| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ning Zhou, Chen-Hung Wang, Shu Zhang, Dong Chuan W. The GLRA1 missense mutation W170S associates lack of Zn2+ potentiation with human hyperekplexia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 45. 2013-12-30. PMID:24198360. |
interestingly, mutant α1(w170s)β glyrs displayed no significant changes in potency or maximum response to glycine, taurine, or β-alanine. |
2013-12-30 |
2023-08-12 |
human |
| Hiromi Hirata, Kazutoyo Ogino, Kenta Yamada, Sophie Leacock, Robert J Harve. Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 37. 2013-12-02. PMID:24027265. |
similar behavioral defects were observed in zebrafish embryos treated with strychnine, which blocks glycine receptors (glyrs), suggesting that the abnormal motor response in mutants may be attributable to a deficit in glycinergic synaptic transmission. |
2013-12-02 |
2023-08-12 |
zebrafish |
| Lu Han, Sahil Talwar, Joseph W Lync. The relative orientation of the TM3 and TM4 domains varies between α1 and α3 glycine receptors. ACS chemical neuroscience. vol 4. issue 2. 2013-10-29. PMID:23421675. |
glycine receptors (glyrs) are anion-conducting members of the pentameric ligand-gated ion channel family. |
2013-10-29 |
2023-08-12 |
Not clear |
| Lu Han, Sahil Talwar, Joseph W Lync. The relative orientation of the TM3 and TM4 domains varies between α1 and α3 glycine receptors. ACS chemical neuroscience. vol 4. issue 2. 2013-10-29. PMID:23421675. |
we previously showed that the dramatic difference in glycine efficacies of α1 and α3 glyrs is largely attributable to their nonconserved tm4 domains. |
2013-10-29 |
2023-08-12 |
Not clear |
| Laetitia Hennekinne, Sabrina Colasse, Antoine Triller, Marianne Renne. Differential control of thrombospondin over synaptic glycine and AMPA receptors in spinal cord neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 28. 2013-09-20. PMID:23843515. |
we show that in cultured rat spinal cord neurons tsp-1 decreased neuronal excitability by reducing the accumulation of excitatory ampa receptors (ampars) and increasing that of inhibitory glycine receptors (glyrs) in synapses. |
2013-09-20 |
2023-08-12 |
rat |
| Victoria M James, Anna Bode, Seo-Kyung Chung, Jennifer L Gill, Maartje Nielsen, Frances M Cowan, Mihailo Vujic, Rhys H Thomas, Mark I Rees, Kirsten Harvey, Angelo Keramidas, Maya Topf, Ieke Ginjaar, Joseph W Lynch, Robert J Harve. Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease. Neurobiology of disease. vol 52. 2013-08-05. PMID:23238346. |
peak currents were also reduced for α(1)β(l285r) glyrs although glycine sensitivity was normal. |
2013-08-05 |
2023-08-12 |
Not clear |
| Victoria M James, Anna Bode, Seo-Kyung Chung, Jennifer L Gill, Maartje Nielsen, Frances M Cowan, Mihailo Vujic, Rhys H Thomas, Mark I Rees, Kirsten Harvey, Angelo Keramidas, Maya Topf, Ieke Ginjaar, Joseph W Lynch, Robert J Harve. Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease. Neurobiology of disease. vol 52. 2013-08-05. PMID:23238346. |
we found that w310c had no effect on glycine sensitivity, but reduced maximal currents in α(1)β glyrs in both homozygous (α(1)β(w310c)) and heterozygous (α(1)ββ(w310c)) stoichiometries. |
2013-08-05 |
2023-08-12 |
Not clear |
| Felix Weltzien, Christian Puller, Gregory A O'Sullivan, Ingo Paarmann, Heinrich Bet. Distribution of the glycine receptor β-subunit in the mouse CNS as revealed by a novel monoclonal antibody. The Journal of comparative neurology. vol 520. issue 17. 2013-05-01. PMID:22592841. |
inhibitory glycine receptors (glyrs) are composed of homologous α- (α1-4) and β-subunits. |
2013-05-01 |
2023-08-12 |
mouse |
| Portia A Kunz, Alain C Burette, Richard J Weinberg, Benjamin D Philpo. Glycine receptors support excitatory neurotransmitter release in developing mouse visual cortex. The Journal of physiology. vol 590. issue 22. 2013-05-01. PMID:22988142. |
glycine receptors (glyrs) are found in most areas of the brain, and their dysfunction can cause severe neurological disorders. |
2013-05-01 |
2023-08-12 |
mouse |
| Kemin Tan, Min Zhou, Rongguang Zhang, Wayne F Anderson, Andrzej Joachimia. The crystal structures of the α-subunit of the α(2)β (2) tetrameric Glycyl-tRNA synthetase. Journal of structural and functional genomics. vol 13. issue 4. 2013-04-19. PMID:23054484. |
glycine is the smallest amino acid and the glycyl-trna synthetase (glyrs) belongs to class ii aarss. |
2013-04-19 |
2023-08-12 |
human |
| Lindsay M McCracken, Yuri A Blednov, James R Trudell, Jillian M Benavidez, Heinrich Betz, R Adron Harri. Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo. The Journal of pharmacology and experimental therapeutics. vol 344. issue 2. 2013-03-28. PMID:23230213. |
among the protein targets of ethanol are glycine receptors (glyrs), which are potentiated by millimolar concentrations of ethanol. |
2013-03-28 |
2023-08-12 |
mouse |
| Sébastien Dutertre, Cord-Michael Becker, Heinrich Bet. Inhibitory glycine receptors: an update. The Journal of biological chemistry. vol 287. issue 48. 2013-02-28. PMID:23038260. |
strychnine-sensitive glycine receptors (glyrs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. |
2013-02-28 |
2023-08-12 |
Not clear |
| Bohdana Hruskova, Johana Trojanova, Akos Kulik, Michaela Kralikova, Kateryna Pysanenko, Zbynek Bures, Josef Syka, Laurence O Trussell, Rostislav Turece. Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 47. 2013-02-01. PMID:23175852. |
the properties of glycine receptors (glyrs) depend upon their subunit composition. |
2013-02-01 |
2023-08-12 |
rat |
| Li Wang, Wei-Guang Li, Chen Huang, Michael X Zhu, Tian-Le Xu, Da-Zheng Wu, Yong L. Subunit-specific inhibition of glycine receptors by curcumol. The Journal of pharmacology and experimental therapeutics. vol 343. issue 2. 2012-12-31. PMID:22892339. |
emerging evidence has suggested that inhibitory glycine receptors (glyrs) are an important molecular target in the treatment of numerous neurological disorders. |
2012-12-31 |
2023-08-12 |
rat |
| Kristof Notelaers, Nick Smisdom, Susana Rocha, Daniel Janssen, Jochen C Meier, Jean-Michel Rigo, Johan Hofkens, Marcel Ameloo. Ensemble and single particle fluorimetric techniques in concerted action to study the diffusion and aggregation of the glycine receptor α3 isoforms in the cell plasma membrane. Biochimica et biophysica acta. vol 1818. issue 12. 2012-12-11. PMID:22906711. |
the spatio-temporal membrane behavior of glycine receptors (glyrs) is known to be of influence on receptor homeostasis and functionality. |
2012-12-11 |
2023-08-12 |
Not clear |
| Katrina Y Choe, James E Olson, Charles W Bourqu. Taurine release by astrocytes modulates osmosensitive glycine receptor tone and excitability in the adult supraoptic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 36. 2012-11-16. PMID:22956842. |
cells can release the free amino acid taurine through volume-regulated anion channels (vracs), and it has been hypothesized that taurine released from glial cells is capable of inhibiting action potential (ap) firing by activating neuronal glycine receptors (glyrs) (hussy et al., 1997). |
2012-11-16 |
2023-08-12 |
rat |
| Susanne Jonsson, Julia Morud, Chris Pickering, Louise Adermark, Mia Ericson, Bo Söderpal. Changes in glycine receptor subunit expression in forebrain regions of the Wistar rat over development. Brain research. vol 1446. 2012-11-13. PMID:22330726. |
glycine receptors (glyrs) are pentameric membrane proteins in the form of either α-homomers or α-β heteromers. |
2012-11-13 |
2023-08-12 |
rat |
| Natascha Schaefer, Nicolas Vogel, Carmen Villman. Glycine receptor mutants of the mouse: what are possible routes of inhibitory compensation? Frontiers in molecular neuroscience. vol 5. 2012-11-05. PMID:23118727. |
in addition to the spontaneous mutations, new insights into understanding of the regulatory pathways in hyperekplexia or glycine encephalopathy arose from the constantly increasing number of knock-out as well as knock-in mutants of glyrs. |
2012-11-05 |
2023-08-12 |
mouse |
| Stephanie C Koch, Keri K Tochiki, Stefan Hirschberg, Maria Fitzgeral. C-fiber activity-dependent maturation of glycinergic inhibition in the spinal dorsal horn of the postnatal rat. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 30. 2012-10-12. PMID:22778407. |
glycinergic inhibitory control emerges in the second postnatal week, coinciding with an expression switch from neonatal α(2) homomeric to predominantly mature α(1)/β glycine receptors (glyrs). |
2012-10-12 |
2023-08-12 |
rat |
| Timothy Lynagh, Joseph W Lync. Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin. Frontiers in molecular neuroscience. vol 5. 2012-10-02. PMID:22586367. |
higher (micromolar) concentrations of ivermectin also activate or modulate vertebrate cys-loop receptors, including the excitatory nicotinic and the inhibitory gaba type-a and glycine receptors (glyrs). |
2012-10-02 |
2023-08-12 |
caenorhabditis_elegans |