi, Kai Kail. Glycine transporter-1 controls nonsynaptic inhibitory actions of glycine receptors in the neonatal rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 30. 2014-09-22. PMID:25057202. |
although functional glycinergic synapses have not been identified in the hippocampus, neurons in this area express cl(-) permeable extrasynaptic glycine receptors (glyrs). |
2014-09-22 |
2023-08-13 |
rat |
| Anda M Chirila, Travis E Brown, Rachel A Bishop, Nicholas W Bellono, Francesco G Pucci, Julie A Kaue. Long-term potentiation of glycinergic synapses triggered by interleukin 1β. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 22. 2014-08-20. PMID:24830427. |
glycine receptors (glyrs) are structurally related to gabaa receptors and have a similar inhibitory role. |
2014-08-20 |
2023-08-13 |
Not clear |
| Louis-Etienne Lorenzo, Antoine G Godin, Feng Wang, Manon St-Louis, Salvatore Carbonetto, Paul W Wiseman, Alfredo Ribeiro-da-Silva, Yves De Koninc. Gephyrin clusters are absent from small diameter primary afferent terminals despite the presence of GABA(A) receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 24. 2014-08-04. PMID:24920633. |
whereas both gaba(a) receptors (gaba(a)rs) and glycine receptors (glyrs) play a role in control of dorsal horn neuron excitability, their relative contribution to inhibition of small diameter primary afferent terminals remains controversial. |
2014-08-04 |
2023-08-13 |
rat |
| Lindsay M McCracken, James R Trudell, Mandy L McCracken, R Adron Harri. Zinc-dependent modulation of α2- and α3-glycine receptor subunits by ethanol. Alcoholism, clinical and experimental research. vol 37. issue 12. 2014-08-01. PMID:23895467. |
strychnine-sensitive glycine receptors (glyrs) are expressed throughout the brain and spinal cord and are among the strongly supported protein targets of alcohol. |
2014-08-01 |
2023-08-12 |
Not clear |
| Kristopher T Kahle, Tarek Z Deeb, Martin Puskarjov, Liliya Silayeva, Bo Liang, Kai Kaila, Stephen J Mos. Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2. Trends in neurosciences. vol 36. issue 12. 2014-07-23. PMID:24139641. |
the k-cl cotransporter kcc2 establishes the low intraneuronal cl- levels required for the hyperpolarizing inhibitory postsynaptic potentials mediated by ionotropic γ-aminobutyric acid receptors (gabaars) and glycine receptors (glyrs). |
2014-07-23 |
2023-08-12 |
Not clear |
| Timothy Lynagh, Alexander Kunz, Bodo Laub. Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activation. ACS chemical neuroscience. vol 4. issue 11. 2014-06-17. PMID:23992940. |
pentameric glycine receptors (glyrs) couple agonist binding to activation of an intrinsic ion channel. |
2014-06-17 |
2023-08-12 |
human |
| Isabel Del Pino, Dennis Koch, Rudolf Schemm, Britta Qualmann, Heinrich Betz, Ingo Paarman. Proteomic analysis of glycine receptor β subunit (GlyRβ)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors. The Journal of biological chemistry. vol 289. issue 16. 2014-06-04. PMID:24509844. |
glycine receptors (glyrs) mediate inhibitory neurotransmission in spinal cord and brainstem. |
2014-06-04 |
2023-08-12 |
mouse |
| Lu Han, Sahil Talwar, Qian Wang, Qiang Shan, Joseph W Lync. Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site. ACS chemical neuroscience. vol 4. issue 10. 2014-05-27. PMID:23834509. |
inflammatory pain sensitization is initiated by prostaglandin-induced phosphorylation of α3 glycine receptors (glyrs) that are specifically located in inhibitory synapses on spinal pain sensory neurons. |
2014-05-27 |
2023-08-12 |
Not clear |
| Timothy Lynagh, Bodo Laub. Opposing effects of the anesthetic propofol at pentameric ligand-gated ion channels mediated by a common site. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 6. 2014-04-01. PMID:24501356. |
we considered this idea by testing propofol modulation of homomeric human glycine receptors (glyrs) and nematode glutamate-gated chloride channels (glucls) recombinantly expressed in xenopus laevis oocytes with electrophysiology. |
2014-04-01 |
2023-08-12 |
human |
| Ariel Avila, Laurent Nguyen, Jean-Michel Rig. Glycine receptors and brain development. Frontiers in cellular neuroscience. vol 7. 2014-03-25. PMID:24155690. |
glycine receptors (glyrs) are ligand-gated chloride ion channels that mediate fast inhibitory neurotransmission in the spinal cord and the brainstem. |
2014-03-25 |
2023-08-12 |
Not clear |
| Wei Xiong, Shao-Rui Chen, Liming He, Kejun Cheng, Yi-Lin Zhao, Hong Chen, De-Pei Li, Gregg E Homanics, John Peever, Kenner C Rice, Ling-gang Wu, Hui-Lin Pan, Li Zhan. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nature neuroscience. vol 17. issue 2. 2014-03-24. PMID:24390226. |
although postsynaptic glycine receptors (glyrs) as αβ heteromers attract considerable research attention, little is known about the role of presynaptic glyrs, likely α homomers, in diseases. |
2014-03-24 |
2023-08-12 |
mouse |
| Ariel Avila, Pía M Vidal, T Neil Dear, Robert J Harvey, Jean-Michel Rigo, Laurent Nguye. Glycine receptor α2 subunit activation promotes cortical interneuron migration. Cell reports. vol 4. issue 4. 2014-03-12. PMID:23954789. |
glycine receptors (glyrs) are detected in the developing cns before synaptogenesis, but their function remains elusive. |
2014-03-12 |
2023-08-12 |
Not clear |
| Ariel Avila, Pía M Vidal, T Neil Dear, Robert J Harvey, Jean-Michel Rigo, Laurent Nguye. Glycine receptor α2 subunit activation promotes cortical interneuron migration. Cell reports. vol 4. issue 4. 2014-03-12. PMID:23954789. |
we discovered that extrasynaptic activation of glyrs containing the α2 subunit in cortical interneurons by endogenous glycine activates voltage-gated calcium channels and promotes calcium influx, which further modulates actomyosin contractility to fine-tune nuclear translocation during migration. |
2014-03-12 |
2023-08-12 |
Not clear |
| Ning Zhou, Chen-Hung Wang, Shu Zhang, Dong Chuan W. The GLRA1 missense mutation W170S associates lack of Zn2+ potentiation with human hyperekplexia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 45. 2013-12-30. PMID:24198360. |
hyperekplexia is a neurological disorder associated primarily with mutations in the α1 subunit of glycine receptors (glyrs) that lead to dysfunction of glycinergic inhibitory transmission. |
2013-12-30 |
2023-08-12 |
human |